GREMLIN Database
OPUAA - Glycine betaine transport ATP-binding protein OpuAA
UniProt: P46920 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 418 (328)
Sequences: 4228 (3725)
Seq/√Len: 205.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_E51_Q5.2121.00
37_K89_N4.0401.00
36_K39_I3.9921.00
125_H168_D2.9911.00
41_K86_T2.8811.00
348_F352_P2.8541.00
76_V226_I2.7841.00
234_L255_E2.7691.00
50_N247_N2.7331.00
339_S343_I2.5751.00
41_K78_M2.5321.00
60_E239_R2.4311.00
126_R134_Y2.4101.00
47_V50_N2.3401.00
39_I85_P2.2601.00
341_Q345_N2.1941.00
40_L87_A2.1881.00
291_V294_D2.1301.00
35_T55_E2.1021.00
123_F126_R1.9621.00
312_I315_V1.9461.00
308_G315_V1.9151.00
300_A308_G1.9061.00
9_K12_V1.8931.00
15_V18_I1.8771.00
311_S315_V1.8701.00
131_N167_P1.8601.00
345_N349_T1.8451.00
295_K298_R1.8241.00
296_G300_A1.8041.00
63_V237_G1.7811.00
36_K54_F1.7611.00
301_L308_G1.7211.00
10_I15_V1.7181.00
9_K13_E1.7161.00
12_V15_V1.7131.00
78_M90_I1.7081.00
308_G314_A1.7041.00
303_L307_L1.7021.00
38_E53_D1.6831.00
10_I13_E1.6711.00
76_V192_L1.6701.00
348_F351_V1.6651.00
298_R301_L1.6571.00
13_E16_S1.6261.00
253_T256_E1.6231.00
297_P300_A1.6111.00
343_I347_E1.6071.00
36_K79_L1.6031.00
78_M85_P1.6021.00
297_P301_L1.5991.00
326_Y329_D1.5831.00
12_V18_I1.5761.00
40_L51_Q1.5511.00
336_S339_S1.5441.00
294_D298_R1.5321.00
63_V233_A1.5251.00
11_K18_I1.5251.00
114_S188_P1.5241.00
12_V21_K1.5221.00
290_T293_I1.5101.00
308_G311_S1.5081.00
333_A351_V1.4991.00
212_L223_I1.4931.00
293_I296_G1.4891.00
62_F241_V1.4871.00
293_I297_P1.4851.00
80_N192_L1.4801.00
308_G312_I1.4801.00
126_R130_E1.4781.00
12_V16_S1.4651.00
304_M308_G1.4501.00
42_A86_T1.4491.00
10_I18_I1.4361.00
39_I78_M1.4361.00
57_Y60_E1.4281.00
145_E148_Q1.4171.00
167_P178_V1.4061.00
41_K83_I1.3951.00
307_L311_S1.3911.00
318_Q322_L1.3871.00
9_K18_I1.3761.00
54_F241_V1.3751.00
351_V355_T1.3681.00
331_K335_E1.3681.00
301_L304_M1.3671.00
350_T354_N1.3611.00
300_A304_M1.3531.00
9_K15_V1.3521.00
135_G182_R1.3451.00
291_V296_G1.3441.00
12_V19_F1.3121.00
252_G256_E1.2991.00
144_Q148_Q1.2961.00
334_A337_D1.2881.00
332_K336_S1.2881.00
12_V20_G1.2861.00
37_K53_D1.2741.00
32_N91_Y1.2671.00
131_N182_R1.2661.00
42_A47_V1.2621.00
335_E339_S1.2611.00
313_Y317_K1.2561.00
11_K21_K1.2501.00
331_K334_A1.2491.00
13_E20_G1.2451.00
14_K18_I1.2441.00
299_V302_T1.2371.00
35_T91_Y1.2331.00
14_K19_F1.2311.00
320_K324_V1.2301.00
302_T305_K1.2281.00
292_R295_K1.2211.00
301_L307_L1.2151.00
330_A334_A1.2071.00
17_K21_K1.1981.00
56_V62_F1.1911.00
141_V144_Q1.1891.00
18_I21_K1.1861.00
143_K146_R1.1801.00
333_A336_S1.1791.00
349_T352_P1.1771.00
