GREMLIN Database
EFP - Elongation factor P
UniProt: P49778 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 185 (182)
Sequences: 2782 (1314)
Seq/√Len: 97.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
132_K171_T3.7451.00
69_T110_S2.9171.00
68_K84_D2.7441.00
18_G43_N2.5741.00
28_V36_F2.5031.00
136_T152_A2.4761.00
153_K159_V2.4731.00
104_Y179_G2.4561.00
73_L90_Q2.4021.00
45_R119_E2.3871.00
132_K155_E2.3341.00
167_N170_D2.3191.00
160_V172_L2.3101.00
130_E171_T2.2491.00
173_V183_S2.2351.00
103_K158_L2.1711.00
14_E61_A2.1561.00
133_V172_L2.1261.00
134_V153_K2.0721.00
135_E168_E1.9811.00
4_V57_G1.9501.00
130_E173_V1.9331.00
81_V92_E1.9101.00
152_A162_V1.8981.00
131_L154_T1.8701.00
132_K168_E1.8471.00
79_Q92_E1.8381.00
69_T112_H1.7641.00
71_Q85_T1.7621.00
132_K169_G1.7341.00
106_L155_E1.7141.00
71_Q110_S1.7031.00
16_D52_K1.7031.00
70_M113_I1.6771.00
135_E153_K1.6711.00
15_V52_K1.6571.00
85_T110_S1.6361.00
75_A95_A1.6241.00
113_I120_T1.6161.00
72_Y75_A1.5581.00
133_V166_V1.5371.00
14_E117_Q1.5071.00
28_V32_K1.5021.00
7_F22_V1.4991.00
75_A78_D1.4951.00
70_M91_L1.4681.00
55_R58_E1.4511.00
134_V154_T1.4471.00
165_F181_Y1.4321.00
148_G164_F1.3800.99
104_Y158_L1.3770.99
76_N79_Q1.3680.99
128_T182_V1.3510.99
94_S97_Q1.3430.99
141_K144_T1.3280.99
131_L155_E1.3180.99
76_N92_E1.3000.99
43_N46_T1.2930.99
13_I60_V1.2740.99
7_F60_V1.2610.99
30_P33_G1.2590.99
39_S54_F1.2470.99
83_M90_Q1.2450.99
74_Y81_V1.2450.99
30_P36_F1.2450.99
13_I41_L1.2390.99
106_L109_M1.2320.99
95_A102_L1.2280.99
127_N177_S1.2140.99
80_H102_L1.2030.98
166_V170_D1.1880.98
32_K36_F1.1880.98
128_T173_V1.1550.98
139_G164_F1.1540.98
154_T174_V1.1500.98
154_T172_L1.1390.98
131_L156_T1.1370.98
103_K179_G1.1220.97
9_T24_D1.1120.97
82_F98_I1.0760.97
14_E116_Y1.0700.97
15_V54_F1.0590.96
133_V152_A1.0560.96
20_W50_Q1.0540.96
134_V155_E1.0520.96
133_V168_E1.0500.96
79_Q94_S1.0490.96
75_A80_H1.0480.96
19_I116_Y1.0460.96
4_V56_A1.0350.96
18_G45_R1.0210.96
12_T19_I1.0070.95
25_F37_V1.0070.95
128_T175_N1.0000.95
4_V22_V0.9960.95
38_R53_T0.9940.95
106_L171_T0.9850.95
173_V182_V0.9830.95
23_V42_R0.9790.95
165_F170_D0.9770.94
136_T151_P0.9730.94
82_F123_I0.9680.94
19_I63_A0.9600.94
154_T158_L0.9590.94
160_V174_V0.9550.94
115_M120_T0.9530.94
67_T124_E0.9320.93
40_K51_E0.9310.93
175_N178_D0.9310.93
71_Q108_N0.9240.93
27_H37_V0.8960.91
149_T161_N0.8920.91
75_A81_V0.8900.91
143_D164_F0.8890.91
78_D95_A0.8770.91
99_E102_L0.8710.90
68_K115_M0.8690.90
9_T25_F0.8580.90
19_I64_Q0.8580.90
80_H95_A0.8570.90
28_V38_R0.8470.89
43_N48_A0.8460.89
12_T67_T0.8420.89
12_T63_A0.8390.89
5_N22_V0.8360.88
4_V7_F0.8350.88
143_D148_G0.8320.88
93_L97_Q0.8290.88
7_F11_L0.8260.88
140_I143_D0.8160.87
80_H98_I0.8130.87
37_V56_A0.8110.87
14_E63_A0.8090.87
19_I44_L0.8020.86
98_I123_I0.8010.86
19_I45_R0.7980.86
136_T140_I0.7960.86
14_E17_G0.7960.86
97_Q119_E0.7950.86
34_A51_E0.7940.86
105_L109_M0.7880.85
154_T159_V0.7860.85
163_P181_Y0.7840.85
