COTSA - BACSU - GREMLIN Contacts

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COTSA - Spore coat protein SA

UniProt:	P46915	Sequences: MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIKDPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDAVFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYSGVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIEEHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDVFVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAERINDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	377 (339)
Sequences:	56813 (48248)
Seq/√Len:	2620.5

ECOLI - RFAG WCAL WCAI GLGA RFAB WBBK WCAC
BACSU - COTSA YTCC YPJH YQGM EPSF GLGA EPSD TUAC TUAH YKVP CGEB TAGE
HALSA - Q9HQQ0 Q9HSW1 Q9HS45 Q9HRP8 Q9HSV4 Q9HQT2 Q9HSV2 Q9HRP9
SULSO - Q97XT7 Q980C8 Q97V61 Q97VL4 Q97ZD3 Q97UM0 Q97UU3 Q97V80 Q97XT8 Q97XT9 Q97XU2 Q7LXI2 Q97XT5 Q7LXM9 Q97XT6 Q97XF6 Q97XT1 Q7LXF8 Q7LXF5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
195_L	274_S	4.769	1.00
224_M	257_T	3.623	1.00
238_L	242_V	3.380	1.00
132_Q	156_K	3.177	1.00
277_F	294_A	3.150	1.00
84_H	373_Y	2.920	1.00
193_I	226_V	2.841	1.00
215_D	332_A	2.717	1.00
226_V	259_I	2.688	1.00
355_E	359_N	2.675	1.00
191_K	224_M	2.674	1.00
196_F	206_P	2.548	1.00
211_Q	244_H	2.502	1.00
217_I	255_H	2.356	1.00
141_G	145_T	2.253	1.00
211_Q	328_P	2.214	1.00
39_T	80_F	2.200	1.00
192_K	339_L	2.166	1.00
205_G	208_I	2.164	1.00
237_E	240_N	2.096	1.00
244_H	248_L	2.049	1.00
305_N	310_P	2.013	1.00
228_I	270_L	2.010	1.00
39_T	78_S	1.996	1.00
213_L	225_M	1.991	1.00
215_D	329_K	1.985	1.00
334_R	337_D	1.981	1.00
193_I	224_M	1.973	1.00
341_S	344_K	1.951	1.00
226_V	257_T	1.939	1.00
194_V	276_V	1.915	1.00
230_S	238_L	1.897	1.00
36_H	370_L	1.883	1.00
4_A	80_F	1.870	1.00
337_D	344_K	1.865	1.00
314_E	317_K	1.855	1.00
84_H	107_S	1.848	1.00
192_K	275_D	1.841	1.00
193_I	273_M	1.839	1.00
313_I	319_G	1.827	1.00
318_N	355_E	1.816	1.00
364_R	368_N	1.788	1.00
345_R	349_G	1.786	1.00
298_G	353_R	1.783	1.00
205_G	282_Q	1.760	1.00
138_D	141_G	1.753	1.00
323_H	330_Q	1.743	1.00
320_Y	334_R	1.739	1.00
161_G	362_W	1.724	1.00
277_F	299_L	1.716	1.00
209_L	225_M	1.704	1.00
39_T	60_V	1.692	1.00
337_D	341_S	1.685	1.00
305_N	323_H	1.681	1.00
141_G	157_T	1.666	1.00
262_V	266_D	1.638	1.00
135_T	155_T	1.636	1.00
106_L	130_V	1.633	1.00
138_D	311_E	1.631	1.00
197_V	267_I	1.619	1.00
336_N	340_S	1.598	1.00
246_H	253_K	1.596	1.00
214_P	248_L	1.584	1.00
132_Q	372_V	1.582	1.00
314_E	355_E	1.571	1.00
213_L	223_V	1.570	1.00
209_L	278_V	1.544	1.00
344_K	347_R	1.529	1.00
327_N	330_Q	1.522	1.00
141_G	155_T	1.519	1.00
317_K	351_Y	1.509	1.00
138_D	157_T	1.491	1.00
