PUNA - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

PUNA - Purine nucleoside phosphorylase 1

UniProt:	P46354	Sequences: MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLKYEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALGVEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDKDLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVANHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	271 (241)
Sequences:	3877 (2299)
Seq/√Len:	148.1

ECOLI - XAPA
BACSU - PUNA
SULSO - MTAP

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
159_D	224_R	4.298	1.00
167_E	179_K	3.535	1.00
183_T	199_L	3.141	1.00
198_F	202_M	3.089	1.00
125_M	206_A	2.996	1.00
183_T	204_S	2.995	1.00
166_A	226_L	2.817	1.00
116_N	205_D	2.583	1.00
185_V	199_L	2.581	1.00
42_K	62_Q	2.579	1.00
65_L	74_I	2.564	1.00
21_K	104_E	2.500	1.00
161_D	224_R	2.499	1.00
39_N	67_T	2.424	1.00
265_A	268_A	2.359	1.00
166_A	266_I	2.300	1.00
157_A	215_V	2.290	1.00
172_D	269_Q	2.288	1.00
137_N	189_S	2.281	1.00
120_R	123_D	2.157	1.00
21_K	72_S	2.152	1.00
92_T	217_V	2.132	1.00
134_M	184_A	1.988	1.00
131_I	204_S	1.916	1.00
67_T	72_S	1.914	1.00
168_K	269_Q	1.900	1.00
44_K	62_Q	1.878	1.00
172_D	265_A	1.862	1.00
62_Q	77_Q	1.861	1.00
21_K	71_V	1.850	1.00
250_E	254_K	1.839	1.00
117_T	200_R	1.823	1.00
37_I	75_A	1.769	1.00
23_G	98_M	1.759	1.00
128_T	179_K	1.753	1.00
206_A	231_I	1.748	1.00
105_A	224_R	1.744	1.00
123_D	178_Q	1.725	1.00
182_Y	208_G	1.715	1.00
38_E	67_T	1.675	1.00
164_S	168_K	1.662	1.00
169_I	265_A	1.661	1.00
169_I	173_L	1.642	1.00
126_I	167_E	1.618	1.00
69_E	268_A	1.611	1.00
25_I	95_V	1.585	1.00
114_G	231_I	1.573	1.00
143_N	220_H	1.566	1.00
99_K	221_A	1.534	1.00
106_L	223_M	1.509	1.00
173_L	261_K	1.508	1.00
126_I	163_S	1.507	1.00
126_I	177_I	1.495	1.00
63_L	74_I	1.493	1.00
246_D	250_E	1.484	1.00
191_E	233_N	1.471	1.00
36_E	264_K	1.454	1.00
87_S	90_K	1.448	1.00
173_L	265_A	1.443	1.00
25_I	108_V	1.434	1.00
69_E	264_K	1.421	1.00
196_V	233_N	1.407	1.00
110_N	229_S	1.396	1.00
170_A	177_I	1.383	1.00
67_T	70_G	1.382	1.00
116_N	119_F	1.376	1.00
108_V	215_V	1.363	1.00
156_S	160_K	1.344	1.00
122_G	251_V	1.325	1.00
158_Y	211_T	1.323	1.00
251_V	254_K	1.322	1.00
196_V	235_A	1.314	1.00
156_S	193_P	1.312	1.00
140_I	186_T	1.300	1.00
115_V	196_V	1.298	1.00
63_L	97_V	1.294	1.00
163_S	167_E	1.291	1.00
197_R	201_T	1.280	1.00
48_I	96_R	1.280	1.00
175_I	258_G	1.257	1.00
127_I	227_G	1.256	1.00
96_R	100_A	1.250	1.00
125_M	231_I	1.247	1.00
169_I	269_Q	1.244	1.00
190_Y	248_V	1.241	1.00
46_E	51_F	1.241	1.00
253_E	256_K	1.220	1.00
32_I	260_L	1.210	1.00
99_K	104_E	1.207	1.00
199_L	204_S	1.198	1.00
82_F	88_M	1.197	1.00
95_V	221_A	1.196	1.00
196_V	237_G	1.190	1.00
99_K	223_M	1.163	1.00
135_G	186_T	1.162	1.00
61_G	79_R	1.158	1.00
131_I	183_T	1.157	1.00
251_V	255_V	1.148	1.00
105_A	162_L	1.147	1.00
60_A	77_Q	1.141	1.00
121_A	234_A	1.140	1.00
241_Q	247_E	1.134	0.99
130_H	158_Y	1.124	0.99
244_S	247_E	1.115	0.99
33_L	68_L	1.107	0.99
189_S	216_I	1.104	0.99
254_K	258_G	1.096	0.99
100_A	147_F	1.078	0.99
119_F	231_I	1.067	0.99
230_C	255_V	1.067	0.99
265_A	269_Q	1.062	0.99
