GREMLIN Database
MUTS - DNA mismatch repair protein MutS
UniProt: P49849 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 858 (786)
Sequences: 4517 (3022)
Seq/√Len: 107.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
569_E631_K5.6241.00
567_V570_G5.1731.00
306_E309_Q5.1501.00
550_S626_C5.0751.00
310_E557_K4.7271.00
444_Y476_R4.4221.00
90_T103_E4.0781.00
313_E557_K3.8141.00
559_E634_V3.7831.00
561_S634_V3.6981.00
566_E634_V3.6681.00
417_N511_L3.6451.00
279_L621_M3.6251.00
568_I632_K3.5541.00
44_E80_K3.4481.00
302_V306_E3.4311.00
207_I210_H3.2921.00
312_V546_F3.2351.00
313_E317_S3.1661.00
619_S638_F3.1391.00
399_Y402_P3.0651.00
639_D673_T3.0141.00
18_H104_V2.9981.00
469_L489_Y2.9831.00
422_E500_L2.9431.00
276_L280_D2.9391.00
546_F626_C2.9101.00
70_A74_I2.8231.00
560_F635_L2.7881.00
392_E396_E2.7331.00
415_G421_D2.7141.00
568_I631_K2.7081.00
262_L295_I2.6591.00
589_C615_I2.6351.00
302_V560_F2.5921.00
257_K262_L2.5251.00
620_I641_I2.5111.00
197_E201_T2.5031.00
568_I588_N2.5021.00
149_N220_F2.5001.00
44_E82_Y2.4981.00
281_E552_N2.4121.00
262_L624_I2.3461.00
40_K82_Y2.3451.00
325_L365_I2.3281.00
566_E590_M2.3261.00
309_Q560_F2.3161.00
618_I628_V2.3091.00
596_Q729_Q2.2891.00
141_L167_V2.2751.00
152_V244_Y2.2641.00
440_Q493_E2.2491.00
393_L522_K2.2461.00
207_I213_N2.2321.00
360_K395_E2.2251.00
302_V562_K2.1801.00
314_T374_H2.1731.00
400_E413_K2.1711.00
36_E39_K2.1451.00
204_H207_I2.1451.00
309_Q313_E2.1291.00
397_A416_Y2.1281.00
418_Q422_E2.1111.00
570_G618_I2.0861.00
306_E557_K2.0861.00
22_F33_M2.0611.00
302_V637_I2.0511.00
597_M700_I2.0451.00
326_R544_Q2.0241.00
91_E101_K2.0191.00
263_T296_D2.0191.00
436_R440_Q2.0121.00
294_W543_L2.0101.00
669_I773_L2.0061.00
420_L508_I2.0031.00
425_D429_N1.9891.00
252_I256_S1.9871.00
316_M551_E1.9811.00
51_S59_K1.9801.00
492_P496_E1.9751.00
88_E105_V1.9521.00
307_E379_E1.9481.00
207_I212_N1.9471.00
569_E588_N1.9451.00
674_K708_G1.9411.00
704_H727_L1.9411.00
313_E627_F1.9371.00
727_L730_L1.9351.00
304_Q307_E1.9331.00
464_V472_L1.9291.00
522_K525_Q1.9281.00
599_L730_L1.9221.00
128_A164_I1.9191.00
432_D436_R1.9111.00
138_G219_T1.9101.00
318_H321_E1.9091.00
398_L519_L1.9071.00
251_K640_Q1.8961.00
598_L733_V1.8951.00
282_T288_G1.8951.00
667_N671_N1.8911.00
559_E632_K1.8861.00
322_R551_E1.8821.00
466_K469_L1.8671.00
385_D529_R1.8441.00
92_D96_A1.8421.00
548_T552_N1.8411.00
210_H213_N1.8371.00
518_E522_K1.8281.00
600_I712_L1.8091.00
678_I709_A1.8021.00
566_E632_K1.8021.00
553_R577_K1.8011.00
526_Y529_R1.7931.00
128_A167_V1.7901.00
439_Q443_E1.7781.00
