GREMLIN Database
COTS - Spore coat protein S
UniProt: P46914 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 351 (277)
Sequences: 4234 (3376)
Seq/√Len: 202.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
81_T88_L4.3051.00
119_S274_A3.8181.00
55_P89_G3.3761.00
122_G275_V3.1791.00
77_P99_D2.8171.00
48_L97_L2.7551.00
66_A80_Q2.7421.00
115_K270_A2.7371.00
38_E100_K2.7001.00
67_H131_Y2.6721.00
115_K271_A2.6531.00
47_L100_K2.6491.00
273_D283_Y2.6041.00
19_P82_K2.4971.00
121_A217_F2.4591.00
118_M271_A2.4261.00
21_H42_D2.3791.00
67_H130_G2.2941.00
80_Q86_S2.2591.00
213_C240_D2.2341.00
192_R196_D2.1811.00
55_P94_S2.1221.00
101_V230_F2.1181.00
111_A267_A2.0711.00
115_K274_A2.0341.00
116_K119_S2.0151.00
71_K130_G1.9871.00
126_H276_Y1.9691.00
39_V97_L1.9631.00
65_H234_L1.9601.00
126_H275_V1.9481.00
69_Q77_P1.9351.00
223_T232_K1.9011.00
246_L268_L1.8961.00
23_D42_D1.8641.00
211_G242_P1.8551.00
20_F97_L1.8521.00
225_I228_E1.8501.00
129_K276_Y1.8341.00
40_E45_P1.8141.00
81_T85_G1.8111.00
188_K192_R1.8091.00
299_I303_Y1.7921.00
79_H99_D1.6911.00
41_T46_K1.6901.00
46_K97_L1.6691.00
186_R189_E1.6671.00
298_A301_H1.6501.00
266_V270_A1.6471.00
110_D113_Q1.6461.00
24_H40_E1.6191.00
148_K152_W1.6111.00
115_K119_S1.6041.00
59_L63_Q1.5701.00
246_L269_L1.5651.00
50_E93_V1.5421.00
249_L268_L1.5301.00
58_M61_I1.5291.00
120_F231_L1.5271.00
184_L188_K1.5161.00
217_F231_L1.5131.00
26_A38_E1.5091.00
189_E192_R1.4911.00
123_H275_V1.4751.00
121_A125_H1.4751.00
267_A271_A1.4631.00
183_M186_R1.4511.00
122_G276_Y1.4451.00
17_Y81_T1.4271.00
301_H305_L1.4081.00
157_L160_N1.4031.00
50_E95_Y1.4001.00
28_K47_L1.3971.00
216_D233_E1.3801.00
140_R143_L1.3791.00
183_M191_L1.3711.00
63_Q131_Y1.3681.00
41_T44_G1.3671.00
189_E193_A1.3671.00
183_M187_G1.3391.00
64_A128_S1.3371.00
18_Y88_L1.3371.00
152_W155_Q1.3351.00
149_L153_K1.3191.00
62_T96_S1.3181.00
54_K57_R1.3141.00
119_S275_V1.3091.00
185_A189_E1.3071.00
22_I25_V1.3061.00
273_D277_P1.3031.00
17_Y88_L1.2991.00
125_H272_Y1.2941.00
119_S123_H1.2871.00
62_T86_S1.2871.00
64_A237_I1.2731.00
156_E159_G1.2711.00
191_L194_L1.2511.00
89_G92_Q1.2371.00
190_A194_L1.2361.00
152_W156_E1.2241.00
149_L152_W1.2221.00
55_P59_L1.2221.00
148_K151_R1.2111.00
115_K267_A1.2091.00
49_K61_I1.2031.00
66_A86_S1.2011.00
141_S145_K1.2001.00
156_E160_N1.1991.00
271_A274_A1.1901.00
38_E45_P1.1781.00
185_A188_K1.1631.00
298_A303_Y1.1411.00
147_H150_Y1.1401.00
187_G190_A1.1251.00
224_E229_P1.1051.00
294_H297_C1.0991.00
207_L281_K1.0971.00
116_K229_P1.0961.00
67_H127_A1.0921.00
73_L124_F1.0901.00
190_A193_A1.0821.00
16_S82_K1.0801.00
159_G162_Q1.0791.00
15_L18_Y1.0761.00
152_W157_L1.0681.00
38_E47_L1.0671.00
153_K156_E1.0591.00
15_L22_I1.0541.00
216_D221_R1.0521.00
117_V217_F1.0491.00
278_L283_Y1.0471.00
118_M122_G1.0391.00
89_G94_S1.0231.00
181_D184_L1.0221.00
219_L252_K1.0221.00
124_F231_L1.0131.00
87_C94_S1.0121.00
221_R233_E1.0021.00
149_L156_E1.0011.00
153_K157_L0.9931.00
