SP3AG - BACSU - GREMLIN Contacts

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SP3AG - Stage III sporulation protein AG

UniProt:	P49784	Sequences: MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFMLVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYENQLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSEEEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRVAVAPKKIKEDS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	229 (189)
Sequences:	440 (392)
Seq/√Len:	28.5

BACSU - SP3AG

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
144_E	152_R	4.693	1.00
128_L	178_Q	4.464	1.00
134_N	162_E	4.384	1.00
124_D	185_R	3.527	1.00
142_T	154_V	3.480	1.00
146_D	150_G	3.474	1.00
136_S	160_E	3.404	1.00
194_V	203_I	3.347	1.00
143_E	153_S	3.103	1.00
187_V	211_L	3.100	1.00
111_I	221_A	3.047	1.00
167_K	172_E	2.998	1.00
146_D	152_R	2.966	1.00
140_T	156_D	2.827	1.00
114_V	203_I	2.711	1.00
107_I	120_V	2.426	0.99
114_V	199_I	2.169	0.98
144_E	150_G	2.105	0.97
144_E	191_A	1.989	0.96
38_V	42_S	1.980	0.96
131_Y	175_V	1.961	0.96
208_T	218_V	1.937	0.96
131_Y	176_V	1.921	0.96
121_V	141_T	1.914	0.96
116_D	192_Q	1.880	0.95
140_T	213_V	1.878	0.95
40_G	47_S	1.742	0.93
185_R	211_L	1.709	0.92
120_V	210_V	1.690	0.91
204_I	220_V	1.669	0.91
152_R	191_A	1.643	0.90
120_V	128_L	1.612	0.89
209_R	218_V	1.604	0.89
105_K	109_E	1.510	0.86
146_D	149_G	1.504	0.86
110_T	118_S	1.497	0.85
97_E	181_K	1.486	0.85
115_D	194_V	1.467	0.84
135_K	161_E	1.450	0.84
219_A	222_P	1.410	0.82
198_Q	202_T	1.410	0.82
107_I	188_L	1.406	0.82
98_K	184_I	1.386	0.81
104_L	207_V	1.375	0.80
124_D	145_T	1.358	0.79
133_K	161_E	1.354	0.79
197_V	200_K	1.351	0.79
43_F	197_V	1.350	0.79
189_V	207_V	1.341	0.78
134_N	163_I	1.287	0.75
123_V	221_A	1.287	0.75
115_D	192_Q	1.282	0.75
99_E	184_I	1.279	0.75
104_L	223_K	1.274	0.75
116_D	223_K	1.271	0.74
97_E	121_V	1.250	0.73
143_E	151_K	1.248	0.73
105_K	127_S	1.229	0.72
179_T	223_K	1.223	0.72
43_F	47_S	1.218	0.71
40_G	43_F	1.216	0.71
168_N	171_K	1.206	0.70
41_V	85_K	1.197	0.70
196_N	203_I	1.192	0.70
109_E	117_V	1.180	0.69
34_L	55_K	1.149	0.67
107_I	201_Q	1.147	0.67
124_D	183_D	1.136	0.66
128_L	183_D	1.132	0.65
111_I	219_A	1.093	0.63
107_I	123_V	1.093	0.63
38_V	46_V	1.085	0.62
149_G	191_A	1.070	0.61
105_K	118_S	1.061	0.60
194_V	222_P	1.057	0.60
116_D	179_T	1.048	0.59
29_K	44_M	1.041	0.59
103_Q	106_E	1.026	0.58
108_L	191_A	1.024	0.58
204_I	215_S	1.009	0.56
125_A	130_V	1.006	0.56
94_D	130_V	1.004	0.56
133_K	213_V	0.992	0.55
145_T	151_K	0.985	0.55
43_F	128_L	0.964	0.53
