GREMLIN Database
QCRA - Menaquinol-cytochrome c reductase iron-sulfur subunit
UniProt: P46911 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 167 (147)
Sequences: 2911 (1784)
Seq/√Len: 147.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_G140_P4.8611.00
79_E83_S3.1551.00
118_K127_L2.9291.00
142_A145_D2.9201.00
29_L32_M2.8521.00
22_G26_A2.7051.00
76_Y92_E2.6201.00
101_K143_P2.5281.00
95_A156_L2.4741.00
54_S57_E2.4401.00
129_E135_V2.3821.00
127_L136_P2.2981.00
128_Y142_A2.1961.00
152_K155_F2.1951.00
97_S145_D2.1761.00
98_P106_T2.0171.00
128_Y141_L1.9341.00
101_K145_D1.8671.00
101_K140_P1.8431.00
99_I106_T1.8251.00
20_V24_M1.7061.00
96_L144_L1.6981.00
129_E133_T1.6891.00
74_A77_E1.5761.00
26_A29_L1.5731.00
136_P141_L1.5591.00
125_Y136_P1.5531.00
96_L146_H1.5511.00
87_F90_G1.5451.00
51_Q155_F1.5431.00
108_N122_P1.5201.00
34_R37_L1.5121.00
83_S86_V1.5111.00
14_N18_T1.5111.00
28_M31_P1.5031.00
53_V58_L1.5021.00
120_F127_L1.4791.00
105_C123_C1.4771.00
70_N77_E1.4711.00
32_M35_F1.4451.00
54_S155_F1.4331.00
15_Y19_G1.4291.00
101_K128_Y1.3991.00
118_K135_V1.3671.00
58_L93_I1.3451.00
149_Q156_L1.3431.00
58_L63_Q1.3331.00
155_F159_G1.3161.00
88_K91_D1.2431.00
17_L21_G1.2011.00
80_E84_A1.1921.00
70_N73_D1.1210.99
18_T22_G1.1130.99
19_G23_F1.1050.99
9_R17_L1.0820.99
53_V63_Q1.0800.99
27_S31_P1.0750.99
154_G159_G1.0680.99
21_G25_A1.0360.99
60_K79_E1.0350.99
78_S81_S1.0320.99
72_V158_L1.0250.99
21_G24_M1.0210.99
15_Y18_T1.0190.99
30_M34_R1.0170.99
26_A30_M1.0150.99
150_E157_Y1.0050.99
120_F125_Y0.9970.99
93_I151_V0.9970.99
25_A28_M0.9900.99
59_T76_Y0.9790.98
23_F27_S0.9770.98
23_F26_A0.9750.98
35_F39_P0.9680.98
71_Q74_A0.9590.98
112_D116_P0.9580.98
62_P119_F0.9510.98
32_M36_A0.9490.98
76_Y79_E0.9320.98
95_A149_Q0.9310.98
87_F91_D0.9270.98
26_A31_P0.9260.98
9_R13_L0.9230.98
6_D9_R0.9220.98
40_V43_S0.9200.98
14_N17_L0.9190.98
53_V74_A0.9170.98
89_N131_D0.9040.97
67_F72_V0.9020.97
106_T128_Y0.8990.97
96_L109_W0.8940.97
98_P128_Y0.8770.97
80_E83_S0.8590.97
129_E147_Y0.8570.96
147_Y158_L0.8560.96
25_A29_L0.8540.96
85_W130_K0.8520.96
90_G151_V0.8510.96
27_S30_M0.8450.96
103_L141_L0.8440.96
36_A40_V0.8350.96
73_D76_Y0.8330.96
40_V45_G0.8310.96
154_G157_Y0.8300.96
10_R13_L0.8130.95
62_P65_F0.8120.95
62_P75_W0.8080.95
55_V93_I0.8070.95
22_G25_A0.8030.95
104_G122_P0.7970.95
95_A147_Y0.7920.95
75_W85_W0.7890.94
71_Q75_W0.7840.94
82_R86_V0.7790.94
58_L65_F0.7710.94
75_W81_S0.7700.94
24_M27_S0.7680.94
