GREMLIN Database
COTSA - Spore coat protein SA
UniProt: P46915 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 377 (339)
Sequences: 56813 (48248)
Seq/√Len: 2620.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_L274_S4.7691.00
224_M257_T3.6231.00
238_L242_V3.3801.00
132_Q156_K3.1771.00
277_F294_A3.1501.00
84_H373_Y2.9201.00
193_I226_V2.8411.00
215_D332_A2.7171.00
226_V259_I2.6881.00
355_E359_N2.6751.00
191_K224_M2.6741.00
196_F206_P2.5481.00
211_Q244_H2.5021.00
217_I255_H2.3561.00
141_G145_T2.2531.00
211_Q328_P2.2141.00
39_T80_F2.2001.00
192_K339_L2.1661.00
205_G208_I2.1641.00
237_E240_N2.0961.00
244_H248_L2.0491.00
305_N310_P2.0131.00
228_I270_L2.0101.00
39_T78_S1.9961.00
213_L225_M1.9911.00
215_D329_K1.9851.00
334_R337_D1.9811.00
193_I224_M1.9731.00
341_S344_K1.9511.00
226_V257_T1.9391.00
194_V276_V1.9151.00
230_S238_L1.8971.00
36_H370_L1.8831.00
4_A80_F1.8701.00
337_D344_K1.8651.00
314_E317_K1.8551.00
84_H107_S1.8481.00
192_K275_D1.8411.00
193_I273_M1.8391.00
313_I319_G1.8271.00
318_N355_E1.8161.00
364_R368_N1.7881.00
345_R349_G1.7861.00
298_G353_R1.7831.00
205_G282_Q1.7601.00
138_D141_G1.7531.00
323_H330_Q1.7431.00
320_Y334_R1.7391.00
161_G362_W1.7241.00
277_F299_L1.7161.00
209_L225_M1.7041.00
39_T60_V1.6921.00
337_D341_S1.6851.00
305_N323_H1.6811.00
141_G157_T1.6661.00
262_V266_D1.6381.00
135_T155_T1.6361.00
106_L130_V1.6331.00
138_D311_E1.6311.00
197_V267_I1.6191.00
336_N340_S1.5981.00
246_H253_K1.5961.00
214_P248_L1.5841.00
132_Q372_V1.5821.00
314_E355_E1.5711.00
213_L223_V1.5701.00
209_L278_V1.5441.00
344_K347_R1.5291.00
327_N330_Q1.5221.00
141_G155_T1.5191.00
317_K351_Y1.5091.00
138_D157_T1.4911.00
330_Q334_R1.4761.00
31_L34_K1.4731.00
314_E318_N1.4581.00
216_I336_N1.4531.00
347_R351_Y1.4521.00
266_D269_R1.4481.00
220_H336_N1.4461.00
320_Y337_D1.4441.00
354_R358_S1.4441.00
263_K266_D1.4321.00
26_E30_P1.4201.00
203_V283_W1.4191.00
208_I282_Q1.4141.00
31_L363_Q1.4071.00
4_A41_F1.4071.00
303_T309_N1.3851.00
262_V270_L1.3811.00
31_L366_A1.3781.00
274_S299_L1.3731.00
208_I328_P1.3691.00
193_I275_D1.3661.00
207_H244_H1.3591.00
328_P332_A1.3471.00
228_I259_I1.3431.00
39_T58_H1.3311.00
226_V270_L1.3291.00
85_V104_F1.3261.00
228_I262_V1.3141.00
96_K100_P1.3051.00
322_I334_R1.3011.00
351_Y354_R1.2901.00
226_V274_S1.2841.00
206_P227_F1.2831.00
194_V335_I1.2801.00
200_L227_F1.2791.00
268_P297_A1.2791.00
145_T152_R1.2771.00
135_T141_G1.2751.00
215_D328_P1.2701.00
212_A331_Y1.2691.00
243_K247_T1.2681.00
194_V278_V1.2681.00
5_L86_C1.2681.00
220_H340_S1.2651.00
196_F209_L1.2541.00
368_N371_S1.2401.00
134_V369_L1.2281.00
138_D142_Q1.2171.00
259_I262_V1.2171.00
167_Y297_A1.2151.00
330_Q333_E1.2151.00
195_L228_I1.2141.00
