GREMLIN Database
YCCK - Uncharacterized oxidoreductase YccK
UniProt: P46905 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (262)
Sequences: 32237 (20131)
Seq/√Len: 1243.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
44_T287_Q3.1191.00
110_E150_K3.0381.00
35_D70_E2.9611.00
73_Q117_K2.7991.00
255_K301_E2.7231.00
109_V145_L2.5611.00
298_T301_E2.4541.00
39_K74_E2.4471.00
106_R148_E2.4101.00
106_R144_E2.3771.00
44_T48_G2.3251.00
254_E304_F2.2561.00
254_E301_E2.1081.00
249_K253_E2.0201.00
39_K70_E2.0041.00
269_T302_V1.9811.00
143_K147_D1.9671.00
299_E303_N1.9471.00
111_K115_R1.9221.00
250_A304_F1.9131.00
83_I118_T1.8951.00
120_Y152_K1.8841.00
194_Y198_Q1.8781.00
144_E148_E1.8681.00
125_Y175_V1.8181.00
195_C202_F1.8091.00
283_P287_Q1.8021.00
85_T121_I1.7981.00
165_Q169_A1.7931.00
18_G52_F1.7681.00
144_E147_D1.7641.00
102_R144_E1.7491.00
270_R306_S1.7421.00
63_R66_E1.7271.00
265_A295_I1.7201.00
257_A295_I1.7051.00
48_G287_Q1.6741.00
66_E115_R1.6661.00
44_T283_P1.6551.00
201_S275_A1.6491.00
34_N37_T1.6441.00
39_K71_V1.6431.00
85_T112_S1.6431.00
48_G290_L1.6431.00
258_D288_D1.6321.00
102_R106_R1.6151.00
247_K250_A1.6131.00
87_G105_L1.6021.00
109_V124_Y1.5991.00
45_A50_V1.5791.00
165_Q194_Y1.5781.00
84_A125_Y1.5681.00
87_G124_Y1.5631.00
291_K294_N1.5611.00
121_I151_I1.5421.00
106_R110_E1.5381.00
147_D170_D1.5291.00
39_K43_R1.5271.00
43_R74_E1.5171.00
303_N307_D1.5121.00
21_A53_I1.5041.00
44_T47_D1.4901.00
12_L153_A1.4901.00
125_Y203_I1.4801.00
141_T144_E1.4791.00
143_K171_G1.4641.00
190_E193_P1.4631.00
57_F108_E1.4561.00
46_L81_L1.4351.00
37_T40_D1.4111.00
43_R75_R1.4061.00
107_S111_K1.4051.00
257_A261_H1.3941.00
110_E114_K1.3811.00
193_P197_K1.3681.00
287_Q291_K1.3551.00
146_K171_G1.3551.00
42_V71_V1.3501.00
196_E271_P1.3441.00
12_L82_I1.3291.00
106_R141_T1.3211.00
168_N194_Y1.3201.00
43_R47_D1.3171.00
160_D163_Q1.3101.00
178_A202_F1.3031.00
145_L151_I1.3021.00
102_R140_G1.2921.00
265_A269_T1.2921.00
53_I68_I1.2861.00
153_A174_E1.2851.00
102_R141_T1.2751.00
304_F307_D1.2681.00
168_N198_Q1.2601.00
35_D39_K1.2561.00
109_V121_I1.2501.00
111_K114_K1.2501.00
151_I154_I1.2481.00
257_A262_V1.2451.00
165_Q197_K1.2391.00
78_R120_Y1.2351.00
280_A285_Q1.2351.00
251_V262_V1.2331.00
161_Y194_Y1.2251.00
258_D261_H1.2191.00
280_A286_L1.2131.00
82_I123_L1.2131.00
247_K304_F1.2071.00
65_E112_S1.2041.00
143_K170_D1.2031.00
123_L175_V1.1991.00
284_E287_Q1.1951.00
78_R118_T1.1951.00
182_L305_I1.1861.00
40_D44_T1.1801.00
250_A254_E1.1631.00
70_E117_K1.1611.00
36_E40_D1.1571.00
69_G117_K1.1491.00
183_I245_V1.1381.00
116_L121_I1.1361.00
192_L196_E1.1321.00
41_L286_L1.1321.00
10_T153_A1.1291.00
146_K174_E1.1261.00
129_P163_Q1.1151.00
66_E70_E1.1071.00
52_F203_I1.1001.00
103_E107_S1.0871.00
180_Y270_R1.0791.00
137_E140_G1.0711.00
248_L259_T1.0711.00
267_L276_I1.0701.00
