GREMLIN Database
RL6 - 50S ribosomal protein L6
UniProt: P46898 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 179 (176)
Sequences: 3800 (2090)
Seq/√Len: 157.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
78_E82_K3.1821.00
74_G78_E3.0231.00
118_P124_I2.6991.00
28_K33_E2.6751.00
45_K54_A2.5251.00
125_E135_K2.4321.00
85_E135_K2.3961.00
103_K117_V2.3011.00
103_K115_E2.2011.00
16_T28_K2.1911.00
87_G166_E2.1281.00
108_V152_V2.1201.00
144_A148_N2.1061.00
53_V73_L2.0791.00
57_S62_H2.0671.00
164_R170_V2.0161.00
134_V142_V1.9561.00
36_R140_E1.9071.00
26_A33_E1.9051.00
91_V164_R1.8941.00
128_S131_K1.8931.00
116_I145_I1.8431.00
136_G142_V1.7571.00
123_E135_K1.7491.00
99_K126_V1.7441.00
24_T35_T1.7241.00
41_D62_H1.7221.00
116_I152_V1.7171.00
87_G133_V1.6761.00
36_R76_M1.6341.00
87_G131_K1.6041.00
24_T37_T1.5891.00
89_E167_G1.5741.00
138_D141_R1.5741.00
26_A35_T1.5461.00
100_S105_V1.5421.00
19_L25_V1.5211.00
46_V51_L1.5091.00
99_K118_P1.4801.00
105_V115_E1.4691.00
10_E50_V1.4471.00
29_G32_G1.4451.00
174_E177_S1.4401.00
102_N120_E1.4361.00
55_R66_H1.4221.00
43_E54_A1.4161.00
108_V163_I1.3901.00
121_G141_R1.3831.00
11_I17_V1.3781.00
68_T72_L1.3691.00
19_L46_V1.3491.00
114_V152_V1.3401.00
131_K166_E1.3261.00
116_I148_N1.3241.00
11_I46_V1.3221.00
25_V73_L1.3001.00
127_P133_V1.2941.00
100_S103_K1.2881.00
82_K85_E1.2821.00
36_R72_L1.2761.00
31_K137_T1.2681.00
43_E56_P1.2281.00
65_L69_T1.2241.00
122_I145_I1.2211.00
38_F44_I1.2191.00
124_I145_I1.2191.00
110_Y114_V1.2001.00
150_R155_P1.1781.00
5_G66_H1.1691.00
27_V76_M1.1621.00
89_E166_E1.1521.00
97_A132_V1.1241.00
55_R63_R1.1081.00
102_N117_V1.1081.00
10_E49_N1.1071.00
31_K135_K1.0960.99
61_E64_A1.0950.99
145_I149_I1.0940.99
97_A106_L1.0930.99
106_L152_V1.0910.99
68_T71_S1.0790.99
140_E144_A1.0630.99
45_K52_T1.0610.99
56_P62_H1.0600.99
151_A154_S1.0490.99
23_N37_T1.0490.99
16_T33_E1.0480.99
150_R168_E1.0440.99
124_I134_V1.0420.99
18_T26_A1.0410.99
22_N37_T1.0340.99
118_P145_I1.0260.99
59_Q62_H1.0240.99
104_L124_I1.0220.99
105_V113_P1.0210.99
51_L73_L1.0210.99
70_R74_G1.0200.99
164_R172_R0.9990.99
155_P161_K0.9930.99
125_E133_V0.9930.99
32_G80_V0.9910.99
42_M56_P0.9870.99
141_R145_I0.9710.99
91_V170_V0.9690.99
85_E133_V0.9670.99
100_S115_E0.9660.99
20_N24_T0.9600.99
39_H65_L0.9520.99
127_P131_K0.9470.98
118_P134_V0.9440.98
89_E131_K0.9390.98
55_R58_D0.9330.98
134_V149_I0.9310.98
17_V51_L0.9310.98
104_L149_I0.9220.98
156_E170_V0.9140.98
110_Y152_V0.9130.98
103_K118_P0.9100.98
98_S105_V0.9070.98
116_I124_I0.9060.98
64_A71_S0.9040.98
42_M62_H0.9040.98
102_N123_E0.8990.98
90_L97_A0.8980.98
41_D57_S0.8950.98
89_E164_R0.8930.98
36_R69_T0.8870.98
157_P172_R0.8830.98
122_I136_G0.8830.98
34_L76_M0.8820.98
107_N113_P0.8820.98
98_S107_N0.8810.98
144_A151_A0.8800.98
31_K83_G0.8650.97
120_E141_R0.8520.97
99_K124_I0.8410.97
29_G80_V0.8370.97
95_Y153_R0.8300.97
41_D56_P0.8170.96
