FNR - BACSU - GREMLIN Contacts

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FNR - Anaerobic regulatory protein

UniProt:	P46908	Sequences: MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDAEELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEVLVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSNSYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKRDYLRCEIECENCPLEICNID	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	238 (207)
Sequences:	8216 (6425)
Seq/√Len:	446.6

ECOLI - FNR CRP YEIL
BACSU - FNR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
46_E	104_V	3.140	1.00
30_K	101_E	2.798	1.00
58_G	95_K	2.776	1.00
206_S	216_H	2.548	1.00
32_E	35_T	2.506	1.00
147_K	187_A	2.454	1.00
96_V	100_G	2.343	1.00
52_S	101_E	2.311	1.00
206_S	214_I	2.306	1.00
15_S	18_L	2.303	1.00
57_I	94_A	2.227	1.00
204_V	220_Y	2.101	1.00
152_Y	199_L	2.093	1.00
54_L	98_E	2.045	1.00
38_F	94_A	2.043	1.00
40_E	93_S	2.037	1.00
198_D	202_K	2.005	1.00
56_E	95_K	1.944	1.00
28_K	101_E	1.933	1.00
106_N	109_K	1.902	1.00
51_Q	103_L	1.890	1.00
132_L	135_I	1.841	1.00
218_R	222_R	1.841	1.00
55_I	94_A	1.837	1.00
40_E	59_K	1.830	1.00
217_K	220_Y	1.829	1.00
39_R	42_M	1.829	1.00
178_N	193_N	1.822	1.00
146_G	149_G	1.817	1.00
147_K	191_S	1.791	1.00
32_E	99_D	1.783	1.00
148_K	198_D	1.762	1.00
112_K	116_Q	1.754	1.00
29_R	104_V	1.732	1.00
30_K	99_D	1.727	1.00
58_G	93_S	1.725	1.00
55_I	100_G	1.722	1.00
151_L	195_M	1.682	1.00
31_M	102_V	1.677	1.00
33_K	98_E	1.673	1.00
107_K	111_E	1.659	1.00
33_K	99_D	1.595	1.00
197_G	201_K	1.591	1.00
148_K	202_K	1.583	1.00
173_N	212_K	1.579	1.00
200_R	207_I	1.540	1.00
115_I	122_F	1.510	1.00
56_E	66_D	1.500	1.00
66_D	183_K	1.498	1.00
31_M	37_L	1.490	1.00
21_L	116_Q	1.482	1.00
56_E	68_T	1.480	1.00
36_Y	95_K	1.477	1.00
171_L	212_K	1.462	1.00
56_E	97_L	1.443	1.00
51_Q	101_E	1.441	1.00
35_T	96_V	1.439	1.00
200_R	206_S	1.421	1.00
85_T	133_R	1.410	1.00
36_Y	93_S	1.407	1.00
171_L	214_I	1.406	1.00
80_E	131_H	1.403	1.00
197_G	200_R	1.401	1.00
36_Y	39_R	1.383	1.00
72_C	76_D	1.340	1.00
199_L	204_V	1.336	1.00
25_I	109_K	1.326	1.00
109_K	112_K	1.317	1.00
159_S	215_L	1.307	1.00
190_E	194_R	1.302	1.00
54_L	100_G	1.274	1.00
154_T	181_L	1.269	1.00
179_Q	183_K	1.248	1.00
219_D	222_R	1.237	1.00
178_N	189_R	1.227	1.00
195_M	198_D	1.206	1.00
50_I	100_G	1.206	1.00
135_I	139_I	1.185	1.00
54_L	97_L	1.171	1.00
18_L	117_N	1.164	1.00
37_L	55_I	1.161	1.00
148_K	195_M	1.148	1.00
187_A	192_V	1.134	1.00
220_Y	223_C	1.132	1.00
195_M	199_L	1.124	1.00
72_C	78_V	1.123	1.00
31_M	35_T	1.119	1.00
141_D	153_S	1.116	1.00
152_Y	156_I	1.116	1.00
115_I	119_A	1.115	1.00
67_L	138_K	1.110	1.00
54_L	71_I	1.110	1.00
12_D	123_E	1.103	1.00
154_T	185_C	1.102	1.00
