GREMLIN Database
QCRC - Menaquinol-cytochrome c reductase cytochrome b/c subunit
UniProt: P46913 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 255 (231)
Sequences: 253 (179)
Seq/√Len: 11.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_K225_E6.4121.00
215_K218_E4.3671.00
137_V141_M4.0950.99
129_E134_K3.8960.99
19_K22_N3.1260.96
18_E21_P3.0300.96
69_R75_D3.0280.96
160_H165_A3.0220.96
68_E78_Y2.9190.95
182_E244_E2.6640.91
88_F153_T2.5880.90
235_F241_Q2.5230.89
151_F155_Q2.4370.87
92_L156_S2.3890.86
91_Q95_Y2.3550.85
83_D226_G2.3460.85
213_G250_S2.3180.84
61_I70_M2.3020.84
113_L133_W2.2850.83
237_G242_L2.2000.81
112_G120_L2.1420.79
191_G194_S2.1420.79
241_Q244_E2.1390.79
77_G105_V2.1310.79
217_D220_K2.0810.77
187_F245_L2.0040.74
198_D201_Q2.0000.74
110_M126_R1.9710.73
187_F193_I1.9480.72
54_I155_Q1.7930.65
108_M158_A1.5890.56
79_I156_S1.5830.55
194_S203_G1.5800.55
59_L66_P1.5690.55
238_N241_Q1.5580.54
174_E179_T1.5450.53
33_K151_F1.5450.53
103_T151_F1.5440.53
167_E170_K1.5280.53
62_V156_S1.5190.52
191_G234_V1.5180.52
56_F65_P1.5050.51
68_E249_I1.5040.51
80_P136_P1.4850.50
44_K153_T1.4830.50
91_Q100_G1.4730.50
147_S175_A1.4690.50
73_P87_L1.4380.48
161_D164_K1.3980.46
188_K212_S1.3920.46
176_D243_E1.3850.45
185_K236_K1.3810.45
220_K246_A1.3760.45
80_P135_R1.3680.45
177_I180_N1.3640.44
108_M221_K1.3600.44
128_T223_A1.3520.44
154_W169_G1.3420.43
73_P111_P1.3380.43
189_E223_A1.3360.43
183_G188_K1.3280.43
43_L94_K1.3240.42
76_T190_Q1.3130.42
189_E198_D1.3070.42
212_S249_I1.3020.41
56_F143_L1.3010.41
108_M123_F1.2980.41
216_P250_S1.2930.41
219_I222_I1.2900.41
33_K129_E1.2450.39
173_K212_S1.2410.38
137_V216_P1.2280.38
19_K206_G1.2260.38
203_G207_P1.2240.38
212_S218_E1.2230.38
162_W168_Q1.2220.38
71_A94_K1.2170.37
98_A206_G1.1950.36
54_I146_I1.1840.36
76_T101_S1.1690.35
205_A229_K1.1690.35
84_W122_P1.1480.34
130_R135_R1.1460.34
165_A168_Q1.1310.33
71_A125_D1.1210.33
124_L141_M1.1060.32
211_D248_F1.1030.32
187_F241_Q1.1010.32
30_Y119_L1.0970.32
42_L45_E1.0940.32
108_M214_L1.0880.32
33_K131_R1.0810.31
109_I238_N1.0800.31
42_L46_W1.0800.31
205_A234_V1.0690.31
37_F85_Y1.0450.30
37_F82_P1.0420.30
241_Q247_K1.0360.29
109_I249_I1.0310.29
31_P90_Y1.0260.29
25_K52_F1.0230.29
148_A187_F1.0140.28
25_K36_A1.0130.28
214_L227_K1.0110.28
216_P220_K1.0110.28
64_Q107_A1.0070.28
187_F214_L1.0060.28
20_K217_D0.9930.28
41_F90_Y0.9900.28
80_P83_D0.9840.27
220_K243_E0.9810.27
58_V70_M0.9730.27
192_C230_M0.9700.27
196_H230_M0.9700.27
192_C195_C0.9700.27
195_C230_M0.9700.27