297_P304_M1.1771.00
122_L131_N1.1771.00
301_L305_K1.1751.00
325_I328_S1.1711.00
331_K337_D1.1701.00
315_V319_K1.1701.00
325_I329_D1.1681.00
15_V19_F1.1651.00
16_S19_F1.1631.00
301_L314_A1.1611.00
346_T349_T1.1591.00
290_T294_D1.1581.00
345_N348_F1.1581.00
307_L315_V1.1551.00
336_S340_L1.1541.00
299_V308_G1.1541.00
233_A237_G1.1521.00
322_L326_Y1.1511.00
244_K247_N1.1481.00
213_L235_R1.1461.00
308_G322_L1.1351.00
306_N310_S1.1221.00
114_S183_A1.1201.00
126_R131_N1.1191.00
315_V322_L1.1121.00
142_D145_E1.1111.00
77_R82_L1.1101.00
11_K19_F1.1011.00
18_I22_Q1.1001.00
329_D332_K1.0981.00
295_K301_L1.0971.00
324_V327_A1.0961.00
299_V303_L1.0911.00
127_T130_E1.0891.00
350_T353_E1.0821.00
15_V21_K1.0801.00
13_E21_K1.0791.00
38_E87_A1.0771.00
162_F165_Q1.0671.00
291_V298_R1.0661.00
343_I346_T1.0621.00
10_I20_G1.0611.00
330_A337_D1.0591.00
43_T48_G1.0571.00
49_V78_M1.0541.00
33_G222_T1.0491.00
322_L325_I1.0471.00
10_I16_S1.0451.00
337_D341_Q1.0351.00
129_L133_E1.0341.00
305_K308_G1.0241.00
340_L343_I1.0211.00
59_G222_T1.0201.00
307_L314_A1.0141.00
192_L224_I1.0101.00
338_L342_D1.0081.00
19_F23_T1.0051.00
130_E133_E1.0041.00
294_D301_L0.9981.00
294_D297_P0.9961.00
10_I24_K0.9961.00
342_D345_N0.9941.00
78_M86_T0.9931.00
21_K24_K0.9931.00
44_G47_V0.9921.00
335_E338_L0.9881.00
293_I298_R0.9811.00
17_K20_G0.9801.00
293_I300_A0.9781.00
11_K15_V0.9751.00
298_R302_T0.9721.00
317_K320_K0.9711.00
13_E18_I0.9701.00
297_P302_T0.9701.00
9_K21_K0.9651.00
10_I21_K0.9621.00
151_L159_L0.9550.99
268_K271_E0.9520.99
144_Q147_Q0.9480.99
43_T83_I0.9460.99
18_I24_K0.9450.99
128_I178_V0.9420.99
351_V354_N0.9400.99
297_P308_G0.9390.99
18_I23_T0.9340.99
258_L261_P0.9330.99
239_R250_Q0.9300.99
80_N115_M0.9270.99
303_L308_G0.9260.99
300_A303_L0.9250.99
112_K186_N0.9250.99
216_H220_G0.9210.99
19_F22_Q0.9210.99
295_K302_T0.9190.99
11_K14_K0.9170.99
94_G110_R0.9170.99
128_I167_P0.9150.99
265_Y268_K0.9140.99
310_S336_S0.9130.99
40_L47_V0.9090.99
349_T353_E0.9060.99
67_L70_S0.8990.99
352_P356_Y0.8980.99
9_K17_K0.8980.99
342_D346_T0.8960.99
321_L329_D0.8930.99
301_L315_V0.8920.99
344_L351_V0.8900.99
344_L348_F0.8890.99
62_F239_R0.8890.99
291_V295_K0.8890.99
56_V222_T0.8890.99
149_K152_E0.8870.99
165_Q169_Q0.8870.99
85_P90_I0.8850.99
77_R83_I0.8800.99
255_E259_M0.8760.99
10_I19_F0.8760.99
225_F236_I0.8750.99
323_G326_Y0.8750.99
320_K323_G0.8740.99
225_F237_G0.8690.99
315_V321_L0.8650.99
321_L326_Y0.8610.99
301_L325_I0.8560.99
307_L312_I0.8560.99
242_L257_I0.8550.99
323_G327_A0.8540.99
16_S20_G0.8540.99
309_I313_Y0.8540.99
333_A337_D0.8530.99
264_E268_K0.8470.99
298_R303_L0.8420.99