364_R367_E1.2121.00
192_K276_V1.1971.00
249_G252_Q1.1951.00
244_H247_T1.1751.00
287_L292_Y1.1691.00
242_V246_H1.1551.00
267_I271_Y1.1451.00
214_P218_E1.1391.00
142_Q145_T1.1321.00
346_E350_K1.1311.00
281_S285_E1.1291.00
239_N242_V1.1281.00
279_C291_H1.1251.00
5_L32_I1.1161.00
332_A336_N1.1141.00
272_T297_A1.1131.00
282_Q326_E1.1101.00
362_W365_V1.1031.00
291_H309_N1.1031.00
349_G352_S1.1001.00
166_T268_P1.0941.00
134_V372_V1.0901.00
239_N243_K1.0741.00
207_H211_Q1.0711.00
135_T144_I1.0691.00
342_S345_R1.0681.00
271_Y297_A1.0681.00
304_S322_I1.0671.00
303_T321_I1.0611.00
24_Y289_R1.0591.00
298_G350_K1.0581.00
193_I274_S1.0571.00
208_I326_E1.0551.00
208_I304_S1.0541.00
322_I331_Y1.0471.00
361_G364_R1.0461.00
191_K222_D1.0441.00
299_L349_G1.0441.00
315_E334_R1.0391.00
192_K223_V1.0391.00
136_V160_S1.0361.00
201_S232_W1.0331.00
365_V368_N1.0331.00
136_V140_I1.0321.00
208_I211_Q1.0311.00
109_H289_R1.0271.00
288_A309_N1.0271.00
344_K348_L1.0241.00
192_K222_D1.0241.00
279_C290_V1.0201.00
264_P267_I1.0171.00
320_Y348_L1.0131.00
230_S261_F1.0091.00
277_F290_V1.0051.00
199_R203_V1.0041.00
338_L348_L1.0041.00
86_C109_H0.9951.00
27_A30_P0.9931.00
280_S331_Y0.9921.00
160_S289_R0.9861.00
295_M301_I0.9831.00
195_L270_L0.9821.00
308_G311_E0.9821.00
285_E288_A0.9791.00
207_H282_Q0.9761.00
215_D218_E0.9691.00
333_E337_D0.9681.00
259_I270_L0.9681.00
268_P272_T0.9621.00
135_T140_I0.9611.00
167_Y268_P0.9591.00
216_I223_V0.9541.00
194_V213_L0.9541.00
211_Q248_L0.9541.00
217_I220_H0.9541.00
142_Q146_S0.9521.00
197_V271_Y0.9481.00
136_V286_P0.9481.00
197_V228_I0.9441.00
5_L29_A0.9421.00
72_G99_A0.9381.00
307_G310_P0.9351.00
365_V369_L0.9331.00
320_Y338_L0.9321.00
216_I335_I0.9281.00
130_V133_I0.9261.00
291_H303_T0.9261.00
207_H240_N0.9261.00
294_A299_L0.9251.00
245_L252_Q0.9211.00
342_S346_E0.9201.00
209_L280_S0.9201.00
105_I134_V0.9191.00
196_F227_F0.9141.00
226_V273_M0.9141.00
143_T146_S0.9141.00
318_N352_S0.9061.00
85_V106_L0.9051.00
350_K354_R0.8981.00
208_I331_Y0.8931.00
204_K285_E0.8931.00
19_G22_Q0.8911.00
295_M352_S0.8911.00
27_A362_W0.8831.00
24_Y109_H0.8831.00
161_G365_V0.8831.00
104_F130_V0.8811.00
231_K237_E0.8811.00
245_L258_F0.8791.00
303_T313_I0.8791.00
243_K246_H0.8781.00
346_E349_G0.8781.00
302_I322_I0.8721.00
29_A40_V0.8721.00
204_K290_V0.8701.00
349_G353_R0.8631.00
210_L245_L0.8621.00
216_I339_L0.8591.00
224_M255_H0.8571.00
72_G76_K0.8571.00
367_E371_S0.8551.00
29_A33_A0.8531.00
212_A332_A0.8521.00
291_H301_I0.8501.00
223_V339_L0.8471.00
90_S93_P0.8451.00
320_Y344_K0.8441.00
348_L351_Y0.8441.00
213_L255_H0.8431.00
163_D166_T0.8411.00
196_F280_S0.8401.00
134_V158_V0.8401.00
237_E241_Y0.8321.00
216_I332_A0.8291.00
276_V338_L0.8291.00
