GREMLIN Database
NATB - ABC transporter permease protein NatB
UniProt: P46904 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 386 (358)
Sequences: 11045 (9192)
Seq/√Len: 485.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
48_Q88_A5.7011.00
79_P91_Y5.0101.00
275_I341_L4.9501.00
75_T78_K4.2741.00
97_E101_Y4.2381.00
82_A88_A3.6901.00
5_I224_G3.5731.00
101_Y106_T3.5341.00
7_K11_I3.4781.00
81_E85_E3.4271.00
6_Y231_T3.4161.00
76_F80_E3.2121.00
6_Y227_L3.0311.00
80_E84_D2.8011.00
217_S220_K2.7281.00
324_N328_L2.6981.00
82_A87_K2.6151.00
83_V91_Y2.4291.00
238_V273_A2.3711.00
9_E225_K2.3671.00
281_L366_I2.3351.00
78_K82_A2.3311.00
356_L360_G2.3271.00
49_Y62_E2.3131.00
94_V98_F2.3101.00
360_G364_V2.3001.00
278_L363_A2.2911.00
289_F372_L2.2281.00
52_A76_F2.1551.00
242_V246_L2.1521.00
276_I338_L2.1431.00
279_S338_L2.1331.00
11_I14_L2.0941.00
52_A93_N2.0791.00
93_N113_Y2.0431.00
76_F93_N1.9711.00
282_L366_I1.9081.00
285_A366_I1.8811.00
351_D354_T1.8771.00
271_A345_L1.8521.00
330_Y336_L1.8321.00
53_V99_D1.8281.00
270_G274_L1.8211.00
55_H58_P1.8111.00
364_V368_I1.8001.00
319_F330_Y1.7851.00
50_T79_P1.7661.00
230_S277_V1.7631.00
340_A358_T1.7001.00
11_I15_R1.7001.00
51_L58_P1.6991.00
230_S281_L1.6981.00
237_G276_I1.6591.00
88_A91_Y1.6311.00
278_L366_I1.6211.00
365_L369_F1.6081.00
10_M235_A1.5921.00
202_E225_K1.5901.00
331_F337_N1.5731.00
308_V311_P1.5501.00
77_A80_E1.5471.00
46_G74_K1.5411.00
81_E84_D1.5401.00
14_L17_R1.5201.00
8_K202_E1.5181.00
46_G72_S1.5141.00
132_L136_K1.5091.00
57_L99_D1.5071.00
275_I359_S1.5021.00
233_G280_A1.4851.00
279_S283_I1.4511.00
63_S66_N1.4481.00
278_L359_S1.4451.00
282_L369_F1.4441.00
371_L375_A1.4431.00
327_D331_F1.4401.00
48_Q82_A1.4361.00
234_V277_V1.4351.00
331_F336_L1.4251.00
357_S361_T1.4121.00
289_F373_A1.3951.00
324_N327_D1.3921.00
312_V316_F1.3871.00
136_K140_V1.3811.00
55_H99_D1.3761.00
56_S59_P1.3671.00
292_I376_C1.3601.00
80_E113_Y1.3471.00
78_K81_E1.3431.00
57_L102_V1.3371.00
77_A81_E1.3351.00
97_E100_S1.3231.00
219_N374_R1.3151.00
140_V143_R1.3091.00
90_A124_A1.3071.00
93_N111_D1.3031.00
129_Q133_D1.2981.00
145_T148_H1.2971.00
219_N223_V1.2921.00
325_Q329_S1.2901.00
242_V245_I1.2881.00
47_E92_L1.2811.00
64_K67_E1.2811.00
275_I345_L1.2791.00
361_T365_L1.2791.00
325_Q328_L1.2791.00
125_M129_Q1.2671.00
328_L331_F1.2661.00
302_S305_S1.2651.00
200_A203_K1.2551.00
133_D136_K1.2531.00
52_A96_K1.2491.00
319_F322_A1.2361.00
289_F376_C1.2311.00
58_P99_D1.2301.00
361_T364_V1.2301.00
337_N361_T1.2251.00
44_D72_S1.2221.00
344_Q348_G1.2201.00
282_L365_L1.2051.00
6_Y224_G1.2041.00
231_T235_A1.2041.00
268_V271_A1.2021.00
328_L332_L1.2011.00
46_G89_D1.1981.00
135_Y139_I1.1961.00
220_K224_G1.1921.00
241_L276_I1.1911.00
282_L362_I1.1891.00
280_A284_S1.1871.00
51_L54_G1.1861.00
336_L340_A1.1771.00
296_S299_E1.1711.00
