BCCP - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

BCCP - Biotin carboxyl carrier protein of acetyl-CoA carboxylase

UniProt:	P49786	Sequences: MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVMQQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGPYVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	159 (151)
Sequences:	3408 (2745)
Seq/√Len:	223.4

ECOLI - BCCP
BACSU - BCCP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
25_E	30_S	4.062	1.00
112_E	133_K	3.409	1.00
105_T	108_S	3.138	1.00
85_T	150_G	3.023	1.00
109_K	135_E	2.736	1.00
111_N	133_K	2.721	1.00
94_A	105_T	2.716	1.00
135_E	157_K	2.668	1.00
138_E	155_L	2.658	1.00
142_E	145_Q	2.644	1.00
23_V	32_K	2.614	1.00
21_E	34_K	2.518	1.00
118_I	125_F	2.488	1.00
97_S	100_A	2.277	1.00
82_H	132_V	2.188	1.00
3_N	6_E	2.133	1.00
83_K	155_L	2.130	1.00
137_V	157_K	2.053	1.00
111_N	114_T	2.027	1.00
148_E	151_Q	2.021	1.00
101_G	105_T	2.011	1.00
82_H	131_E	2.004	1.00
83_K	152_P	2.004	1.00
140_L	152_P	1.977	1.00
106_A	138_E	1.936	1.00
20_D	36_H	1.920	1.00
95_S	143_N	1.894	1.00
14_I	33_L	1.825	1.00
14_I	22_F	1.812	1.00
15_D	18_T	1.791	1.00
139_V	154_F	1.677	1.00
23_V	30_S	1.615	1.00
108_S	114_T	1.610	1.00
136_I	154_F	1.600	1.00
86_S	119_V	1.577	1.00
104_V	154_F	1.546	1.00
81_L	155_L	1.496	1.00
134_G	156_V	1.454	1.00
89_V	149_Y	1.407	1.00
5_K	9_E	1.367	1.00
95_S	102_P	1.340	1.00
117_C	154_F	1.336	1.00
140_L	155_L	1.326	1.00
94_A	143_N	1.318	1.00
92_F	117_C	1.311	1.00
19_I	33_L	1.279	1.00
84_I	156_V	1.265	1.00
116_V	154_F	1.210	1.00
21_E	32_K	1.201	1.00
20_D	37_E	1.193	1.00
94_A	142_E	1.176	1.00
8_H	13_A	1.157	1.00
84_I	116_V	1.146	1.00
80_N	157_K	1.143	1.00
78_D	81_L	1.135	1.00
130_A	134_G	1.133	1.00
9_E	12_K	1.130	1.00
14_I	17_S	1.123	1.00
137_V	155_L	1.119	1.00
124_L	150_G	1.097	1.00
96_S	103_Y	1.077	1.00
26_N	29_V	1.069	1.00
15_D	35_K	1.037	1.00
141_V	151_Q	1.030	1.00
124_L	129_E	1.026	1.00
145_Q	151_Q	1.025	1.00
44_M	47_A	1.023	1.00
106_A	139_V	1.019	1.00
96_S	100_A	1.018	1.00
11_I	19_I	1.007	1.00
11_I	33_L	0.963	1.00
104_V	136_I	0.955	1.00
132_V	156_V	0.949	1.00
115_V	127_E	0.941	1.00
103_Y	115_V	0.931	1.00
95_S	99_E	0.928	1.00
25_E	28_G	0.924	1.00
86_S	126_N	0.907	0.99
8_H	12_K	0.906	0.99
113_N	131_E	0.895	0.99
43_V	46_Q	0.892	0.99
98_P	103_Y	0.889	0.99
121_A	126_N	0.874	0.99
12_K	15_D	0.874	0.99
4_I	9_E	0.871	0.99
47_A	51_P	0.864	0.99
13_A	31_L	0.862	0.99
12_K	16_E	0.856	0.99
66_Q	69_A	0.848	0.99
103_Y	118_I	0.845	0.99
125_F	143_N	0.838	0.99
115_V	129_E	0.836	0.99
104_V	114_T	0.831	0.99
112_E	130_A	0.829	0.99
109_K	133_K	0.824	0.99
5_K	8_H	0.820	0.99
104_V	139_V	0.818	0.99
6_E	9_E	0.816	0.99
48_P	51_P	0.815	0.99
7_I	22_F	0.813	0.99
81_L	137_V	0.807	0.99
37_E	40_T	0.804	0.99
122_M	126_N	0.802	0.99
118_I	126_N	0.801	0.99
11_I	17_S	0.801	0.99
8_H	16_E	0.798	0.99
11_I	14_I	0.797	0.99
124_L	127_E	0.794	0.99
4_I	7_I	0.779	0.98
25_E	29_V	0.770	0.98
20_D	34_K	0.769	0.98
121_A	127_E	0.768	0.98
64_A	70_P	0.764	0.98