302_I334_R0.8281.00
195_L271_Y0.8251.00
217_I221_P0.8231.00
25_L86_C0.8201.00
271_Y299_L0.8201.00
164_L361_G0.8181.00
295_M355_E0.8151.00
291_H312_V0.8141.00
240_N244_H0.8141.00
323_H327_N0.8141.00
214_P217_I0.8101.00
23_I27_A0.8081.00
249_G253_K0.8061.00
300_P349_G0.8051.00
278_V335_I0.8041.00
156_K372_V0.8031.00
23_I264_P0.7981.00
270_L273_M0.7971.00
159_Y311_E0.7961.00
279_C309_N0.7961.00
361_G365_V0.7921.00
329_K333_E0.7891.00
295_M318_N0.7861.00
269_R273_M0.7841.00
240_N243_K0.7831.00
73_A77_K0.7811.00
145_T155_T0.7801.00
207_H237_E0.7781.00
139_Y142_Q0.7771.00
214_P252_Q0.7731.00
212_A328_P0.7731.00
156_K368_N0.7721.00
95_L99_A0.7701.00
158_V372_V0.7661.00
103_V131_A0.7621.00
159_Y368_N0.7621.00
315_E318_N0.7611.00
24_Y107_S0.7601.00
82_L373_Y0.7591.00
211_Q214_P0.7581.00
110_N203_V0.7571.00
275_D345_R0.7571.00
300_P338_L0.7561.00
313_I321_I0.7561.00
97_K104_F0.7531.00
276_V335_I0.7521.00
211_Q215_D0.7511.00
39_T43_I0.7491.00
306_R309_N0.7481.00
355_E360_F0.7461.00
369_L373_Y0.7441.00
204_K281_S0.7431.00
269_R272_T0.7431.00
27_A31_L0.7401.00
348_L352_S0.7361.00
37_E58_H0.7321.00
24_Y160_S0.7321.00
139_Y143_T0.7321.00
27_A163_D0.7271.00
245_L248_L0.7251.00
305_N321_I0.7231.00
316_G337_D0.7231.00
347_R350_K0.7201.00
196_F277_F0.7171.00
362_W366_A0.7171.00
252_Q255_H0.7161.00
143_T147_R0.7161.00
105_I132_Q0.7121.00
74_E78_S0.7111.00
125_I129_S0.7111.00
333_E336_N0.7111.00
109_H136_V0.7111.00
302_I338_L0.7091.00
198_G206_P0.7091.00
202_K207_H0.7091.00
310_P321_I0.7071.00
121_A125_I0.7041.00
136_V289_R0.7041.00
97_K100_P0.7011.00
202_K237_E0.7001.00
86_C107_S0.6991.00
196_F225_M0.6931.00
170_R272_T0.6921.00
264_P268_P0.6911.00
304_S324_D0.6891.00
248_L252_Q0.6881.00
194_V223_V0.6871.00
197_V277_F0.6861.00
288_A291_H0.6851.00
262_V267_I0.6831.00
30_P55_D0.6811.00
121_A124_E0.6791.00
198_G204_K0.6781.00
338_L345_R0.6751.00
33_A38_V0.6721.00
156_K159_Y0.6701.00
216_I220_H0.6701.00
323_H326_E0.6701.00
304_S331_Y0.6681.00
84_H369_L0.6661.00
279_C288_A0.6651.00
337_D340_S0.6651.00
23_I26_E0.6651.00
324_D327_N0.6641.00
200_L238_L0.6631.00
295_M349_G0.6621.00
158_V369_L0.6561.00
329_K332_A0.6561.00
24_Y369_L0.6511.00
80_F102_A0.6471.00
189_H224_M0.6471.00
159_Y360_F0.6471.00
292_Y360_F0.6461.00
353_R356_A0.6451.00
231_K238_L0.6421.00
287_L360_F0.6401.00
65_D69_E0.6391.00
343_E347_R0.6381.00
82_L105_I0.6381.00
366_A370_L0.6371.00
192_K342_S0.6371.00
124_E128_D0.6361.00
35_K38_V0.6351.00
202_K282_Q0.6331.00
206_P237_E0.6321.00
117_K120_Q0.6301.00
19_G199_R0.6241.00
194_V339_L0.6221.00
318_N351_Y0.6201.00
158_V368_N0.6191.00
270_L274_S0.6171.00
213_L216_I0.6141.00
205_G280_S0.6131.00
5_L38_V0.6111.00
343_E346_E0.6091.00
