GREMLIN Database
QCRB - Menaquinol-cytochrome c reductase cytochrome b subunit
UniProt: P46912 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 224 (201)
Sequences: 3611 (1148)
Seq/√Len: 80.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
105_M136_M5.1761.00
47_L104_M3.1051.00
139_L200_L3.0211.00
69_D72_N3.0091.00
52_T208_M2.8721.00
67_V186_A2.7231.00
127_I131_L2.6311.00
135_V207_L2.5621.00
109_T133_F2.5601.00
163_A177_L2.5081.00
171_T175_T2.4811.00
138_G200_L2.4421.00
58_S93_M2.3861.00
24_D29_E2.3401.00
138_G163_A2.3211.00
60_M199_F2.2791.00
67_V72_N2.2161.00
150_M154_F2.1361.00
65_Y79_Y2.1041.00
136_M204_L2.0711.00
68_P190_T2.0171.00
81_Q91_R1.9971.00
48_T104_M1.9341.00
81_Q92_G1.9201.00
49_F212_F1.8791.00
112_V117_A1.8661.00
62_L80_L1.8431.00
120_K218_Q1.7531.00
14_D29_E1.7431.00
63_T194_A1.7411.00
164_E174_K1.7341.00
54_I93_M1.7321.00
128_V207_L1.7081.00
142_T195_I1.7071.00
134_F138_G1.7071.00
89_I93_M1.6811.00
127_I130_V1.6801.00
139_L204_L1.6771.00
128_V210_A1.6761.00
121_P124_L1.6501.00
52_T101_V1.6301.00
56_V205_F1.6231.00
26_E30_H1.5931.00
73_A76_S1.5661.00
23_A28_P1.5390.99
124_L127_I1.4910.99
69_D190_T1.4760.99
61_F64_M1.4740.99
148_W153_L1.4590.99
51_V104_M1.4470.99
101_V136_M1.4260.99
68_P73_A1.4210.99
20_R24_D1.4100.99
148_W189_L1.4070.99
69_D186_A1.3990.99
132_I204_L1.3860.99
14_D17_P1.3830.99
124_L217_K1.3820.99
26_E212_F1.3380.99
52_T56_V1.3270.98
86_F89_I1.3260.98
195_I200_L1.3070.98
205_F208_M1.2930.98
190_T194_A1.2640.98
72_N186_A1.2560.98
63_T193_F1.2530.98
51_V100_L1.2480.98
119_K208_M1.2250.97
160_L178_A1.2190.97
67_V190_T1.2140.97
14_D24_D1.2130.97
148_W176_L1.2110.97
65_Y84_V1.2100.97
125_N218_Q1.2060.97
128_V214_M1.2000.97
70_I186_A1.2000.97
55_Q219_G1.1900.97
200_L203_A1.1480.96
174_K178_A1.1480.96
135_V200_L1.1440.96
195_I203_A1.1240.96
60_M198_F1.1180.96
48_T105_M1.1010.95
184_V188_T1.0970.95
78_Y81_Q1.0890.95
22_I26_E1.0840.95
141_F159_G1.0830.95
46_G50_F1.0820.95
160_L174_K1.0780.95
144_Y147_P1.0760.94
105_M204_L1.0750.94
79_Y84_V1.0720.94
163_A173_V1.0700.94
131_L207_L1.0510.94
25_H28_P1.0470.94
131_L134_F1.0430.94
149_D155_A1.0430.94
46_G49_F1.0310.93
172_Q175_T1.0300.93
43_C47_L1.0270.93
51_V136_M1.0230.93
167_P170_G1.0160.93
76_S80_L1.0100.92
80_L87_G1.0100.92
55_Q97_G1.0030.92
17_P131_L0.9990.92
78_Y82_N0.9900.92
157_K161_Q0.9900.92
72_N75_E0.9900.92
157_K160_L0.9890.92
132_I136_M0.9850.91
77_V173_V0.9750.91
22_I213_I0.9730.91
150_M153_L0.9590.90
129_G211_H0.9400.89
202_A206_G0.9370.89
30_H48_T0.9300.89
64_M195_I0.9280.89
76_S87_G0.9150.88
192_F195_I0.9080.88
206_G210_A0.9010.87
148_W154_F0.8980.87
64_M194_A0.8980.87
18_M217_K0.8930.87
43_C46_G0.8900.87
116_G119_K0.8860.86
129_G144_Y0.8860.86
145_L156_T0.8840.86
124_L214_M0.8810.86
30_H46_G0.8780.86
56_V60_M0.8750.86
16_T20_R0.8740.86
68_P72_N0.8620.85
132_I208_M0.8600.85
213_I217_K0.8590.85
125_N215_I0.8580.85
28_P38_S0.8560.84
111_R191_R0.8530.84
149_D152_A0.8390.83
215_I220_I0.8300.83
43_C49_F0.8230.82
108_H129_G0.8170.82
24_D28_P0.8160.81
18_M213_I0.8120.81
145_L174_K0.8020.80
160_L164_E0.7960.80
71_K75_E0.7950.80
84_V87_G0.7930.80
147_P155_A0.7890.79
17_P21_D0.7870.79
159_G162_I0.7860.79
96_W162_I0.7720.78
161_Q174_K0.7720.78
158_V162_I0.7710.78
168_L172_Q0.7700.78
132_I135_V0.7660.77
21_D25_H0.7570.76
135_V204_L0.7540.76
