GREMLIN Database
SP3AD - Stage III sporulation protein AD
UniProt: P49781 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 133 (127)
Sequences: 472 (375)
Seq/√Len: 33.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
15_A37_A6.7301.00
12_G102_I5.2751.00
83_A106_G3.4091.00
87_A91_K2.4200.99
4_D48_Q2.2940.99
20_L125_I2.1360.99
74_L78_G2.0810.98
45_L104_L2.0240.98
23_K27_P1.9970.98
42_F83_A1.8860.97
96_G100_S1.8700.97
90_T122_I1.8620.97
46_V82_I1.8540.97
84_E88_Q1.8130.96
71_E90_T1.8000.96
8_I41_I1.7540.95
111_L115_V1.5170.90
38_G101_K1.5160.90
38_G97_A1.5020.90
26_K121_I1.5010.90
84_E117_I1.4950.90
107_K110_I1.4590.88
95_Q105_A1.4410.88
28_T90_T1.4390.88
9_V82_I1.4330.87
42_F88_Q1.4230.87
121_I124_T1.4100.87
33_I117_I1.4090.87
72_T110_I1.4040.86
86_G102_I1.4010.86
68_V72_T1.3900.86
91_K103_E1.3860.86
6_V14_I1.3790.85
10_G91_K1.3760.85
33_I128_L1.3610.85
105_A128_L1.3370.84
91_K96_G1.2700.80
120_V124_T1.2500.79
23_K59_I1.2110.77
72_T82_I1.2030.76
35_V57_E1.1850.75
19_S97_A1.1800.75
9_V86_G1.1520.73
77_I81_Y1.1320.72
81_Y85_F1.1250.71
91_K125_I1.1240.71
39_C43_L1.1240.71
20_L23_K1.1210.71
35_V109_L1.1120.70
34_V97_A1.1060.70
109_L113_M1.1030.70
5_I9_V1.1030.70
31_F86_G1.0990.70
9_V109_L1.0960.69
73_I77_I1.0940.69
59_I100_S1.0780.68
115_V119_T1.0650.67
29_F118_L1.0610.67
97_A127_G1.0600.67
65_V86_G1.0500.66
76_I110_I1.0340.65
14_I17_F1.0260.64
76_I117_I1.0140.63
26_K125_I1.0120.63
13_L45_L1.0060.63
18_L27_P0.9950.62
62_N91_K0.9790.60
7_Q82_I0.9750.60
16_T56_I0.9710.60
93_A103_E0.9700.60
59_I98_I0.9610.59
20_L24_E0.9360.57
56_I78_G0.9360.57
68_V106_G0.9170.55
41_I125_I0.9150.55
53_I60_A0.8890.53
52_I112_V0.8870.53
8_I86_G0.8860.53
89_L117_I0.8860.53
78_G84_E0.8760.52
71_E122_I0.8650.51
8_I46_V0.8640.51
65_V89_L0.8590.51
22_V33_I0.8580.51
79_I109_L0.8540.50
55_M115_V0.8530.50
31_F129_I0.8470.50
18_L43_L0.8420.49
109_L126_L0.8380.49
111_L121_I0.8310.48
61_I74_L0.8270.48
60_A80_A0.8230.48
62_N121_I0.8210.47
11_L49_I0.8190.47
8_I42_F0.8130.47
49_I58_K0.8080.46
34_V44_Y0.8070.46
119_T123_E0.8000.46
8_I111_L0.7970.45
20_L45_L0.7960.45
56_I121_I0.7910.45
45_L70_V0.7860.45
88_Q100_S0.7850.44
44_Y57_E0.7820.44
45_L120_V0.7770.44
15_A19_S0.7760.44
38_G110_I0.7750.44
55_M119_T0.7710.43
80_A89_L0.7650.43
81_Y117_I0.7590.42
31_F35_V0.7580.42
26_K89_L0.7570.42
5_I66_N0.7550.42
104_L111_L0.7540.42
12_G98_I0.7530.42
50_Y57_E0.7460.41
4_D109_L0.7440.41
7_Q125_I0.7320.40
101_K107_K0.7320.40
50_Y76_I0.7290.40
4_D112_V0.7210.39
22_V25_Q0.7200.39
36_F112_V0.7170.39
14_I112_V0.7110.38
66_N113_M0.7100.38
28_T125_I0.7050.38
10_G95_Q0.7000.38
28_T122_I0.6980.37
35_V61_I0.6920.37
38_G114_A0.6870.37
28_T121_I0.6860.36
58_K127_G0.6850.36
22_V27_P0.6810.36
22_V30_A0.6770.36
35_V54_R0.6750.36
14_I46_V0.6740.36
80_A95_Q0.6730.35
91_K97_A0.6690.35
76_I114_A0.6660.35
49_I110_I0.6620.35
10_G24_E0.6600.34
100_S103_E0.6590.34
14_I98_I0.6560.34
29_F67_M0.6550.34
14_I106_G0.6440.33
106_G122_I0.6350.33
10_G105_A0.6340.33
18_L32_L0.6320.32
44_Y122_I0.6270.32
23_K103_E0.6120.31
71_E99_A0.6120.31
51_D83_A0.6110.31
16_T99_A0.6110.31
54_R58_K0.6090.31
8_I58_K0.6070.31
8_I85_F0.5990.30
42_F99_A0.5970.30
63_A76_I0.5930.30
73_I108_I0.5890.29
34_V98_I0.5850.29
42_F87_A0.5850.29
69_Y107_K0.5850.29
58_K70_V0.5780.29
90_T96_G0.5740.28
93_A102_I0.5600.27
38_G82_I0.5500.27
28_T54_R0.5490.27
47_D67_M0.5470.26
46_V95_Q0.5460.26
10_G97_A0.5460.26
17_F129_I0.5430.26
7_Q80_A0.5420.26
84_E122_I0.5410.26
104_L113_M0.5400.26
52_I118_L0.5360.26
22_V56_I0.5210.25
105_A114_A0.5210.25
19_S96_G0.5200.25
12_G90_T0.5130.24
102_I106_G0.5110.24
24_E95_Q0.5080.24
53_I73_I0.5080.24
5_I41_I0.5080.24
19_S118_L0.5060.24
24_E123_E0.5060.24
77_I82_I0.5040.24
34_V74_L0.5030.24
11_L14_I0.5000.24
12_G129_I0.5000.24
30_A72_T0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mt1A 3 0.8722 4.1 0.949 Contact Map
3w9iA 3 0.8722 3.4 0.951 Contact Map
3ne5A 3 0.8722 3.3 0.951 Contact Map
4k0jA 3 0.797 3.2 0.951 Contact Map
4dx5A 3 0.8496 3.2 0.951 Contact Map
4bemA 3 0.5188 2.9 0.952 Contact Map
4v1gA 3 0.5338 2.3 0.955 Contact Map
3zk1A 5 0.5414 2.1 0.956 Contact Map
2ekfA 1 0.2105 2.1 0.956 Contact Map
1a91A 1 0.5038 1.7 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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