YWIC - BACSU - GREMLIN Contacts

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YWIC - Uncharacterized protein YwiC

UniProt:	P46909	Sequences: MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYLAVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMYFARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVKSVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTIGILEIVNACFFLAVMCLFITR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	239 (233)
Sequences:	303 (246)
Seq/√Len:	16.1

BACSU - YWIC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
157_F	174_W	3.735	1.00
165_E	168_N	3.630	1.00
151_F	155_S	3.264	0.99
6_P	12_W	3.154	0.99
220_I	224_V	2.858	0.98
161_S	218_I	2.686	0.97
123_C	149_A	2.681	0.97
100_H	114_N	2.644	0.96
175_S	205_A	2.539	0.95
5_I	41_F	2.460	0.94
19_F	36_F	2.391	0.93
160_K	165_E	2.346	0.93
183_P	202_S	2.346	0.93
41_F	71_P	2.321	0.92
8_Q	11_A	2.265	0.91
12_W	163_I	2.263	0.91
41_F	184_F	2.247	0.91
119_V	156_S	2.240	0.91
203_L	207_F	2.237	0.91
9_H	12_W	2.178	0.90
52_A	64_W	2.116	0.88
100_H	115_D	2.101	0.88
229_F	233_M	2.073	0.87
161_S	167_K	2.026	0.86
103_F	114_N	2.021	0.86
214_P	217_T	1.892	0.82
115_D	119_V	1.849	0.80
161_S	166_R	1.811	0.79
43_Y	115_D	1.802	0.78
91_V	95_P	1.790	0.78
116_V	153_I	1.780	0.77
138_D	180_L	1.754	0.76
174_W	177_G	1.714	0.75
46_V	89_V	1.666	0.72
146_L	185_L	1.666	0.72
23_M	28_P	1.660	0.72
67_Y	73_C	1.659	0.72
74_C	234_C	1.648	0.72
42_L	151_F	1.641	0.71
115_D	160_K	1.620	0.70
100_H	104_A	1.606	0.70
35_L	204_R	1.605	0.69
34_P	79_S	1.596	0.69
46_V	100_H	1.576	0.68
100_H	103_F	1.555	0.67
32_H	129_S	1.529	0.66
182_L	198_F	1.519	0.65
6_P	10_G	1.495	0.64
81_F	172_A	1.493	0.64
15_L	171_F	1.490	0.64
197_A	229_F	1.474	0.63
100_H	118_G	1.468	0.62
191_A	196_L	1.439	0.61
20_L	60_P	1.418	0.60
44_L	68_Y	1.411	0.59
46_V	50_T	1.408	0.59
15_L	97_F	1.389	0.58
89_V	124_S	1.384	0.58
69_G	184_F	1.366	0.57
46_V	118_G	1.353	0.56
50_T	104_A	1.353	0.56
40_L	227_C	1.345	0.55
7_K	47_Y	1.332	0.55
62_Q	66_C	1.332	0.55
46_V	93_L	1.323	0.54
212_D	220_I	1.312	0.54
103_F	108_N	1.276	0.51
80_V	84_P	1.268	0.51
62_Q	224_V	1.267	0.51
184_F	234_C	1.266	0.51
202_S	215_V	1.265	0.51
171_F	174_W	1.258	0.50
181_L	198_F	1.250	0.50
155_S	176_W	1.245	0.50
120_L	218_I	1.241	0.49
26_G	38_G	1.239	0.49
33_I	184_F	1.227	0.49
172_A	176_W	1.223	0.48
8_Q	204_R	1.215	0.48
232_V	235_L	1.209	0.48
149_A	235_L	1.196	0.47
91_V	106_R	1.178	0.46
177_G	203_L	1.171	0.45
172_A	209_H	1.168	0.45
49_V	157_F	1.162	0.45
109_E	123_C	1.154	0.44
71_P	78_I	1.154	0.44
32_H	35_L	1.148	0.44
48_P	64_W	1.148	0.44
101_M	195_F	1.140	0.44
7_K	209_H	1.121	0.42
79_S	86_L	1.118	0.42
99_I	117_A	1.116	0.42
149_A	195_F	1.093	0.41
61_Y	205_A	1.091	0.41
44_L	47_Y	1.089	0.41
68_Y	160_K	1.088	0.41
104_A	141_A	1.088	0.41
177_G	181_L	1.085	0.40
161_S	175_S	1.081	0.40
149_A	185_L	1.080	0.40
105_R	109_E	1.077	0.40
50_T	100_H	1.077	0.40
48_P	100_H	1.071	0.40
112_L	166_R	1.070	0.40
6_P	9_H	1.067	0.39
176_W	233_M	1.065	0.39