50_I	72_C	1.100	1.00
56_E	71_I	1.096	1.00
48_Y	102_V	1.082	1.00
44_A	89_R	1.065	1.00
54_L	73_Q	1.064	1.00
14_I	18_L	1.060	1.00
159_S	218_R	1.050	1.00
61_T	65_K	1.050	1.00
179_Q	189_R	1.049	1.00
71_I	97_L	1.049	1.00
57_I	72_C	1.048	1.00
189_R	193_N	1.033	1.00
34_H	95_K	1.027	1.00
50_I	55_I	1.026	1.00
52_S	74_K	1.025	1.00
48_Y	104_V	1.018	1.00
121_T	125_M	1.017	1.00
111_E	122_F	1.011	1.00
66_D	95_K	1.009	1.00
108_N	112_K	1.002	1.00
21_L	24_S	1.001	1.00
57_I	92_L	0.996	1.00
114_L	121_T	0.992	1.00
111_E	115_I	0.992	1.00
38_F	92_L	0.991	1.00
207_I	213_I	0.985	1.00
18_L	21_L	0.969	1.00
185_C	192_V	0.968	1.00
125_M	128_M	0.968	1.00
59_K	140_R	0.964	1.00
16_S	20_E	0.961	1.00
37_L	102_V	0.956	1.00
178_N	207_I	0.954	1.00
154_T	184_F	0.953	1.00
208_D	214_I	0.944	1.00
28_K	51_Q	0.937	1.00
151_L	185_C	0.936	1.00
118_G	121_T	0.926	1.00
26_S	105_I	0.917	1.00
29_R	102_V	0.895	1.00
31_M	55_I	0.892	1.00
60_L	66_D	0.891	1.00
113_E	120_L	0.890	1.00
47_L	110_L	0.888	1.00
20_E	24_S	0.887	1.00
208_D	212_K	0.884	1.00
27_T	104_V	0.879	1.00
28_K	103_L	0.877	1.00
31_M	100_G	0.872	1.00
148_K	199_L	0.859	1.00
152_Y	221_L	0.858	1.00
141_D	157_R	0.855	1.00
152_Y	204_V	0.851	1.00
114_L	117_N	0.848	1.00
47_L	105_I	0.838	1.00
37_L	78_V	0.833	1.00
26_S	103_L	0.832	1.00
40_E	140_R	0.832	1.00
58_G	66_D	0.828	1.00
36_Y	58_G	0.827	1.00
82_T	92_L	0.827	1.00
73_Q	76_D	0.823	1.00
21_L	25_I	0.818	1.00
123_E	127_W	0.816	1.00
48_Y	78_V	0.814	1.00
18_L	119_A	0.807	1.00
112_K	115_I	0.806	1.00
31_M	96_V	0.799	1.00
149_G	152_Y	0.794	1.00
50_I	75_H	0.792	1.00
191_S	194_R	0.792	1.00
25_I	112_K	0.788	1.00
79_G	82_T	0.787	1.00
47_L	77_I	0.774	1.00
50_I	74_K	0.773	1.00
188_A	191_S	0.770	1.00
145_H	153_S	0.765	1.00
119_A	123_E	0.763	1.00
137_S	157_R	0.761	1.00
67_L	143_L	0.758	1.00
40_E	60_L	0.757	1.00
202_K	220_Y	0.754	1.00
32_E	96_V	0.751	1.00
55_I	102_V	0.751	1.00
47_L	83_L	0.749	1.00
46_E	106_N	0.745	1.00
122_F	126_K	0.738	1.00
130_T	134_K	0.737	1.00
160_N	222_R	0.736	1.00
193_N	197_G	0.734	1.00
189_R	192_V	0.734	1.00
56_E	180_D	0.733	1.00
55_I	78_V	0.727	1.00
196_L	207_I	0.724	1.00
52_S	98_E	0.724	1.00
219_D	223_C	0.722	1.00
128_M	132_L	0.722	1.00
117_N	121_T	0.719	1.00
50_I	102_V	0.719	1.00
159_S	170_I	0.718	1.00
20_E	23_E	0.716	1.00
59_K	137_S	0.714	1.00
49_L	77_I	0.709	1.00
182_A	187_A	0.708	1.00
85_T	88_P	0.705	1.00
110_L	120_L	0.702	1.00
187_A	191_S	0.702	1.00
45_E	106_N	0.699	1.00
50_I	73_Q	0.697	1.00
127_W	131_H	0.695	1.00
110_L	114_L	0.694	1.00
153_S	157_R	0.694	1.00
39_R	93_S	0.689	1.00
215_L	218_R	0.689	1.00
60_L	93_S	0.681	1.00
177_T	180_D	0.678	1.00
181_L	192_V	0.676	1.00
154_T	158_L	0.675	1.00
123_E	126_K	0.672	1.00
25_I	114_L	0.671	1.00