42_Y55_Q0.7480.76
151_K154_F0.7470.75
79_Y83_E0.7400.75
39_A42_Y0.7390.75
45_G143_G0.7360.74
212_F215_I0.7300.74
186_A190_T0.7270.73
216_R220_I0.7270.73
60_M105_M0.7230.73
173_V177_L0.7210.73
23_A169_I0.7190.73
40_F50_F0.7170.72
69_D119_K0.7170.72
131_L166_T0.7150.72
16_T19_W0.7140.72
86_F118_Y0.7100.72
18_M21_D0.7090.72
62_L118_Y0.7080.71
63_T198_F0.7080.71
128_V209_A0.7060.71
152_A155_A0.7060.71
38_S171_T0.7060.71
14_D218_Q0.7040.71
102_I117_A0.7040.71
145_L178_A0.6980.70
80_L90_V0.6960.70
121_P127_I0.6910.70
17_P124_L0.6780.68
154_F160_L0.6740.68
53_V206_G0.6710.67
26_E31_V0.6700.67
23_A26_E0.6680.67
108_H141_F0.6670.67
40_F125_N0.6620.66
65_Y187_Q0.6590.66
172_Q205_F0.6580.66
164_E178_A0.6540.65
35_H149_D0.6480.65
25_H205_F0.6470.65
156_T184_V0.6470.65
18_M22_I0.6420.64
132_I207_L0.6420.64
73_A132_I0.6410.64
141_F189_L0.6390.64
124_L131_L0.6370.63
136_M206_G0.6360.63
120_K125_N0.6340.63
120_K208_M0.6340.63
78_Y92_G0.6340.63
88_Q91_R0.6330.63
14_D22_I0.6320.63
102_I159_G0.6270.62
35_H38_S0.6270.62
121_P217_K0.6260.62
57_L107_L0.6260.62
75_E79_Y0.6250.62
38_S42_Y0.6220.62
125_N136_M0.6200.61
74_W101_V0.6200.61
16_T21_D0.6190.61
144_Y155_A0.6180.61
43_C220_I0.6180.61
124_L128_V0.6170.61
92_G121_P0.6150.61
46_G220_I0.6150.61
209_A213_I0.6140.61
27_V220_I0.6120.60
105_M109_T0.6100.60
214_M218_Q0.6100.60
70_I73_A0.6090.60
138_G142_T0.6070.60
148_W160_L0.6070.60
26_E213_I0.6060.60
27_V46_G0.6020.59
149_D176_L0.6010.59
108_H111_R0.6010.59
142_T200_L0.6000.59
59_G94_H0.5960.58
154_F188_T0.5960.58
144_Y151_K0.5940.58
52_T205_F0.5920.58
73_A82_N0.5910.58
130_V134_F0.5850.57
117_A221_S0.5850.57
171_T206_G0.5830.57
207_L210_A0.5830.57
116_G120_K0.5810.56
77_V91_R0.5800.56
27_V31_V0.5780.56
19_W22_I0.5750.56
58_S82_N0.5720.55
26_E29_E0.5700.55
44_F107_L0.5670.55
104_M142_T0.5660.54
71_K119_K0.5660.54
128_V131_L0.5650.54
41_V44_F0.5630.54
86_F173_V0.5600.54
51_V97_G0.5590.54
145_L148_W0.5570.53
103_V107_L0.5560.53
17_P24_D0.5540.53
103_V136_M0.5520.53
146_L189_L0.5490.52
106_F133_F0.5470.52
90_V105_M0.5450.52
206_G209_A0.5450.52
39_A47_L0.5420.51
127_I134_F0.5420.51
22_I209_A0.5400.51
179_G191_R0.5380.51
181_P189_L0.5360.51
138_G155_A0.5300.50
67_V71_K0.5280.49
68_P186_A0.5270.49
162_I174_K0.5270.49
20_R26_E0.5260.49
50_F54_I0.5260.49
69_D210_A0.5250.49
141_F158_V0.5240.49
19_W203_A0.5230.49
166_T173_V0.5230.49
37_F118_Y0.5220.49
169_I177_L0.5200.48
174_K181_P0.5200.48
121_P132_I0.5180.48
176_L189_L0.5180.48
25_H212_F0.5160.48
53_V209_A0.5150.48
110_L121_P0.5150.48
92_G194_A0.5140.48
119_K185_G0.5130.48
81_Q132_I0.5070.47
53_V131_L0.5060.47
68_P71_K0.5050.46
125_N128_V0.5050.46
44_F116_G0.5040.46
138_G209_A0.5030.46
100_L103_V0.5020.46
105_M208_M0.5010.46
53_V205_F0.5010.46
79_Y157_K0.5010.46
57_L180_H0.5010.46
139_L150_M0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyA 2 0.9598 100 0.043 Contact Map
4ogqA 2 0.9554 100 0.064 Contact Map
3cx5C 2 0.9375 100 0.087 Contact Map
1pp9C 2 0.8929 100 0.107 Contact Map
1kqfC 3 0.683 79 0.938 Contact Map
4gd3A 2 0.7098 69.9 0.943 Contact Map
1zcdA 1 0.7857 18.7 0.96 Contact Map
4ld7A 5 0.3036 17.5 0.96 Contact Map
1zoyC 1 0.5312 13.4 0.962 Contact Map
4e0tA 4 0.2723 13.3 0.962 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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