GREMLIN Database
ACCC1 - Biotin carboxylase 1
UniProt: P49787 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 450 (392)
Sequences: 19443 (10881)
Seq/√Len: 549.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
149_N174_E3.8901.00
145_V178_I3.3451.00
68_S72_L3.2751.00
4_K27_E3.2311.00
173_T176_E3.2211.00
257_D261_K3.1111.00
140_N143_E3.1111.00
132_P201_K2.9101.00
93_E111_S2.8891.00
62_N65_N2.8121.00
279_D284_R2.7791.00
396_T399_E2.6101.00
153_Y174_E2.5651.00
253_E257_D2.5551.00
71_K98_V2.4421.00
93_E97_E2.3921.00
172_R176_E2.3401.00
315_K320_M2.3061.00
134_S150_E2.2891.00
125_Q265_A2.2741.00
249_S253_E2.2611.00
394_G399_E2.1901.00
242_S304_V2.1021.00
123_M262_A2.0951.00
254_Q284_R2.0871.00
88_N114_G2.0651.00
260_V264_K2.0581.00
67_V98_V2.0451.00
7_I18_I2.0291.00
94_L98_V2.0161.00
147_L150_E2.0011.00
172_R204_E2.0001.00
20_A23_E1.9991.00
121_E125_Q1.9841.00
118_V121_E1.9671.00
174_E178_I1.9621.00
248_D251_I1.9531.00
395_K399_E1.9301.00
63_V94_L1.9101.00
258_A285_Y1.8911.00
258_A261_K1.8871.00
217_N269_T1.8821.00
254_Q258_A1.8411.00
178_I182_K1.8311.00
170_V202_Y1.8301.00
306_G330_E1.8271.00
204_E280_Y1.8131.00
311_K315_K1.8021.00
338_C404_M1.8021.00
312_E323_S1.7951.00
355_E379_I1.7831.00
5_L103_V1.7711.00
67_V71_K1.6591.00
147_L151_I1.6561.00
145_V174_E1.6531.00
111_S118_V1.6461.00
185_Q195_P1.6431.00
121_E124_K1.6381.00
141_V182_K1.6351.00
23_E311_K1.6191.00
78_I100_V1.6121.00
117_D121_E1.6071.00
20_A311_K1.5811.00
251_I254_Q1.5771.00
351_P354_G1.5751.00
214_L312_E1.5651.00
21_C28_T1.5601.00
141_V178_I1.5571.00
49_F69_V1.5541.00
15_V44_M1.5461.00
179_N183_I1.5451.00
306_G332_E1.5441.00
64_T94_L1.5321.00
112_K122_T1.5241.00
141_V145_V1.5161.00
65_N68_S1.5141.00
263_A266_V1.5051.00
96_E107_A1.4991.00
146_S150_E1.4951.00
398_D402_A1.4901.00
139_E143_E1.4871.00
106_S109_A1.4851.00
374_Y377_Y1.4841.00
254_Q257_D1.4811.00
134_S147_L1.4731.00
4_K29_V1.4711.00
69_V73_T1.4691.00
141_V181_I1.4451.00
253_E256_G1.4421.00
261_K264_K1.4411.00
251_I278_Y1.4381.00
22_R46_D1.4361.00
47_E73_T1.4351.00
263_A267_G1.4161.00
68_S71_K1.4051.00
146_S149_N1.3991.00
160_T196_G1.3941.00
214_L271_A1.3931.00
122_T126_A1.3901.00
122_T125_Q1.3891.00
34_E37_K1.3841.00
201_K286_Y1.3801.00
203_I288_M1.3741.00
280_Y283_Q1.3741.00
70_A100_V1.3691.00
95_C100_V1.3661.00
108_D112_K1.3641.00
101_T318_S1.3621.00
303_M393_Y1.3611.00
148_A155_V1.3581.00
27_E47_E1.3501.00
96_E106_S1.3491.00
142_E146_S1.3471.00
5_L21_C1.3401.00