70_P	73_E	0.760	0.98
117_C	127_E	0.759	0.98
136_I	156_V	0.750	0.98
7_I	127_E	0.744	0.98
18_T	35_K	0.743	0.98
45_Q	49_A	0.742	0.98
43_V	47_A	0.739	0.98
88_M	91_T	0.737	0.98
4_I	12_K	0.735	0.98
62_P	67_A	0.735	0.98
112_E	132_V	0.722	0.97
44_M	76_K	0.720	0.97
14_I	124_L	0.710	0.97
17_S	33_L	0.709	0.97
120_E	123_K	0.706	0.97
140_L	151_Q	0.705	0.97
94_A	102_P	0.704	0.97
14_I	35_K	0.704	0.97
47_A	50_A	0.698	0.97
113_N	130_A	0.688	0.96
70_P	74_A	0.688	0.96
24_Y	29_V	0.685	0.96
44_M	48_P	0.683	0.96
56_A	59_A	0.682	0.96
91_T	118_I	0.671	0.96
80_N	155_L	0.660	0.95
37_E	41_V	0.655	0.95
93_Y	125_F	0.653	0.95
67_A	73_E	0.652	0.95
117_C	153_L	0.652	0.95
10_L	17_S	0.652	0.95
98_P	123_K	0.651	0.95
88_M	121_A	0.650	0.95
56_A	60_V	0.647	0.95
88_M	122_M	0.646	0.95
60_V	63_Q	0.645	0.95
88_M	126_N	0.645	0.95
36_H	40_T	0.643	0.95
95_S	125_F	0.641	0.95
66_Q	71_A	0.641	0.95
82_H	156_V	0.640	0.95
86_S	89_V	0.639	0.95
130_A	133_K	0.639	0.95
7_I	124_L	0.639	0.95
46_Q	49_A	0.619	0.94
113_N	116_V	0.617	0.93
92_F	131_E	0.615	0.93
104_V	108_S	0.615	0.93
130_A	136_I	0.614	0.93
20_D	38_A	0.607	0.93
9_E	15_D	0.598	0.92
79_E	83_K	0.597	0.92
88_M	124_L	0.597	0.92
14_I	19_I	0.596	0.92
38_A	42_Q	0.593	0.92
68_A	71_A	0.587	0.92
57_P	60_V	0.586	0.92
45_Q	48_P	0.586	0.92
66_Q	70_P	0.585	0.92
65_Q	68_A	0.583	0.91
92_F	104_V	0.582	0.91
60_V	72_Q	0.582	0.91
6_E	11_I	0.582	0.91
61_Q	73_E	0.578	0.91
43_V	50_A	0.578	0.91
118_I	124_L	0.574	0.91
7_I	10_L	0.573	0.91
81_L	157_K	0.571	0.91
85_T	152_P	0.570	0.90
123_K	126_N	0.566	0.90
102_P	105_T	0.566	0.90
57_P	76_K	0.561	0.90
110_V	156_V	0.558	0.90
92_F	124_L	0.557	0.89
61_Q	64_A	0.556	0.89
103_Y	140_L	0.555	0.89
127_E	149_Y	0.555	0.89
63_Q	66_Q	0.554	0.89
98_P	118_I	0.551	0.89
89_V	148_E	0.551	0.89
69_A	72_Q	0.550	0.89
69_A	74_A	0.547	0.89
119_V	149_Y	0.547	0.89
36_H	39_G	0.542	0.88
32_K	35_K	0.541	0.88
118_I	128_I	0.538	0.88
43_V	48_P	0.536	0.88
84_I	131_E	0.535	0.87
152_P	155_L	0.534	0.87
134_G	151_Q	0.533	0.87
59_A	67_A	0.528	0.87
82_H	116_V	0.528	0.87
31_L	35_K	0.527	0.87
102_P	144_G	0.526	0.87
93_Y	103_Y	0.523	0.86
95_S	118_I	0.521	0.86
129_E	146_L	0.517	0.86
24_Y	88_M	0.514	0.85
17_S	26_N	0.514	0.85
76_K	81_L	0.514	0.85
146_L	149_Y	0.513	0.85
93_Y	146_L	0.511	0.85
117_C	131_E	0.511	0.85
117_C	124_L	0.511	0.85
58_Q	71_A	0.509	0.85
91_T	126_N	0.507	0.85
86_S	92_F	0.506	0.84
117_C	129_E	0.502	0.84
4_I	33_L	0.502	0.84
42_Q	45_Q	0.501	0.84
63_Q	73_E	0.501	0.84
13_A	29_V	0.500	0.84
92_F	141_V	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4hr7B	1	0.5031	100	0.291	Contact Map
3va7A	1	0.8868	99.9	0.556	Contact Map
3hblA	4	0.7799	99.8	0.588	Contact Map
2qf7A	4	0.7421	99.8	0.59	Contact Map
4qshA	4	0.761	99.8	0.591	Contact Map
3bg3A	4	0.7484	99.8	0.599	Contact Map
4rcnA	6	0.7484	99.8	0.61	Contact Map
3n6rA	1	0.8805	99.7	0.628	Contact Map
5a35A	1	0.5283	99.7	0.629	Contact Map
3u9tA	3	0.3836	99.7	0.631	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0064 seconds.