GREMLIN Database
SP3AE - Stage III sporulation protein AE
UniProt: P49782 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 399 (375)
Sequences: 519 (448)
Seq/√Len: 23.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
331_A371_F4.6211.00
103_E333_K4.2471.00
244_L346_A4.0421.00
162_Y166_A3.8941.00
215_I252_A3.6421.00
327_A378_S3.5141.00
342_K361_D3.3511.00
155_S341_Y2.8990.99
159_A337_L2.8250.99
320_V382_F2.6720.99
141_Y145_Y2.5830.99
118_T348_L2.5720.99
100_L366_S2.5610.99
115_I146_M2.4980.98
216_V373_A2.3700.98
114_L311_L2.3450.97
117_L144_V2.3120.97
163_A310_L2.3070.97
342_K364_S2.2680.97
193_S197_F2.2150.96
94_K97_F2.1380.96
299_D319_G2.1190.95
8_L14_I2.1140.95
173_F326_I2.0990.95
163_A374_L2.0350.94
104_V343_L2.0260.94
202_L257_L1.9910.94
240_Q361_D1.9900.94
100_L379_L1.9730.93
14_I21_I1.9330.92
314_T323_L1.9280.92
338_A368_I1.9150.92
238_V315_V1.9070.92
171_T213_Q1.9060.92
15_I290_I1.8830.91
257_L379_L1.8720.91
289_F308_S1.8480.91
337_L367_V1.8460.91
160_I238_V1.8250.90
189_G283_K1.8240.90
40_Q43_E1.8220.90
128_Q380_M1.8020.90
311_L378_S1.7720.89
253_L373_A1.7720.89
16_A19_A1.7600.88
54_I364_S1.7380.88
115_I348_L1.7330.88
203_F230_S1.7270.87
90_Q94_K1.7200.87
16_A234_E1.7190.87
100_L339_F1.6950.86
197_F385_L1.6860.86
259_I321_A1.6760.86
265_S372_A1.6720.86
129_N136_V1.6540.85
251_G255_V1.6480.85
252_A332_I1.6480.85
177_L334_V1.6300.84
43_E47_A1.6230.84
225_I290_I1.5990.83
8_L11_A1.5970.83
93_L96_L1.5760.82
38_A50_E1.5660.82
11_A14_I1.5650.82
248_I252_A1.5460.81
319_G342_K1.5420.81
315_V319_G1.5310.80
266_V318_L1.5120.79
291_P294_G1.5120.79
55_G59_N1.5110.79
118_T382_F1.5040.79
110_L170_M1.5000.79
259_I339_F1.4980.79
118_T268_G1.4860.78
84_D161_N1.4850.78
114_L153_L1.4750.77
335_L371_F1.4480.76
9_L44_R1.4430.76
123_I194_A1.4330.75
185_L190_G1.4240.75
240_Q247_N1.4050.74
214_N252_A1.3930.73
257_L296_M1.3890.73
39_E43_E1.3870.73
9_L16_A1.3790.72
12_V123_I1.3780.72
184_L315_V1.3700.72
114_L146_M1.3690.72
114_L354_G1.3640.72
10_L21_I1.3620.71
81_I323_L1.3590.71
311_L376_I1.3560.71
18_R22_V1.3560.71
115_I216_V1.3540.71
44_R48_S1.3480.71
233_T334_V1.3420.70
238_V272_A1.3390.70
211_L256_F1.3380.70
338_A364_S1.3310.70
184_L283_K1.3280.69
122_V351_L1.3230.69
14_I17_G1.3230.69
306_S332_I1.3060.68
263_V290_I1.3030.68
114_L344_A1.2990.68
101_F281_T1.2970.68
111_L120_F1.2900.67
103_E312_K1.2850.67
119_I297_F1.2830.67
191_A278_T1.2790.67
117_L171_T1.2770.66
149_I212_I1.2720.66
245_L347_I1.2600.65
341_Y350_P1.2550.65
185_L309_L1.2500.65
11_A17_G1.2480.65
101_F178_I1.2420.64
260_F299_D1.2380.64
120_F238_V1.2380.64
230_S342_K1.2360.64
13_L22_V1.2350.64
116_L384_S1.2330.64
257_L380_M1.2250.63
92_W376_I1.2140.62
267_Q316_G1.2130.62
314_T384_S1.2120.62
150_I177_L1.2100.62
212_I253_L1.2080.62
236_Y349_Q1.2060.62
188_S284_F1.2020.62
52_D123_I1.1970.61
50_E53_K1.1940.61
196_F327_A1.1920.61
348_L357_I1.1920.61
268_G312_K1.1900.61
305_I316_G1.1890.61
268_G282_A1.1860.61