192_C196_H0.9700.27
18_E113_L0.9680.27
54_I128_T0.9540.26
188_K241_Q0.9540.26
94_K106_G0.9450.26
113_L250_S0.9410.26
99_A103_T0.9380.25
174_E189_E0.9320.25
165_A186_V0.9300.25
235_F245_L0.9250.25
182_E186_V0.9240.25
56_F190_Q0.9230.25
225_E243_E0.9200.25
194_S198_D0.9150.25
30_Y241_Q0.9080.24
43_L106_G0.9060.24
183_G248_F0.9060.24
181_A244_E0.9000.24
151_F154_W0.8980.24
52_F169_G0.8970.24
105_V174_E0.8970.24
34_T160_H0.8940.24
38_W81_L0.8930.24
109_I137_V0.8910.24
194_S206_G0.8900.24
118_L138_A0.8810.23
70_M75_D0.8810.23
93_L153_T0.8790.23
127_G208_S0.8700.23
80_P138_A0.8680.23
203_G206_G0.8640.23
215_K250_S0.8620.23
216_P243_E0.8610.23
183_G187_F0.8610.23
80_P202_G0.8600.23
217_D239_D0.8570.23
101_S251_E0.8510.22
31_P106_G0.8510.22
83_D87_L0.8500.22
154_W181_A0.8460.22
183_G210_V0.8420.22
187_F244_E0.8420.22
234_V251_E0.8270.22
198_D215_K0.8260.21
129_E151_F0.8250.21
76_T125_D0.8190.21
189_E232_A0.8180.21
109_I170_K0.8140.21
91_Q109_I0.8130.21
18_E108_M0.8130.21
68_E118_L0.8100.21
180_N186_V0.8090.21
94_K125_D0.8080.21
23_I175_A0.8080.21
132_P233_G0.8020.21
39_P82_P0.8010.21
216_P249_I0.7990.21
104_V137_V0.7970.21
178_D237_G0.7960.20
183_G186_V0.7950.20
105_V109_I0.7930.20
78_Y128_T0.7920.20
233_G237_G0.7880.20
146_I227_K0.7870.20
65_P139_V0.7850.20
248_F252_T0.7820.20
51_V124_L0.7810.20
37_F152_L0.7800.20
80_P130_R0.7780.20
85_Y152_L0.7750.20
214_L222_I0.7680.20
18_E22_N0.7670.20
89_L156_S0.7640.19
18_E186_V0.7640.19
50_A178_D0.7630.19
78_Y155_Q0.7620.19
19_K25_K0.7560.19
25_K34_T0.7460.19
31_P112_G0.7430.19
123_F141_M0.7430.19
54_I251_E0.7410.19
191_G213_G0.7400.19
20_K23_I0.7380.19
126_R205_A0.7380.19
25_K183_G0.7380.19
45_E55_G0.7360.19
20_K70_M0.7340.19
104_V148_A0.7330.19
62_V220_K0.7300.18
82_P93_L0.7260.18
186_V248_F0.7240.18
60_T116_G0.7210.18
136_P202_G0.7180.18
128_T133_W0.7170.18
234_V237_G0.7160.18
165_A191_G0.7160.18
121_A138_A0.7140.18
140_G145_A0.7080.18
214_L229_K0.7070.18
25_K184_Y0.7050.18
224_V244_E0.7040.18
146_I190_Q0.7040.18
222_I226_G0.7020.18
187_F198_D0.6970.17
70_M76_T0.6960.17
86_F153_T0.6860.17
163_A170_K0.6850.17
187_F227_K0.6830.17
176_D180_N0.6800.17
208_S218_E0.6790.17
146_I213_G0.6760.17
164_K176_D0.6730.17
203_G248_F0.6710.17
200_L219_I0.6680.17
18_E89_L0.6660.17
40_N104_V0.6610.16
91_Q107_A0.6610.16
157_V168_Q0.6570.16
22_N54_I0.6560.16
102_F119_L0.6560.16
33_K165_A0.6550.16
188_K191_G0.6550.16
126_R147_S0.6530.16
91_Q94_K0.6520.16
20_K158_A0.6480.16
186_V244_E0.6470.16
49_G53_L0.6470.16
190_Q236_K0.6460.16
