GREMLIN Database
FNR - Anaerobic regulatory protein
UniProt: P46908 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 238 (207)
Sequences: 8216 (6425)
Seq/√Len: 446.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
46_E104_V3.1401.00
30_K101_E2.7981.00
58_G95_K2.7761.00
206_S216_H2.5481.00
32_E35_T2.5061.00
147_K187_A2.4541.00
96_V100_G2.3431.00
52_S101_E2.3111.00
206_S214_I2.3061.00
15_S18_L2.3031.00
57_I94_A2.2271.00
204_V220_Y2.1011.00
152_Y199_L2.0931.00
54_L98_E2.0451.00
38_F94_A2.0431.00
40_E93_S2.0371.00
198_D202_K2.0051.00
56_E95_K1.9441.00
28_K101_E1.9331.00
106_N109_K1.9021.00
51_Q103_L1.8901.00
132_L135_I1.8411.00
218_R222_R1.8411.00
55_I94_A1.8371.00
40_E59_K1.8301.00
217_K220_Y1.8291.00
39_R42_M1.8291.00
178_N193_N1.8221.00
146_G149_G1.8171.00
147_K191_S1.7911.00
32_E99_D1.7831.00
148_K198_D1.7621.00
112_K116_Q1.7541.00
29_R104_V1.7321.00
30_K99_D1.7271.00
58_G93_S1.7251.00
55_I100_G1.7221.00
151_L195_M1.6821.00
31_M102_V1.6771.00
33_K98_E1.6731.00
107_K111_E1.6591.00
33_K99_D1.5951.00
197_G201_K1.5911.00
148_K202_K1.5831.00
173_N212_K1.5791.00
200_R207_I1.5401.00
115_I122_F1.5101.00
56_E66_D1.5001.00
66_D183_K1.4981.00
31_M37_L1.4901.00
21_L116_Q1.4821.00
56_E68_T1.4801.00
36_Y95_K1.4771.00
171_L212_K1.4621.00
56_E97_L1.4431.00
51_Q101_E1.4411.00
35_T96_V1.4391.00
200_R206_S1.4211.00
85_T133_R1.4101.00
36_Y93_S1.4071.00
171_L214_I1.4061.00
80_E131_H1.4031.00
197_G200_R1.4011.00
36_Y39_R1.3831.00
72_C76_D1.3401.00
199_L204_V1.3361.00
25_I109_K1.3261.00
109_K112_K1.3171.00
159_S215_L1.3071.00
190_E194_R1.3021.00
54_L100_G1.2741.00
154_T181_L1.2691.00
179_Q183_K1.2481.00
219_D222_R1.2371.00
178_N189_R1.2271.00
195_M198_D1.2061.00
50_I100_G1.2061.00
135_I139_I1.1851.00
54_L97_L1.1711.00
18_L117_N1.1641.00
37_L55_I1.1611.00
148_K195_M1.1481.00
187_A192_V1.1341.00
220_Y223_C1.1321.00
195_M199_L1.1241.00
72_C78_V1.1231.00
31_M35_T1.1191.00
141_D153_S1.1161.00
152_Y156_I1.1161.00
115_I119_A1.1151.00
67_L138_K1.1101.00
54_L71_I1.1101.00
12_D123_E1.1031.00
154_T185_C1.1021.00
50_I72_C1.1001.00
56_E71_I1.0961.00
48_Y102_V1.0821.00
44_A89_R1.0651.00
54_L73_Q1.0641.00
14_I18_L1.0601.00
159_S218_R1.0501.00
61_T65_K1.0501.00
179_Q189_R1.0491.00
71_I97_L1.0491.00
57_I72_C1.0481.00
189_R193_N1.0331.00
34_H95_K1.0271.00
50_I55_I1.0261.00
52_S74_K1.0251.00
48_Y104_V1.0181.00
121_T125_M1.0171.00
111_E122_F1.0111.00
66_D95_K1.0091.00
108_N112_K1.0021.00
21_L24_S1.0011.00
57_I92_L0.9961.00
114_L121_T0.9921.00
111_E115_I0.9921.00
38_F92_L0.9911.00
207_I213_I0.9851.00
18_L21_L0.9691.00
185_C192_V0.9681.00
125_M128_M0.9681.00
59_K140_R0.9641.00
16_S20_E0.9611.00
37_L102_V0.9561.00
178_N207_I0.9541.00
154_T184_F0.9531.00
208_D214_I0.9441.00
28_K51_Q0.9371.00
151_L185_C0.9361.00
118_G121_T0.9261.00
26_S105_I0.9171.00
29_R102_V0.8951.00
31_M55_I0.8921.00
60_L66_D0.8911.00
113_E120_L0.8901.00
47_L110_L0.8881.00
20_E24_S0.8871.00
208_D212_K0.8841.00
27_T104_V0.8791.00
28_K103_L0.8771.00
31_M100_G0.8721.00
148_K199_L0.8591.00
152_Y221_L0.8581.00
141_D157_R0.8551.00
152_Y204_V0.8511.00
114_L117_N0.8481.00
47_L105_I0.8381.00
37_L78_V0.8331.00
26_S103_L0.8321.00
40_E140_R0.8321.00
58_G66_D0.8281.00
36_Y58_G0.8271.00
82_T92_L0.8271.00
73_Q76_D0.8231.00
21_L25_I0.8181.00
123_E127_W0.8161.00
48_Y78_V0.8141.00
18_L119_A0.8071.00
112_K115_I0.8061.00
31_M96_V0.7991.00