114_L222_L1.1850.60
94_K135_T1.1830.60
165_E169_T1.1780.60
283_K292_V1.1760.60
101_F245_L1.1760.60
151_L361_D1.1750.60
111_L344_A1.1740.60
334_V374_L1.1680.59
151_L167_I1.1640.59
226_L300_A1.1590.59
190_G317_I1.1550.58
123_I185_L1.1480.58
80_F298_T1.1410.57
282_A344_A1.1400.57
290_I334_V1.1350.57
11_A16_A1.1350.57
41_L44_R1.1290.57
286_T290_I1.1290.57
10_L16_A1.1290.57
184_L199_P1.1240.56
189_G275_D1.1220.56
126_L144_V1.1210.56
148_L195_A1.1170.56
91_E114_L1.1070.55
119_I386_T1.1040.55
13_L290_I1.1000.55
179_P218_P1.0970.54
10_L18_R1.0960.54
59_N323_L1.0950.54
136_V380_M1.0840.54
55_G119_I1.0840.54
171_T175_L1.0830.53
163_A174_I1.0800.53
312_K333_K1.0780.53
237_K258_T1.0720.53
266_V348_L1.0670.52
151_L172_S1.0630.52
16_A96_L1.0580.52
123_I327_A1.0560.52
296_M302_D1.0510.51
13_L17_G1.0500.51
114_L323_L1.0480.51
245_L345_A1.0470.51
282_A331_A1.0460.51
42_A45_T1.0430.51
245_L259_I1.0430.51
54_I339_F1.0420.51
258_T277_I1.0390.50
110_L340_I1.0390.50
193_S224_A1.0270.50
138_K355_P1.0200.49
168_Q172_S1.0200.49
151_L326_I1.0170.49
141_Y355_P1.0140.49
161_N222_L1.0120.49
297_F344_A1.0110.48
10_L47_A1.0100.48
38_A44_R1.0080.48
84_D385_L1.0030.48
11_A78_M1.0020.48
113_T137_S1.0000.48
167_I312_K0.9990.48
21_I40_Q0.9980.48
121_C345_A0.9970.47
238_V286_T0.9940.47
50_E165_E0.9940.47
198_H223_S0.9910.47
280_R300_A0.9890.47
230_S261_L0.9840.47
265_S292_V0.9820.46
47_A215_I0.9810.46
87_F317_I0.9790.46
23_Q168_Q0.9730.46
118_T339_F0.9720.46
104_V243_N0.9680.45
272_A386_T0.9650.45
56_E274_T0.9540.45
265_S287_G0.9540.45
127_L130_A0.9490.44
261_L265_S0.9490.44
44_R56_E0.9470.44
215_I240_Q0.9460.44
119_I159_A0.9440.44
367_V387_V0.9430.44
292_V299_D0.9380.43
329_F333_K0.9380.43
11_A56_E0.9360.43
12_V211_L0.9360.43
38_A48_S0.9330.43
119_I344_A0.9320.43
119_I328_A0.9310.43
114_L208_S0.9300.43
120_F323_L0.9300.43
122_V270_S0.9270.43
22_V48_S0.9240.42
207_T322_I0.9220.42
120_F220_I0.9200.42
308_S382_F0.9190.42
278_T300_A0.9160.42
19_A25_A0.9160.42
364_S376_I0.9140.42
264_I278_T0.9140.42
12_V15_I0.9120.42
124_L144_V0.9120.42
145_Y220_I0.9110.42
83_G212_I0.9080.41
142_S327_A0.9070.41
43_E46_A0.9050.41
19_A94_K0.9040.41
18_R21_I0.9030.41
8_L22_V0.9020.41
271_A361_D0.8990.41
37_T161_N0.8920.40
168_Q259_I0.8880.40
14_I274_T0.8880.40
79_E127_L0.8860.40
181_L197_F0.8860.40
67_G154_N0.8860.40
198_H292_V0.8810.40
122_V370_I0.8790.39
12_V20_E0.8780.39
59_N191_A0.8700.39
109_K113_T0.8690.39
307_A383_L0.8680.39
283_K344_A0.8670.39
170_M370_I0.8620.38
39_E271_A0.8590.38
303_T319_G0.8570.38
8_L56_E0.8570.38
100_L311_L0.8560.38
64_E74_K0.8560.38
73_Q318_L0.8560.38
284_F328_A0.8550.38
220_I305_I0.8490.37
112_G292_V0.8470.37
117_L273_V0.8450.37
178_I206_N0.8410.37
111_L124_L0.8400.37
383_L391_A0.8400.37
121_C144_V0.8380.37
139_V232_M0.8370.37
257_L376_I0.8360.37
100_L336_S0.8330.36
104_V241_L0.8320.36
230_S290_I0.8310.36
211_L325_C0.8300.36
342_K382_F0.8300.36
229_V236_Y0.8280.36
254_A299_D0.8270.36
22_V26_G0.8250.36