37_F	137_N	0.963	0.53
111_I	190_V	0.961	0.53
42_S	46_V	0.950	0.52
93_I	121_V	0.944	0.51
100_Y	121_V	0.943	0.51
128_L	180_K	0.939	0.51
203_I	209_R	0.935	0.51
134_N	155_T	0.934	0.51
36_V	74_K	0.922	0.50
75_E	78_A	0.921	0.50
204_I	209_R	0.921	0.50
115_D	184_I	0.921	0.50
127_S	179_T	0.917	0.49
214_P	219_A	0.916	0.49
96_Y	182_P	0.912	0.49
40_G	96_Y	0.908	0.49
37_F	129_K	0.903	0.48
49_L	210_V	0.893	0.47
30_Y	38_V	0.882	0.47
163_I	216_H	0.875	0.46
132_E	205_E	0.871	0.46
29_K	32_Y	0.871	0.46
120_V	123_V	0.860	0.45
45_L	137_N	0.842	0.44
126_T	216_H	0.829	0.43
136_S	172_E	0.828	0.43
166_I	172_E	0.828	0.43
39_L	50_F	0.826	0.42
74_K	95_D	0.825	0.42
46_V	221_A	0.823	0.42
78_A	88_K	0.817	0.42
107_I	136_S	0.815	0.42
140_T	209_R	0.812	0.41
57_E	85_K	0.805	0.41
175_V	200_K	0.799	0.40
121_V	125_A	0.799	0.40
33_F	189_V	0.791	0.40
142_T	150_G	0.791	0.40
133_K	175_V	0.788	0.40
209_R	216_H	0.786	0.39
37_F	218_V	0.782	0.39
201_Q	213_V	0.782	0.39
212_D	217_R	0.780	0.39
20_K	33_F	0.779	0.39
41_V	171_K	0.776	0.39
115_D	193_G	0.776	0.39
35_F	39_L	0.773	0.38
49_L	163_I	0.771	0.38
37_F	183_D	0.770	0.38
122_N	185_R	0.765	0.38
124_D	180_K	0.762	0.38
192_Q	223_K	0.760	0.37
189_V	208_T	0.759	0.37
166_I	199_I	0.754	0.37
24_K	53_P	0.754	0.37
191_A	194_V	0.751	0.37
170_D	180_K	0.751	0.37
107_I	208_T	0.747	0.37
142_T	152_R	0.746	0.36
181_K	222_P	0.744	0.36
188_L	206_A	0.743	0.36
188_L	210_V	0.743	0.36
107_I	178_Q	0.741	0.36
167_K	170_D	0.741	0.36
149_G	152_R	0.740	0.36
32_Y	218_V	0.738	0.36
115_D	118_S	0.737	0.36
35_F	216_H	0.737	0.36
171_K	184_I	0.733	0.36
211_L	217_R	0.728	0.35
97_E	140_T	0.719	0.35
106_E	175_V	0.718	0.34
46_V	145_T	0.717	0.34
39_L	92_S	0.715	0.34
161_E	216_H	0.712	0.34
160_E	184_I	0.710	0.34
94_D	217_R	0.710	0.34
105_K	203_I	0.710	0.34
163_I	208_T	0.708	0.34
166_I	218_V	0.707	0.34
38_V	147_K	0.705	0.34
58_N	157_Q	0.701	0.33
24_K	36_V	0.699	0.33
131_Y	217_R	0.697	0.33
43_F	172_E	0.689	0.32
150_G	191_A	0.685	0.32
122_N	147_K	0.683	0.32
157_Q	160_E	0.682	0.32
32_Y	202_T	0.681	0.32
107_I	190_V	0.681	0.32
136_S	185_R	0.676	0.32
178_Q	221_A	0.673	0.31
211_L	214_P	0.667	0.31
103_Q	148_E	0.664	0.31
158_S	192_Q	0.662	0.31
125_A	129_K	0.661	0.31
209_R	224_K	0.659	0.30
65_V	84_S	0.656	0.30
191_A	203_I	0.655	0.30
46_V	216_H	0.653	0.30
158_S	194_V	0.653	0.30
45_L	180_K	0.652	0.30
205_E	213_V	0.651	0.30
40_G	133_K	0.643	0.29
97_E	103_Q	0.643	0.29
48_Q	154_V	0.642	0.29
58_N	102_N	0.641	0.29
46_V	49_L	0.639	0.29
33_F	143_E	0.638	0.29
57_E	168_N	0.637	0.29
209_R	219_A	0.637	0.29
