GREMLIN Database
GGAA - Minor teichoic acid biosynthesis protein GgaA
UniProt: P46917 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 446 (377)
Sequences: 1068 (965)
Seq/√Len: 49.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
8_I46_S5.2281.00
166_R170_T4.8141.00
79_L89_I3.6971.00
20_E53_F3.6251.00
17_Y209_R3.5891.00
39_D65_K3.5801.00
6_I22_V3.4511.00
80_S174_L3.4351.00
82_V86_S3.4331.00
66_I69_S3.3931.00
51_E65_K3.3601.00
75_R93_D3.3251.00
27_I32_N3.0771.00
9_Y68_N3.0151.00
66_I74_A2.9751.00
16_R52_S2.9001.00
87_K111_C2.8141.00
76_N175_F2.7021.00
26_S104_Q2.6711.00
40_D70_G2.6001.00
41_G66_I2.5121.00
75_R91_F2.5031.00
11_S94_S2.4971.00
89_I169_L2.4811.00
34_E62_K2.4571.00
10_N42_S2.4281.00
40_D68_N2.4191.00
47_P65_K2.4151.00
47_P63_I2.4011.00
3_S34_E2.3921.00
27_I107_Y2.3871.00
34_E86_S2.3641.00
50_C63_I2.3611.00
186_I190_Q2.3241.00
10_N43_V2.3111.00
35_L61_I2.2751.00
2_F163_F2.2681.00
39_D42_S2.2611.00
169_L187_F2.1921.00
11_S211_R2.1741.00
6_I18_S2.1301.00
2_F107_Y2.1241.00
22_V92_L2.1231.00
38_I74_A2.0801.00
9_Y40_D2.0751.00
12_E45_S2.0571.00
116_V199_G2.0531.00
90_G103_L2.0381.00
27_I33_I1.9971.00
104_Q108_D1.9820.99
41_G74_A1.9370.99
255_Q259_V1.9080.99
98_F102_A1.9010.99
69_S73_A1.8790.99
3_S86_S1.8770.99
251_L255_Q1.8760.99
15_L46_S1.8550.99
69_S74_A1.8250.99
121_L205_K1.7870.99
8_I94_S1.7690.99
66_I73_A1.7530.99
39_D47_P1.7400.99
71_P217_L1.7170.99
359_N362_Y1.7110.98
33_I103_L1.6950.98
2_F103_L1.6920.98
75_R183_E1.6700.98
236_Y239_L1.6440.98
126_T209_R1.6110.98
66_I77_C1.5910.98
117_N165_R1.5910.98
105_S203_E1.5830.97
47_P51_E1.5820.97
6_I35_L1.5660.97
79_L169_L1.5580.97
6_I92_L1.5560.97
64_M81_N1.5540.97
70_G183_E1.5490.97
16_R20_E1.5480.97
64_M77_C1.5370.97
77_C81_N1.5280.97
344_A351_L1.5210.97
5_I82_V1.5110.97
71_P75_R1.5020.97
37_L50_C1.4960.96
82_V166_R1.4910.96
227_R231_L1.4840.96
90_G163_F1.4820.96
54_K63_I1.4810.96
73_A177_E1.4730.96
349_L354_T1.4630.96
235_C238_T1.4570.96
390_I394_G1.4520.96
176_D186_I1.4390.96
216_S219_D1.4370.96
8_I37_L1.4050.95
101_N105_S1.3820.94
25_Q96_D1.3780.94
9_Y70_G1.3760.94
98_F103_L1.3480.94
22_V33_I1.3310.93
96_D159_I1.3270.93
106_V121_L1.3260.93
237_M240_L1.3240.93
3_S36_I1.3220.93
102_A106_V1.3210.93
228_Y231_L1.3050.93
51_E54_K1.3020.92
12_E49_I1.3010.92
106_V163_F1.2980.92
146_I150_N1.2930.92
173_V190_Q1.2780.92