144_V295_R0.8250.36
104_V252_A0.8240.36
143_I276_G0.8230.36
83_G119_I0.8230.36
79_E248_I0.8220.36
10_L19_A0.8210.36
295_R298_T0.8210.36
10_L325_C0.8200.36
59_N215_I0.8190.35
136_V224_A0.8190.35
289_F300_A0.8180.35
180_L317_I0.8180.35
238_V349_Q0.8170.35
89_P151_L0.8160.35
193_S314_T0.8160.35
9_L23_Q0.8150.35
145_Y156_F0.8150.35
181_L199_P0.8150.35
304_V364_S0.8140.35
45_T50_E0.8130.35
189_G199_P0.8120.35
59_N96_L0.8100.35
224_A366_S0.8090.35
316_G389_I0.8000.34
298_T366_S0.7990.34
240_Q320_V0.7980.34
9_L37_T0.7970.34
124_L346_A0.7930.34
334_V383_L0.7930.34
156_F381_F0.7930.34
272_A354_G0.7890.34
246_R250_I0.7840.33
126_L293_L0.7840.33
205_M212_I0.7830.33
347_I354_G0.7830.33
189_G260_F0.7820.33
211_L373_A0.7790.33
181_L272_A0.7780.33
12_V252_A0.7750.33
311_L363_I0.7720.33
120_F228_I0.7700.32
17_G343_L0.7700.32
12_V351_L0.7680.32
55_G217_M0.7670.32
264_I292_V0.7660.32
10_L243_N0.7630.32
15_I21_I0.7620.32
118_T357_I0.7590.32
168_Q213_Q0.7590.32
226_L303_T0.7580.32
88_S151_L0.7570.32
119_I378_S0.7540.31
26_G48_S0.7540.31
205_M384_S0.7510.31
81_I310_L0.7510.31
13_L86_S0.7480.31
199_P333_K0.7480.31
183_A213_Q0.7460.31
166_A326_I0.7440.31
113_T271_A0.7440.31
199_P299_D0.7430.31
56_E336_S0.7430.31
24_A346_A0.7400.31
25_A47_A0.7400.31
243_N290_I0.7400.31
199_P292_V0.7370.30
262_G324_I0.7350.30
267_Q295_R0.7350.30
96_L306_S0.7350.30
379_L387_V0.7340.30
17_G40_Q0.7320.30
323_L382_F0.7300.30
83_G274_T0.7300.30
292_V372_A0.7290.30
258_T378_S0.7280.30
9_L191_A0.7240.30
55_G77_L0.7180.29
208_S211_L0.7160.29
161_N321_A0.7150.29
99_Y332_I0.7130.29
89_P93_L0.7100.29
19_A64_E0.7100.29
14_I38_A0.7090.29
14_I18_R0.7090.29
155_S267_Q0.7070.29
169_T215_I0.7060.29
244_L380_M0.7060.29
330_P350_P0.7060.29
220_I373_A0.7050.29
124_L282_A0.7020.28
41_L45_T0.7020.28
108_G264_I0.7020.28
15_I44_R0.7010.28
284_F289_F0.6990.28
8_L38_A0.6960.28
272_A289_F0.6940.28
293_L383_L0.6940.28
10_L168_Q0.6940.28
174_I205_M0.6920.28
8_L18_R0.6890.28
279_L387_V0.6890.28
18_R26_G0.6870.28
114_L235_Q0.6850.27
118_T253_L0.6850.27
14_I26_G0.6830.27
228_I282_A0.6830.27
153_L258_T0.6830.27
15_I26_G0.6820.27
142_S278_T0.6790.27
298_T367_V0.6780.27
293_L345_A0.6760.27
17_G165_E0.6740.27
22_V37_T0.6740.27
363_I380_M0.6730.27
300_A303_T0.6720.27
176_A263_V0.6710.27
143_I307_A0.6710.27
124_L199_P0.6700.27
13_L19_A0.6690.27
287_G292_V0.6670.26
257_L311_L0.6650.26
105_L216_V0.6640.26
106_A332_I0.6620.26
19_A192_V0.6620.26
331_A375_A0.6570.26
127_L270_S0.6550.26
54_I248_I0.6550.26
58_W322_I0.6550.26
74_K80_F0.6540.26
229_V374_L0.6530.26
201_I205_M0.6500.26
18_R47_A0.6500.26
199_P295_R0.6480.25
53_K88_S0.6470.25
332_I376_I0.6470.25
162_Y333_K0.6470.25
40_Q63_T0.6470.25
110_L140_A0.6460.25
159_A367_V0.6460.25
258_T284_F0.6460.25
259_I274_T0.6430.25
255_V374_L0.6410.25
10_L52_D0.6380.25
194_A325_C0.6370.25
168_Q306_S0.6360.25
67_G379_L0.6350.25
173_F300_A0.6330.25
122_V239_T0.6310.25
19_A59_N0.6310.25
321_A357_I0.6300.25