198_D	201_K	0.670	1.00
190_E	193_N	0.668	1.00
58_G	68_T	0.663	1.00
156_I	222_R	0.659	1.00
160_N	218_R	0.656	1.00
203_G	216_H	0.654	1.00
139_I	142_L	0.651	1.00
85_T	130_T	0.651	1.00
82_T	91_M	0.648	1.00
22_L	113_E	0.641	0.99
147_K	150_A	0.640	0.99
178_N	192_V	0.640	0.99
85_T	126_K	0.639	0.99
164_V	173_N	0.639	0.99
52_S	99_D	0.638	0.99
111_E	126_K	0.635	0.99
79_G	91_M	0.633	0.99
49_L	103_L	0.633	0.99
83_L	107_K	0.629	0.99
158_L	172_I	0.629	0.99
55_I	96_V	0.629	0.99
155_L	199_L	0.627	0.99
81_L	132_L	0.626	0.99
17_D	20_E	0.622	0.99
141_D	145_H	0.622	0.99
96_V	99_D	0.620	0.99
151_L	181_L	0.616	0.99
156_I	160_N	0.614	0.99
136_Q	139_I	0.614	0.99
204_V	216_H	0.613	0.99
37_L	96_V	0.610	0.99
216_H	220_Y	0.604	0.99
155_L	213_I	0.604	0.99
26_S	51_Q	0.603	0.99
18_L	123_E	0.603	0.99
151_L	192_V	0.599	0.99
158_L	162_Y	0.598	0.99
45_E	108_N	0.598	0.99
178_N	194_R	0.598	0.99
204_V	221_L	0.598	0.99
156_I	204_V	0.597	0.99
78_V	94_A	0.591	0.99
178_N	190_E	0.588	0.99
14_I	19_Y	0.588	0.99
81_L	91_M	0.587	0.99
154_T	157_R	0.584	0.99
151_L	199_L	0.581	0.99
140_R	144_L	0.580	0.99
163_G	169_G	0.577	0.99
114_L	124_F	0.570	0.99
73_Q	161_S	0.563	0.99
109_K	113_E	0.563	0.99
15_S	117_N	0.560	0.99
60_L	64_G	0.560	0.99
174_I	213_I	0.559	0.99
155_L	196_L	0.555	0.98
147_K	185_C	0.555	0.98
157_R	161_S	0.554	0.98
35_T	99_D	0.552	0.98
156_I	218_R	0.550	0.98
72_C	94_A	0.550	0.98
164_V	169_G	0.550	0.98
113_E	117_N	0.549	0.98
84_F	138_K	0.546	0.98
156_I	221_L	0.546	0.98
57_I	69_L	0.546	0.98
182_A	192_V	0.544	0.98
81_L	136_Q	0.542	0.98
158_L	161_S	0.541	0.98
162_Y	172_I	0.540	0.98
154_T	176_L	0.536	0.98
19_Y	23_E	0.534	0.98
23_E	26_S	0.534	0.98
118_G	122_F	0.531	0.98
21_L	113_E	0.531	0.98
180_D	183_K	0.530	0.98
84_F	125_M	0.530	0.98
147_K	192_V	0.527	0.98
178_N	197_G	0.524	0.98
131_H	134_K	0.523	0.98
119_A	122_F	0.522	0.98
163_G	170_I	0.520	0.98
204_V	215_L	0.520	0.98
81_L	92_L	0.519	0.98
147_K	195_M	0.518	0.98
42_M	89_R	0.516	0.98
142_L	150_A	0.514	0.97
176_L	184_F	0.514	0.97
129_S	133_R	0.512	0.97
57_I	70_R	0.512	0.97
79_G	89_R	0.510	0.97
21_L	117_N	0.507	0.97
125_M	129_S	0.503	0.97
91_M	133_R	0.502	0.97
67_L	144_L	0.501	0.97
179_Q	210_S	0.500	0.97

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4cydA	2	0.937	100	0.225	Contact Map
3i54A	2	0.9328	100	0.227	Contact Map
3e97A	2	0.9118	100	0.23	Contact Map
3dkwA	2	0.9244	100	0.234	Contact Map
3dv8A	2	0.8992	100	0.238	Contact Map
2gauA	2	0.916	100	0.239	Contact Map
4ev0A	2	0.8992	100	0.255	Contact Map
3fx3A	2	0.9496	100	0.256	Contact Map
1zybA	2	0.895	100	0.268	Contact Map
3iwzA	2	0.8487	100	0.276	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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