13_S49_N0.8080.96
7_K70_R0.8010.96
121_G136_G0.8010.96
86_R167_G0.7980.96
31_K123_E0.7980.96
119_E141_R0.7950.96
61_E65_L0.7940.96
110_Y153_R0.7910.95
63_R66_H0.7840.95
164_R167_G0.7820.95
108_V112_H0.7720.95
38_F73_L0.7650.95
27_V81_S0.7650.95
150_R165_Y0.7610.94
96_R129_Q0.7540.94
146_A165_Y0.7520.94
18_T28_K0.7490.94
66_H177_S0.7460.94
11_I51_L0.7370.93
42_M53_V0.7370.93
42_M65_L0.7350.93
39_H69_T0.7290.93
12_P15_V0.7280.93
15_V81_S0.7260.93
53_V69_T0.7190.93
47_E50_V0.7190.93
91_V167_G0.7180.92
32_G137_T0.7150.92
34_L137_T0.7120.92
104_L132_V0.7120.92
41_D61_E0.7110.92
39_H61_E0.7090.92
47_E52_T0.7020.92
64_A68_T0.7010.92
4_V71_S0.7000.91
80_V137_T0.6990.91
88_L132_V0.6970.91
90_L108_V0.6960.91
141_R148_N0.6950.91
145_I148_N0.6940.91
39_H42_M0.6920.91
122_I134_V0.6880.91
9_L77_V0.6850.91
44_I53_V0.6710.90
96_R107_N0.6640.89
156_E172_R0.6630.89
15_V80_V0.6610.89
156_E159_K0.6560.89
8_L50_V0.6540.88
20_N26_A0.6470.88
17_V27_V0.6460.88
14_D30_P0.6430.88
8_L70_R0.6370.87
99_K125_E0.6360.87
60_K64_A0.6280.86
16_T46_V0.6260.86
8_L52_T0.6240.86
88_L134_V0.6220.86
20_N23_N0.6190.86
165_Y168_E0.6150.85
9_L74_G0.6140.85
160_G172_R0.6130.85
19_L51_L0.6130.85
87_G127_P0.6100.85
70_R77_V0.6090.85
88_L146_A0.6080.85
71_S75_N0.6070.85
6_K54_A0.6010.84
110_Y154_S0.6000.84
86_R165_Y0.6000.84
148_N152_V0.5990.84
155_P170_V0.5950.83
11_I14_D0.5950.83
153_R163_I0.5930.83
25_V46_V0.5920.83
99_K105_V0.5860.82
5_G175_G0.5860.82
23_N43_E0.5850.82
9_L70_R0.5830.82
58_D61_E0.5830.82
65_L68_T0.5820.82
114_V163_I0.5810.82
156_E174_E0.5780.82
27_V36_R0.5780.82
2_S5_G0.5770.81
91_V130_T0.5760.81
145_I152_V0.5760.81
6_K55_R0.5740.81
92_G162_G0.5550.79
142_V146_A0.5540.79
104_L126_V0.5520.79
34_L80_V0.5510.78
34_L138_D0.5490.78
11_I77_V0.5480.78
122_I141_R0.5430.77
57_S66_H0.5430.77
6_K63_R0.5410.77
58_D66_H0.5410.77
18_T46_V0.5400.77
71_S74_G0.5380.77
172_R175_G0.5340.76
86_R169_V0.5340.76
85_E166_E0.5330.76
68_T177_S0.5310.76
37_T76_M0.5300.76
144_A147_A0.5250.75
126_V132_V0.5250.75
74_G82_K0.5230.75
38_F69_T0.5230.75
164_R169_V0.5220.75
84_F142_V0.5210.74
118_P122_I0.5190.74
148_N151_A0.5180.74
103_K124_I0.5160.74
156_E160_G0.5160.74
106_L132_V0.5150.74
10_E13_S0.5140.74
27_V34_L0.5140.74
118_P142_V0.5110.73
53_V70_R0.5090.73
91_V154_S0.5070.73
42_M55_R0.5060.72
19_L44_I0.5020.72
113_P126_V0.5020.72
93_V161_K0.5000.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rb6H 1 0.9721 100 0.009 Contact Map
2zjrE 1 0.9553 100 0.009 Contact Map
3bboI 1 0.9944 100 0.01 Contact Map
1nkwE 1 0.9721 100 0.01 Contact Map
1rl6A 1 0.9162 100 0.033 Contact Map
4tp9G 1 0.9832 100 0.035 Contact Map
1vw4F 1 0.9441 100 0.045 Contact Map
3j21F 1 0.9832 100 0.181 Contact Map
1vq8E 1 0.9162 100 0.191 Contact Map
4a17E 1 0.9665 100 0.217 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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