149_G152_Y0.7941.00
50_I75_H0.7921.00
191_S194_R0.7921.00
25_I112_K0.7881.00
79_G82_T0.7871.00
47_L77_I0.7741.00
50_I74_K0.7731.00
188_A191_S0.7701.00
145_H153_S0.7651.00
119_A123_E0.7631.00
137_S157_R0.7611.00
67_L143_L0.7581.00
40_E60_L0.7571.00
202_K220_Y0.7541.00
32_E96_V0.7511.00
55_I102_V0.7511.00
47_L83_L0.7491.00
46_E106_N0.7451.00
122_F126_K0.7381.00
130_T134_K0.7371.00
160_N222_R0.7361.00
193_N197_G0.7341.00
189_R192_V0.7341.00
56_E180_D0.7331.00
55_I78_V0.7271.00
196_L207_I0.7241.00
52_S98_E0.7241.00
219_D223_C0.7221.00
128_M132_L0.7221.00
117_N121_T0.7191.00
50_I102_V0.7191.00
159_S170_I0.7181.00
20_E23_E0.7161.00
59_K137_S0.7141.00
49_L77_I0.7091.00
182_A187_A0.7081.00
85_T88_P0.7051.00
110_L120_L0.7021.00
187_A191_S0.7021.00
45_E106_N0.6991.00
50_I73_Q0.6971.00
127_W131_H0.6951.00
110_L114_L0.6941.00
153_S157_R0.6941.00
39_R93_S0.6891.00
215_L218_R0.6891.00
60_L93_S0.6811.00
177_T180_D0.6781.00
181_L192_V0.6761.00
154_T158_L0.6751.00
123_E126_K0.6721.00
25_I114_L0.6711.00
198_D201_K0.6701.00
190_E193_N0.6681.00
58_G68_T0.6631.00
156_I222_R0.6591.00
160_N218_R0.6561.00
203_G216_H0.6541.00
139_I142_L0.6511.00
85_T130_T0.6511.00
82_T91_M0.6481.00
22_L113_E0.6410.99
147_K150_A0.6400.99
178_N192_V0.6400.99
85_T126_K0.6390.99
164_V173_N0.6390.99
52_S99_D0.6380.99
111_E126_K0.6350.99
79_G91_M0.6330.99
49_L103_L0.6330.99
83_L107_K0.6290.99
158_L172_I0.6290.99
55_I96_V0.6290.99
155_L199_L0.6270.99
81_L132_L0.6260.99
17_D20_E0.6220.99
141_D145_H0.6220.99
96_V99_D0.6200.99
151_L181_L0.6160.99
156_I160_N0.6140.99
136_Q139_I0.6140.99
204_V216_H0.6130.99
37_L96_V0.6100.99
216_H220_Y0.6040.99
155_L213_I0.6040.99
26_S51_Q0.6030.99
18_L123_E0.6030.99
151_L192_V0.5990.99
158_L162_Y0.5980.99
45_E108_N0.5980.99
178_N194_R0.5980.99
204_V221_L0.5980.99
156_I204_V0.5970.99
78_V94_A0.5910.99
178_N190_E0.5880.99
14_I19_Y0.5880.99
81_L91_M0.5870.99
154_T157_R0.5840.99
151_L199_L0.5810.99
140_R144_L0.5800.99
163_G169_G0.5770.99
114_L124_F0.5700.99
73_Q161_S0.5630.99
109_K113_E0.5630.99
15_S117_N0.5600.99
60_L64_G0.5600.99
174_I213_I0.5590.99
155_L196_L0.5550.98
147_K185_C0.5550.98
157_R161_S0.5540.98
35_T99_D0.5520.98
156_I218_R0.5500.98
72_C94_A0.5500.98
164_V169_G0.5500.98
113_E117_N0.5490.98
84_F138_K0.5460.98
156_I221_L0.5460.98
57_I69_L0.5460.98
182_A192_V0.5440.98
81_L136_Q0.5420.98
158_L161_S0.5410.98
162_Y172_I0.5400.98
154_T176_L0.5360.98
19_Y23_E0.5340.98
23_E26_S0.5340.98
118_G122_F0.5310.98
21_L113_E0.5310.98
180_D183_K0.5300.98
84_F125_M0.5300.98
147_K192_V0.5270.98
178_N197_G0.5240.98
131_H134_K0.5230.98
119_A122_F0.5220.98
163_G170_I0.5200.98
204_V215_L0.5200.98
81_L92_L0.5190.98
147_K195_M0.5180.98
42_M89_R0.5160.98
142_L150_A0.5140.97
176_L184_F0.5140.97
129_S133_R0.5120.97
57_I70_R0.5120.97
79_G89_R0.5100.97
21_L117_N0.5070.97
125_M129_S0.5030.97
91_M133_R0.5020.97
67_L144_L0.5010.97
179_Q210_S0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cydA 2 0.937 100 0.225 Contact Map
3i54A 2 0.9328 100 0.227 Contact Map
3e97A 2 0.9118 100 0.23 Contact Map
3dkwA 2 0.9244 100 0.234 Contact Map
3dv8A 2 0.8992 100 0.238 Contact Map
2gauA 2 0.916 100 0.239 Contact Map
4ev0A 2 0.8992 100 0.255 Contact Map
3fx3A 2 0.9496 100 0.256 Contact Map
1zybA 2 0.895 100 0.268 Contact Map
3iwzA 2 0.8487 100 0.276 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0083 seconds.