GREMLIN Database
BCCP - Biotin carboxyl carrier protein of acetyl-CoA carboxylase
UniProt: P49786 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 159 (151)
Sequences: 3408 (2745)
Seq/√Len: 223.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_E30_S4.0621.00
112_E133_K3.4091.00
105_T108_S3.1381.00
85_T150_G3.0231.00
109_K135_E2.7361.00
111_N133_K2.7211.00
94_A105_T2.7161.00
135_E157_K2.6681.00
138_E155_L2.6581.00
142_E145_Q2.6441.00
23_V32_K2.6141.00
21_E34_K2.5181.00
118_I125_F2.4881.00
97_S100_A2.2771.00
82_H132_V2.1881.00
3_N6_E2.1331.00
83_K155_L2.1301.00
137_V157_K2.0531.00
111_N114_T2.0271.00
148_E151_Q2.0211.00
101_G105_T2.0111.00
82_H131_E2.0041.00
83_K152_P2.0041.00
140_L152_P1.9771.00
106_A138_E1.9361.00
20_D36_H1.9201.00
95_S143_N1.8941.00
14_I33_L1.8251.00
14_I22_F1.8121.00
15_D18_T1.7911.00
139_V154_F1.6771.00
23_V30_S1.6151.00
108_S114_T1.6101.00
136_I154_F1.6001.00
86_S119_V1.5771.00
104_V154_F1.5461.00
81_L155_L1.4961.00
134_G156_V1.4541.00
89_V149_Y1.4071.00
5_K9_E1.3671.00
95_S102_P1.3401.00
117_C154_F1.3361.00
140_L155_L1.3261.00
94_A143_N1.3181.00
92_F117_C1.3111.00
19_I33_L1.2791.00
84_I156_V1.2651.00
116_V154_F1.2101.00
21_E32_K1.2011.00
20_D37_E1.1931.00
94_A142_E1.1761.00
8_H13_A1.1571.00
84_I116_V1.1461.00
80_N157_K1.1431.00
78_D81_L1.1351.00
130_A134_G1.1331.00
9_E12_K1.1301.00
14_I17_S1.1231.00
137_V155_L1.1191.00
124_L150_G1.0971.00
96_S103_Y1.0771.00
26_N29_V1.0691.00
15_D35_K1.0371.00
141_V151_Q1.0301.00
124_L129_E1.0261.00
145_Q151_Q1.0251.00
44_M47_A1.0231.00
106_A139_V1.0191.00
96_S100_A1.0181.00
11_I19_I1.0071.00
11_I33_L0.9631.00
104_V136_I0.9551.00
132_V156_V0.9491.00
115_V127_E0.9411.00
103_Y115_V0.9311.00
95_S99_E0.9281.00
25_E28_G0.9241.00
86_S126_N0.9070.99
8_H12_K0.9060.99
113_N131_E0.8950.99
43_V46_Q0.8920.99
98_P103_Y0.8890.99
121_A126_N0.8740.99
12_K15_D0.8740.99
4_I9_E0.8710.99
47_A51_P0.8640.99
13_A31_L0.8620.99
12_K16_E0.8560.99
66_Q69_A0.8480.99
103_Y118_I0.8450.99
125_F143_N0.8380.99
115_V129_E0.8360.99
104_V114_T0.8310.99
112_E130_A0.8290.99
109_K133_K0.8240.99
5_K8_H0.8200.99
104_V139_V0.8180.99
6_E9_E0.8160.99
48_P51_P0.8150.99
7_I22_F0.8130.99
81_L137_V0.8070.99
37_E40_T0.8040.99
122_M126_N0.8020.99
118_I126_N0.8010.99
11_I17_S0.8010.99
8_H16_E0.7980.99
11_I14_I0.7970.99
124_L127_E0.7940.99
4_I7_I0.7790.98
25_E29_V0.7700.98
20_D34_K0.7690.98
121_A127_E0.7680.98
64_A70_P0.7640.98
70_P73_E0.7600.98
117_C127_E0.7590.98
136_I156_V0.7500.98
7_I127_E0.7440.98
18_T35_K0.7430.98
45_Q49_A0.7420.98
