GREMLIN Database
GPDA - Glycerol-3-phosphate dehydrogenase [NAD(P)+]
UniProt: P46919 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 345 (327)
Sequences: 4245 (2741)
Seq/√Len: 151.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_R123_E3.3701.00
227_G237_F3.3651.00
62_T68_A3.3281.00
45_E52_N3.2641.00
31_A37_I3.0751.00
114_L122_I3.0591.00
309_Q313_N2.8131.00
139_S152_V2.8031.00
34_A38_H2.6571.00
136_S185_V2.6251.00
78_A104_V2.5731.00
38_H42_E2.5471.00
5_T72_A2.5271.00
3_K26_E2.5091.00
198_A307_L2.4541.00
18_L56_S2.4071.00
64_D67_E2.3801.00
263_L268_Y2.3751.00
41_N61_G2.3511.00
191_L290_A2.3431.00
268_Y276_E2.3231.00
85_R109_E2.2611.00
271_E275_E2.1901.00
16_L104_V2.1391.00
12_W144_V2.1291.00
295_K305_E2.1001.00
147_R173_N2.0911.00
45_E54_K2.0581.00
316_K319_T2.0511.00
22_D147_R2.0411.00
5_T68_A2.0221.00
39_Q47_K2.0041.00
152_V174_F1.9921.00
140_H248_V1.9551.00
121_E157_K1.9521.00
269_K272_D1.9321.00
306_A320_A1.9211.00
9_A31_A1.8521.00
37_I61_G1.8081.00
260_A281_V1.7991.00
291_Y295_K1.7761.00
203_D212_K1.7591.00
88_L120_M1.7561.00
262_N266_K1.7551.00
170_I329_K1.7431.00
40_I61_G1.7381.00
156_S162_A1.7381.00
291_Y308_H1.7261.00
309_Q315_Q1.7021.00
188_G241_T1.6951.00
308_H312_F1.6871.00
39_Q43_L1.6701.00
301_M304_T1.6561.00
258_W262_N1.6531.00
315_Q320_A1.6501.00
74_V100_V1.6491.00
294_S301_M1.6491.00
55_L59_I1.6441.00
21_T59_I1.6391.00
11_S279_M1.6061.00
85_R114_L1.6011.00
133_V156_S1.5951.00
74_V165_V1.5871.00
315_Q323_S1.5821.00
287_T307_L1.5781.00
159_M163_E1.5701.00
39_Q45_E1.5681.00
227_G232_G1.5601.00
133_V161_A1.5601.00
81_T116_I1.5541.00
230_M297_Y1.5521.00
268_Y272_D1.5471.00
139_S150_T1.5141.00
86_E90_Q1.5051.00
74_V168_L1.4991.00
16_L76_I1.4781.00
201_I310_V1.4741.00
143_E210_N1.4721.00
34_A63_T1.4671.00
26_E60_K1.4671.00
20_L169_F1.4561.00
291_Y305_E1.4501.00
85_R122_I1.4461.00
216_I247_I1.4401.00
46_N49_Y1.4361.00
69_V91_A1.4351.00
180_P233_N1.4241.00
133_V165_V1.4221.00
84_I116_I1.4121.00
100_V161_A1.4051.00
53_V146_L1.4041.00
19_V174_F1.4021.00
253_V262_N1.3901.00
291_Y304_T1.3881.00
66_K94_F1.3851.00
195_I219_G1.3601.00
205_L317_V1.3311.00
44_H57_T1.3271.00
226_L293_L1.3271.00
224_A228_T1.3171.00
120_M132_I1.3111.00
21_T58_S1.2991.00
263_L273_V1.2981.00
33_R48_D1.2961.00
288_K312_F1.2951.00
102_V165_V1.2921.00
9_A29_V1.2911.00
277_M281_V1.2881.00
220_L243_V1.2871.00
43_L47_K1.2811.00
62_T67_E1.2771.00
22_D173_N1.2731.00
54_K57_T1.2711.00
76_I169_F1.2631.00
28_C62_T1.2521.00
154_A165_V1.2521.00
259_R278_G1.2471.00
23_N171_N1.2441.00
205_L318_E1.2411.00
140_H254_H1.2301.00