406_R410_E1.3341.00
262_A267_G1.3331.00
303_M391_I1.3331.00
145_V149_N1.3321.00
94_L97_E1.3251.00
262_A265_A1.3221.00
211_I255_M1.3141.00
153_Y173_T1.3101.00
137_I196_G1.3101.00
49_F73_T1.2941.00
93_E108_D1.2921.00
120_R200_E1.2871.00
148_A153_Y1.2811.00
262_A266_V1.2791.00
5_L26_I1.2781.00
124_K132_P1.2671.00
214_L316_V1.2661.00
112_K118_V1.2611.00
119_A123_M1.2611.00
368_R371_S1.2541.00
63_V67_V1.2501.00
294_I309_L1.2471.00
143_E146_S1.2391.00
106_S269_T1.2361.00
139_E196_G1.2341.00
113_M290_M1.2211.00
122_T265_A1.2201.00
117_D137_I1.2151.00
338_C389_K1.2051.00
155_V199_I1.2001.00
32_Y37_K1.1991.00
19_R23_E1.1931.00
213_V263_A1.1921.00
249_S252_R1.1891.00
4_K47_E1.1881.00
169_R184_T1.1871.00
405_K409_S1.1821.00
355_E378_S1.1801.00
215_A221_T1.1681.00
341_N385_S1.1661.00
52_G61_L1.1641.00
43_Q374_Y1.1601.00
95_C102_F1.1571.00
70_A78_I1.1551.00
179_N182_K1.1541.00
138_I147_L1.1541.00
250_E254_Q1.1471.00
399_E403_R1.1471.00
46_D49_F1.1441.00
368_R372_A1.1431.00
18_I44_M1.1391.00
132_P151_I1.1371.00
394_G403_R1.1341.00
142_E145_V1.1301.00
141_V185_Q1.1221.00
182_K186_Q1.1201.00
124_K130_I1.1181.00
144_A181_I1.1141.00
126_A265_A1.1121.00
392_T404_M1.1111.00
256_G260_V1.1061.00
205_D280_Y1.1061.00
402_A406_R1.1021.00
78_I95_C1.0991.00
181_I197_V1.0971.00
175_E179_N1.0931.00
307_T312_E1.0911.00
373_A377_Y1.0891.00
67_V94_L1.0871.00
120_R130_I1.0821.00
354_G358_M1.0811.00
370_D373_A1.0761.00
213_V274_V1.0711.00
406_R409_S1.0701.00
115_T160_T1.0691.00
401_I405_K1.0681.00
252_R256_G1.0641.00
390_V407_A1.0621.00
121_E133_G1.0621.00
375_P379_I1.0581.00
390_V411_F1.0561.00
144_A177_L1.0541.00
356_I373_A1.0521.00
156_I170_V1.0511.00
17_I79_H1.0501.00
123_M287_F1.0471.00
108_D111_S1.0471.00
224_L227_R1.0461.00
24_L315_K1.0461.00
247_L251_I1.0461.00
209_V278_Y1.0431.00
45_A48_A1.0421.00
376_G379_I1.0401.00
30_A41_H1.0361.00
218_Y321_E1.0331.00
403_R406_R1.0321.00
93_E107_A1.0321.00
29_V33_S1.0311.00
149_N178_I1.0301.00
96_E269_T1.0141.00
334_W395_K1.0121.00
129_P284_R1.0121.00
211_I256_G1.0091.00
339_R342_A1.0061.00
26_I318_S1.0051.00
373_A376_G1.0031.00
361_P411_F1.0001.00
248_D283_Q0.9981.00
176_E179_N0.9971.00
101_T217_N0.9931.00
92_A102_F0.9881.00
63_V91_F0.9831.00
124_K134_S0.9821.00
117_D160_T0.9791.00
67_V97_E0.9741.00
250_E253_E0.9741.00
151_I155_V0.9661.00
37_K40_L0.9661.00
138_I144_A0.9611.00
363_G366_G0.9591.00
5_L314_I0.9571.00
157_I197_V0.9571.00
66_I95_C0.9461.00
347_K350_M0.9421.00