19_I53_F1.2770.92
11_S18_S1.2680.91
102_A121_L1.2680.91
72_S76_N1.2400.91
71_P93_D1.2350.90
93_D183_E1.2150.90
48_Q51_E1.2130.90
147_N150_N1.1980.89
17_Y97_A1.1880.89
106_V119_A1.1850.88
91_F175_F1.1760.88
218_V222_W1.1700.88
384_K388_K1.1620.87
92_L98_F1.1590.87
341_V369_R1.1550.87
49_I53_F1.1490.87
23_L61_I1.1410.86
373_K378_L1.1390.86
106_V110_F1.1370.86
217_L221_S1.1310.86
254_L258_I1.1280.86
325_A329_I1.1270.86
110_F165_R1.1220.85
110_F163_F1.1200.85
117_N196_K1.1200.85
71_P183_E1.1160.85
99_S207_F1.1120.85
217_L224_N1.1110.85
95_D184_D1.1050.85
14_Y209_R1.1000.84
236_Y240_L1.0990.84
218_V221_S1.0980.84
187_F191_L1.0930.84
17_Y126_T1.0820.83
327_E330_K1.0750.83
96_D206_Y1.0710.83
168_T195_E1.0670.82
10_N44_D1.0610.82
383_R386_L1.0490.81
216_S222_W1.0490.81
76_N95_D1.0440.81
38_I78_G1.0340.80
345_K351_L1.0240.80
92_L206_Y1.0240.80
62_K85_R1.0210.80
62_K81_N1.0170.79
133_H136_N1.0170.79
240_L243_S1.0160.79
71_P94_S1.0150.79
96_D209_R1.0120.79
251_L257_L1.0100.79
25_Q208_Y1.0090.79
45_S48_Q1.0080.79
173_V187_F1.0020.78
239_L243_S1.0000.78
8_I15_L0.9990.78
5_I166_R0.9980.78
10_N46_S0.9970.78
101_N104_Q0.9920.78
111_C165_R0.9900.77
76_N79_L0.9900.77
110_F119_A0.9890.77
19_I23_L0.9850.77
4_I22_V0.9840.77
42_S68_N0.9840.77
108_D112_D0.9840.77
94_S211_R0.9830.77
107_Y111_C0.9820.77
82_V89_I0.9780.77
68_N71_P0.9710.76
71_P159_I0.9590.75
215_D218_V0.9590.75
250_V258_I0.9590.75
10_N68_N0.9580.75
357_F369_R0.9550.75
96_D208_Y0.9520.75
16_R53_F0.9510.75
390_I393_W0.9450.74
145_V148_I0.9440.74
92_L103_L0.9430.74
109_F199_G0.9420.74
124_Y207_F0.9370.73
102_A161_G0.9370.73
300_Q304_E0.9360.73
143_T147_N0.9330.73
253_Y257_L0.9240.72
216_S221_S0.9230.72
38_I77_C0.9220.72
220_R223_F0.9200.72
278_L282_E0.9190.72
159_I175_F0.9160.72
251_L254_L0.9140.72
97_A126_T0.9120.71
3_S78_G0.9100.71
44_D68_N0.9040.71
7_P94_S0.9040.71
22_V60_N0.9020.71
375_F378_L0.9010.70
11_S209_R0.9000.70
360_Q369_R0.8940.70
110_F118_I0.8910.70
251_L259_V0.8880.69
117_N195_E0.8840.69
76_N187_F0.8830.69
264_L267_Y0.8830.69
6_I19_I0.8820.69
238_T243_S0.8810.69
79_L82_V0.8750.68
390_I395_Y0.8720.68
23_L53_F0.8720.68
42_S46_S0.8720.68
146_I149_L0.8700.68
250_V254_L0.8700.68
168_T194_K0.8690.68
68_N95_D0.8660.67
354_T358_I0.8620.67
8_I11_S0.8610.67
173_V195_E0.8610.67
46_S94_S0.8560.66
219_D222_W0.8520.66
