GREMLIN Database
SP3AG - Stage III sporulation protein AG
UniProt: P49784 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (189)
Sequences: 440 (392)
Seq/√Len: 28.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
144_E152_R4.6931.00
128_L178_Q4.4641.00
134_N162_E4.3841.00
124_D185_R3.5271.00
142_T154_V3.4801.00
146_D150_G3.4741.00
136_S160_E3.4041.00
194_V203_I3.3471.00
143_E153_S3.1031.00
187_V211_L3.1001.00
111_I221_A3.0471.00
167_K172_E2.9981.00
146_D152_R2.9661.00
140_T156_D2.8271.00
114_V203_I2.7111.00
107_I120_V2.4260.99
114_V199_I2.1690.98
144_E150_G2.1050.97
144_E191_A1.9890.96
38_V42_S1.9800.96
131_Y175_V1.9610.96
208_T218_V1.9370.96
131_Y176_V1.9210.96
121_V141_T1.9140.96
116_D192_Q1.8800.95
140_T213_V1.8780.95
40_G47_S1.7420.93
185_R211_L1.7090.92
120_V210_V1.6900.91
204_I220_V1.6690.91
152_R191_A1.6430.90
120_V128_L1.6120.89
209_R218_V1.6040.89
105_K109_E1.5100.86
146_D149_G1.5040.86
110_T118_S1.4970.85
97_E181_K1.4860.85
115_D194_V1.4670.84
135_K161_E1.4500.84
219_A222_P1.4100.82
198_Q202_T1.4100.82
107_I188_L1.4060.82
98_K184_I1.3860.81
104_L207_V1.3750.80
124_D145_T1.3580.79
133_K161_E1.3540.79
197_V200_K1.3510.79
43_F197_V1.3500.79
189_V207_V1.3410.78
134_N163_I1.2870.75
123_V221_A1.2870.75
115_D192_Q1.2820.75
99_E184_I1.2790.75
104_L223_K1.2740.75
116_D223_K1.2710.74
97_E121_V1.2500.73
143_E151_K1.2480.73
105_K127_S1.2290.72
179_T223_K1.2230.72
43_F47_S1.2180.71
40_G43_F1.2160.71
168_N171_K1.2060.70
41_V85_K1.1970.70
196_N203_I1.1920.70
109_E117_V1.1800.69
34_L55_K1.1490.67
107_I201_Q1.1470.67
124_D183_D1.1360.66
128_L183_D1.1320.65
111_I219_A1.0930.63
107_I123_V1.0930.63
38_V46_V1.0850.62
149_G191_A1.0700.61
105_K118_S1.0610.60
194_V222_P1.0570.60
116_D179_T1.0480.59
29_K44_M1.0410.59
103_Q106_E1.0260.58
108_L191_A1.0240.58
204_I215_S1.0090.56
125_A130_V1.0060.56
94_D130_V1.0040.56
133_K213_V0.9920.55
145_T151_K0.9850.55
43_F128_L0.9640.53
37_F137_N0.9630.53
111_I190_V0.9610.53
42_S46_V0.9500.52
93_I121_V0.9440.51
100_Y121_V0.9430.51
128_L180_K0.9390.51
203_I209_R0.9350.51
134_N155_T0.9340.51
36_V74_K0.9220.50
75_E78_A0.9210.50
204_I209_R0.9210.50
115_D184_I0.9210.50
127_S179_T0.9170.49
214_P219_A0.9160.49
96_Y182_P0.9120.49
40_G96_Y0.9080.49
37_F129_K0.9030.48
49_L210_V0.8930.47
30_Y38_V0.8820.47
163_I216_H0.8750.46
132_E205_E0.8710.46
29_K32_Y0.8710.46
120_V123_V0.8600.45
45_L137_N0.8420.44
126_T216_H0.8290.43
136_S172_E0.8280.43
166_I172_E0.8280.43
39_L50_F0.8260.42
74_K95_D0.8250.42
46_V221_A0.8230.42
78_A88_K0.8170.42
107_I136_S0.8150.42
140_T209_R0.8120.41
57_E85_K0.8050.41
175_V200_K0.7990.40
121_V125_A0.7990.40
33_F189_V0.7910.40
142_T150_G0.7910.40
133_K175_V0.7880.40
209_R216_H0.7860.39
37_F218_V0.7820.39
201_Q213_V0.7820.39
212_D217_R0.7800.39
20_K33_F0.7790.39
41_V171_K0.7760.39
115_D193_G0.7760.39
35_F39_L0.7730.38
49_L163_I0.7710.38
37_F183_D0.7700.38
122_N185_R0.7650.38
124_D180_K0.7620.38
192_Q223_K0.7600.37
189_V208_T0.7590.37
166_I199_I0.7540.37
24_K53_P0.7540.37
191_A194_V0.7510.37
170_D180_K0.7510.37
107_I208_T0.7470.37
142_T152_R0.7460.36
181_K222_P0.7440.36
188_L206_A0.7430.36
188_L210_V0.7430.36
107_I178_Q0.7410.36
