GREMLIN Database
SP3AH - Stage III sporulation protein AH
UniProt: P49785 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 218 (200)
Sequences: 283 (263)
Seq/√Len: 18.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
117_R155_E4.2441.00
6_T9_L3.2110.99
92_E95_T3.1620.99
154_T205_K2.8270.98
183_V196_I2.7730.98
4_K10_L2.5800.97
134_T137_E2.5690.97
93_K98_T2.4260.96
95_T98_T2.3270.95
93_K96_V2.2210.93
20_S23_Y2.2080.93
162_I181_I2.1840.93
79_D136_K2.1190.92
91_S94_G2.1140.92
181_I200_V2.1010.91
5_Q12_M2.0860.91
117_R172_V2.0680.91
5_Q9_L2.0050.89
92_E96_V1.9980.89
151_V174_A1.9380.87
4_K110_R1.8830.86
176_G192_K1.8500.85
5_Q20_S1.8450.85
174_A179_I1.7920.83
16_V25_M1.7670.82
5_Q14_S1.7220.80
5_Q23_Y1.7200.80
9_L23_Y1.7060.80
153_G182_T1.7010.79
12_M19_L1.6990.79
5_Q19_L1.6850.79
71_E76_G1.6790.78
6_T20_S1.6380.77
128_V141_A1.6270.76
59_K79_D1.6250.76
73_G81_S1.5890.74
17_V20_S1.5830.74
121_R172_V1.5790.74
179_I208_K1.5530.73
113_L159_E1.5370.72
90_A93_K1.5350.72
72_D77_T1.5330.72
25_M28_E1.5300.72
12_M23_Y1.5020.70
86_T89_E1.4970.70
131_D134_T1.4720.69
124_L198_D1.4720.69
56_Q72_D1.4650.68
6_T19_L1.4560.68
155_E204_I1.4520.67
104_D108_T1.4210.66
59_K68_K1.3930.64
195_A202_K1.3930.64
169_D210_V1.3840.64
27_P118_S1.3700.63
74_T84_K1.3650.62
193_A197_I1.3640.62
141_A172_V1.3530.62
6_T18_V1.3510.62
74_T77_T1.3490.62
125_N129_S1.3320.61
114_E162_I1.3320.61
14_S20_S1.3240.60
38_E41_A1.3240.60
176_G208_K1.3230.60
68_K71_E1.3170.60
6_T23_Y1.3090.59
61_K79_D1.3080.59
21_V25_M1.3020.59
63_G67_E1.3010.59
9_L12_M1.2910.58
160_T163_K1.2830.58
20_S24_I1.2790.57
183_V188_H1.2760.57
124_L154_T1.2410.55
106_F193_A1.2270.54
92_E98_T1.2130.53
135_A146_T1.2110.53
14_S18_V1.1820.51
120_E124_L1.1810.51
6_T12_M1.1810.51
125_N162_I1.1810.51
110_R169_D1.1780.51
64_T80_S1.1670.50
9_L210_V1.1350.48
69_G72_D1.1250.48
16_V21_V1.1240.48
41_A79_D1.1190.47
66_T70_K1.1130.47
58_T72_D1.1040.46
12_M20_S1.0970.46
122_E177_D1.0920.46
163_K169_D1.0830.45
10_L130_S1.0750.45
64_T68_K1.0550.43
9_L113_L1.0510.43
40_S73_G1.0460.43
150_E183_V1.0440.43
133_A142_Y1.0400.42
4_K7_V1.0380.42
150_E177_D1.0340.42
97_V100_T1.0320.42
10_L16_V1.0260.42
57_D75_K1.0140.41
59_K64_T1.0030.40
105_L210_V0.9910.40
167_Y193_A0.9860.39
5_Q24_I0.9850.39
13_L196_I0.9830.39
72_D75_K0.9790.39
155_E172_V0.9770.39
17_V26_S0.9750.39
58_T68_K0.9710.38
153_G197_I0.9640.38
58_T80_S0.9630.38
10_L21_V0.9630.38
3_K26_S0.9620.38
41_A70_K0.9610.38
21_V24_I0.9610.38
60_E67_E0.9540.37
16_V162_I0.9360.36
21_V27_P0.9320.36
63_G66_T0.9290.36
137_E181_I0.9210.35
43_D55_K0.9110.35
18_V197_I0.9040.34
58_T63_G0.8970.34
180_N203_E0.8850.33
14_S21_V0.8820.33
76_G79_D0.8800.33
11_T18_V0.8790.33
71_E75_K0.8780.33
60_E70_K0.8770.33
74_T78_K0.8730.33
114_E118_S0.8710.33
34_Q75_K0.8660.32
91_S95_T0.8650.32
73_G79_D0.8510.32
16_V24_I0.8400.31
74_T85_E0.8390.31
168_E186_D0.8370.31
9_L20_S0.8330.31
21_V110_R0.8170.30
21_V202_K0.8160.30
178_K205_K0.8160.30
115_D203_E0.8130.30
28_E170_A0.8050.29
63_G68_K0.8040.29
188_H192_K0.8040.29
138_K194_T0.8030.29
6_T14_S0.8030.29
62_S81_S0.7940.29
14_S193_A0.7820.28
57_D65_E0.7820.28
71_E205_K0.7800.28
67_E70_K0.7780.28
180_N195_A0.7770.28
76_G86_T0.7760.28
197_I203_E0.7730.27