149_T159_V0.7840.85
93_L120_T0.7750.84
91_L115_M0.7750.84
151_P161_N0.7700.84
7_F39_S0.7630.83
141_K145_A0.7580.83
135_E159_V0.7560.83
76_N81_V0.7550.83
70_M111_V0.7540.83
140_I164_F0.7540.83
75_A102_L0.7540.83
20_W41_L0.7510.82
31_G35_A0.7500.82
67_T114_M0.7440.82
136_T168_E0.7400.81
139_G152_A0.7370.81
66_E118_D0.7360.81
29_K32_K0.7340.81
101_E122_G0.7320.81
84_D87_S0.7300.81
38_R51_E0.7260.80
82_F93_L0.7260.80
63_A116_Y0.7200.80
170_D184_R0.7190.80
13_I22_V0.7170.79
115_M118_D0.7090.79
134_V156_T0.7030.78
25_F39_S0.6910.77
11_L22_V0.6910.77
5_N9_T0.6880.76
33_G53_T0.6860.76
24_D40_K0.6840.76
78_D93_L0.6760.75
32_K35_A0.6740.75
28_V35_A0.6720.75
136_T162_V0.6710.75
33_G38_R0.6670.74
31_G36_F0.6630.74
3_S6_D0.6600.73
98_I101_E0.6550.73
44_L114_M0.6540.73
29_K53_T0.6460.72
137_E151_P0.6450.72
71_Q90_Q0.6420.71
175_N182_V0.6400.71
85_T88_Y0.6400.71
14_E19_I0.6390.71
11_L62_K0.6390.71
151_P159_V0.6340.70
5_N37_V0.6270.70
82_F111_V0.6170.68
28_V33_G0.6160.68
4_V60_V0.6150.68
72_Y81_V0.6150.68
40_K49_I0.6140.68
67_T112_H0.6110.68
19_I121_L0.6090.67
72_Y102_L0.6070.67
27_H31_G0.6070.67
82_F113_I0.6060.67
129_V176_T0.6050.67
112_H124_E0.6010.66
78_D94_S0.5970.66
4_V58_E0.5960.66
33_G36_F0.5960.66
13_I52_K0.5940.65
18_G46_T0.5940.65
106_L131_L0.5930.65
65_I114_M0.5930.65
52_K60_V0.5930.65
148_G151_P0.5920.65
165_F184_R0.5900.65
84_D91_L0.5890.65
138_P152_A0.5890.65
109_M126_P0.5880.65
139_G148_G0.5880.65
29_K33_G0.5860.64
22_V25_F0.5850.64
138_P145_A0.5840.64
7_F57_G0.5800.64
64_Q118_D0.5790.64
28_V31_G0.5790.64
26_Q39_S0.5720.63
34_A55_R0.5680.62
83_M88_Y0.5660.62
111_V123_I0.5660.62
128_T177_S0.5650.62
43_N119_E0.5640.61
28_V34_A0.5620.61
139_G143_D0.5600.61
53_T147_G0.5590.61
137_E148_G0.5580.61
54_F93_L0.5580.61
103_K156_T0.5570.61
138_P167_N0.5530.60
21_R67_T0.5530.60
139_G151_P0.5510.60
154_T160_V0.5500.60
109_M129_V0.5480.59
42_R49_I0.5470.59
44_L122_G0.5450.59
5_N60_V0.5440.59
73_L108_N0.5440.59
56_A71_Q0.5420.58
132_K170_D0.5410.58
71_Q83_M0.5400.58
12_T21_R0.5380.58
68_K118_D0.5360.58
137_E149_T0.5360.58
114_M122_G0.5340.57
29_K42_R0.5340.57
13_I50_Q0.5310.57
19_I117_Q0.5290.57
7_F13_I0.5290.57
35_A56_A0.5240.56
27_H35_A0.5220.56
133_V170_D0.5210.56
146_S149_T0.5200.55
78_D96_T0.5190.55
29_K34_A0.5180.55
31_G56_A0.5170.55
140_I172_L0.5150.55
24_D57_G0.5150.55
6_D37_V0.5130.54
100_E103_K0.5100.54
103_K159_V0.5080.54
84_D88_Y0.5080.54
129_V156_T0.5070.54
147_G165_F0.5030.53
125_L128_T0.5000.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3treA 1 0.6973 100 0.048 Contact Map
1ybyA 2 0.9784 100 0.049 Contact Map
1uebA 1 0.9946 100 0.05 Contact Map
3a5zB 1 0.7243 100 0.051 Contact Map
3oyyA 1 0.9946 100 0.053 Contact Map
1bkbA 3 0.6865 100 0.496 Contact Map
1iz6A 1 0.6973 100 0.504 Contact Map
2eifA 1 0.6649 100 0.506 Contact Map
3er0A 1 0.7243 100 0.514 Contact Map
3hksA 1 0.7243 100 0.518 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0071 seconds.