167_K170_D0.7410.36
149_G152_R0.7400.36
32_Y218_V0.7380.36
115_D118_S0.7370.36
35_F216_H0.7370.36
171_K184_I0.7330.36
211_L217_R0.7280.35
97_E140_T0.7190.35
106_E175_V0.7180.34
46_V145_T0.7170.34
39_L92_S0.7150.34
161_E216_H0.7120.34
160_E184_I0.7100.34
94_D217_R0.7100.34
105_K203_I0.7100.34
163_I208_T0.7080.34
166_I218_V0.7070.34
38_V147_K0.7050.34
58_N157_Q0.7010.33
24_K36_V0.6990.33
131_Y217_R0.6970.33
43_F172_E0.6890.32
150_G191_A0.6850.32
122_N147_K0.6830.32
157_Q160_E0.6820.32
32_Y202_T0.6810.32
107_I190_V0.6810.32
136_S185_R0.6760.32
178_Q221_A0.6730.31
211_L214_P0.6670.31
103_Q148_E0.6640.31
158_S192_Q0.6620.31
125_A129_K0.6610.31
209_R224_K0.6590.30
65_V84_S0.6560.30
191_A203_I0.6550.30
46_V216_H0.6530.30
158_S194_V0.6530.30
45_L180_K0.6520.30
205_E213_V0.6510.30
40_G133_K0.6430.29
97_E103_Q0.6430.29
48_Q154_V0.6420.29
58_N102_N0.6410.29
46_V49_L0.6390.29
33_F143_E0.6380.29
57_E168_N0.6370.29
209_R219_A0.6370.29
138_K155_T0.6350.29
76_K92_S0.6350.29
108_L117_V0.6350.29
38_V49_L0.6330.29
160_E168_N0.6330.29
199_I206_A0.6320.29
178_Q195_D0.6310.29
101_E124_D0.6280.28
65_V115_D0.6270.28
115_D176_V0.6220.28
97_E222_P0.6200.28
102_N105_K0.6180.28
22_G65_V0.6150.28
26_K37_F0.6130.28
78_A94_D0.6120.27
130_V163_I0.6100.27
125_A178_Q0.6070.27
205_E212_D0.6040.27
47_S130_V0.6030.27
137_N159_S0.6020.27
34_L100_Y0.5960.27
144_E149_G0.5960.27
126_T210_V0.5950.26
81_F85_K0.5930.26
194_V200_K0.5920.26
126_T214_P0.5910.26
108_L221_A0.5890.26
201_Q211_L0.5890.26
175_V211_L0.5890.26
111_I200_K0.5880.26
123_V184_I0.5870.26
220_V223_K0.5850.26
111_I138_K0.5820.26
202_T219_A0.5780.25
100_Y181_K0.5750.25
33_F54_E0.5720.25
120_V211_L0.5710.25
77_T90_K0.5680.25
174_P214_P0.5670.25
92_S143_E0.5670.25
107_I207_V0.5660.25
89_P102_N0.5650.25
20_K23_E0.5640.25
172_E204_I0.5640.25
122_N126_T0.5620.25
162_E189_V0.5620.25
162_E218_V0.5610.24
38_V175_V0.5600.24
20_K24_K0.5580.24
135_K196_N0.5570.24
45_L177_V0.5530.24
46_V165_M0.5530.24
218_V222_P0.5520.24
180_K218_V0.5520.24
116_D154_V0.5470.24
127_S181_K0.5460.24
127_S220_V0.5440.23
185_R209_R0.5430.23
121_V185_R0.5420.23
126_T173_T0.5400.23
85_K94_D0.5400.23
99_E103_Q0.5400.23
21_D34_L0.5380.23
96_Y99_E0.5370.23
38_V99_E0.5350.23
36_V75_E0.5350.23
194_V212_D0.5330.23
81_F154_V0.5330.23
47_S211_L0.5320.23
123_V167_K0.5280.23
195_D210_V0.5270.23
75_E80_V0.5260.23
32_Y220_V0.5250.22
143_E148_E0.5240.22
125_A185_R0.5240.22
124_D139_N0.5190.22
162_E200_K0.5160.22
40_G190_V0.5150.22
103_Q135_K0.5140.22
38_V43_F0.5140.22
39_L53_P0.5130.22
168_N173_T0.5090.22
100_Y211_L0.5060.21
56_T76_K0.5030.21
213_V216_H0.5020.21
212_D220_V0.5020.21
58_N88_K0.5010.21
45_L154_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4oycA 1 0.393 46 0.945 Contact Map
3ne5A 3 0.821 36.2 0.948 Contact Map
2kogA 1 0.214 30.2 0.95 Contact Map
4mt1A 3 0.8166 19.5 0.954 Contact Map
2m8rA 1 0.2009 19.2 0.954 Contact Map
2wkbA 3 0.4629 19.1 0.954 Contact Map
3djhA 3 0.4585 16.9 0.956 Contact Map
3w9iA 3 0.821 15.4 0.956 Contact Map
3hd7A 1 0.214 14 0.957 Contact Map
3kanA 3 0.4454 12.9 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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