301_L311_S0.8400.99
298_R304_M0.8340.99
296_G301_L0.8300.99
12_V17_K0.8270.98
296_G302_T0.8260.98
301_L322_L0.8210.98
318_Q325_I0.8190.98
42_A45_S0.8180.98
266_V270_V0.8170.98
352_P355_T0.8170.98
341_Q348_F0.8150.98
345_N356_Y0.8100.98
309_I312_I0.8100.98
12_V22_Q0.8070.98
338_L341_Q0.8060.98
310_S314_A0.8030.98
145_E149_K0.8030.98
300_A315_V0.8030.98
41_K74_T0.8030.98
127_T131_N0.8010.98
16_S24_K0.7990.98
328_S331_K0.7980.98
289_E292_R0.7980.98
312_I316_D0.7920.98
311_S314_A0.7910.98
337_D351_V0.7880.98
60_E238_D0.7870.98
296_G308_G0.7870.98
15_V20_G0.7850.98
70_S243_M0.7840.98
37_K91_Y0.7810.98
205_R229_D0.7810.98
153_S185_T0.7750.98
13_E17_K0.7750.98
9_K14_K0.7730.98
34_K92_I0.7710.98
49_V52_A0.7710.98
152_E156_L0.7700.98
332_K335_E0.7680.98
291_V297_P0.7670.98
188_P215_L0.7670.98
316_D320_K0.7670.98
283_H287_R0.7650.98
292_R296_G0.7630.97
345_N351_V0.7620.97
142_D147_Q0.7570.97
124_P168_D0.7530.97
266_V269_F0.7510.97
153_S181_A0.7490.97
284_I287_R0.7450.97
316_D319_K0.7430.97
321_L324_V0.7400.97
322_L327_A0.7380.97
136_L139_Q0.7320.97
13_E24_K0.7290.97
212_L236_I0.7270.97
300_A305_K0.7230.96
301_L321_L0.7190.96
329_D333_A0.7190.96
123_F131_N0.7170.96
344_L347_E0.7160.96
319_K322_L0.7160.96
321_L325_I0.7150.96
148_Q152_E0.7120.96
10_I23_T0.7120.96
36_K90_I0.7110.96
16_S21_K0.7100.96
277_K280_T0.7090.96
299_V305_K0.7060.96
322_L329_D0.7060.96
296_G299_V0.7040.96
10_I14_K0.7010.96
116_V176_Q0.7000.96
286_K291_V0.6990.96
143_K147_Q0.6970.96
347_E350_T0.6950.96
267_E270_V0.6950.96
271_E274_D0.6920.96
347_E351_V0.6910.95
288_A292_R0.6870.95
306_N309_I0.6800.95
131_N134_Y0.6750.95
278_V282_G0.6730.95
318_Q321_L0.6730.95
292_R298_R0.6730.95
284_I289_E0.6710.95
296_G303_L0.6690.95
32_N35_T0.6690.95
263_N266_V0.6670.95
65_M242_L0.6660.94
144_Q149_K0.6650.94
328_S332_K0.6640.94
215_L223_I0.6620.94
310_S313_Y0.6620.94
302_T306_N0.6620.94
286_K289_E0.6610.94
34_K190_I0.6590.94
308_G328_S0.6590.94
242_L261_P0.6570.94
289_E293_I0.6570.94
237_G240_I0.6560.94
17_K23_T0.6540.94
300_A318_Q0.6530.94
334_A351_V0.6530.94
321_L328_S0.6510.94
314_A317_K0.6510.94
227_T233_A0.6480.94
274_D278_V0.6480.94
295_K308_G0.6460.94
265_Y269_F0.6450.93
301_L309_I0.6400.93
225_F233_A0.6370.93
176_Q184_L0.6360.93
10_I17_K0.6360.93
9_K23_T0.6350.93
153_S156_L0.6350.93
30_L93_D0.6350.93
295_K299_V0.6340.93
75_L243_M0.6330.93
11_K22_Q0.6310.93
317_K321_L0.6300.93
282_G285_M0.6270.93
346_T350_T0.6270.93
301_L312_I0.6260.92
128_I134_Y0.6260.92
294_D308_G0.6240.92
187_D190_I0.6230.92
62_F224_I0.6230.92
261_P266_V0.6230.92
264_E267_E0.6210.92
278_V281_A0.6210.92