73_G80_S0.7720.27
63_G72_D0.7710.27
10_L25_M0.7710.27
13_L172_V0.7710.27
19_L23_Y0.7700.27
25_M188_H0.7700.27
120_E123_E0.7630.27
155_E203_E0.7630.27
202_K212_V0.7590.27
60_E86_T0.7560.27
81_S84_K0.7560.27
145_M191_S0.7560.27
37_S153_G0.7510.26
95_T205_K0.7510.26
20_S109_Y0.7500.26
17_V24_I0.7500.26
124_L153_G0.7470.26
117_R166_G0.7450.26
11_T121_R0.7440.26
83_D130_S0.7430.26
10_L13_L0.7420.26
57_D61_K0.7420.26
84_K87_S0.7400.26
36_Q186_D0.7390.26
183_V192_K0.7370.26
9_L24_I0.7300.25
38_E55_K0.7290.25
179_I209_D0.7230.25
150_E154_T0.7220.25
193_A212_V0.7200.25
110_R163_K0.7160.25
72_D78_K0.7160.25
97_V102_D0.7130.25
11_T14_S0.7040.24
94_G98_T0.7030.24
5_Q197_I0.6990.24
57_D68_K0.6990.24
127_I141_A0.6970.24
59_K63_G0.6960.24
13_L18_V0.6890.24
157_Q203_E0.6850.23
185_S192_K0.6840.23
80_S168_E0.6800.23
57_D76_G0.6790.23
20_S199_L0.6760.23
96_V189_S0.6710.23
147_A150_E0.6700.23
138_K155_E0.6680.23
19_L24_I0.6630.22
24_I188_H0.6590.22
197_I212_V0.6560.22
36_Q77_T0.6560.22
17_V115_D0.6540.22
110_R155_E0.6520.22
121_R145_M0.6460.22
159_E172_V0.6420.21
36_Q81_S0.6370.21
71_E175_E0.6360.21
55_K69_G0.6350.21
69_G147_A0.6340.21
138_K166_G0.6340.21
166_G179_I0.6290.21
121_R127_I0.6290.21
159_E182_T0.6280.21
115_D190_K0.6270.21
78_K81_S0.6260.21
151_V185_S0.6230.21
96_V99_E0.6170.20
61_K68_K0.6170.20
5_Q18_V0.6160.20
115_D149_S0.6150.20
57_D176_G0.6140.20
12_M205_K0.6120.20
10_L14_S0.6110.20
61_K64_T0.6100.20
14_S25_M0.6060.20
145_M160_T0.6030.20
68_K87_S0.6020.20
4_K22_Y0.6020.20
110_R161_L0.6010.20
181_I206_T0.6000.20
88_A91_S0.5950.20
99_E110_R0.5940.20
59_K70_K0.5930.19
124_L204_I0.5920.19
79_D87_S0.5880.19
56_Q62_S0.5860.19
106_F162_I0.5800.19
37_S75_K0.5780.19
72_D85_E0.5760.19
149_S213_T0.5750.19
11_T158_L0.5740.19
11_T130_S0.5710.19
86_T132_D0.5690.19
150_E205_K0.5680.19
61_K71_E0.5650.18
105_L212_V0.5650.18
69_G73_G0.5650.18
121_R180_N0.5610.18
106_F110_R0.5600.18
118_S192_K0.5580.18
7_V19_L0.5550.18
14_S27_P0.5550.18
180_N202_K0.5530.18
61_K168_E0.5490.18
7_V71_E0.5470.18
154_T173_N0.5460.18
76_G192_K0.5450.18
41_A81_S0.5430.18
23_Y196_I0.5420.18
33_V39_K0.5410.18
115_D173_N0.5410.18
93_K97_V0.5410.18
35_M80_S0.5400.17
139_S175_E0.5350.17
3_K137_E0.5350.17
19_L25_M0.5350.17
106_F188_H0.5340.17
66_T85_E0.5310.17
115_D158_L0.5300.17
106_F169_D0.5290.17
6_T161_L0.5240.17
58_T73_G0.5230.17
110_R194_T0.5210.17
61_K65_E0.5190.17
15_L126_A0.5190.17
36_Q63_G0.5150.17
157_Q198_D0.5150.17
102_D188_H0.5130.17
124_L155_E0.5130.17
68_K81_S0.5120.16
75_K181_I0.5120.16
92_E97_V0.5120.16
60_E78_K0.5120.16
131_D212_V0.5110.16
61_K67_E0.5080.16
22_Y212_V0.5070.16
56_Q61_K0.5060.16
7_V128_V0.5020.16
166_G195_A0.5010.16
125_N156_K0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3tufA 2 0.5275 100 0.402 Contact Map
4g1iA 1 0.4266 43.2 0.938 Contact Map
2wssS 1 0.5596 36 0.941 Contact Map
3j6dA 3 0.5459 24.8 0.946 Contact Map
1xs3A 1 0.3211 17.6 0.949 Contact Map
1jb0X 1 0.1193 10.8 0.954 Contact Map
3tr3A 2 0.3119 9.7 0.955 Contact Map
3j7aR 1 0.2798 9.3 0.955 Contact Map
2mcqA 1 0.3028 9.3 0.955 Contact Map
3zg1A 2 0.4908 8.7 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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