13_K17_E1.7761.00
294_W542_A1.7751.00
9_Q13_K1.7711.00
248_E301_R1.7681.00
441_E444_Y1.7611.00
333_Y358_S1.7561.00
571_R576_E1.7481.00
736_R751_K1.7471.00
18_H107_L1.7461.00
701_E776_R1.7461.00
128_A141_L1.7311.00
283_K326_R1.7231.00
776_R779_D1.7211.00
514_E518_E1.7151.00
205_V210_H1.7101.00
546_F624_I1.7071.00
315_L325_L1.7001.00
555_Y621_M1.6951.00
250_M300_I1.6901.00
665_A699_I1.6851.00
10_Q25_F1.6841.00
356_K395_E1.6801.00
74_I108_I1.6791.00
309_Q557_K1.6761.00
441_E477_Y1.6701.00
283_K330_K1.6691.00
265_T274_S1.6661.00
555_Y573_P1.6591.00
703_V707_I1.6521.00
453_G461_Y1.6481.00
153_L216_I1.6441.00
419_K422_E1.6441.00
397_A519_L1.6431.00
265_T270_N1.6401.00
389_D529_R1.6401.00
127_I223_L1.6391.00
305_I560_F1.6351.00
290_L542_A1.6331.00
301_R304_Q1.6331.00
390_V523_V1.6331.00
299_L304_Q1.6331.00
142_S227_L1.6291.00
290_L538_S1.6251.00
345_G521_E1.6181.00
771_G775_A1.6181.00
24_F70_A1.6171.00
376_K539_E1.6091.00
204_H212_N1.6011.00
331_E361_Q1.5891.00
780_I784_L1.5741.00
678_I703_V1.5731.00
122_S288_G1.5691.00
295_I624_I1.5671.00
570_G614_Q1.5651.00
776_R780_I1.5551.00
449_S467_A1.5551.00
569_E749_Q1.5511.00
429_N432_D1.5491.00
414_D424_R1.5491.00
326_R548_T1.5451.00
680_F683_I1.5381.00
440_Q444_Y1.5371.00
311_M376_K1.5321.00
619_S677_L1.5281.00
120_H123_E1.5261.00
195_S201_T1.5251.00
360_K391_L1.5241.00
353_I356_K1.5171.00
568_I590_M1.5141.00
465_T468_N1.5091.00
310_E313_E1.5081.00
207_I211_L1.5081.00
202_D207_I1.5041.00
208_I213_N1.4911.00
665_A680_F1.4841.00
431_K505_E1.4841.00
414_D425_D1.4821.00
163_E166_S1.4741.00
279_L549_I1.4691.00
468_N471_L1.4671.00
462_I477_Y1.4601.00
309_Q312_V1.4431.00
743_T765_Q1.4431.00
347_V351_D1.4311.00
204_H208_I1.4281.00
216_I243_V1.4251.00
704_H729_Q1.4161.00
142_S238_L1.4041.00
565_V619_S1.4011.00
279_L624_I1.3991.00
733_V752_E1.3961.00
444_Y477_Y1.3941.00
702_Y706_H1.3841.00
704_H730_L1.3831.00
12_L35_F1.3821.00
349_A411_L1.3741.00
616_A679_L1.3731.00
40_K44_E1.3721.00
202_D210_H1.3671.00
549_I553_R1.3661.00
380_R536_Q1.3621.00
447_I464_V1.3561.00
393_L519_L1.3541.00
762_H778_Q1.3501.00
65_V70_A1.3451.00
734_H751_K1.3441.00
521_E525_Q1.3381.00
55_G59_K1.3381.00
204_H210_H1.3381.00
412_I515_L1.3371.00
438_E442_R1.3340.99
78_I108_I1.3330.99
611_Y750_I1.3320.99
463_E486_A1.3310.99
695_L699_I1.3290.99
122_S280_D1.3270.99
33_M41_A1.3270.99
479_R487_E1.3270.99
567_V618_I1.3270.99
731_K752_E1.3250.99
196_I201_T1.3240.99
342_V347_V1.3210.99
589_C611_Y1.3100.99
765_Q771_G1.3030.99
352_L523_V1.3000.99
703_V711_T1.2980.99
383_R532_Q1.2940.99
