GREMLIN Database
YQHV - Uncharacterized protein YqhV
UniProt: P49779 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 93 (86)
Sequences: 155 (121)
Seq/√Len: 13.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_L86_L3.6450.99
12_V33_M3.0620.97
80_I90_G2.9870.97
29_A45_V2.8700.96
85_V89_A2.8410.95
32_V45_V2.3540.88
31_I34_L1.9380.76
60_T63_V1.8970.74
68_I75_A1.8040.70
44_V88_L1.7520.68
55_L59_I1.7410.67
16_A39_V1.7350.67
35_V71_Q1.6940.65
82_T86_L1.6670.64
9_N69_A1.6570.63
10_S67_Q1.6520.63
25_I32_V1.6510.63
20_V27_L1.5720.59
23_S27_L1.5590.58
40_R71_Q1.5470.58
36_T45_V1.5470.58
75_A81_F1.5450.58
28_T33_M1.5280.57
18_L23_S1.4790.54
11_T14_T1.4710.54
44_V47_S1.3880.49
44_V63_V1.2630.43
66_Y71_Q1.2060.40
21_L82_T1.2000.40
41_K63_V1.1850.39
15_M34_L1.1700.38
27_L76_K1.1620.38
61_M67_Q1.1570.38
40_R67_Q1.1410.37
87_I92_H1.1390.37
20_V59_I1.1360.37
9_N40_R1.1240.36
15_M64_G1.1170.36
11_T88_L1.0980.35
52_V86_L1.0390.32
10_S61_M1.0220.31
41_K60_T1.0080.31
27_L63_V1.0070.31
51_I61_M1.0060.30
25_I82_T0.9990.30
35_V40_R0.9980.30
51_I79_L0.9670.29
9_N35_V0.9650.29
47_S60_T0.9590.28
25_I55_L0.9580.28
78_I84_V0.9520.28
29_A77_L0.9310.27
12_V16_A0.9210.27
29_A33_M0.9100.26
48_I80_I0.9090.26
9_N38_D0.9090.26
12_V36_T0.9050.26
9_N14_T0.8930.26
17_G24_M0.8880.25
61_M77_L0.8810.25
37_N41_K0.8780.25
47_S79_L0.8620.24
43_V57_F0.8430.24
14_T77_L0.8260.23
14_T45_V0.8100.23
36_T82_T0.7900.22
29_A65_I0.7790.21
74_Y77_L0.7780.21
20_V23_S0.7740.21
36_T55_L0.7730.21
8_I37_N0.7590.21
23_S57_F0.7510.20
69_A75_A0.7380.20
32_V48_I0.7220.19
33_M87_I0.7200.19
57_F67_Q0.7130.19
8_I13_L0.7060.19
7_N84_V0.7040.19
42_A49_L0.6980.19
31_I81_F0.6930.19
40_R51_I0.6630.18
67_Q71_Q0.6540.17
39_V80_I0.6530.17
62_T74_Y0.6510.17
32_V36_T0.6420.17
18_L47_S0.6360.17
62_T88_L0.6360.17
10_S35_V0.6340.17
9_N65_I0.6330.17
25_I45_V0.6270.17
40_R92_H0.6240.16
20_V24_M0.6240.16
13_L37_N0.6220.16
41_K88_L0.6210.16
8_I34_L0.6130.16
16_A34_L0.6090.16
15_M43_V0.6070.16
18_L61_M0.5920.16
23_S63_V0.5840.15
57_F61_M0.5830.15
55_L66_Y0.5780.15
9_N92_H0.5780.15
59_I69_A0.5730.15
23_S41_K0.5700.15
31_I55_L0.5690.15
13_L87_I0.5660.15
45_V57_F0.5650.15
20_V68_I0.5640.15
27_L31_I0.5520.14
44_V60_T0.5510.14
36_T66_Y0.5500.14
58_I74_Y0.5490.14
45_V75_A0.5340.14
64_G76_K0.5270.14
45_V92_H0.5210.14
62_T81_F0.5210.14
57_F60_T0.5170.14
41_K72_L0.5160.14
32_V68_I0.5130.13
64_G90_G0.5110.13
21_L68_I0.5100.13
58_I86_L0.5080.13
82_T89_A0.5080.13
78_I90_G0.5070.13
58_I88_L0.5030.13
12_V72_L0.5020.13
59_I84_V0.5020.13
30_A37_N0.5020.13
24_M47_S0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i0uA 4 0.9355 7 0.936 Contact Map
4ev6A 3 0.9355 6.4 0.937 Contact Map
1wazA 1 0.4409 3.5 0.944 Contact Map
2lzrA 1 0.2581 2.9 0.947 Contact Map
1wglA 1 0.4731 2.4 0.949 Contact Map
1p3qQ 2 0.3871 2.4 0.949 Contact Map
2dhyA 1 0.4624 2.3 0.949 Contact Map
2qksA 4 0.9462 1.7 0.953 Contact Map
2i68A 2 0.6989 1.2 0.957 Contact Map
3fmgA 3 0.1828 1.1 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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