330_Q	334_R	1.476	1.00
31_L	34_K	1.473	1.00
314_E	318_N	1.458	1.00
216_I	336_N	1.453	1.00
347_R	351_Y	1.452	1.00
266_D	269_R	1.448	1.00
220_H	336_N	1.446	1.00
320_Y	337_D	1.444	1.00
354_R	358_S	1.444	1.00
263_K	266_D	1.432	1.00
26_E	30_P	1.420	1.00
203_V	283_W	1.419	1.00
208_I	282_Q	1.414	1.00
31_L	363_Q	1.407	1.00
4_A	41_F	1.407	1.00
303_T	309_N	1.385	1.00
262_V	270_L	1.381	1.00
31_L	366_A	1.378	1.00
274_S	299_L	1.373	1.00
208_I	328_P	1.369	1.00
193_I	275_D	1.366	1.00
207_H	244_H	1.359	1.00
328_P	332_A	1.347	1.00
228_I	259_I	1.343	1.00
39_T	58_H	1.331	1.00
226_V	270_L	1.329	1.00
85_V	104_F	1.326	1.00
228_I	262_V	1.314	1.00
96_K	100_P	1.305	1.00
322_I	334_R	1.301	1.00
351_Y	354_R	1.290	1.00
226_V	274_S	1.284	1.00
206_P	227_F	1.283	1.00
194_V	335_I	1.280	1.00
200_L	227_F	1.279	1.00
268_P	297_A	1.279	1.00
145_T	152_R	1.277	1.00
135_T	141_G	1.275	1.00
215_D	328_P	1.270	1.00
212_A	331_Y	1.269	1.00
243_K	247_T	1.268	1.00
194_V	278_V	1.268	1.00
5_L	86_C	1.268	1.00
220_H	340_S	1.265	1.00
196_F	209_L	1.254	1.00
368_N	371_S	1.240	1.00
134_V	369_L	1.228	1.00
138_D	142_Q	1.217	1.00
259_I	262_V	1.217	1.00
167_Y	297_A	1.215	1.00
330_Q	333_E	1.215	1.00
195_L	228_I	1.214	1.00
364_R	367_E	1.212	1.00
192_K	276_V	1.197	1.00
249_G	252_Q	1.195	1.00
244_H	247_T	1.175	1.00
287_L	292_Y	1.169	1.00
242_V	246_H	1.155	1.00
267_I	271_Y	1.145	1.00
214_P	218_E	1.139	1.00
142_Q	145_T	1.132	1.00
346_E	350_K	1.131	1.00
281_S	285_E	1.129	1.00
239_N	242_V	1.128	1.00
279_C	291_H	1.125	1.00
5_L	32_I	1.116	1.00
332_A	336_N	1.114	1.00
272_T	297_A	1.113	1.00
282_Q	326_E	1.110	1.00
362_W	365_V	1.103	1.00
291_H	309_N	1.103	1.00
349_G	352_S	1.100	1.00
166_T	268_P	1.094	1.00
134_V	372_V	1.090	1.00
239_N	243_K	1.074	1.00
207_H	211_Q	1.071	1.00
135_T	144_I	1.069	1.00
342_S	345_R	1.068	1.00
271_Y	297_A	1.068	1.00
304_S	322_I	1.067	1.00
303_T	321_I	1.061	1.00
24_Y	289_R	1.059	1.00
298_G	350_K	1.058	1.00
193_I	274_S	1.057	1.00
208_I	326_E	1.055	1.00
208_I	304_S	1.054	1.00
322_I	331_Y	1.047	1.00
361_G	364_R	1.046	1.00
191_K	222_D	1.044	1.00
299_L	349_G	1.044	1.00
315_E	334_R	1.039	1.00
192_K	223_V	1.039	1.00
136_V	160_S	1.036	1.00
201_S	232_W	1.033	1.00
365_V	368_N	1.033	1.00
136_V	140_I	1.032	1.00
208_I	211_Q	1.031	1.00
109_H	289_R	1.027	1.00
288_A	309_N	1.027	1.00
344_K	348_L	1.024	1.00
192_K	222_D	1.024	1.00
279_C	290_V	1.020	1.00
264_P	267_I	1.017	1.00
320_Y	348_L	1.013	1.00
230_S	261_F	1.009	1.00
277_F	290_V	1.005	1.00
199_R	203_V	1.004	1.00
338_L	348_L	1.004	1.00
86_C	109_H	0.995	1.00
27_A	30_P	0.993	1.00
280_S	331_Y	0.992	1.00
160_S	289_R	0.986	1.00
295_M	301_I	0.983	1.00
195_L	270_L	0.982	1.00