142_L154_I1.0701.00
104_F107_S1.0651.00
66_E114_K1.0571.00
286_L290_L1.0561.00
246_D250_A1.0541.00
110_E148_E1.0501.00
165_Q198_Q1.0481.00
43_R71_V1.0461.00
249_K259_T1.0441.00
179_E184_Q1.0361.00
9_K174_E1.0351.00
250_A253_E1.0351.00
143_K146_K1.0341.00
268_L292_T1.0341.00
102_R137_E1.0281.00
136_A166_D1.0281.00
52_F84_A1.0271.00
126_V142_L1.0241.00
246_D249_K1.0241.00
51_N82_I1.0101.00
182_L263_A0.9911.00
261_H291_K0.9891.00
145_L150_K0.9881.00
21_A68_I0.9861.00
100_N126_V0.9821.00
70_E74_E0.9821.00
101_S104_F0.9751.00
175_V203_I0.9731.00
10_T174_E0.9651.00
15_K50_V0.9601.00
40_D283_P0.9601.00
72_V81_L0.9531.00
156_A173_L0.9511.00
145_L148_E0.9511.00
15_K51_N0.9501.00
161_Y165_Q0.9381.00
189_K193_P0.9371.00
264_L292_T0.9361.00
261_H288_D0.9341.00
77_V80_E0.9281.00
203_I275_A0.9201.00
254_E298_T0.9171.00
42_V53_I0.9141.00
156_A164_L0.9131.00
140_G144_E0.9131.00
122_D152_K0.9121.00
84_A203_I0.9121.00
284_E288_D0.9071.00
57_F104_F0.9071.00
196_E272_A0.9061.00
193_P196_E0.9001.00
16_R268_L0.8991.00
288_D291_K0.8951.00
106_R109_V0.8941.00
65_E115_R0.8921.00
57_F91_E0.8801.00
251_V255_K0.8801.00
255_K298_T0.8721.00
143_K154_I0.8691.00
300_D303_N0.8661.00
154_I173_L0.8571.00
10_T146_K0.8531.00
303_N306_S0.8491.00
269_T296_E0.8471.00
270_R302_V0.8461.00
176_F195_C0.8451.00
35_D63_R0.8361.00
141_T145_L0.8351.00
113_L150_K0.8351.00
300_D304_F0.8331.00
84_A123_L0.8311.00
265_A292_T0.8281.00
107_S110_E0.8271.00
16_R293_L0.8191.00
192_L202_F0.8151.00
201_S274_D0.8141.00
40_D43_R0.8131.00
158_N205_Y0.8091.00
282_R285_Q0.8071.00
140_G143_K0.8071.00
185_R188_E0.8051.00
262_V295_I0.8021.00
21_A64_S0.7971.00
166_D169_A0.7971.00
90_K99_D0.7881.00
19_F45_A0.7851.00
106_R145_L0.7841.00
185_R306_S0.7831.00
263_A267_L0.7751.00
164_L200_I0.7701.00
195_C200_I0.7561.00
180_Y192_L0.7541.00
194_Y197_K0.7531.00
139_A167_F0.7481.00
139_A173_L0.7471.00
204_P207_P0.7461.00
161_Y191_L0.7431.00
42_V46_L0.7421.00
269_T299_E0.7411.00
218_T249_K0.7411.00
18_G278_P0.7381.00
156_A176_F0.7371.00
257_A294_N0.7361.00
128_F158_N0.7361.00
207_P278_P0.7331.00
36_E39_K0.7271.00
85_T124_Y0.7271.00
79_N120_Y0.7261.00
168_N172_Y0.7251.00
57_F115_R0.7231.00
41_L283_P0.7221.00
204_P276_I0.7211.00
19_F24_V0.7191.00
44_T286_L0.7181.00
55_T68_I0.7181.00
130_D133_T0.7161.00
248_L305_I0.7151.00
113_L118_T0.7071.00
109_V150_K0.7051.00
48_G291_K0.7001.00
12_L152_K0.6941.00
255_K262_V0.6901.00
100_N138_V0.6901.00
257_A265_A0.6891.00
105_L138_V0.6871.00
281_K285_Q0.6861.00
266_W306_S0.6851.00
191_L195_C0.6851.00
146_K153_A0.6821.00
297_L302_V0.6811.00
139_A154_I0.6781.00
46_L53_I0.6781.00
38_G67_L0.6761.00
262_V297_L0.6761.00
57_F111_K0.6731.00
156_A159_L0.6691.00
51_N80_E0.6691.00
48_G286_L0.6681.00
251_V301_E0.6681.00
105_L145_L0.6671.00
285_Q288_D0.6641.00
50_V290_L0.6631.00
138_V141_T0.6631.00