43_V47_A0.7390.98
88_M91_T0.7370.98
4_I12_K0.7350.98
62_P67_A0.7350.98
112_E132_V0.7220.97
44_M76_K0.7200.97
14_I124_L0.7100.97
17_S33_L0.7090.97
120_E123_K0.7060.97
140_L151_Q0.7050.97
94_A102_P0.7040.97
14_I35_K0.7040.97
47_A50_A0.6980.97
113_N130_A0.6880.96
70_P74_A0.6880.96
24_Y29_V0.6850.96
44_M48_P0.6830.96
56_A59_A0.6820.96
91_T118_I0.6710.96
80_N155_L0.6600.95
37_E41_V0.6550.95
93_Y125_F0.6530.95
67_A73_E0.6520.95
117_C153_L0.6520.95
10_L17_S0.6520.95
98_P123_K0.6510.95
88_M121_A0.6500.95
56_A60_V0.6470.95
88_M122_M0.6460.95
60_V63_Q0.6450.95
88_M126_N0.6450.95
36_H40_T0.6430.95
95_S125_F0.6410.95
66_Q71_A0.6410.95
82_H156_V0.6400.95
86_S89_V0.6390.95
130_A133_K0.6390.95
7_I124_L0.6390.95
46_Q49_A0.6190.94
113_N116_V0.6170.93
92_F131_E0.6150.93
104_V108_S0.6150.93
130_A136_I0.6140.93
20_D38_A0.6070.93
9_E15_D0.5980.92
79_E83_K0.5970.92
88_M124_L0.5970.92
14_I19_I0.5960.92
38_A42_Q0.5930.92
68_A71_A0.5870.92
57_P60_V0.5860.92
45_Q48_P0.5860.92
66_Q70_P0.5850.92
65_Q68_A0.5830.91
92_F104_V0.5820.91
60_V72_Q0.5820.91
6_E11_I0.5820.91
61_Q73_E0.5780.91
43_V50_A0.5780.91
118_I124_L0.5740.91
7_I10_L0.5730.91
81_L157_K0.5710.91
85_T152_P0.5700.90
123_K126_N0.5660.90
102_P105_T0.5660.90
57_P76_K0.5610.90
110_V156_V0.5580.90
92_F124_L0.5570.89
61_Q64_A0.5560.89
103_Y140_L0.5550.89
127_E149_Y0.5550.89
63_Q66_Q0.5540.89
98_P118_I0.5510.89
89_V148_E0.5510.89
69_A72_Q0.5500.89
69_A74_A0.5470.89
119_V149_Y0.5470.89
36_H39_G0.5420.88
32_K35_K0.5410.88
118_I128_I0.5380.88
43_V48_P0.5360.88
84_I131_E0.5350.87
152_P155_L0.5340.87
134_G151_Q0.5330.87
59_A67_A0.5280.87
82_H116_V0.5280.87
31_L35_K0.5270.87
102_P144_G0.5260.87
93_Y103_Y0.5230.86
95_S118_I0.5210.86
129_E146_L0.5170.86
24_Y88_M0.5140.85
17_S26_N0.5140.85
76_K81_L0.5140.85
146_L149_Y0.5130.85
93_Y146_L0.5110.85
117_C131_E0.5110.85
117_C124_L0.5110.85
58_Q71_A0.5090.85
91_T126_N0.5070.85
86_S92_F0.5060.84
117_C129_E0.5020.84
4_I33_L0.5020.84
42_Q45_Q0.5010.84
63_Q73_E0.5010.84
13_A29_V0.5000.84
92_F141_V0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hr7B 1 0.5031 100 0.291 Contact Map
3va7A 1 0.8868 99.9 0.556 Contact Map
3hblA 4 0.7799 99.8 0.588 Contact Map
2qf7A 4 0.7421 99.8 0.59 Contact Map
4qshA 4 0.761 99.8 0.591 Contact Map
3bg3A 4 0.7484 99.8 0.599 Contact Map
4rcnA 6 0.7484 99.8 0.61 Contact Map
3n6rA 1 0.8805 99.7 0.628 Contact Map
5a35A 1 0.5283 99.7 0.629 Contact Map
3u9tA 3 0.3836 99.7 0.631 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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