203_G211_D0.6460.16
71_A82_P0.6440.16
92_L132_P0.6440.16
132_P237_G0.6420.16
106_G142_M0.6410.16
84_W130_R0.6400.16
173_K190_Q0.6390.16
202_G226_G0.6390.16
175_A217_D0.6370.16
39_P122_P0.6350.16
82_P85_Y0.6330.16
210_V244_E0.6330.16
95_Y111_P0.6320.16
19_K232_A0.6310.16
101_S126_R0.6300.16
59_L63_H0.6270.16
165_A227_K0.6230.15
148_A173_K0.6230.15
179_T189_E0.6220.15
126_R200_L0.6190.15
65_P70_M0.6170.15
115_F193_I0.6150.15
21_P150_V0.6150.15
229_K232_A0.6140.15
179_T242_L0.6130.15
175_A178_D0.6020.15
150_V217_D0.6010.15
67_L130_R0.5950.15
178_D184_Y0.5930.15
52_F180_N0.5910.15
126_R229_K0.5900.15
47_M248_F0.5880.15
207_P231_P0.5880.15
146_I176_D0.5850.14
129_E215_K0.5820.14
239_D242_L0.5770.14
134_K138_A0.5760.14
80_P231_P0.5750.14
215_K221_K0.5740.14
56_F177_I0.5740.14
180_N215_K0.5740.14
42_L48_V0.5740.14
87_L228_G0.5710.14
173_K187_F0.5700.14
189_E241_Q0.5690.14
99_A151_F0.5690.14
108_M147_S0.5670.14
37_F93_L0.5650.14
82_P122_P0.5650.14
160_H169_G0.5620.14
72_D200_L0.5610.14
136_P231_P0.5610.14
29_E68_E0.5580.14
58_V62_V0.5570.14
182_E239_D0.5560.14
43_L56_F0.5560.14
167_E173_K0.5530.14
64_Q72_D0.5530.14
221_K245_L0.5520.14
199_N225_E0.5490.14
119_L159_T0.5470.14
18_E217_D0.5460.14
81_L90_Y0.5460.14
55_G124_L0.5460.14
18_E191_G0.5430.13
39_P84_W0.5420.13
71_A91_Q0.5410.13
216_P247_K0.5410.13
71_A85_Y0.5410.13
62_V99_A0.5370.13
179_T250_S0.5370.13
130_R197_G0.5360.13
26_D36_A0.5360.13
92_L111_P0.5360.13
119_L148_A0.5350.13
156_S161_D0.5340.13
18_E210_V0.5320.13
56_F105_V0.5310.13
149_A180_N0.5300.13
240_K251_E0.5290.13
138_A159_T0.5280.13
91_Q106_G0.5230.13
22_N220_K0.5200.13
148_A214_L0.5200.13
133_W149_A0.5190.13
52_F239_D0.5170.13
81_L105_V0.5170.13
120_L209_L0.5170.13
41_F45_E0.5160.13
39_P85_Y0.5160.13
35_E142_M0.5120.13
174_E180_N0.5100.13
233_G247_K0.5070.13
143_L147_S0.5050.13
99_A247_K0.5040.13
65_P107_A0.5040.13
27_Y30_Y0.5030.13
116_G145_A0.5020.13
188_K251_E0.5020.13
146_I211_D0.5010.13
177_I183_G0.5010.13
52_F183_G0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyA 2 0.7647 99.9 0.747 Contact Map
4ogqB 1 0.6157 99.9 0.752 Contact Map
3cx5C 2 0.698 99.9 0.763 Contact Map
1pp9C 2 0.6784 99.9 0.769 Contact Map
3mk7B 1 0.4784 99.7 0.799 Contact Map
3mk7C 2 0.6157 99.7 0.802 Contact Map
3wfdC 1 0.4627 99.7 0.813 Contact Map
4pwaA 3 0.3098 99.6 0.817 Contact Map
1w2lA 1 0.2941 99.6 0.823 Contact Map
3oa8A 1 0.3255 99.6 0.826 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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