116_V	232_V	1.063	0.39
28_P	35_L	1.060	0.39
15_L	57_Q	1.043	0.38
20_L	146_L	1.035	0.38
26_G	130_C	1.033	0.38
13_A	17_I	1.032	0.37
154_G	178_Y	1.027	0.37
187_A	231_A	1.026	0.37
58_S	151_F	1.021	0.37
56_K	157_F	1.019	0.37
17_I	152_F	1.017	0.37
14_M	18_P	1.013	0.36
200_P	225_N	1.010	0.36
103_F	117_A	1.006	0.36
36_F	97_F	1.005	0.36
89_V	131_W	0.996	0.36
97_F	124_S	0.988	0.35
17_I	230_L	0.986	0.35
150_L	162_V	0.983	0.35
109_E	115_D	0.972	0.34
104_A	148_S	0.967	0.34
159_V	175_S	0.959	0.34
99_I	199_I	0.958	0.34
213_W	218_I	0.949	0.33
24_V	185_L	0.946	0.33
103_F	111_A	0.946	0.33
44_L	175_S	0.940	0.33
14_M	110_R	0.937	0.32
4_L	115_D	0.937	0.32
38_G	90_G	0.935	0.32
39_W	204_R	0.930	0.32
26_G	181_L	0.927	0.32
66_C	235_L	0.926	0.32
43_Y	160_K	0.926	0.32
98_L	177_G	0.923	0.32
8_Q	54_K	0.915	0.31
86_L	206_W	0.914	0.31
147_Q	233_M	0.911	0.31
24_V	82_H	0.911	0.31
150_L	182_L	0.910	0.31
25_K	28_P	0.901	0.31
33_I	134_M	0.900	0.31
161_S	206_W	0.898	0.31
132_L	178_Y	0.892	0.30
201_S	225_N	0.891	0.30
86_L	132_L	0.887	0.30
112_L	116_V	0.882	0.30
45_A	232_V	0.881	0.30
46_V	155_S	0.880	0.30
81_F	113_L	0.879	0.30
4_L	64_W	0.876	0.29
60_P	79_S	0.876	0.29
48_P	229_F	0.868	0.29
47_Y	64_W	0.864	0.29
81_F	180_L	0.861	0.29
91_V	107_K	0.860	0.29
15_L	115_D	0.859	0.29
16_L	36_F	0.853	0.28
6_P	11_A	0.850	0.28
120_L	153_I	0.850	0.28
124_S	127_F	0.849	0.28
92_S	192_G	0.847	0.28
201_S	229_F	0.840	0.28
15_L	160_K	0.838	0.28
70_F	94_L	0.831	0.27
74_C	180_L	0.829	0.27
144_I	182_L	0.825	0.27
36_F	144_I	0.821	0.27
125_G	209_H	0.821	0.27
5_I	75_F	0.812	0.26
10_G	13_A	0.811	0.26
205_A	219_G	0.811	0.26
92_S	177_G	0.809	0.26
116_V	185_L	0.809	0.26
103_F	115_D	0.807	0.26
22_G	69_G	0.798	0.26
86_L	93_L	0.798	0.26
114_N	160_K	0.789	0.25
41_F	75_F	0.788	0.25
43_Y	154_G	0.787	0.25
6_P	13_A	0.780	0.25
71_P	199_I	0.778	0.25
18_P	219_G	0.777	0.25
74_C	143_F	0.775	0.25
123_C	182_L	0.774	0.25
62_Q	129_S	0.774	0.25
44_L	114_N	0.772	0.25
161_S	170_A	0.771	0.25
98_L	235_L	0.769	0.25
112_L	185_L	0.768	0.24
110_R	204_R	0.768	0.24
80_V	103_F	0.768	0.24
76_L	90_G	0.763	0.24
101_M	107_K	0.759	0.24
151_F	213_W	0.758	0.24
48_P	118_G	0.755	0.24
223_I	231_A	0.755	0.24
171_F	218_I	0.754	0.24
7_K	11_A	0.753	0.24
48_P	68_Y	0.752	0.24
28_P	69_G	0.749	0.24
149_A	184_F	0.746	0.24
24_V	70_F	0.746	0.24
180_L	211_R	0.745	0.24
93_L	128_A	0.745	0.24
71_P	169_R	0.740	0.23
60_P	91_V	0.739	0.23
6_P	34_P	0.736	0.23
144_I	199_I	0.727	0.23
47_Y	150_L	0.724	0.23
100_H	111_A	0.723	0.23
120_L	124_S	0.721	0.23
181_L	196_L	0.719	0.22
130_C	138_D	0.718	0.22
216_K	220_I	0.718	0.22
28_P	196_L	0.716	0.22
168_N	171_F	0.716	0.22
53_L	101_M	0.714	0.22
126_G	130_C	0.711	0.22
81_F	196_L	0.707	0.22
59_K	62_Q	0.706	0.22
122_F	145_F	0.706	0.22
9_H	15_L	0.703	0.22
9_H	152_F	0.699	0.22
95_P	233_M	0.696	0.22
114_N	117_A	0.691	0.21
53_L	104_A	0.687	0.21
37_L	75_F	0.686	0.21
177_G	211_R	0.685	0.21
4_L	145_F	0.685	0.21
109_E	117_A	0.684	0.21
38_G	94_L	0.683	0.21
54_K	133_G	0.683	0.21