314_A322_L0.6200.92
15_V22_Q0.6190.92
291_V301_L0.6170.92
289_E294_D0.6170.92
275_L278_V0.6160.92
195_E228_H0.6160.92
349_T356_Y0.6150.92
132_T137_E0.6140.92
303_L315_V0.6110.92
287_R290_T0.6110.92
302_T309_I0.6090.91
154_L157_V0.6080.91
132_T150_A0.6080.91
147_Q151_L0.6060.91
334_A341_Q0.6060.91
155_K161_G0.6040.91
56_V224_I0.6040.91
322_L328_S0.6010.91
157_V174_M0.6010.91
129_L132_T0.6000.91
293_I301_L0.5990.91
339_S342_D0.5990.91
146_R149_K0.5990.91
304_M318_Q0.5990.91
82_L121_A0.5970.91
300_A307_L0.5960.91
125_H166_Y0.5950.90
263_N267_E0.5940.90
295_K300_A0.5940.90
282_G286_K0.5920.90
202_P206_K0.5890.90
39_I90_I0.5890.90
79_L224_I0.5870.90
285_M289_E0.5870.90
190_I224_I0.5860.90
136_L185_T0.5850.90
209_Q231_D0.5850.90
291_V300_A0.5840.90
279_L283_H0.5830.90
300_A314_A0.5810.89
143_K149_K0.5800.89
189_D221_K0.5760.89
116_V183_A0.5760.89
334_A338_L0.5730.89
227_T232_E0.5730.89
279_L282_G0.5710.89
287_R291_V0.5690.88
20_G24_K0.5670.88
290_T295_K0.5660.88
16_S23_T0.5660.88
261_P265_Y0.5650.88
320_K326_Y0.5640.88
256_E259_M0.5580.87
303_L311_S0.5580.87
291_V299_V0.5570.87
31_A57_Y0.5560.87
40_L50_N0.5550.87
129_L164_H0.5540.87
29_M111_K0.5530.87
11_K20_G0.5530.87
264_E270_V0.5530.87
127_T164_H0.5500.87
143_K148_Q0.5500.87
314_A318_Q0.5500.87
64_I75_L0.5480.87
295_K303_L0.5470.86
243_M248_I0.5470.86
42_A87_A0.5460.86
253_T257_I0.5460.86
11_K16_S0.5460.86
313_Y316_D0.5440.86
304_M311_S0.5430.86
193_M223_I0.5410.86
283_H286_K0.5400.86
166_Y169_Q0.5380.86
305_K311_S0.5380.86
284_I288_A0.5370.85
314_A321_L0.5360.85
298_R308_G0.5360.85
300_A311_S0.5360.85
290_T297_P0.5360.85
151_L163_E0.5350.85
299_V304_M0.5340.85
284_I292_R0.5310.85
304_M307_L0.5290.85
225_F232_E0.5280.84
231_D235_R0.5270.84
338_L348_F0.5250.84
320_K325_I0.5230.84
75_L79_L0.5200.84
132_T145_E0.5190.83
296_G307_L0.5160.83
129_L150_A0.5150.83
142_D148_Q0.5140.83
302_T325_I0.5120.83
51_Q247_N0.5110.83
132_T139_Q0.5080.82
14_K21_K0.5080.82
297_P307_L0.5070.82
29_M33_G0.5060.82
308_G317_K0.5050.82
347_E354_N0.5050.82
11_K17_K0.5030.82
303_L306_N0.5020.81
341_Q344_L0.5020.81
150_A157_V0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ry2A 2 0.6244 100 0.294 Contact Map
4f4cA 1 0.6053 100 0.302 Contact Map
4q9hA 1 0.6364 100 0.321 Contact Map
4a82A 2 0.634 100 0.323 Contact Map
3zdqA 2 0.6053 100 0.324 Contact Map
3b5xA 2 0.634 100 0.326 Contact Map
4mrsA 2 0.6555 100 0.327 Contact Map
3b60A 2 0.634 100 0.328 Contact Map
3nh6A 1 0.6244 100 0.33 Contact Map
3tuiC 2 0.7967 100 0.331 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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