138_K	155_T	0.635	0.29
76_K	92_S	0.635	0.29
108_L	117_V	0.635	0.29
38_V	49_L	0.633	0.29
160_E	168_N	0.633	0.29
199_I	206_A	0.632	0.29
178_Q	195_D	0.631	0.29
101_E	124_D	0.628	0.28
65_V	115_D	0.627	0.28
115_D	176_V	0.622	0.28
97_E	222_P	0.620	0.28
102_N	105_K	0.618	0.28
22_G	65_V	0.615	0.28
26_K	37_F	0.613	0.28
78_A	94_D	0.612	0.27
130_V	163_I	0.610	0.27
125_A	178_Q	0.607	0.27
205_E	212_D	0.604	0.27
47_S	130_V	0.603	0.27
137_N	159_S	0.602	0.27
34_L	100_Y	0.596	0.27
144_E	149_G	0.596	0.27
126_T	210_V	0.595	0.26
81_F	85_K	0.593	0.26
194_V	200_K	0.592	0.26
126_T	214_P	0.591	0.26
108_L	221_A	0.589	0.26
201_Q	211_L	0.589	0.26
175_V	211_L	0.589	0.26
111_I	200_K	0.588	0.26
123_V	184_I	0.587	0.26
220_V	223_K	0.585	0.26
111_I	138_K	0.582	0.26
202_T	219_A	0.578	0.25
100_Y	181_K	0.575	0.25
33_F	54_E	0.572	0.25
120_V	211_L	0.571	0.25
77_T	90_K	0.568	0.25
174_P	214_P	0.567	0.25
92_S	143_E	0.567	0.25
107_I	207_V	0.566	0.25
89_P	102_N	0.565	0.25
20_K	23_E	0.564	0.25
172_E	204_I	0.564	0.25
122_N	126_T	0.562	0.25
162_E	189_V	0.562	0.25
162_E	218_V	0.561	0.24
38_V	175_V	0.560	0.24
20_K	24_K	0.558	0.24
135_K	196_N	0.557	0.24
45_L	177_V	0.553	0.24
46_V	165_M	0.553	0.24
218_V	222_P	0.552	0.24
180_K	218_V	0.552	0.24
116_D	154_V	0.547	0.24
127_S	181_K	0.546	0.24
127_S	220_V	0.544	0.23
185_R	209_R	0.543	0.23
121_V	185_R	0.542	0.23
126_T	173_T	0.540	0.23
85_K	94_D	0.540	0.23
99_E	103_Q	0.540	0.23
21_D	34_L	0.538	0.23
96_Y	99_E	0.537	0.23
38_V	99_E	0.535	0.23
36_V	75_E	0.535	0.23
194_V	212_D	0.533	0.23
81_F	154_V	0.533	0.23
47_S	211_L	0.532	0.23
123_V	167_K	0.528	0.23
195_D	210_V	0.527	0.23
75_E	80_V	0.526	0.23
32_Y	220_V	0.525	0.22
143_E	148_E	0.524	0.22
125_A	185_R	0.524	0.22
124_D	139_N	0.519	0.22
162_E	200_K	0.516	0.22
40_G	190_V	0.515	0.22
103_Q	135_K	0.514	0.22
38_V	43_F	0.514	0.22
39_L	53_P	0.513	0.22
168_N	173_T	0.509	0.22
100_Y	211_L	0.506	0.21
56_T	76_K	0.503	0.21
213_V	216_H	0.502	0.21
212_D	220_V	0.502	0.21
58_N	88_K	0.501	0.21
45_L	154_V	0.500	0.21

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4oycA	1	0.393	46	0.945	Contact Map
3ne5A	3	0.821	36.2	0.948	Contact Map
2kogA	1	0.214	30.2	0.95	Contact Map
4mt1A	3	0.8166	19.5	0.954	Contact Map
2m8rA	1	0.2009	19.2	0.954	Contact Map
2wkbA	3	0.4629	19.1	0.954	Contact Map
3djhA	3	0.4585	16.9	0.956	Contact Map
3w9iA	3	0.821	15.4	0.956	Contact Map
3hd7A	1	0.214	14	0.957	Contact Map
3kanA	3	0.4454	12.9	0.958	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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