308_G	311_E	0.982	1.00
285_E	288_A	0.979	1.00
207_H	282_Q	0.976	1.00
215_D	218_E	0.969	1.00
333_E	337_D	0.968	1.00
259_I	270_L	0.968	1.00
268_P	272_T	0.962	1.00
135_T	140_I	0.961	1.00
167_Y	268_P	0.959	1.00
216_I	223_V	0.954	1.00
194_V	213_L	0.954	1.00
211_Q	248_L	0.954	1.00
217_I	220_H	0.954	1.00
142_Q	146_S	0.952	1.00
197_V	271_Y	0.948	1.00
136_V	286_P	0.948	1.00
197_V	228_I	0.944	1.00
5_L	29_A	0.942	1.00
72_G	99_A	0.938	1.00
307_G	310_P	0.935	1.00
365_V	369_L	0.933	1.00
320_Y	338_L	0.932	1.00
216_I	335_I	0.928	1.00
130_V	133_I	0.926	1.00
291_H	303_T	0.926	1.00
207_H	240_N	0.926	1.00
294_A	299_L	0.925	1.00
245_L	252_Q	0.921	1.00
342_S	346_E	0.920	1.00
209_L	280_S	0.920	1.00
105_I	134_V	0.919	1.00
196_F	227_F	0.914	1.00
226_V	273_M	0.914	1.00
143_T	146_S	0.914	1.00
318_N	352_S	0.906	1.00
85_V	106_L	0.905	1.00
350_K	354_R	0.898	1.00
208_I	331_Y	0.893	1.00
204_K	285_E	0.893	1.00
19_G	22_Q	0.891	1.00
295_M	352_S	0.891	1.00
27_A	362_W	0.883	1.00
24_Y	109_H	0.883	1.00
161_G	365_V	0.883	1.00
104_F	130_V	0.881	1.00
231_K	237_E	0.881	1.00
245_L	258_F	0.879	1.00
303_T	313_I	0.879	1.00
243_K	246_H	0.878	1.00
346_E	349_G	0.878	1.00
302_I	322_I	0.872	1.00
29_A	40_V	0.872	1.00
204_K	290_V	0.870	1.00
349_G	353_R	0.863	1.00
210_L	245_L	0.862	1.00
216_I	339_L	0.859	1.00
224_M	255_H	0.857	1.00
72_G	76_K	0.857	1.00
367_E	371_S	0.855	1.00
29_A	33_A	0.853	1.00
212_A	332_A	0.852	1.00
291_H	301_I	0.850	1.00
223_V	339_L	0.847	1.00
90_S	93_P	0.845	1.00
320_Y	344_K	0.844	1.00
348_L	351_Y	0.844	1.00
213_L	255_H	0.843	1.00
163_D	166_T	0.841	1.00
196_F	280_S	0.840	1.00
134_V	158_V	0.840	1.00
237_E	241_Y	0.832	1.00
216_I	332_A	0.829	1.00
276_V	338_L	0.829	1.00
302_I	334_R	0.828	1.00
195_L	271_Y	0.825	1.00
217_I	221_P	0.823	1.00
25_L	86_C	0.820	1.00
271_Y	299_L	0.820	1.00
164_L	361_G	0.818	1.00
295_M	355_E	0.815	1.00
291_H	312_V	0.814	1.00
240_N	244_H	0.814	1.00
323_H	327_N	0.814	1.00
214_P	217_I	0.810	1.00
23_I	27_A	0.808	1.00
249_G	253_K	0.806	1.00
300_P	349_G	0.805	1.00
278_V	335_I	0.804	1.00
156_K	372_V	0.803	1.00
23_I	264_P	0.798	1.00
270_L	273_M	0.797	1.00
159_Y	311_E	0.796	1.00
279_C	309_N	0.796	1.00
361_G	365_V	0.792	1.00
329_K	333_E	0.789	1.00
295_M	318_N	0.786	1.00
269_R	273_M	0.784	1.00
240_N	243_K	0.783	1.00
73_A	77_K	0.781	1.00
145_T	155_T	0.780	1.00
207_H	237_E	0.778	1.00
139_Y	142_Q	0.777	1.00
214_P	252_Q	0.773	1.00
212_A	328_P	0.773	1.00
156_K	368_N	0.772	1.00
95_L	99_A	0.770	1.00
158_V	372_V	0.766	1.00
103_V	131_A	0.762	1.00
159_Y	368_N	0.762	1.00
315_E	318_N	0.761	1.00
24_Y	107_S	0.760	1.00
82_L	373_Y	0.759	1.00
211_Q	214_P	0.758	1.00
110_N	203_V	0.757	1.00