243_F247_S1.1701.00
127_L132_L1.1621.00
254_N268_V1.1601.00
333_I336_L1.1601.00
10_M231_T1.1521.00
211_L221_V1.1481.00
359_S363_A1.1481.00
138_E141_Q1.1481.00
222_L374_R1.1421.00
60_A63_S1.1341.00
143_R146_N1.1321.00
180_P184_L1.1321.00
181_M184_L1.1301.00
202_E207_S1.1211.00
76_F91_Y1.1171.00
51_L62_E1.1131.00
183_I191_A1.1111.00
344_Q350_V1.1111.00
174_M177_A1.1041.00
350_V354_T1.0991.00
289_F369_F1.0911.00
139_I142_Q1.0861.00
127_L131_A1.0851.00
31_M244_L1.0831.00
53_V97_E1.0821.00
110_V113_Y1.0761.00
10_M228_A1.0681.00
184_L190_G1.0681.00
83_V88_A1.0671.00
312_V315_M1.0671.00
224_G228_A1.0611.00
314_P318_I1.0461.00
138_E142_Q1.0451.00
294_S299_E1.0411.00
51_L55_H1.0401.00
178_I182_L1.0371.00
148_H151_Q1.0341.00
5_I216_V1.0331.00
134_Q137_N1.0311.00
142_Q145_T1.0221.00
185_T189_S1.0171.00
130_S134_Q1.0141.00
92_L112_V1.0131.00
286_M307_V1.0011.00
64_K138_E0.9981.00
6_Y228_A0.9971.00
184_L191_A0.9961.00
146_N150_D0.9951.00
200_A204_D0.9941.00
147_K150_D0.9931.00
337_N358_T0.9921.00
131_A135_Y0.9891.00
155_Q158_T0.9861.00
62_E66_N0.9851.00
99_D103_N0.9761.00
182_L185_T0.9761.00
31_M35_V0.9751.00
368_I372_L0.9681.00
184_L338_L0.9661.00
135_Y138_E0.9651.00
272_S342_F0.9631.00
32_L243_F0.9621.00
179_L182_L0.9561.00
174_M178_I0.9561.00
196_L300_A0.9531.00
294_S303_Y0.9491.00
306_L310_L0.9481.00
305_S309_F0.9461.00
340_A344_Q0.9341.00
269_I273_A0.9341.00
115_N118_D0.9271.00
270_G273_A0.9241.00
287_E291_S0.9231.00
322_A327_D0.9201.00
199_M202_E0.9201.00
128_V131_A0.9181.00
271_A274_L0.9111.00
10_M14_L0.9061.00
330_Y333_I0.9051.00
47_E90_A0.9011.00
16_D19_T0.9011.00
299_E303_Y0.8901.00
338_L341_L0.8851.00
307_V310_L0.8841.00
119_Q122_S0.8841.00
285_A370_F0.8831.00
363_A367_A0.8791.00
227_L231_T0.8781.00
369_F373_A0.8771.00
337_N340_A0.8741.00
179_L190_G0.8731.00
8_K12_D0.8661.00
123_N127_L0.8651.00
35_V248_T0.8621.00
344_Q354_T0.8581.00
309_F312_V0.8561.00
91_Y113_Y0.8511.00
137_N141_Q0.8491.00
299_E302_S0.8461.00
285_A369_F0.8461.00
176_S181_M0.8341.00
39_E42_L0.8321.00
226_W284_S0.8291.00
50_T91_Y0.8281.00
251_F254_N0.8271.00
323_P327_D0.8271.00
180_P190_G0.8261.00
120_G123_N0.8231.00
323_P326_F0.8231.00
307_V311_P0.8201.00
353_A357_S0.8191.00
180_P183_I0.8181.00
289_F293_M0.8161.00
59_P63_S0.8151.00
66_N73_V0.8131.00
366_I369_F0.8101.00
28_M32_L0.8091.00
58_P62_E0.8061.00
207_S210_A0.8051.00
158_T161_Q0.8041.00
139_I143_R0.8001.00
48_Q91_Y0.7991.00
31_M34_L0.7971.00
358_T362_I0.7961.00
101_Y108_F0.7951.00
344_Q358_T0.7941.00
53_V94_V0.7911.00
203_K208_I0.7881.00
40_S43_S0.7811.00
61_L94_V0.7791.00
175_L179_L0.7771.00
133_D137_N0.7761.00
159_I162_K0.7751.00
275_I355_I0.7681.00
276_I342_F0.7661.00
4_H7_K0.7631.00
319_F327_D0.7621.00
304_M308_V0.7621.00
54_G58_P0.7611.00
58_P94_V0.7601.00
288_L373_A0.7591.00
76_F79_P0.7581.00
180_P191_A0.7571.00
185_T188_V0.7561.00