235_C240_L0.8520.66
265_F269_N0.8510.66
292_K295_K0.8500.66
168_T191_L0.8490.66
389_T393_W0.8480.66
216_S220_R0.8460.66
237_M241_M0.8460.66
5_I38_I0.8450.65
27_I31_E0.8430.65
14_Y18_S0.8390.65
389_T394_G0.8330.64
76_N177_E0.8330.64
97_A207_F0.8300.64
173_V186_I0.8280.64
164_Y188_F0.8270.64
171_S174_L0.8270.64
52_S55_N0.8260.64
110_F116_V0.8240.63
143_T146_I0.8230.63
153_K156_H0.8230.63
217_L222_W0.8210.63
19_I35_L0.8210.63
215_D219_D0.8200.63
27_I87_K0.8190.63
92_L175_F0.8190.63
359_N363_E0.8140.63
37_L46_S0.8110.62
110_F157_F0.8100.62
159_I188_F0.8100.62
3_S82_V0.8070.62
34_E82_V0.8050.62
357_F360_Q0.8030.61
58_P228_Y0.8030.61
60_N96_D0.8010.61
5_I78_G0.8000.61
46_S198_Y0.7980.61
261_H265_F0.7970.61
353_L356_H0.7960.61
40_D74_A0.7940.61
20_E24_N0.7870.60
71_P182_W0.7840.60
46_S68_N0.7810.59
90_G102_A0.7770.59
38_I81_N0.7740.59
27_I37_L0.7730.59
164_Y187_F0.7720.58
103_L163_F0.7700.58
25_Q209_R0.7690.58
323_T327_E0.7680.58
7_P40_D0.7680.58
192_L210_K0.7620.57
93_D96_D0.7620.57
326_L330_K0.7610.57
344_A347_K0.7590.57
227_R230_Y0.7590.57
247_Y251_L0.7590.57
378_L383_R0.7590.57
254_L269_N0.7580.57
91_F183_E0.7580.57
145_V197_R0.7550.57
251_L258_I0.7530.57
234_E238_T0.7520.56
75_R78_G0.7510.56
309_M314_F0.7500.56
221_S224_N0.7480.56
75_R96_D0.7480.56
219_D223_F0.7460.56
382_K388_K0.7440.56
145_V149_L0.7440.56
247_Y250_V0.7400.55
279_D282_E0.7370.55
377_R386_L0.7340.55
139_F142_G0.7320.54
144_R148_I0.7310.54
97_A209_R0.7280.54
14_Y211_R0.7280.54
343_S346_I0.7270.54
9_Y95_D0.7260.54
169_L173_V0.7250.54
118_I162_T0.7240.54
324_E327_E0.7220.53
18_S182_W0.7210.53
37_L61_I0.7210.53
120_V162_T0.7200.53
241_M244_F0.7170.53
335_L338_S0.7150.53
246_K250_V0.7110.52
4_I33_I0.7090.52
238_T241_M0.7090.52
90_G98_F0.7060.52
114_E117_N0.7040.52
382_K393_W0.7010.51
71_P91_F0.6960.51
75_R162_T0.6960.51
5_I36_I0.6950.51
217_L220_R0.6910.50
4_I103_L0.6910.50
25_Q32_N0.6900.50
173_V191_L0.6870.50
41_G69_S0.6870.50
102_A205_K0.6820.49
119_A163_F0.6820.49
252_P255_Q0.6800.49
116_V119_A0.6790.49
251_L262_I0.6780.49
40_D93_D0.6780.49
7_P75_R0.6770.49
98_F106_V0.6760.49
96_D161_G0.6750.49
91_F102_A0.6750.49
10_N39_D0.6740.48
164_Y191_L0.6730.48
40_D96_D0.6710.48
151_D156_H0.6690.48
103_L107_Y0.6680.48
249_I254_L0.6680.48
173_V176_D0.6680.48
342_T354_T0.6670.48
326_L329_I0.6660.48
102_A208_Y0.6660.48
9_Y94_S0.6640.47