275_D	345_R	0.757	1.00
300_P	338_L	0.756	1.00
313_I	321_I	0.756	1.00
97_K	104_F	0.753	1.00
276_V	335_I	0.752	1.00
211_Q	215_D	0.751	1.00
39_T	43_I	0.749	1.00
306_R	309_N	0.748	1.00
355_E	360_F	0.746	1.00
369_L	373_Y	0.744	1.00
204_K	281_S	0.743	1.00
269_R	272_T	0.743	1.00
27_A	31_L	0.740	1.00
348_L	352_S	0.736	1.00
37_E	58_H	0.732	1.00
24_Y	160_S	0.732	1.00
139_Y	143_T	0.732	1.00
27_A	163_D	0.727	1.00
245_L	248_L	0.725	1.00
305_N	321_I	0.723	1.00
316_G	337_D	0.723	1.00
347_R	350_K	0.720	1.00
196_F	277_F	0.717	1.00
362_W	366_A	0.717	1.00
252_Q	255_H	0.716	1.00
143_T	147_R	0.716	1.00
105_I	132_Q	0.712	1.00
74_E	78_S	0.711	1.00
125_I	129_S	0.711	1.00
333_E	336_N	0.711	1.00
109_H	136_V	0.711	1.00
302_I	338_L	0.709	1.00
198_G	206_P	0.709	1.00
202_K	207_H	0.709	1.00
310_P	321_I	0.707	1.00
121_A	125_I	0.704	1.00
136_V	289_R	0.704	1.00
97_K	100_P	0.701	1.00
202_K	237_E	0.700	1.00
86_C	107_S	0.699	1.00
196_F	225_M	0.693	1.00
170_R	272_T	0.692	1.00
264_P	268_P	0.691	1.00
304_S	324_D	0.689	1.00
248_L	252_Q	0.688	1.00
194_V	223_V	0.687	1.00
197_V	277_F	0.686	1.00
288_A	291_H	0.685	1.00
262_V	267_I	0.683	1.00
30_P	55_D	0.681	1.00
121_A	124_E	0.679	1.00
198_G	204_K	0.678	1.00
338_L	345_R	0.675	1.00
33_A	38_V	0.672	1.00
156_K	159_Y	0.670	1.00
216_I	220_H	0.670	1.00
323_H	326_E	0.670	1.00
304_S	331_Y	0.668	1.00
84_H	369_L	0.666	1.00
279_C	288_A	0.665	1.00
337_D	340_S	0.665	1.00
23_I	26_E	0.665	1.00
324_D	327_N	0.664	1.00
200_L	238_L	0.663	1.00
295_M	349_G	0.662	1.00
158_V	369_L	0.656	1.00
329_K	332_A	0.656	1.00
24_Y	369_L	0.651	1.00
80_F	102_A	0.647	1.00
189_H	224_M	0.647	1.00
159_Y	360_F	0.647	1.00
292_Y	360_F	0.646	1.00
353_R	356_A	0.645	1.00
231_K	238_L	0.642	1.00
287_L	360_F	0.640	1.00
65_D	69_E	0.639	1.00
343_E	347_R	0.638	1.00
82_L	105_I	0.638	1.00
366_A	370_L	0.637	1.00
192_K	342_S	0.637	1.00
124_E	128_D	0.636	1.00
35_K	38_V	0.635	1.00
202_K	282_Q	0.633	1.00
206_P	237_E	0.632	1.00
117_K	120_Q	0.630	1.00
19_G	199_R	0.624	1.00
194_V	339_L	0.622	1.00
318_N	351_Y	0.620	1.00
158_V	368_N	0.619	1.00
270_L	274_S	0.617	1.00
213_L	216_I	0.614	1.00
205_G	280_S	0.613	1.00
5_L	38_V	0.611	1.00
343_E	346_E	0.609	1.00
145_T	149_P	0.608	1.00
7_A	21_I	0.607	1.00
7_A	25_L	0.607	1.00
278_V	331_Y	0.606	1.00
28_V	369_L	0.606	1.00
222_D	255_H	0.604	1.00
315_E	320_Y	0.603	1.00
141_G	152_R	0.602	1.00
105_I	373_Y	0.601	1.00
98_Q	129_S	0.600	1.00
33_A	56_G	0.600	1.00
363_Q	367_E	0.597	1.00
96_K	99_A	0.597	1.00
107_S	369_L	0.596	1.00
29_A	38_V	0.595	1.00
35_K	370_L	0.595	1.00
188_L	273_M	0.593	1.00
85_V	93_P	0.593	1.00
117_K	121_A	0.592	1.00
192_K	195_L	0.591	1.00
135_T	157_T	0.591	1.00