340_I387_V0.6300.25
156_F350_P0.6280.24
247_N344_A0.6280.24
165_E168_Q0.6260.24
127_L272_A0.6260.24
209_G389_I0.6260.24
199_P209_G0.6250.24
58_W180_L0.6250.24
139_V335_L0.6240.24
133_Q370_I0.6220.24
130_A158_V0.6200.24
192_V195_A0.6200.24
177_L217_M0.6140.24
92_W321_A0.6140.24
216_V252_A0.6110.24
188_S356_V0.6110.24
240_Q286_T0.6090.23
101_F131_F0.6080.23
90_Q343_L0.6030.23
41_L271_A0.6010.23
133_Q161_N0.6010.23
233_T293_L0.5990.23
38_A47_A0.5980.23
13_L18_R0.5960.23
338_A348_L0.5940.23
140_A333_K0.5940.23
11_A39_E0.5930.23
187_S308_S0.5930.23
185_L390_T0.5910.23
262_G330_P0.5910.23
356_V363_I0.5900.23
244_L282_A0.5900.23
225_I244_L0.5900.23
201_I338_A0.5890.22
203_F307_A0.5870.22
11_A20_E0.5850.22
53_K92_W0.5850.22
80_F271_A0.5840.22
38_A165_E0.5840.22
157_H176_A0.5820.22
14_I20_E0.5810.22
115_I269_A0.5790.22
9_L26_G0.5790.22
77_L220_I0.5770.22
267_Q384_S0.5750.22
60_D64_E0.5750.22
268_G283_K0.5750.22
321_A327_A0.5700.22
246_R365_K0.5680.21
148_L156_F0.5680.21
120_F303_T0.5660.21
334_V367_V0.5660.21
19_A90_Q0.5640.21
44_R64_E0.5570.21
211_L255_V0.5560.21
312_K374_L0.5560.21
199_P283_K0.5550.21
26_G63_T0.5550.21
64_E82_N0.5550.21
163_A370_I0.5530.21
309_L370_I0.5530.21
199_P377_V0.5510.21
60_D207_T0.5500.21
306_S388_I0.5480.21
223_S310_L0.5470.20
89_P277_I0.5470.20
362_V390_T0.5460.20
83_G183_A0.5460.20
311_L386_T0.5430.20
10_L290_I0.5430.20
25_A59_N0.5420.20
44_R47_A0.5400.20
190_G226_L0.5400.20
52_D332_I0.5400.20
44_R50_E0.5390.20
220_I249_A0.5390.20
83_G127_L0.5390.20
89_P367_V0.5380.20
293_L320_V0.5370.20
293_L309_L0.5350.20
198_H308_S0.5340.20
117_L262_G0.5330.20
127_L352_G0.5330.20
193_S343_L0.5320.20
272_A292_V0.5320.20
182_L185_L0.5320.20
98_S117_L0.5320.20
62_M264_I0.5310.20
122_V158_V0.5300.20
16_A326_I0.5290.20
64_E88_S0.5280.20
57_F388_I0.5280.20
277_I314_T0.5270.20
150_I154_N0.5270.20
304_V340_I0.5270.20
42_A252_A0.5260.20
208_S370_I0.5260.20
255_V334_V0.5230.19
223_S254_A0.5220.19
223_S366_S0.5220.19
13_L26_G0.5210.19
262_G266_V0.5210.19
12_V60_D0.5190.19
127_L230_S0.5180.19
273_V292_V0.5180.19
115_I212_I0.5150.19
200_V389_I0.5130.19
39_E45_T0.5120.19
16_A44_R0.5110.19
104_V270_S0.5100.19
293_L336_S0.5090.19
46_A94_K0.5090.19
77_L126_L0.5090.19
14_I325_C0.5080.19
182_L242_A0.5060.19
173_F353_G0.5060.19
116_L232_M0.5050.19
114_L356_V0.5030.19
195_A347_I0.5020.19
42_A83_G0.5020.19
26_G40_Q0.5010.18
48_S167_I0.5010.18
203_F340_I0.5010.18
140_A307_A0.5010.18
23_Q52_D0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wdoA 1 0.213 24.4 0.968 Contact Map
3rvyA 3 0.0677 13.5 0.972 Contact Map
4pypA 1 0.0627 10.2 0.973 Contact Map
4pj0U 1 0.2356 10.2 0.973 Contact Map
4bgnA 3 0.0952 9 0.974 Contact Map
4m64A 1 0.0977 8 0.974 Contact Map
4ltoA 3 0.1629 7.3 0.975 Contact Map
3m91B 1 0.0777 7.1 0.975 Contact Map
1tizA 1 0.1654 6.6 0.975 Contact Map
3nbmA 1 0.2431 6.1 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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