183_E206_Y0.6630.47
7_P78_G0.6630.47
341_V344_A0.6630.47
321_E325_A0.6610.47
38_I166_R0.6600.47
15_L37_L0.6600.47
109_F116_V0.6580.47
254_L265_F0.6560.47
262_I265_F0.6560.47
256_F264_L0.6560.47
169_L191_L0.6550.47
257_L260_Y0.6540.46
4_I92_L0.6530.46
158_Y161_G0.6530.46
326_L333_R0.6520.46
18_S88_F0.6490.46
260_Y264_L0.6490.46
40_D94_S0.6490.46
389_T392_V0.6470.46
232_L235_C0.6450.46
70_G95_D0.6440.45
288_D291_I0.6430.45
4_I165_R0.6420.45
25_Q104_Q0.6390.45
71_P186_I0.6380.45
349_L361_Y0.6370.45
11_S19_I0.6360.45
261_H268_P0.6360.45
79_L91_F0.6350.45
38_I198_Y0.6340.44
18_S94_S0.6340.44
342_T347_K0.6320.44
255_Q261_H0.6310.44
173_V178_S0.6280.44
75_R184_D0.6280.44
367_N382_K0.6270.44
72_S183_E0.6250.44
88_F165_R0.6250.44
71_P181_F0.6230.43
11_S14_Y0.6200.43
345_K352_E0.6200.43
8_I74_A0.6180.43
324_E328_N0.6160.43
254_L257_L0.6160.43
284_R302_I0.6160.43
344_A350_R0.6150.43
71_P74_A0.6140.42
44_D70_G0.6140.42
266_L286_F0.6140.42
162_T188_F0.6120.42
188_F209_R0.6120.42
238_T242_D0.6120.42
255_Q258_I0.6110.42
286_F339_C0.6110.42
332_E335_L0.6100.42
380_K383_R0.6090.42
248_D251_L0.6080.42
36_I61_I0.6070.42
123_V160_G0.6060.42
46_S49_I0.6060.42
330_K334_V0.6060.42
34_E169_L0.6050.42
116_V162_T0.6040.41
357_F370_I0.6040.41
25_Q98_F0.6040.41
236_Y242_D0.6030.41
341_V371_Y0.6030.41
185_A188_F0.6020.41
349_L356_H0.6020.41
11_S68_N0.6010.41
117_N120_V0.6010.41
88_F111_C0.6000.41
235_C239_L0.6000.41
305_Q310_Y0.5990.41
370_I384_K0.5990.41
72_S175_F0.5980.41
253_Y256_F0.5980.41
71_P208_Y0.5980.41
378_L385_E0.5980.41
18_S21_S0.5970.41
375_F380_K0.5960.41
144_R147_N0.5950.41
74_A93_D0.5950.41
107_Y163_F0.5930.40
159_I211_R0.5890.40
280_Q283_Q0.5860.40
120_V161_G0.5860.40
11_S37_L0.5840.39
26_S93_D0.5820.39
370_I377_R0.5820.39
346_I395_Y0.5800.39
8_I50_C0.5800.39
231_L236_Y0.5790.39
76_N184_D0.5770.39
192_L198_Y0.5770.39
58_P98_F0.5760.39
192_L207_F0.5750.39
298_D301_F0.5750.39
98_F206_Y0.5750.39
50_C61_I0.5750.39
7_P11_S0.5730.38
351_L370_I0.5730.38
39_D184_D0.5710.38
343_S350_R0.5710.38
382_K390_I0.5700.38
183_E208_Y0.5700.38
25_Q93_D0.5700.38
73_A77_C0.5680.38
75_R102_A0.5680.38
375_F381_C0.5670.38
61_I298_D0.5660.38
391_E394_G0.5650.38
357_F371_Y0.5650.38
321_E329_I0.5630.37
353_L371_Y0.5630.37
7_P183_E0.5620.37
340_T355_G0.5610.37
339_C367_N0.5600.37
15_L21_S0.5600.37