302_V309_Q1.2880.99
205_V209_E1.2870.99
595_R731_K1.2850.99
128_A172_I1.2830.99
383_R539_E1.2730.99
33_M63_C1.2710.99
417_N518_E1.2710.99
311_M543_L1.2670.99
132_A175_S1.2670.99
570_G589_C1.2650.99
139_L163_E1.2650.99
306_E310_E1.2610.99
623_Q638_F1.2600.99
281_E549_I1.2550.99
41_A47_I1.2530.99
217_T221_L1.2500.99
202_D205_V1.2500.99
18_H21_A1.2480.99
595_R752_E1.2460.99
564_E636_P1.2450.99
127_I142_S1.2450.99
286_M538_S1.2440.99
205_V212_N1.2430.99
665_A683_I1.2410.99
765_Q778_Q1.2360.99
249_A297_R1.2350.99
300_I637_I1.2340.99
321_E372_L1.2340.99
24_F33_M1.2330.99
305_I309_Q1.2330.99
356_K394_L1.2300.99
597_M704_H1.2290.99
735_V750_I1.2280.99
325_L544_Q1.2220.99
198_D201_T1.2190.99
40_K43_Q1.2140.99
353_I402_P1.2110.99
567_V589_C1.2100.99
194_I199_G1.2060.99
299_L305_I1.2050.99
311_M374_H1.2040.99
130_V172_I1.2020.99
205_V208_I1.1990.99
490_I495_K1.1970.99
123_E292_K1.1960.99
17_E103_E1.1920.99
511_L514_E1.1920.99
42_S49_L1.1900.99
209_E212_N1.1890.99
195_S199_G1.1880.99
554_H631_K1.1850.99
140_A219_T1.1830.99
22_F41_A1.1810.99
328_R365_I1.1800.99
132_A137_Y1.1780.99
22_F40_K1.1780.99
349_A513_Y1.1750.99
314_T373_A1.1740.99
560_F636_P1.1740.99
92_D95_A1.1700.99
136_G153_L1.1610.99
332_V358_S1.1610.99
636_P710_K1.1580.99
151_A220_F1.1520.99
128_A169_A1.1510.98
393_L397_A1.1490.98
309_Q624_I1.1480.98
274_S277_W1.1480.98
564_E675_N1.1480.98
196_I199_G1.1470.98
367_Q370_A1.1460.98
315_L544_Q1.1430.98
148_E242_Q1.1430.98
342_V524_K1.1390.98
91_E96_A1.1390.98
437_L440_Q1.1390.98
306_E559_E1.1370.98
51_S55_G1.1360.98
129_S173_V1.1330.98
414_D428_R1.1330.98
322_R548_T1.1330.98
92_D98_G1.1260.98
449_S468_N1.1260.98
10_Q14_I1.1250.98
208_I211_L1.1130.98
204_H211_L1.1110.98
722_V725_D1.1070.98
90_T101_K1.1040.98
142_S223_L1.1010.98
322_R544_Q1.1010.98
328_R361_Q1.0970.98
71_S117_K1.0950.98
742_G778_Q1.0900.98
561_S636_P1.0880.98
16_A19_Q1.0870.98
21_A107_L1.0820.98
556_T627_F1.0810.98
701_E705_D1.0770.98
522_K526_Y1.0750.98
358_S537_M1.0660.98
259_N266_I1.0660.98
365_I537_M1.0640.97
7_M27_L1.0580.97
364_G367_Q1.0570.97
399_Y403_P1.0540.97
15_K37_D1.0530.97
426_A500_L1.0530.97
55_G58_E1.0510.97
153_L215_D1.0510.97
589_C614_Q1.0500.97
569_E586_P1.0500.97
312_V316_M1.0500.97
592_G595_R1.0460.97
257_K296_D1.0460.97
35_F60_I1.0450.97
290_L294_W1.0420.97
496_E500_L1.0400.97
737_A744_V1.0400.97
323_E548_T1.0390.97
724_E752_E1.0380.97
309_Q627_F1.0360.97
588_N749_Q1.0330.97
420_L515_L1.0310.97
7_M62_M1.0300.97
673_T676_S1.0290.97
5_T10_Q1.0270.97
206_T210_H1.0260.97
26_R88_E1.0250.97
