GREMLIN Database
RL18 - 50S ribosomal protein L18
UniProt: P46899 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (115)
Sequences: 2808 (1506)
Seq/√Len: 140.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
91_S119_K3.5111.00
76_K79_E3.2531.00
92_D119_K3.2421.00
71_T108_A2.8941.00
15_H98_G2.7801.00
86_A91_S2.5221.00
83_K87_E2.5031.00
79_E83_K2.4661.00
70_D73_A2.3551.00
44_I85_A2.2101.00
60_D84_R2.1401.00
31_L42_A2.1141.00
75_T115_E2.0541.00
80_L84_R1.9711.00
82_A116_A1.9421.00
46_D49_N1.8591.00
40_I109_L1.8151.00
72_S75_T1.6981.00
56_A80_L1.6751.00
6_S9_A1.6391.00
113_A118_L1.5511.00
75_T112_A1.5311.00
58_T73_A1.5141.00
32_N98_G1.4831.00
10_A14_R1.4621.00
67_S70_D1.4541.00
66_E76_K1.4451.00
112_A116_A1.4321.00
80_L83_K1.3911.00
107_K111_D1.3591.00
24_G29_P1.3581.00
75_T79_E1.3121.00
8_N12_L1.2931.00
23_S48_V1.2851.00
79_E115_E1.2741.00
32_N45_I1.2711.00
12_L15_H1.2481.00
29_P47_D1.2431.00
44_I81_V1.2371.00
11_R100_Y1.2251.00
83_K86_A1.1971.00
85_A118_L1.1911.00
76_K80_L1.1871.00
51_V88_K1.1711.00
44_I93_V1.1701.00
12_L16_A1.1510.99
69_G105_R1.1220.99
35_R105_R1.1040.99
37_N69_G1.1000.99
79_E112_A1.0960.99
26_A48_V1.0840.99
18_V22_L1.0730.99
56_A84_R1.0550.99
82_A112_A1.0340.99
39_H58_T1.0330.99
84_R88_K1.0300.99
16_A20_A1.0200.99
31_L81_V1.0050.98
42_A81_V0.9960.98
109_L112_A0.9930.98
72_S76_K0.9830.98
69_G73_A0.9650.98
70_D105_R0.9610.98
71_T75_T0.9410.98
61_K64_N0.9320.98
44_I90_I0.9280.97
11_R99_G0.9150.97
86_A116_A0.9130.97
62_D65_V0.9100.97
39_H59_L0.9030.97
69_G72_S0.8860.97
28_R92_D0.8850.97
34_F100_Y0.8750.96
81_V113_A0.8660.96
31_L113_A0.8650.96
11_R15_H0.8560.96
56_A60_D0.8500.96
14_R39_H0.8480.96
63_L76_K0.8460.96
61_K65_V0.8430.96
93_V120_F0.8390.95
31_L93_V0.8150.95
40_I77_V0.8090.94
8_N100_Y0.8060.94
78_G113_A0.8060.94
14_R17_R0.7970.94
53_L90_I0.7910.94
20_A23_S0.7760.93
79_E116_A0.7710.93
47_D52_T0.7690.93
24_G47_D0.7680.93
54_A84_R0.7660.93
78_G109_L0.7600.92
68_T73_A0.7580.92
75_T108_A0.7560.92
60_D80_L0.7430.91
82_A113_A0.7420.91
86_A119_K0.7230.90
34_F41_Y0.7210.90
32_N100_Y0.7140.90
78_G112_A0.7080.89
20_A24_G0.7060.89
81_V109_L0.6960.89
62_D84_R0.6960.89
19_R98_G0.6920.88
26_A49_N0.6900.88
15_H25_T0.6880.88
15_H99_G0.6810.88
81_V118_L0.6760.87
13_K16_A0.6750.87
77_V109_L0.6730.87
8_N11_R0.6680.87
102_Y114_R0.6600.86
46_D51_V0.6520.85
24_G27_E0.6520.85
45_I50_G0.6510.85
71_T74_A0.6510.85
21_K25_T0.6480.85
14_R101_L0.6460.85
56_A77_V0.6440.84
58_T68_T0.6410.84
74_A78_G0.6380.84
83_K116_A0.6330.83
11_R24_G0.6290.83
47_D50_G0.6210.82
29_P53_L0.6200.82
75_T111_D0.6120.81
15_H32_N0.6110.81
85_A113_A0.6080.81
35_R68_T0.6070.81
68_T105_R0.6050.81
32_N52_T0.6030.80
67_S73_A0.6020.80
71_T107_K0.5990.80
16_A21_K0.5980.80
7_K99_G0.5940.79
63_L66_E0.5910.79
108_A111_D0.5880.79
41_Y57_S0.5880.79
54_A90_I0.5860.79
8_N32_N0.5770.77
71_T105_R0.5730.77
27_E92_D0.5720.77
34_F37_N0.5720.77
29_P94_V0.5700.77
60_D77_V0.5680.76
51_V55_S0.5640.76
15_H18_V0.5620.76
16_A32_N0.5510.74
54_A88_K0.5490.74
55_S77_V0.5460.74
60_D63_L0.5410.73
42_A109_L0.5400.73
82_A118_L0.5390.73
41_Y107_K0.5310.71
89_G115_E0.5300.71
30_R47_D0.5290.71
37_N67_S0.5290.71
18_V25_T0.5280.71
29_P46_D0.5230.70
7_K37_N0.5220.70
46_D50_G0.5220.70
7_K11_R0.5190.70
73_A105_R0.5160.69
62_D83_K0.5160.69
14_R63_L0.5150.69
74_A105_R0.5130.69
100_Y106_V0.5100.68
40_I58_T0.5090.68
84_R87_E0.5080.68
21_K24_G0.5030.67
105_R118_L0.5000.67
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bboQ 1 0.9833 100 0.158 Contact Map
1ovyA 1 0.8083 100 0.187 Contact Map
4rb6S 1 0.9167 100 0.206 Contact Map
4tp9O 1 0.0167 100 0.208 Contact Map
2zjrL 1 0.8417 100 0.22 Contact Map
4w20D 1 1 100 0.305 Contact Map
3j7yP 1 0.9583 100 0.305 Contact Map
3j39D 1 1 100 0.31 Contact Map
1vx7R 1 1 100 0.311 Contact Map
1vq8N 1 0.9667 100 0.315 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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