350_R356_H0.5590.37
143_T148_I0.5590.37
341_V355_G0.5580.37
43_V46_S0.5570.37
281_Q287_V0.5570.37
22_V26_S0.5560.37
248_D252_P0.5540.37
159_I164_Y0.5520.36
93_D161_G0.5520.36
90_G206_Y0.5510.36
75_R211_R0.5510.36
256_F260_Y0.5500.36
344_A373_K0.5500.36
95_D160_G0.5490.36
71_P188_F0.5490.36
44_D49_I0.5490.36
246_K254_L0.5480.36
373_K376_K0.5480.36
12_E195_E0.5480.36
263_K268_P0.5470.36
34_E85_R0.5470.36
117_N121_L0.5460.36
162_T195_E0.5450.36
320_K327_E0.5450.36
15_L53_F0.5440.36
14_Y67_E0.5430.36
4_I37_L0.5430.36
86_S164_Y0.5420.35
346_I349_L0.5410.35
318_L321_E0.5400.35
361_Y370_I0.5400.35
3_S90_G0.5400.35
90_G121_L0.5370.35
255_Q262_I0.5360.35
8_I206_Y0.5360.35
308_P311_Y0.5360.35
41_G73_A0.5350.35
79_L174_L0.5340.35
39_D68_N0.5340.35
352_E364_M0.5320.35
162_T186_I0.5310.34
68_N183_E0.5300.34
384_K389_T0.5300.34
374_Y377_R0.5290.34
40_D75_R0.5290.34
226_K231_L0.5280.34
41_G206_Y0.5280.34
342_T346_I0.5280.34
176_D199_G0.5270.34
247_Y254_L0.5270.34
38_I157_F0.5260.34
349_L358_I0.5250.34
340_T343_S0.5220.34
36_I278_L0.5210.33
353_L391_E0.5200.33
45_S49_I0.5200.33
118_I191_L0.5190.33
75_R175_F0.5180.33
49_I208_Y0.5170.33
39_D44_D0.5170.33
215_D220_R0.5170.33
278_L314_F0.5160.33
25_Q49_I0.5150.33
387_K392_V0.5150.33
71_P160_G0.5150.33
37_L86_S0.5140.33
96_D184_D0.5130.33
76_N93_D0.5130.33
106_V161_G0.5120.33
378_L386_L0.5120.33
297_I301_F0.5110.33
139_F361_Y0.5110.33
102_A206_Y0.5110.33
169_L181_F0.5090.32
249_I255_Q0.5080.32
22_V34_E0.5080.32
348_G354_T0.5080.32
259_V267_Y0.5060.32
211_R219_D0.5060.32
11_S15_L0.5060.32
48_Q220_R0.5060.32
185_A205_K0.5060.32
376_K383_R0.5050.32
93_D211_R0.5050.32
356_H365_K0.5050.32
21_S25_Q0.5040.32
71_P210_K0.5040.32
72_S186_I0.5030.32
74_A186_I0.5020.32
360_Q363_E0.5020.32
135_L138_R0.5020.32
74_A211_R0.5020.32
158_Y169_L0.5010.32
258_I267_Y0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l7iA 4 0.3004 100 0.348 Contact Map
3bcvA 2 0.4013 100 0.502 Contact Map
1qg8A 1 0.4955 100 0.52 Contact Map
2z86A 2 0.5605 100 0.528 Contact Map
2d7iA 1 0.9058 100 0.581 Contact Map
1xhbA 1 0.8565 100 0.588 Contact Map
5ajoA 1 0.8744 100 0.605 Contact Map
4fixA 3 0.9058 100 0.616 Contact Map
3ckjA 2 0.5717 100 0.624 Contact Map
2nxvA 4 0.5045 100 0.627 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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