92_D100_V1.0210.97
623_Q637_I1.0200.97
650_D655_Q1.0190.97
24_F65_V1.0180.97
85_A107_L1.0170.97
138_G153_L1.0170.97
312_V547_A1.0160.97
53_D59_K1.0160.97
264_E269_K1.0160.97
765_Q774_I1.0140.97
35_F55_G1.0110.97
294_W299_L1.0100.97
150_L242_Q1.0100.97
391_L395_E1.0080.97
130_V160_V1.0060.96
419_K507_N1.0040.96
26_R67_Y1.0010.96
543_L546_F1.0000.96
666_K670_V0.9990.96
513_Y517_T0.9940.96
557_K627_F0.9920.96
138_G216_I0.9900.96
422_E426_A0.9900.96
733_V750_I0.9900.96
250_M641_I0.9890.96
564_E710_K0.9890.96
192_A195_S0.9870.96
56_A59_K0.9850.96
433_W497_K0.9850.96
78_I113_V0.9840.96
339_A530_L0.9830.96
560_F563_D0.9810.96
316_M627_F0.9800.96
309_Q546_F0.9780.96
204_H213_N0.9770.96
721_T754_A0.9770.96
623_Q635_L0.9760.96
289_R334_D0.9760.96
27_L52_R0.9740.96
618_I633_A0.9690.96
194_I201_T0.9670.96
163_E244_Y0.9660.96
14_I104_V0.9660.96
123_E170_R0.9660.96
769_L773_L0.9650.96
256_S643_T0.9620.95
14_I23_L0.9620.95
306_E560_F0.9610.95
7_M25_F0.9550.95
13_K101_K0.9540.95
545_C549_I0.9540.95
694_A697_Q0.9530.95
294_W539_E0.9530.95
362_V537_M0.9520.95
435_A438_E0.9440.95
282_T545_C0.9440.95
516_F520_R0.9430.95
591_M598_L0.9400.95
128_A139_L0.9390.95
598_L611_Y0.9370.95
655_Q663_L0.9360.95
449_S465_T0.9350.95
257_K263_T0.9350.95
32_E64_G0.9340.95
724_E730_L0.9320.95
770_P773_L0.9320.95
672_A707_I0.9300.95
465_T469_L0.9300.95
469_L472_L0.9280.94
23_L87_C0.9280.94
191_G194_I0.9250.94
263_T276_L0.9250.94
250_M620_I0.9250.94
565_V615_I0.9240.94
173_V222_R0.9210.94
309_Q316_M0.9210.94
248_E304_Q0.9210.94
96_A99_V0.9200.94
389_D526_Y0.9200.94
744_V762_H0.9140.94
353_I357_E0.9130.94
618_I629_P0.9130.94
370_A381_A0.9120.94
133_C215_D0.9120.94
23_L85_A0.9050.94
205_V213_N0.9040.94
250_M624_I0.9000.94
619_S635_L0.9000.94
253_D640_Q0.8970.93
387_C533_L0.8970.93
455_N461_Y0.8910.93
734_H754_A0.8880.93
497_K500_L0.8880.93
265_T273_G0.8880.93
132_A135_N0.8870.93
271_K274_S0.8870.93
265_T268_S0.8860.93
93_P100_V0.8860.93
518_E521_E0.8850.93
279_L545_C0.8850.93
300_I675_N0.8830.93
51_S58_E0.8820.93
51_S56_A0.8820.93
437_L441_E0.8790.93
202_D208_I0.8770.93
734_H737_A0.8760.93
565_V636_P0.8750.93
638_F710_K0.8740.92
339_A527_I0.8720.92
372_L377_A0.8710.92
736_R749_Q0.8710.92
218_K222_R0.8700.92
314_T378_K0.8680.92
152_V163_E0.8680.92
376_K379_E0.8650.92
12_L16_A0.8640.92
395_E413_K0.8600.92
13_K16_A0.8590.92
411_L513_Y0.8570.92
312_V627_F0.8570.92
560_F637_I0.8540.92
124_N143_D0.8530.92
612_M714_S0.8530.92
316_M550_S0.8510.91
124_N148_E0.8500.91
106_Q115_D0.8430.91
440_Q476_R0.8430.91
269_K274_S0.8420.91