122_S125_M0.7551.00
311_P335_F0.7501.00
184_L335_F0.7481.00
278_L362_I0.7481.00
8_K11_I0.7471.00
208_I221_V0.7451.00
230_S284_S0.7451.00
360_G363_A0.7441.00
234_V238_V0.7441.00
59_P62_E0.7431.00
51_L99_D0.7421.00
226_W285_A0.7381.00
311_P333_I0.7371.00
186_S190_G0.7351.00
50_T53_V0.7341.00
126_Q129_Q0.7331.00
287_E304_M0.7271.00
190_G236_S0.7271.00
75_T79_P0.7261.00
9_E228_A0.7261.00
60_A64_K0.7261.00
142_Q146_N0.7251.00
79_P82_A0.7241.00
226_W281_L0.7221.00
201_G205_R0.7211.00
56_S60_A0.7201.00
140_V144_L0.7191.00
136_K139_I0.7191.00
357_S360_G0.7191.00
32_L36_F0.7181.00
137_N140_V0.7171.00
188_V192_M0.7171.00
181_M186_S0.7131.00
143_R147_K0.7121.00
33_G36_F0.7121.00
289_F292_I0.7071.00
204_D297_V0.7061.00
176_S180_P0.7051.00
341_L345_L0.7051.00
177_A191_A0.7041.00
320_S324_N0.7031.00
201_G204_D0.7011.00
161_Q164_A0.7011.00
26_V30_M0.7001.00
352_P356_L0.7001.00
179_L185_T0.6991.00
82_A85_E0.6981.00
216_V221_V0.6971.00
187_I191_A0.6941.00
30_M34_L0.6931.00
355_I358_T0.6931.00
124_A127_L0.6921.00
177_A188_V0.6911.00
80_E91_Y0.6901.00
367_A371_L0.6891.00
180_P187_I0.6851.00
302_S306_L0.6841.00
65_L128_V0.6821.00
236_S240_A0.6821.00
200_A300_A0.6821.00
74_K88_A0.6811.00
122_S127_L0.6801.00
370_F374_R0.6801.00
283_I287_E0.6781.00
127_L136_K0.6781.00
86_G115_N0.6781.00
177_A185_T0.6761.00
350_V355_I0.6761.00
21_L25_L0.6741.00
164_A167_E0.6731.00
114_G118_D0.6731.00
189_S192_M0.6721.00
317_F339_H0.6691.00
51_L94_V0.6681.00
202_E206_K0.6681.00
286_M369_F0.6671.00
181_M192_M0.6661.00
144_L148_H0.6621.00
198_I225_K0.6621.00
90_A112_V0.6601.00
131_A136_K0.6591.00
53_V58_P0.6591.00
146_N149_I0.6591.00
176_S188_V0.6581.00
188_V191_A0.6581.00
36_F247_S0.6551.00
366_I370_F0.6531.00
114_G121_S0.6521.00
95_P109_K0.6521.00
192_M196_L0.6461.00
181_M190_G0.6451.00
197_D200_A0.6421.00
165_D168_K0.6421.00
313_F317_F0.6421.00
177_A180_P0.6411.00
100_S104_S0.6401.00
76_F113_Y0.6371.00
362_I365_L0.6371.00
13_A232_F0.6361.00
83_V113_Y0.6341.00
176_S184_L0.6341.00
177_A190_G0.6341.00
175_L178_I0.6331.00
271_A355_I0.6331.00
174_M192_M0.6321.00
215_P218_R0.6311.00
249_V252_T0.6301.00
206_K209_E0.6301.00
271_A275_I0.6281.00
372_L375_A0.6271.00
292_I373_A0.6261.00
285_A373_A0.6231.00
166_E169_G0.6221.00
312_V318_I0.6180.99
138_E144_L0.6170.99
5_I221_V0.6160.99
23_T26_V0.6160.99
174_M181_M0.6160.99
121_S125_M0.6150.99
175_L190_G0.6140.99
108_F112_V0.6120.99
70_E74_K0.6120.99
211_L225_K0.6110.99
337_N365_L0.6090.99
184_L187_I0.6060.99
178_I189_S0.6060.99
188_V283_I0.6050.99
332_L365_L0.6040.99
111_D114_G0.6030.99
61_L98_F0.6020.99
92_L110_V0.6010.99
58_P61_L0.6010.99
284_S288_L0.6000.99
129_Q132_L0.5990.99
290_I303_Y0.5990.99
191_A287_E0.5980.99
338_L346_L0.5970.99
134_Q138_E0.5950.99
241_L272_S0.5950.99
153_V156_P0.5940.99
145_T151_Q0.5940.99
198_I201_G0.5940.99
299_E306_L0.5920.99