124_F234_L0.9901.00
112_E115_K0.9901.00
248_I251_N0.9871.00
209_H282_Q0.9861.00
34_R49_K0.9851.00
125_H245_D0.9711.00
53_M61_I0.9691.00
20_F46_K0.9681.00
182_K185_A0.9610.99
152_W160_N0.9570.99
117_V249_L0.9550.99
160_N163_I0.9540.99
122_G126_H0.9520.99
51_A96_S0.9500.99
76_A99_D0.9440.99
117_V222_L0.9390.99
153_K160_N0.9370.99
209_H276_Y0.9300.99
15_L39_V0.9240.99
299_I306_K0.9150.99
18_Y81_T0.9150.99
35_K50_E0.9140.99
187_G191_L0.9140.99
101_V223_T0.9110.99
121_A245_D0.9110.99
263_D267_A0.9070.99
65_H78_I0.8940.99
118_M268_L0.8940.99
184_L187_G0.8880.99
250_L286_L0.8870.99
10_I91_D0.8870.99
63_Q66_A0.8800.99
36_I47_L0.8770.99
120_F123_H0.8770.99
59_L85_G0.8720.99
279_T282_Q0.8710.99
157_L161_M0.8620.99
66_A70_E0.8610.99
256_K261_D0.8600.99
15_L97_L0.8600.99
66_A69_Q0.8580.99
243_S285_V0.8570.99
180_A184_L0.8530.99
179_H183_M0.8500.99
146_W149_L0.8480.99
81_T84_G0.8470.99
151_R155_Q0.8430.99
261_D264_F0.8390.99
90_T95_Y0.8360.99
246_L278_L0.8330.98
280_E284_E0.8320.98
250_L265_M0.8310.98
143_L150_Y0.8270.98
10_I13_E0.8250.98
78_I99_D0.8210.98
119_S271_A0.8200.98
114_M264_F0.8190.98
247_R290_L0.8180.98
209_H242_P0.8170.98
299_I302_K0.8160.98
74_P123_H0.8140.98
181_D185_A0.8100.98
214_F221_R0.8090.98
150_Y153_K0.8060.98
106_M222_L0.8020.98
299_I307_Q0.8000.98
154_L158_E0.7980.98
211_G276_Y0.7930.98
296_F299_I0.7930.98
128_S211_G0.7930.98
271_A275_V0.7890.98
148_K153_K0.7860.98
179_H182_K0.7860.98
161_M164_A0.7840.98
270_A273_D0.7790.98
300_G305_L0.7770.98
256_K259_V0.7760.98
147_H154_L0.7710.98
153_K158_E0.7710.98
9_Q12_S0.7690.97
215_Q244_R0.7690.97
192_R195_D0.7680.97
155_Q158_E0.7680.97
178_K182_K0.7670.97
301_H304_Y0.7610.97
13_E16_S0.7600.97
71_K127_A0.7590.97
104_K223_T0.7570.97
126_H129_K0.7470.97
140_R144_G0.7470.97
236_S293_P0.7410.97
48_L95_Y0.7360.97
221_R235_H0.7350.97
14_I90_T0.7320.97
25_V39_V0.7320.97
242_P276_Y0.7320.97
151_R156_E0.7300.97
297_C301_H0.7260.96
72_G123_H0.7250.96
13_E17_Y0.7240.96
46_K99_D0.7240.96
10_I14_I0.7230.96
36_I235_H0.7210.96
102_T225_I0.7200.96
298_A302_K0.7170.96
73_L127_A0.7160.96
61_I65_H0.7150.96
150_Y154_L0.7150.96
64_A212_F0.7140.96
26_A40_E0.7130.96
34_R235_H0.7090.96
67_H70_E0.7070.96
304_Y307_Q0.7050.96
114_M267_A0.7040.96
76_A230_F0.7010.96
151_R154_L0.7000.96
298_A305_L0.6990.96
36_I218_T0.6990.96
81_T87_C0.6980.96
33_G236_S0.6980.96
51_A58_M0.6980.96
34_R220_A0.6960.95
299_I304_Y0.6960.95
20_F41_T0.6950.95
139_K142_R0.6950.95
141_S144_G0.6940.95
66_A77_P0.6910.95
220_A252_K0.6890.95
263_D266_V0.6890.95
150_Y156_E0.6880.95
45_P100_K0.6870.95
303_Y306_K0.6780.95
32_S49_K0.6770.95
65_H75_I0.6750.95
147_H151_R0.6750.95
191_L195_D0.6710.94
218_T252_K0.6710.94
17_Y82_K0.6700.94
31_K35_K0.6700.94
247_R289_D0.6690.94
190_A195_D0.6670.94
149_L154_L0.6660.94
91_D95_Y0.6660.94
295_L298_A0.6650.94
46_K79_H0.6620.94
212_F239_Y0.6610.94
49_K218_T0.6590.94
125_H128_S0.6530.94
129_K209_H0.6530.94
130_G135_D0.6530.94