145_T149_P0.6081.00
7_A21_I0.6071.00
7_A25_L0.6071.00
278_V331_Y0.6061.00
28_V369_L0.6061.00
222_D255_H0.6041.00
315_E320_Y0.6031.00
141_G152_R0.6021.00
105_I373_Y0.6011.00
98_Q129_S0.6001.00
33_A56_G0.6001.00
363_Q367_E0.5971.00
96_K99_A0.5971.00
107_S369_L0.5961.00
29_A38_V0.5951.00
35_K370_L0.5951.00
188_L273_M0.5931.00
85_V93_P0.5931.00
117_K121_A0.5921.00
192_K195_L0.5911.00
135_T157_T0.5911.00
33_A36_H0.5901.00
352_S355_E0.5901.00
9_E22_Q0.5901.00
168_H272_T0.5881.00
139_Y310_P0.5871.00
212_A335_I0.5871.00
276_V302_I0.5871.00
195_L277_F0.5871.00
306_R310_P0.5831.00
217_I223_V0.5811.00
271_Y290_V0.5791.00
200_L206_P0.5781.00
221_P340_S0.5771.00
83_V97_K0.5771.00
209_L213_L0.5761.00
188_L226_V0.5751.00
313_I318_N0.5741.00
277_F301_I0.5741.00
163_D167_Y0.5731.00
322_I330_Q0.5721.00
34_K363_Q0.5721.00
367_E370_L0.5721.00
74_E77_K0.5701.00
168_H171_W0.5691.00
345_R348_L0.5671.00
229_G260_Q0.5661.00
216_I221_P0.5651.00
208_I212_A0.5641.00
192_K345_R0.5641.00
24_Y28_V0.5631.00
104_F131_A0.5631.00
137_S140_I0.5611.00
205_G326_E0.5601.00
210_L256_V0.5591.00
21_I87_N0.5571.00
200_L231_K0.5571.00
5_L84_H0.5511.00
341_S345_R0.5501.00
55_D58_H0.5491.00
125_I128_D0.5471.00
275_D342_S0.5441.00
140_I143_T0.5441.00
30_P34_K0.5441.00
202_K240_N0.5431.00
190_G222_D0.5431.00
359_N364_R0.5431.00
138_D159_Y0.5421.00
193_I270_L0.5411.00
305_N324_D0.5401.00
165_K168_H0.5401.00
166_T264_P0.5401.00
351_Y355_E0.5371.00
109_H160_S0.5371.00
302_I335_I0.5371.00
242_V258_F0.5361.00
24_Y86_C0.5361.00
83_V102_A0.5351.00
294_A301_I0.5341.00
245_L256_V0.5341.00
100_P103_V0.5331.00
281_S288_A0.5331.00
199_R204_K0.5321.00
107_S134_V0.5301.00
5_L373_Y0.5301.00
145_T154_K0.5281.00
290_V294_A0.5271.00
283_W286_P0.5261.00
295_M356_A0.5251.00
212_A216_I0.5241.00
221_P336_N0.5231.00
225_M256_V0.5221.00
207_H241_Y0.5221.00
140_I286_P0.5211.00
228_I267_I0.5211.00
27_A289_R0.5171.00
205_G304_S0.5131.00
195_L299_L0.5121.00
288_A292_Y0.5121.00
75_L80_F0.5111.00
30_P33_A0.5111.00
164_L296_A0.5101.00
4_A39_T0.5101.00
220_H223_V0.5101.00
280_S304_S0.5091.00
80_F83_V0.5061.00
76_K100_P0.5061.00
52_E61_H0.5051.00
159_Y365_V0.5051.00
271_Y277_F0.5031.00
31_L362_W0.5021.00
28_V31_L0.5011.00
292_Y312_V0.5001.00
108_V140_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.9788 100 0.142 Contact Map
3c48A 2 0.9496 100 0.151 Contact Map
4n9wA 1 0.8859 100 0.159 Contact Map
3okpA 1 0.9469 100 0.164 Contact Map
1rzuA 1 0.9602 100 0.165 Contact Map
3froA 3 0.9655 100 0.166 Contact Map
2qzsA 1 0.9576 100 0.179 Contact Map
2x6qA 1 0.9443 100 0.187 Contact Map
3oy2A 2 0.9257 100 0.19 Contact Map
2jjmA 4 0.9072 100 0.202 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0115 seconds.