600_I750_I0.8410.91
194_I198_D0.8400.91
615_I677_L0.8390.91
33_M65_V0.8380.91
309_Q621_M0.8370.91
357_E360_K0.8370.91
628_V633_A0.8350.91
8_I35_F0.8350.91
151_A241_V0.8350.91
281_E545_C0.8330.91
148_E293_Q0.8320.91
305_I637_I0.8320.91
250_M623_Q0.8310.90
650_D653_S0.8300.90
39_K43_Q0.8270.90
312_V322_R0.8250.90
555_Y576_E0.8250.90
335_L530_L0.8250.90
30_F64_G0.8250.90
328_R364_G0.8250.90
197_E200_E0.8240.90
202_D212_N0.8230.90
94_K101_K0.8220.90
206_T211_L0.8220.90
130_V139_L0.8220.90
612_M615_I0.8220.90
250_M619_S0.8210.90
542_A546_F0.8200.90
192_A201_T0.8190.90
131_S218_K0.8180.90
141_L150_L0.8170.90
560_F622_A0.8160.90
694_A698_A0.8160.90
249_A299_L0.8160.90
149_N223_L0.8150.90
422_E425_D0.8150.90
775_A778_Q0.8140.90
393_L398_L0.8120.89
535_K539_E0.8110.89
412_I519_L0.8080.89
271_K276_L0.8060.89
273_G277_W0.8050.89
307_E375_D0.8040.89
208_I212_N0.8010.89
385_D389_D0.8010.89
316_M547_A0.8000.89
690_Y717_Y0.7990.89
433_W437_L0.7990.89
314_T318_H0.7980.89
642_F671_N0.7970.89
309_Q626_C0.7960.89
350_R403_P0.7950.88
239_Q531_Q0.7950.88
74_I118_G0.7950.88
36_E40_K0.7930.88
562_K675_N0.7900.88
437_L491_T0.7900.88
416_Y518_E0.7900.88
90_T94_K0.7890.88
605_M610_T0.7880.88
238_L241_V0.7860.88
290_L293_Q0.7850.88
320_F324_D0.7830.88
324_D368_L0.7830.88
39_K42_S0.7820.88
780_I783_E0.7810.88
132_A157_L0.7810.88
268_S272_K0.7800.87
426_A437_L0.7790.87
664_E713_F0.7780.87
343_A527_I0.7780.87
493_E496_E0.7760.87
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305_I454_F0.5060.57
719_E761_I0.5060.57
198_D545_C0.5060.57
42_S63_C0.5060.57
118_G252_I0.5050.57
564_E634_V0.5050.57
12_L127_I0.5050.57
463_E488_R0.5050.57
458_F461_Y0.5040.57
9_Q53_D0.5040.57
458_F490_I0.5030.57
227_L238_L0.5030.57
286_M534_A0.5020.57
53_D99_V0.5020.57
213_N217_T0.5020.57
12_L17_E0.5020.57
500_L507_N0.5020.57
126_F146_T0.5020.57
368_L371_S0.5020.57
450_L459_G0.5010.57
5_T14_I0.5010.57
411_L516_F0.5010.57
320_F323_E0.5010.57
253_D667_N0.5010.57
25_F99_V0.5000.56
437_L462_I0.5000.56
430_G497_K0.5000.56
70_A84_V0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wb9A 2 0.8963 100 0.246 Contact Map
3thxA 1 0.9184 100 0.262 Contact Map
2o8bB 1 0.8881 100 0.263 Contact Map
3thxB 1 0.9301 100 0.287 Contact Map
1ewqA 2 0.8706 100 0.291 Contact Map
4hseA 1 0.331 99.3 0.945 Contact Map
2px0A 4 0.2879 98.8 0.954 Contact Map
4uxhA 3 0.19 98.8 0.955 Contact Map
2i3bA 1 0.155 98.8 0.955 Contact Map
2r8rA 1 0.2284 98.8 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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