253_E256_Q0.6621.00
17_I268_L0.6621.00
108_E111_K0.6601.00
248_L263_A0.6571.00
257_A291_K0.6541.00
251_V304_F0.6531.00
192_L270_R0.6521.00
161_Y190_E0.6521.00
109_V113_L0.6501.00
243_K246_D0.6461.00
185_R189_K0.6461.00
219_Q246_D0.6451.00
112_S124_Y0.6441.00
22_N206_F0.6381.00
142_L146_K0.6381.00
134_P137_E0.6311.00
105_L141_T0.6291.00
252_A262_V0.6291.00
87_G100_N0.6261.00
41_L280_A0.6251.00
14_V52_F0.6251.00
267_L272_A0.6191.00
37_T283_P0.6181.00
247_K308_I0.6171.00
165_Q168_N0.6161.00
252_A259_T0.6161.00
260_A288_D0.6151.00
23_A210_S0.6151.00
113_L119_D0.6121.00
242_L246_D0.6121.00
297_L301_E0.6091.00
113_L121_I0.6081.00
135_L138_V0.6071.00
125_Y155_G0.6071.00
14_V275_A0.6061.00
58_I88_A0.6041.00
163_Q166_D0.6021.00
207_P267_L0.6021.00
101_S138_V0.6011.00
180_Y267_L0.5991.00
245_V249_K0.5981.00
146_K151_I0.5981.00
106_R150_K0.5971.00
121_I124_Y0.5921.00
192_L272_A0.5921.00
180_Y202_F0.5901.00
182_L266_W0.5901.00
24_V41_L0.5861.00
262_V301_E0.5831.00
215_G218_T0.5771.00
180_Y185_R0.5741.00
140_G170_D0.5731.00
167_F173_L0.5731.00
251_V308_I0.5701.00
46_L51_N0.5691.00
9_K172_Y0.5691.00
53_I72_V0.5671.00
65_E85_T0.5601.00
188_E193_P0.5601.00
218_T246_D0.5601.00
47_D283_P0.5601.00
26_G67_L0.5591.00
156_A167_F0.5581.00
283_P286_L0.5561.00
251_V254_E0.5551.00
42_V68_I0.5541.00
126_V138_V0.5541.00
87_G108_E0.5541.00
113_L120_Y0.5541.00
124_Y151_I0.5531.00
183_I212_L0.5531.00
162_Q165_Q0.5521.00
301_E304_F0.5521.00
252_A255_K0.5521.00
255_K295_I0.5511.00
212_L245_V0.5461.00
17_I293_L0.5461.00
18_G277_I0.5451.00
46_L77_V0.5441.00
52_F82_I0.5441.00
136_A140_G0.5441.00
68_I71_V0.5431.00
8_G201_S0.5431.00
243_K247_K0.5421.00
78_R122_D0.5421.00
18_G275_A0.5401.00
46_L75_R0.5401.00
57_F88_A0.5391.00
109_V141_T0.5381.00
124_Y142_L0.5371.00
63_R67_L0.5361.00
25_G64_S0.5361.00
8_G14_V0.5341.00
24_V38_G0.5341.00
265_A296_E0.5331.00
19_F41_L0.5331.00
164_L195_C0.5291.00
248_L252_A0.5281.00
268_L276_I0.5281.00
242_L245_V0.5281.00
55_T64_S0.5281.00
292_T295_I0.5271.00
265_A293_L0.5251.00
41_L281_K0.5241.00
91_E104_F0.5241.00
54_D177_Q0.5221.00
261_H295_I0.5181.00
168_N200_I0.5171.00
99_D104_F0.5161.00
89_H100_N0.5141.00
35_D67_L0.5141.00
178_A191_L0.5081.00
194_Y200_I0.5061.00
112_S115_R0.5051.00
46_L71_V0.5051.00
262_V305_I0.5051.00
180_Y272_A0.5021.00
206_F210_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.9903 100 0.079 Contact Map
1pz1A 1 0.9935 100 0.083 Contact Map
3n2tA 1 0.9871 100 0.095 Contact Map
4xk2A 5 0.9226 100 0.099 Contact Map
3v0sA 1 0.871 100 0.102 Contact Map
3eauA 3 0.9774 100 0.114 Contact Map
3erpA 6 0.929 100 0.115 Contact Map
1lqaA 2 0.9806 100 0.116 Contact Map
3lutA 3 0.9742 100 0.117 Contact Map
3n6qA 5 0.929 100 0.123 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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