175_E178_I0.9391.00
156_I202_Y0.9371.00
64_T68_S0.9371.00
21_C314_I0.9361.00
264_K267_G0.9341.00
280_Y284_R0.9341.00
169_R180_G0.9331.00
341_N408_L0.9321.00
129_P258_A0.9321.00
220_N223_H0.9301.00
134_S138_I0.9291.00
4_K76_D0.9281.00
407_A410_E0.9231.00
69_V75_T0.9171.00
312_E315_K0.9141.00
21_C79_H0.9121.00
246_A278_Y0.9121.00
224_L228_D0.9101.00
26_I29_V0.9101.00
375_P378_S0.9081.00
161_A194_N0.9061.00
204_E279_D0.9041.00
314_I318_S0.9041.00
128_V287_F0.9011.00
278_Y285_Y0.9001.00
6_L70_A0.8961.00
79_H313_Q0.8951.00
24_L308_D0.8951.00
201_K284_R0.8931.00
358_M362_P0.8931.00
124_K133_G0.8841.00
181_I185_Q0.8821.00
255_M258_A0.8781.00
18_I45_A0.8761.00
24_L311_K0.8751.00
336_I400_A0.8731.00
30_A45_A0.8681.00
138_I143_E0.8641.00
222_I324_L0.8621.00
169_R183_I0.8621.00
225_G228_D0.8611.00
31_V51_I0.8581.00
32_Y48_A0.8571.00
302_E391_I0.8571.00
148_A181_I0.8531.00
145_V182_K0.8531.00
106_S267_G0.8521.00
25_G311_K0.8511.00
95_C98_V0.8491.00
153_Y177_L0.8471.00
91_F95_C0.8451.00
274_V290_M0.8441.00
369_V388_A0.8361.00
34_E38_D0.8341.00
30_A34_E0.8321.00
117_D196_G0.8301.00
394_G400_A0.8291.00
203_I286_Y0.8271.00
7_I21_C0.8261.00
255_M285_Y0.8251.00
103_V314_I0.8251.00
132_P150_E0.8241.00
6_L31_V0.8231.00
334_W393_Y0.8231.00
18_I28_T0.8221.00
220_N264_K0.8201.00
171_A180_G0.8151.00
226_E244_S0.8151.00
143_E147_L0.8141.00
358_M412_V0.8131.00
332_E393_Y0.8131.00
84_F89_A0.8131.00
215_A263_A0.8081.00
221_T260_V0.8081.00
226_E252_R0.8071.00
32_Y35_A0.8051.00
299_P302_E0.8041.00
211_I259_A0.8041.00
148_A152_G0.8011.00
157_I181_I0.8001.00
320_M324_L0.7921.00
254_Q285_Y0.7911.00
392_T407_A0.7901.00
157_I180_G0.7871.00
219_G264_K0.7811.00
115_T196_G0.7811.00
144_A199_I0.7791.00
109_A269_T0.7771.00
29_V34_E0.7771.00
325_K328_D0.7761.00
8_A91_F0.7751.00
70_A95_C0.7681.00
214_L223_H0.7661.00
28_T32_Y0.7631.00
218_Y267_G0.7611.00
358_M375_P0.7601.00
399_E402_A0.7551.00
148_A177_L0.7541.00
261_K265_A0.7521.00
259_A263_A0.7481.00
22_R28_T0.7481.00
33_S37_K0.7481.00
134_S143_E0.7471.00
357_K412_V0.7451.00
367_V392_T0.7441.00
4_K73_T0.7431.00
15_V41_H0.7431.00
259_A276_F0.7431.00
215_A264_K0.7371.00
263_A272_G0.7351.00
141_V177_L0.7341.00
183_I186_Q0.7331.00
90_D111_S0.7321.00
283_Q286_Y0.7301.00
30_A33_S0.7291.00
367_V407_A0.7281.00
156_I168_I0.7271.00
356_I359_Y0.7271.00
355_E358_M0.7271.00
93_E96_E0.7261.00
369_V372_A0.7251.00
240_E300_V0.7231.00
338_C341_N0.7221.00
315_K318_S0.7221.00
223_H256_G0.7211.00