54_S154_G0.7650.93
40_V44_T0.7620.93
60_K78_S0.7620.93
45_G48_D0.7610.93
109_W120_F0.7600.93
48_D67_F0.7560.93
78_S83_S0.7460.93
72_V76_Y0.7410.92
57_E60_K0.7400.92
152_K157_Y0.7330.92
96_L110_N0.7190.91
109_W119_F0.7190.91
118_K125_Y0.7180.91
70_N74_A0.7090.91
39_P42_K0.7050.90
31_P35_F0.7030.90
69_I77_E0.6980.90
75_W119_F0.6960.90
106_T122_P0.6930.90
74_A78_S0.6820.89
101_K144_L0.6810.89
41_L106_T0.6800.89
8_S15_Y0.6750.88
134_N143_P0.6730.88
21_G26_A0.6730.88
11_Q14_N0.6720.88
7_I11_Q0.6710.88
28_M32_M0.6710.88
57_E63_Q0.6710.88
33_V38_D0.6680.88
71_Q76_Y0.6670.88
78_S82_R0.6670.88
68_K71_Q0.6650.88
24_M28_M0.6640.87
38_D141_L0.6570.87
75_W78_S0.6560.87
111_S127_L0.6480.86
69_I72_V0.6470.86
94_V146_H0.6450.86
67_F71_Q0.6390.85
71_Q79_E0.6370.85
36_A103_L0.6350.85
35_F38_D0.6350.85
82_R85_W0.6340.85
71_Q78_S0.6340.85
72_V79_E0.6290.85
12_F15_Y0.6280.84
102_H124_H0.6280.84
89_N94_V0.6280.84
51_Q141_L0.6270.84
88_K92_E0.6230.84
152_K156_L0.6170.83
31_P36_A0.6110.83
68_K145_D0.6060.82
38_D42_K0.6040.82
72_V78_S0.6000.82
73_D77_E0.5980.81
65_F119_F0.5970.81
33_V36_A0.5950.81
42_K56_D0.5930.81
9_R15_Y0.5920.81
127_L135_V0.5890.80
151_V156_L0.5870.80
21_G33_V0.5780.79
98_P147_Y0.5740.79
65_F68_K0.5740.79
12_F109_W0.5720.79
89_N92_E0.5710.78
18_T25_A0.5690.78
37_L40_V0.5680.78
125_Y128_Y0.5670.78
45_G49_M0.5660.78
11_Q15_Y0.5660.78
20_V23_F0.5640.78
21_G31_P0.5630.77
112_D135_V0.5620.77
65_F72_V0.5600.77
11_Q17_L0.5580.77
100_C105_C0.5400.75
29_L33_V0.5380.74
16_T20_V0.5350.74
70_N76_Y0.5340.74
58_L67_F0.5320.73
72_V77_E0.5310.73
35_F103_L0.5300.73
24_M37_L0.5300.73
18_T116_P0.5280.73
70_N79_E0.5270.73
13_L31_P0.5250.72
90_G149_Q0.5230.72
8_S12_F0.5170.71
108_N111_S0.5170.71
110_N116_P0.5140.71
38_D43_S0.5110.70
96_L132_G0.5100.70
81_S84_A0.5080.70
83_S92_E0.5070.70
97_S106_T0.5070.70
49_M53_V0.5060.70
66_D71_Q0.5030.69
64_R69_I0.5020.69
54_S58_L0.5020.69
102_H105_C0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2qjyC 2 0.8802 100 0.351 Contact Map
3cx5E 1 0.9162 100 0.362 Contact Map
4ogqD 1 0.8802 100 0.37 Contact Map
4aayB 1 0.7186 100 0.394 Contact Map
4d6tE 1 0.2814 100 0.4 Contact Map
1pp9E 1 0.9162 100 0.409 Contact Map
2nwfA 1 0.6527 99.9 0.543 Contact Map
1jm1A 1 0.8024 99.8 0.558 Contact Map
1nykA 1 0.7904 99.8 0.558 Contact Map
1rieA 1 0.6587 99.8 0.581 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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