176_S179_L0.5920.99
6_Y10_M0.5910.99
141_Q145_T0.5880.99
61_L135_Y0.5880.99
50_T75_T0.5870.99
71_I74_K0.5860.99
372_L376_C0.5840.99
304_M317_F0.5830.99
13_A228_A0.5810.99
273_A276_I0.5800.99
98_F135_Y0.5790.99
341_L346_L0.5760.99
176_S183_I0.5750.99
9_E13_A0.5750.99
176_S190_G0.5740.99
222_L370_F0.5730.99
184_L188_V0.5720.99
27_P300_A0.5720.99
306_L311_P0.5690.99
114_G125_M0.5690.99
30_M189_S0.5690.99
322_A325_Q0.5670.99
238_V269_I0.5670.99
9_E221_V0.5660.99
375_A378_L0.5660.99
182_L188_V0.5650.99
101_Y109_K0.5650.99
271_A359_S0.5650.99
174_M186_S0.5640.99
126_Q130_S0.5640.99
22_L26_V0.5640.99
4_H8_K0.5630.99
186_S191_A0.5630.99
128_V132_L0.5630.99
182_L186_S0.5610.99
125_M128_V0.5600.99
313_F316_F0.5590.99
210_A214_T0.5580.99
356_L359_S0.5570.99
5_I9_E0.5570.99
89_D115_N0.5570.99
300_A304_M0.5570.99
355_I359_S0.5560.99
130_S133_D0.5560.99
113_Y116_S0.5560.99
353_A356_L0.5550.99
194_I197_D0.5540.99
354_T357_S0.5520.99
341_L344_Q0.5510.99
83_V86_G0.5500.99
352_P355_I0.5480.99
358_T361_T0.5480.99
181_M189_S0.5470.99
61_L132_L0.5470.99
341_L362_I0.5460.99
290_I304_M0.5460.99
105_M108_F0.5460.99
285_A292_I0.5450.99
60_A142_Q0.5440.99
156_P159_I0.5410.99
187_I190_G0.5390.99
241_L269_I0.5390.99
334_P341_L0.5380.99
241_L245_I0.5380.99
76_F111_D0.5380.99
222_L373_A0.5380.99
13_A23_T0.5370.99
31_M240_A0.5370.99
157_F161_Q0.5360.99
54_G59_P0.5340.99
182_L190_G0.5330.98
49_Y73_V0.5330.98
17_R20_I0.5330.98
155_Q159_I0.5320.98
363_A366_I0.5310.98
224_G227_L0.5300.98
115_N121_S0.5270.98
177_A187_I0.5270.98
341_L355_I0.5220.98
179_L191_A0.5220.98
183_I189_S0.5210.98
342_F346_L0.5210.98
202_E221_V0.5210.98
341_L359_S0.5200.98
57_L135_Y0.5200.98
216_V220_K0.5190.98
179_L183_I0.5190.98
369_F372_L0.5190.98
321_K324_N0.5190.98
203_K207_S0.5180.98
39_E43_S0.5170.98
163_E166_E0.5160.98
178_I183_I0.5150.98
185_T190_G0.5140.98
305_S312_V0.5130.98
132_L143_R0.5130.98
142_Q147_K0.5130.98
110_V115_N0.5120.98
335_F339_H0.5120.98
226_W230_S0.5110.98
361_T368_I0.5110.98
114_G117_I0.5100.98
235_A238_V0.5090.98
288_L291_S0.5090.98
290_I294_S0.5090.98
277_V281_L0.5090.98
9_E198_I0.5070.98
120_G128_V0.5070.98
180_P185_T0.5060.98
301_Q306_L0.5060.98
47_E73_V0.5040.98
141_Q146_N0.5040.98
252_T269_I0.5020.98
337_N341_L0.5020.98
94_V110_V0.5010.98
108_F115_N0.5000.98
147_K151_Q0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cniA 2 0.3549 99.6 0.721 Contact Map
2p0sA 2 0.3187 97.8 0.853 Contact Map
4tllA 1 0.4275 13.7 0.952 Contact Map
3cnbA 1 0.2927 7.6 0.957 Contact Map
3cg4A 1 0.2979 7.4 0.957 Contact Map
2wswA 3 0.4378 7.2 0.957 Contact Map
2qvgA 1 0.2876 6.5 0.959 Contact Map
3hdvA 3 0.2979 5.9 0.959 Contact Map
1dz3A 2 0.272 5.7 0.959 Contact Map
3hdgA 2 0.3005 5.5 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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