44_H61_G1.2211.00
53_V145_G1.2211.00
115_R118_E1.2111.00
116_I119_I1.2051.00
203_D258_W1.1931.00
142_E254_H1.1901.00
114_L118_E1.1811.00
41_N44_H1.1651.00
3_K28_C1.1651.00
142_E146_L1.1501.00
270_L284_V1.1471.00
226_L230_M1.1461.00
77_V120_M1.1461.00
86_E89_R1.1451.00
109_E112_S1.1421.00
18_L147_R1.1341.00
229_K297_Y1.1331.00
101_F124_L1.1311.00
85_R123_E1.1251.00
41_N60_K1.1140.99
74_V102_V1.1140.99
81_T286_T1.1120.99
226_L301_M1.1100.99
260_A273_V1.1010.99
18_L22_D1.0990.99
260_A284_V1.0940.99
77_V88_L1.0930.99
84_I105_S1.0930.99
134_V182_I1.0930.99
263_L266_K1.0860.99
155_S185_V1.0860.99
17_A59_I1.0780.99
273_V277_M1.0750.99
131_D158_S1.0740.99
292_Q295_K1.0740.99
65_M91_A1.0720.99
75_I99_A1.0660.99
14_T55_L1.0630.99
260_A270_L1.0570.99
306_A323_S1.0540.99
37_I63_T1.0510.99
36_L40_I1.0500.99
14_T46_N1.0470.99
308_H313_N1.0400.99
319_T322_E1.0320.99
28_C71_D1.0290.99
160_R163_E1.0280.99
76_I104_V1.0230.99
37_I41_N1.0100.99
263_L276_E1.0080.99
306_A315_Q1.0080.99
69_V75_I1.0020.99
148_H211_A1.0010.99
82_K285_R0.9890.99
187_I191_L0.9840.99
159_M180_P0.9820.99
30_W65_M0.9810.99
300_K327_R0.9780.99
209_D254_H0.9760.99
153_T179_N0.9740.99
197_L260_A0.9640.98
40_I55_L0.9630.98
35_D38_H0.9600.98
77_V91_A0.9600.98
33_R49_Y0.9580.98
209_D252_S0.9570.98
309_Q314_G0.9560.98
270_L311_L0.9540.98
36_L39_Q0.9520.98
154_A176_V0.9500.98
162_A178_T0.9500.98
269_K273_V0.9470.98
87_V90_Q0.9470.98
50_L145_G0.9460.98
82_K110_P0.9440.98
96_T99_A0.9430.98
195_I223_I0.9430.98
109_E119_I0.9410.98
92_V124_L0.9410.98
221_A225_R0.9370.98
3_K71_D0.9360.98
152_V176_V0.9330.98
113_L296_K0.9310.98
103_H120_M0.9300.98
111_D292_Q0.9270.98
259_R263_L0.9250.98
32_H83_A0.9230.98
27_V59_I0.9130.98
228_T234_P0.9130.98
19_V23_N0.9080.98
287_T311_L0.9010.98
33_R36_L0.9010.98
4_V168_L0.8980.98
288_K292_Q0.8950.98
73_D98_K0.8950.98
85_R119_I0.8920.97
158_S161_A0.8920.97
115_R183_I0.8920.97
113_L292_Q0.8900.97
60_K67_E0.8860.97
167_D329_K0.8780.97
272_D276_E0.8720.97
198_A215_L0.8720.97
288_K313_N0.8690.97
195_I304_T0.8640.97
28_C60_K0.8640.97
7_L30_W0.8610.97
100_V164_E0.8590.97
66_K70_S0.8570.97
31_A36_L0.8560.97
16_L169_F0.8560.97
309_Q323_S0.8550.97
117_S132_I0.8530.97
305_E309_Q0.8520.97
7_L91_A0.8480.97
108_I289_A0.8430.96
5_T28_C0.8420.96
322_E326_A0.8410.96
77_V84_I0.8390.96
194_I290_A0.8230.96
206_G266_K0.8220.96
47_K52_N0.8220.96
6_M59_I0.8190.96
306_A309_Q0.8180.96
209_D212_K0.8140.96
327_R330_T0.8120.96
11_S49_Y0.8090.95
29_V61_G0.8090.95
300_K305_E0.8070.95
131_D161_A0.8070.95
77_V105_S0.8060.95
69_V72_A0.8060.95
110_P289_A0.8030.95