270_A274_A0.6500.94
267_A270_A0.6480.93
33_G235_H0.6470.93
54_K58_M0.6450.93
47_L76_A0.6430.93
184_L195_D0.6390.93
63_Q133_C0.6380.93
186_R190_A0.6370.93
122_G274_A0.6370.93
61_I236_S0.6360.93
183_M194_L0.6350.93
262_T266_V0.6350.93
103_G226_E0.6340.93
76_A101_V0.6300.92
111_A263_D0.6280.92
45_P102_T0.6270.92
254_M260_W0.6250.92
73_L120_F0.6250.92
296_F300_G0.6230.92
281_K284_E0.6230.92
49_K247_R0.6230.92
14_I88_L0.6200.92
300_G303_Y0.6200.92
241_L285_V0.6200.92
140_R160_N0.6140.91
145_K148_K0.6130.91
32_S252_K0.6120.91
149_L160_N0.6090.91
151_R160_N0.6070.91
54_K61_I0.6060.91
299_I305_L0.6050.91
210_G241_L0.6020.91
34_R61_I0.6000.91
15_L48_L0.5950.90
156_E163_I0.5950.90
210_G239_Y0.5940.90
236_S248_I0.5930.90
118_M249_L0.5930.90
126_H270_A0.5920.90
285_V288_I0.5890.90
31_K36_I0.5890.90
243_S282_Q0.5880.90
238_T244_R0.5880.90
154_L157_L0.5870.90
300_G307_Q0.5850.89
17_Y83_N0.5850.89
298_A304_Y0.5840.89
156_E161_M0.5840.89
30_N220_A0.5820.89
154_L160_N0.5820.89
142_R145_K0.5810.89
269_L279_T0.5810.89
103_G216_D0.5790.89
123_H127_A0.5760.89
113_Q240_D0.5760.89
277_P280_E0.5760.89
126_H130_G0.5750.89
61_I237_I0.5750.89
55_P61_I0.5750.89
39_V48_L0.5730.88
46_K100_K0.5730.88
143_L147_H0.5670.88
112_E116_K0.5650.88
67_H71_K0.5640.88
246_L286_L0.5630.88
54_K60_F0.5620.87
12_S16_S0.5610.87
297_C300_G0.5600.87
43_H70_E0.5600.87
157_L163_I0.5590.87
143_L151_R0.5580.87
49_K52_Q0.5570.87
60_F212_F0.5550.87
11_V14_I0.5540.87
193_A196_D0.5540.87
148_K156_E0.5540.87
147_H162_Q0.5520.87
193_A288_I0.5480.86
215_Q238_T0.5460.86
147_H191_L0.5440.86
290_L293_P0.5430.86
57_R60_F0.5420.86
158_E161_M0.5420.86
157_L164_A0.5420.86
79_H97_L0.5400.85
154_L188_K0.5390.85
182_K189_E0.5390.85
183_M190_A0.5380.85
147_H156_E0.5370.85
300_G304_Y0.5360.85
129_K181_D0.5360.85
58_M62_T0.5340.85
180_A187_G0.5330.85
105_E226_E0.5320.84
178_K184_L0.5310.84
121_A124_F0.5290.84
228_E269_L0.5250.84
158_E162_Q0.5240.84
145_K150_Y0.5240.84
155_Q159_G0.5230.83
245_D272_Y0.5200.83
117_V231_L0.5200.83
35_K93_V0.5200.83
285_V289_D0.5190.83
82_K91_D0.5160.83
49_K235_H0.5150.83
246_L272_Y0.5150.83
144_G149_L0.5140.82
218_T235_H0.5130.82
184_L191_L0.5110.82
49_K236_S0.5090.82
287_W291_A0.5090.82
162_Q165_A0.5080.82
12_S21_H0.5070.82
218_T236_S0.5060.81
59_L86_S0.5060.81
281_K285_V0.5050.81
123_H126_H0.5040.81
151_R195_D0.5030.81
243_S289_D0.5030.81
147_H157_L0.5030.81
298_A306_K0.5030.81
132_V135_D0.5020.81
242_P282_Q0.5010.81
33_G52_Q0.5000.81
23_D26_A0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2q83A 1 0.9259 100 0.317 Contact Map
4pdyA 1 0.9316 100 0.332 Contact Map
2ppqA 2 0.8661 100 0.423 Contact Map
4ocvA 1 0.9316 100 0.435 Contact Map
1zylA 1 0.9031 100 0.497 Contact Map
3i1aA 1 0.9145 100 0.534 Contact Map
3jr1A 1 0.812 100 0.587 Contact Map
3mesA 2 0.8775 100 0.591 Contact Map
3atsA 1 0.849 100 0.593 Contact Map
3fegA 2 0.8205 100 0.593 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0102 seconds.