242_S300_V0.7211.00
51_I69_V0.7201.00
155_V171_A0.7201.00
120_R131_V0.7161.00
339_R343_E0.7151.00
358_M361_P0.7151.00
359_Y380_P0.7141.00
27_E46_D0.7141.00
4_K74_G0.7131.00
113_M266_V0.7121.00
331_F334_W0.7121.00
277_I288_M0.7111.00
92_A96_E0.7101.00
71_K97_E0.7091.00
45_A49_F0.7091.00
212_Q271_A0.7081.00
337_E342_A0.7051.00
90_D94_L0.7031.00
241_E397_R0.7011.00
257_D260_V0.7001.00
215_A269_T0.6961.00
28_T33_S0.6951.00
4_K28_T0.6901.00
157_I171_A0.6871.00
313_Q317_A0.6851.00
261_K266_V0.6831.00
227_R241_E0.6821.00
117_D198_Y0.6811.00
343_E354_G0.6791.00
192_F195_P0.6761.00
207_R278_Y0.6741.00
96_E108_D0.6731.00
29_V32_Y0.6721.00
96_E102_F0.6711.00
362_P366_G0.6691.00
269_T316_V0.6671.00
247_L252_R0.6671.00
279_D286_Y0.6651.00
107_A111_S0.6641.00
21_C26_I0.6641.00
359_Y362_P0.6641.00
19_R369_V0.6631.00
239_L338_C0.6611.00
149_N153_Y0.6611.00
151_I201_K0.6611.00
24_L314_I0.6611.00
209_V244_S0.6601.00
213_V259_A0.6591.00
131_V203_I0.6591.00
409_S412_V0.6581.00
215_A219_G0.6581.00
372_A377_Y0.6581.00
218_Y319_G0.6581.00
382_Y413_I0.6571.00
67_V100_V0.6551.00
115_T161_A0.6541.00
35_A38_D0.6521.00
68_S98_V0.6521.00
304_V331_F0.6491.00
337_E401_I0.6481.00
360_L412_V0.6481.00
213_V272_G0.6471.00
203_I279_D0.6471.00
300_V303_M0.6471.00
92_A95_C0.6441.00
28_T47_E0.6441.00
61_L91_F0.6431.00
171_A176_E0.6431.00
121_E137_I0.6411.00
324_L328_D0.6371.00
225_G304_V0.6371.00
362_P407_A0.6351.00
101_T269_T0.6341.00
25_G314_I0.6341.00
228_D244_S0.6341.00
392_T400_A0.6331.00
31_V66_I0.6311.00
397_R401_I0.6311.00
259_A274_V0.6301.00
330_E333_G0.6241.00
336_I401_I0.6241.00
20_A24_L0.6241.00
359_Y411_F0.6231.00
349_F352_S0.6231.00
65_N69_V0.6221.00
157_I199_I0.6221.00
180_G184_T0.6191.00
327_E330_E0.6181.00
207_R246_A0.6171.00
312_E324_L0.6171.00
337_E341_N0.6171.00
8_A66_I0.6161.00
255_M259_A0.6141.00
305_T331_F0.6141.00
30_A35_A0.6141.00
352_S356_I0.6121.00
206_F280_Y0.6121.00
34_E53_P0.6071.00
6_L75_T0.6071.00
185_Q197_V0.6071.00
148_A151_I0.6041.00
5_L310_I0.6041.00
356_I361_P0.6031.00
268_Y272_G0.6021.00
184_T197_V0.6011.00
109_A267_G0.6011.00
118_V122_T0.6001.00
388_A411_F0.6001.00
244_S247_L0.5991.00
268_Y292_T0.5981.00
115_T118_V0.5981.00
363_G367_V0.5961.00
141_V144_A0.5951.00
344_N347_K0.5941.00
160_T198_Y0.5941.00
83_G86_A0.5941.00
152_G174_E0.5941.00
369_V411_F0.5941.00
336_I341_N0.5931.00
171_A177_L0.5921.00
74_G98_V0.5921.00
237_K240_E0.5911.00
148_A199_I0.5881.00
172_R202_Y0.5881.00