154_A169_F0.8020.95
248_V254_H0.8020.95
81_T105_S0.8000.95
177_Y218_R0.7990.95
253_V259_R0.7980.95
71_D96_T0.7920.95
39_Q48_D0.7910.95
95_I99_A0.7790.94
6_M17_A0.7770.94
109_E114_L0.7730.94
48_D278_G0.7720.94
207_Y321_V0.7720.94
117_S186_E0.7710.94
28_C72_A0.7710.94
38_H41_N0.7700.94
248_V252_S0.7680.94
19_V171_N0.7670.94
191_L223_I0.7630.94
118_E121_E0.7630.94
271_E314_G0.7610.94
102_V133_V0.7580.94
260_A277_M0.7580.94
140_H209_D0.7490.93
18_L55_L0.7480.93
100_V165_V0.7480.93
229_K299_V0.7460.93
216_I250_C0.7460.93
268_Y273_V0.7450.93
133_V154_A0.7370.93
163_E167_D0.7350.93
103_H132_I0.7340.93
263_L277_M0.7260.92
74_V164_E0.7250.92
270_L273_V0.7220.92
155_S182_I0.7210.92
243_V247_I0.7200.92
291_Y313_N0.7200.92
5_T75_I0.7190.92
140_H252_S0.7190.92
18_L53_V0.7180.92
18_L145_G0.7150.92
4_V25_N0.7150.92
226_L294_S0.7140.91
272_D275_E0.7120.91
29_V44_H0.7120.91
33_R37_I0.7110.91
108_I187_I0.7080.91
166_Q178_T0.7070.91
292_Q296_K0.7060.91
7_L77_V0.7050.91
300_K330_T0.6990.91
224_A234_P0.6970.90
199_A258_W0.6960.90
264_L270_L0.6940.90
270_L274_L0.6940.90
281_V284_V0.6860.90
273_V281_V0.6850.90
319_T323_S0.6850.90
21_T56_S0.6800.89
89_R92_V0.6800.89
230_M293_L0.6750.89
7_L87_V0.6730.89
102_V135_L0.6730.89
309_Q320_A0.6730.89
151_T214_A0.6720.89
259_R262_N0.6700.89
142_E248_V0.6670.88
80_P83_A0.6670.88
18_L59_I0.6670.88
293_L296_K0.6650.88
266_K276_E0.6640.88
56_S59_I0.6640.88
290_A304_T0.6590.88
139_S248_V0.6580.88
121_E182_I0.6570.88
223_I246_L0.6530.87
318_E322_E0.6510.87
293_L297_Y0.6500.87
18_L173_N0.6500.87
224_A235_L0.6490.87
45_E51_P0.6430.87
91_A94_F0.6400.86
15_A50_L0.6400.86
224_A237_F0.6390.86
161_A164_E0.6380.86
177_Y327_R0.6380.86
199_A212_K0.6370.86
92_V126_S0.6370.86
159_M331_H0.6360.86
20_L23_N0.6350.86
159_M162_A0.6330.86
69_V99_A0.6320.86
188_G243_V0.6320.86
44_H55_L0.6310.86
147_R171_N0.6300.86
88_L123_E0.6290.85
33_R83_A0.6280.85
211_A214_A0.6260.85
191_L301_M0.6260.85
228_T235_L0.6260.85
142_E209_D0.6250.85
108_I190_A0.6230.85
68_A72_A0.6220.85
259_R277_M0.6210.85
65_M87_V0.6190.85
85_R112_S0.6190.85
166_Q329_K0.6180.84
252_S258_W0.6180.84
9_A36_L0.6170.84
95_I101_F0.6170.84
212_K251_T0.6160.84
114_L123_E0.6140.84
7_L75_I0.6110.84
84_I120_M0.6100.84
135_L174_F0.6070.83
88_L92_V0.6070.83
73_D96_T0.6050.83
14_T29_V0.6030.83
5_T71_D0.6020.83
115_R186_E0.6020.83
49_Y80_P0.5980.82
260_A274_L0.5970.82
135_L154_A0.5970.82
179_N185_V0.5970.82
32_H36_L0.5960.82
83_A86_E0.5950.82
82_K105_S0.5950.82
193_N249_T0.5940.82
110_P285_R0.5930.82
110_P288_K0.5920.82
14_T49_Y0.5910.82
273_V276_E0.5900.82