77_M	231_A	0.682	0.21
64_W	229_F	0.673	0.21
147_Q	178_Y	0.670	0.21
84_P	222_E	0.668	0.20
116_V	169_R	0.668	0.20
60_P	107_K	0.667	0.20
104_A	109_E	0.665	0.20
66_C	70_F	0.664	0.20
32_H	114_N	0.664	0.20
5_I	10_G	0.663	0.20
24_V	81_F	0.661	0.20
50_T	79_S	0.659	0.20
161_S	172_A	0.654	0.20
76_L	155_S	0.653	0.20
54_K	70_F	0.652	0.20
51_L	121_F	0.652	0.20
24_V	66_C	0.649	0.20
173_Y	177_G	0.642	0.19
32_H	111_A	0.641	0.19
161_S	213_W	0.638	0.19
124_S	214_P	0.638	0.19
114_N	198_F	0.637	0.19
73_C	148_S	0.635	0.19
15_L	51_L	0.633	0.19
43_Y	129_S	0.632	0.19
187_A	206_W	0.629	0.19
106_R	149_A	0.627	0.19
17_I	215_V	0.627	0.19
40_L	152_F	0.626	0.19
68_Y	112_L	0.625	0.19
115_D	165_E	0.622	0.19
168_N	232_V	0.620	0.19
16_L	142_W	0.620	0.19
184_F	199_I	0.617	0.19
117_A	122_F	0.616	0.19
184_F	235_L	0.614	0.18
51_L	57_Q	0.612	0.18
18_P	110_R	0.611	0.18
94_L	138_D	0.611	0.18
110_R	219_G	0.610	0.18
51_L	109_E	0.607	0.18
81_F	228_F	0.602	0.18
64_W	151_F	0.600	0.18
15_L	45_A	0.600	0.18
80_V	215_V	0.599	0.18
75_F	108_N	0.598	0.18
158_Y	218_I	0.597	0.18
83_K	86_L	0.597	0.18
35_L	205_A	0.596	0.18
61_Y	104_A	0.594	0.18
8_Q	95_P	0.593	0.18
14_M	219_G	0.593	0.18
19_F	44_L	0.592	0.18
98_L	140_W	0.591	0.18
27_G	91_V	0.589	0.18
43_Y	159_V	0.587	0.18
115_D	153_I	0.586	0.18
176_W	209_H	0.583	0.17
53_L	228_F	0.582	0.17
37_L	232_V	0.581	0.17
109_E	114_N	0.580	0.17
186_S	231_A	0.577	0.17
187_A	235_L	0.577	0.17
202_S	205_A	0.575	0.17
24_V	53_L	0.571	0.17
152_F	157_F	0.567	0.17
64_W	89_V	0.563	0.17
157_F	171_F	0.563	0.17
64_W	128_A	0.562	0.17
65_M	127_F	0.559	0.17
31_W	170_A	0.558	0.17
26_G	210_G	0.557	0.17
93_L	96_L	0.554	0.16
98_L	106_R	0.553	0.16
85_P	133_G	0.553	0.16
180_L	230_L	0.550	0.16
54_K	216_K	0.549	0.16
21_L	158_Y	0.549	0.16
70_F	73_C	0.547	0.16
25_K	144_I	0.546	0.16
146_L	212_D	0.545	0.16
73_C	86_L	0.545	0.16
13_A	222_E	0.543	0.16
25_K	119_V	0.539	0.16
20_L	161_S	0.535	0.16
138_D	181_L	0.535	0.16
51_L	151_F	0.534	0.16
154_G	163_I	0.534	0.16
42_L	115_D	0.534	0.16
128_A	190_G	0.533	0.16
173_Y	181_L	0.533	0.16
48_P	89_V	0.532	0.16
87_I	210_G	0.529	0.16
8_Q	123_C	0.529	0.16
86_L	224_V	0.523	0.15
17_I	196_L	0.522	0.15
137_L	141_A	0.521	0.15
31_W	99_I	0.521	0.15
21_L	148_S	0.520	0.15
29_V	70_F	0.518	0.15
74_C	203_L	0.517	0.15
49_V	65_M	0.515	0.15
99_I	218_I	0.505	0.15
20_L	187_A	0.503	0.15
114_N	152_F	0.503	0.15
8_Q	110_R	0.502	0.15
7_K	10_G	0.502	0.15
89_V	111_A	0.501	0.15
168_N	229_F	0.501	0.15
185_L	234_C	0.500	0.15

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4tq3A	1	0.9372	40.4	0.956	Contact Map
3l1lA	2	0.4854	33.8	0.958	Contact Map
1ckkB	1	0.1004	15.9	0.964	Contact Map
4od4A	1	0.9205	11.4	0.967	Contact Map
4ryoA	1	0.6151	9	0.968	Contact Map
3giaA	1	0.4895	8.5	0.968	Contact Map
3rceA	1	0.7573	8.4	0.969	Contact Map
1iq5B	1	0.0921	6.4	0.97	Contact Map
4ujrC	1	0.2427	4.9	0.972	Contact Map
3wajA	1	0.7657	3.9	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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