258_A262_A0.5851.00
398_D401_I0.5851.00
131_V288_M0.5831.00
404_M408_L0.5831.00
112_K125_Q0.5820.99
216_D219_G0.5820.99
328_D331_F0.5810.99
34_E39_A0.5810.99
223_H260_V0.5800.99
216_D322_L0.5800.99
225_G331_F0.5790.99
180_G183_I0.5790.99
309_L313_Q0.5790.99
157_I177_L0.5770.99
15_V40_L0.5770.99
258_A276_F0.5740.99
327_E331_F0.5740.99
13_I294_I0.5730.99
360_L375_P0.5730.99
219_G222_I0.5720.99
232_Q237_K0.5710.99
315_K323_S0.5700.99
31_V38_D0.5700.99
84_F88_N0.5690.99
66_I78_I0.5670.99
106_S217_N0.5660.99
216_D220_N0.5650.99
31_V34_E0.5650.99
25_G29_V0.5640.99
36_D39_A0.5630.99
225_G329_V0.5620.99
40_L374_Y0.5620.99
365_L403_R0.5620.99
138_I199_I0.5600.99
299_P337_E0.5600.99
314_I317_A0.5590.99
134_S137_I0.5580.99
324_L329_V0.5580.99
248_D278_Y0.5570.99
215_A220_N0.5560.99
355_E359_Y0.5550.99
350_M353_P0.5550.99
33_S36_D0.5550.99
364_G403_R0.5540.99
89_A111_S0.5520.99
70_A75_T0.5510.99
78_I102_F0.5490.99
112_K292_T0.5490.99
155_V201_K0.5480.99
340_I343_E0.5470.99
122_T266_V0.5460.99
289_E293_R0.5450.99
101_T314_I0.5450.99
402_A405_K0.5440.99
116_K158_K0.5440.99
44_M48_A0.5440.99
166_K191_A0.5410.99
256_G259_A0.5410.99
123_M128_V0.5400.99
140_N181_I0.5390.99
168_I235_L0.5380.99
251_I283_Q0.5370.99
27_E30_A0.5360.99
366_G403_R0.5360.99
254_Q261_K0.5360.99
31_V35_A0.5350.99
373_A379_I0.5340.99
250_E283_Q0.5310.99
279_D283_Q0.5300.99
176_E180_G0.5290.99
120_R124_K0.5280.99
209_V247_L0.5280.99
83_G164_G0.5280.99
25_G28_T0.5260.99
386_M391_I0.5260.99
386_M389_K0.5260.99
316_V322_L0.5230.99
224_L304_V0.5230.99
219_G223_H0.5210.99
77_A317_A0.5210.99
119_A287_F0.5210.99
361_P410_E0.5190.99
71_K100_V0.5190.99
35_A39_A0.5180.99
147_L199_I0.5170.99
153_Y172_R0.5170.99
30_A73_T0.5150.99
262_A290_M0.5130.99
63_V88_N0.5120.99
142_E178_I0.5090.99
80_P102_F0.5090.99
224_L305_T0.5080.99
76_D101_T0.5080.99
29_V47_E0.5060.99
271_A294_I0.5040.99
144_A147_L0.5030.99
225_G229_C0.5010.99
333_G393_Y0.5010.99
170_V235_L0.5000.98
207_R244_S0.5000.98
307_T323_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3n6rA 1 0.84 100 0.31 Contact Map
3va7A 1 0.8356 100 0.316 Contact Map
3u9tA 3 0.9667 100 0.317 Contact Map
2qf7A 4 0.8933 100 0.322 Contact Map
4qshA 4 0.8578 100 0.325 Contact Map
4rcnA 6 0.9089 100 0.327 Contact Map
3hblA 4 0.9956 100 0.336 Contact Map
3jrxA 1 0.9267 100 0.339 Contact Map
4mv4A 2 0.9733 100 0.34 Contact Map
2vpqA 2 0.9911 100 0.344 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0127 seconds.