33_A	36_H	0.590	1.00
352_S	355_E	0.590	1.00
9_E	22_Q	0.590	1.00
168_H	272_T	0.588	1.00
139_Y	310_P	0.587	1.00
212_A	335_I	0.587	1.00
276_V	302_I	0.587	1.00
195_L	277_F	0.587	1.00
306_R	310_P	0.583	1.00
217_I	223_V	0.581	1.00
271_Y	290_V	0.579	1.00
200_L	206_P	0.578	1.00
221_P	340_S	0.577	1.00
83_V	97_K	0.577	1.00
209_L	213_L	0.576	1.00
188_L	226_V	0.575	1.00
313_I	318_N	0.574	1.00
277_F	301_I	0.574	1.00
163_D	167_Y	0.573	1.00
322_I	330_Q	0.572	1.00
34_K	363_Q	0.572	1.00
367_E	370_L	0.572	1.00
74_E	77_K	0.570	1.00
168_H	171_W	0.569	1.00
345_R	348_L	0.567	1.00
229_G	260_Q	0.566	1.00
216_I	221_P	0.565	1.00
208_I	212_A	0.564	1.00
192_K	345_R	0.564	1.00
24_Y	28_V	0.563	1.00
104_F	131_A	0.563	1.00
137_S	140_I	0.561	1.00
205_G	326_E	0.560	1.00
210_L	256_V	0.559	1.00
21_I	87_N	0.557	1.00
200_L	231_K	0.557	1.00
5_L	84_H	0.551	1.00
341_S	345_R	0.550	1.00
55_D	58_H	0.549	1.00
125_I	128_D	0.547	1.00
275_D	342_S	0.544	1.00
140_I	143_T	0.544	1.00
30_P	34_K	0.544	1.00
202_K	240_N	0.543	1.00
190_G	222_D	0.543	1.00
359_N	364_R	0.543	1.00
138_D	159_Y	0.542	1.00
193_I	270_L	0.541	1.00
305_N	324_D	0.540	1.00
165_K	168_H	0.540	1.00
166_T	264_P	0.540	1.00
351_Y	355_E	0.537	1.00
109_H	160_S	0.537	1.00
302_I	335_I	0.537	1.00
242_V	258_F	0.536	1.00
24_Y	86_C	0.536	1.00
83_V	102_A	0.535	1.00
294_A	301_I	0.534	1.00
245_L	256_V	0.534	1.00
100_P	103_V	0.533	1.00
281_S	288_A	0.533	1.00
199_R	204_K	0.532	1.00
107_S	134_V	0.530	1.00
5_L	373_Y	0.530	1.00
145_T	154_K	0.528	1.00
290_V	294_A	0.527	1.00
283_W	286_P	0.526	1.00
295_M	356_A	0.525	1.00
212_A	216_I	0.524	1.00
221_P	336_N	0.523	1.00
225_M	256_V	0.522	1.00
207_H	241_Y	0.522	1.00
140_I	286_P	0.521	1.00
228_I	267_I	0.521	1.00
27_A	289_R	0.517	1.00
205_G	304_S	0.513	1.00
195_L	299_L	0.512	1.00
288_A	292_Y	0.512	1.00
75_L	80_F	0.511	1.00
30_P	33_A	0.511	1.00
164_L	296_A	0.510	1.00
4_A	39_T	0.510	1.00
220_H	223_V	0.510	1.00
280_S	304_S	0.509	1.00
80_F	83_V	0.506	1.00
76_K	100_P	0.506	1.00
52_E	61_H	0.505	1.00
159_Y	365_V	0.505	1.00
271_Y	277_F	0.503	1.00
31_L	362_W	0.502	1.00
28_V	31_L	0.501	1.00
292_Y	312_V	0.500	1.00
108_V	140_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r60A	1	0.9788	100	0.142	Contact Map
3c48A	2	0.9496	100	0.151	Contact Map
4n9wA	1	0.8859	100	0.159	Contact Map
3okpA	1	0.9469	100	0.164	Contact Map
1rzuA	1	0.9602	100	0.165	Contact Map
3froA	3	0.9655	100	0.166	Contact Map
2qzsA	1	0.9576	100	0.179	Contact Map
2x6qA	1	0.9443	100	0.187	Contact Map
3oy2A	2	0.9257	100	0.19	Contact Map
2jjmA	4	0.9072	100	0.202	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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