4_V74_V0.5900.82
162_A166_Q0.5880.81
155_S179_N0.5880.81
65_M90_Q0.5850.81
67_E70_S0.5840.81
79_V83_A0.5830.81
26_E58_S0.5820.81
20_L76_I0.5810.81
83_A87_V0.5800.80
19_V22_D0.5790.80
11_S142_E0.5770.80
270_L281_V0.5750.80
190_A286_T0.5750.80
163_E331_H0.5740.80
181_D236_T0.5740.80
274_L284_V0.5730.80
248_V253_V0.5730.80
247_I260_A0.5710.79
130_K158_S0.5700.79
22_D171_N0.5680.79
135_L176_V0.5680.79
126_S130_K0.5660.79
92_V123_E0.5660.79
284_V311_L0.5650.79
188_G237_F0.5640.79
199_A247_I0.5620.78
315_Q319_T0.5610.78
153_T241_T0.5610.78
117_S182_I0.5600.78
8_G79_V0.5600.78
253_V258_W0.5590.78
181_D184_G0.5590.78
216_I251_T0.5580.78
185_V241_T0.5580.78
82_K286_T0.5570.78
328_G331_H0.5560.78
264_L273_V0.5550.78
7_L65_M0.5550.78
88_L124_L0.5530.77
72_A75_I0.5520.77
44_H54_K0.5520.77
81_T289_A0.5510.77
15_A140_H0.5490.77
294_S299_V0.5490.77
178_T331_H0.5490.77
88_L132_I0.5490.77
112_S122_I0.5470.77
139_S144_V0.5460.76
265_G273_V0.5440.76
260_A263_L0.5430.76
125_P130_K0.5410.76
103_H115_R0.5410.76
226_L297_Y0.5410.76
11_S79_V0.5400.76
100_V133_V0.5400.76
218_R240_L0.5400.76
121_E132_I0.5390.75
44_H60_K0.5360.75
136_S189_G0.5350.75
118_E183_I0.5350.75
140_H253_V0.5340.75
193_N245_D0.5340.75
44_H58_S0.5320.75
293_L299_V0.5310.74
32_H49_Y0.5310.74
120_M124_L0.5290.74
144_V152_V0.5290.74
159_M178_T0.5270.74
17_A29_V0.5260.74
7_L69_V0.5250.74
84_I88_L0.5220.73
15_A145_G0.5220.73
205_L215_L0.5220.73
222_E302_P0.5210.73
172_H322_E0.5200.73
95_I124_L0.5200.73
201_I262_N0.5200.73
166_Q176_V0.5190.73
259_R279_M0.5180.73
177_Y225_R0.5170.72
232_G237_F0.5170.72
88_L91_A0.5160.72
284_V312_F0.5150.72
180_P331_H0.5140.72
119_I123_E0.5140.72
213_A248_V0.5140.72
207_Y211_A0.5140.72
140_H152_V0.5130.72
286_T290_A0.5100.71
273_V278_G0.5090.71
102_V169_F0.5090.71
109_E122_I0.5090.71
156_S161_A0.5080.71
175_R327_R0.5080.71
179_N287_T0.5080.71
244_G282_E0.5070.71
70_S96_T0.5070.71
69_V96_T0.5060.71
327_R332_E0.5050.71
131_D156_S0.5050.71
110_P292_Q0.5040.71
103_H117_S0.5040.71
138_P244_G0.5040.71
202_T215_L0.5030.70
11_S14_T0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yj8A 2 0.9362 100 0.52 Contact Map
3k96A 2 0.9391 100 0.525 Contact Map
1evyA 2 0.9652 100 0.528 Contact Map
1x0vA 2 0.942 100 0.55 Contact Map
1txgA 2 0.9275 100 0.556 Contact Map
1z82A 2 0.9072 100 0.56 Contact Map
4fgwA 2 0.9275 100 0.572 Contact Map
1np3A 4 0.8261 100 0.642 Contact Map
2p4qA 2 0.8841 100 0.646 Contact Map
4tskA 3 0.8406 100 0.663 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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