108_V	227_G	1.060	0.99
165_L	269_Q	1.058	0.99
119_F	178_Q	1.055	0.99
120_R	234_A	1.054	0.99
95_V	106_L	1.053	0.99
22_I	267_V	1.044	0.99
44_K	51_F	1.038	0.99
245_H	249_M	1.034	0.99
169_I	266_I	1.007	0.99
226_L	266_I	1.004	0.99
196_V	238_I	0.984	0.99
103_V	223_M	0.983	0.99
114_G	119_F	0.979	0.98
124_L	230_C	0.967	0.98
165_L	168_K	0.966	0.98
133_F	183_T	0.965	0.98
86_Y	90_K	0.963	0.98
175_I	262_L	0.959	0.98
74_I	98_M	0.950	0.98
136_T	140_I	0.946	0.98
42_K	79_R	0.938	0.98
184_A	212_V	0.936	0.98
23_G	103_V	0.928	0.98
190_Y	245_H	0.928	0.98
163_S	179_K	0.917	0.98
84_E	87_S	0.910	0.98
199_L	207_V	0.906	0.98
197_R	200_R	0.903	0.97
128_T	163_S	0.897	0.97
96_R	220_H	0.897	0.97
156_S	159_D	0.892	0.97
184_A	213_P	0.889	0.97
196_V	236_A	0.887	0.97
43_L	65_L	0.884	0.97
136_T	186_T	0.879	0.97
230_C	259_F	0.877	0.97
249_M	253_E	0.876	0.97
132_N	135_G	0.876	0.97
154_M	216_I	0.875	0.97
107_I	263_V	0.873	0.97
232_S	252_T	0.873	0.97
124_L	228_I	0.867	0.97
191_E	196_V	0.866	0.97
211_T	227_G	0.864	0.97
123_D	176_P	0.863	0.97
185_V	233_N	0.861	0.97
131_I	198_F	0.857	0.97
169_I	172_D	0.853	0.96
200_R	238_I	0.848	0.96
112_A	206_A	0.845	0.96
257_A	261_K	0.845	0.96
197_R	205_D	0.840	0.96
110_N	211_T	0.835	0.96
153_D	243_L	0.835	0.96
118_E	178_Q	0.832	0.96
63_L	101_L	0.824	0.96
48_I	63_L	0.823	0.96
236_A	243_L	0.823	0.96
112_A	231_I	0.819	0.95
88_M	91_V	0.818	0.95
238_I	243_L	0.817	0.95
82_F	186_T	0.816	0.95
135_G	139_L	0.814	0.95
76_M	98_M	0.812	0.95
156_S	219_N	0.812	0.95
44_K	47_D	0.812	0.95
84_E	143_N	0.809	0.95
255_V	258_G	0.806	0.95
143_N	148_G	0.800	0.95
167_E	171_K	0.797	0.95
74_I	103_V	0.797	0.95
162_L	226_L	0.795	0.95
115_V	199_L	0.794	0.95
127_I	206_A	0.791	0.95
168_K	171_K	0.787	0.94
114_G	234_A	0.787	0.94
126_I	166_A	0.786	0.94
170_A	262_L	0.785	0.94
177_I	262_L	0.785	0.94
93_F	97_V	0.783	0.94
42_K	64_V	0.783	0.94
107_I	266_I	0.775	0.94
245_H	248_V	0.775	0.94
36_E	260_L	0.768	0.94
165_L	266_I	0.767	0.94
233_N	238_I	0.766	0.94
159_D	219_N	0.766	0.94
165_L	169_I	0.759	0.93
42_K	77_Q	0.757	0.93
130_H	154_M	0.756	0.93
139_L	216_I	0.751	0.93
228_I	262_L	0.750	0.93
137_N	140_I	0.749	0.93
50_E	93_F	0.747	0.93
215_V	225_V	0.740	0.92
20_P	65_L	0.737	0.92
193_P	236_A	0.737	0.92
105_A	159_D	0.736	0.92
132_N	137_N	0.736	0.92
120_R	176_P	0.734	0.92
237_G	243_L	0.733	0.92
239_L	242_P	0.733	0.92
99_K	222_G	0.732	0.92
119_F	125_M	0.731	0.92
82_F	136_T	0.730	0.92
88_M	213_P	0.728	0.92
258_G	261_K	0.728	0.92
233_N	237_G	0.727	0.92
185_V	191_E	0.727	0.92
37_I	66_G	0.721	0.91
185_V	196_V	0.719	0.91
160_K	164_S	0.719	0.91
129_D	157_A	0.718	0.91
247_E	250_E	0.716	0.91
134_M	186_T	0.715	0.91
128_T	180_G	0.711	0.91
129_D	181_V	0.707	0.91
157_A	192_T	0.703	0.90
130_H	192_T	0.703	0.90
138_P	143_N	0.700	0.90
126_I	228_I	0.695	0.90
196_V	243_L	0.695	0.90
212_V	215_V	0.692	0.90
47_D	97_V	0.688	0.89
139_L	212_V	0.688	0.89
155_S	236_A	0.678	0.89
107_I	226_L	0.677	0.89
197_R	238_I	0.677	0.89
43_L	101_L	0.676	0.89
133_F	199_L	0.669	0.88
22_I	71_V	0.667	0.88
261_K	264_K	0.665	0.88
74_I	101_L	0.663	0.88
193_P	233_N	0.662	0.88
123_D	258_G	0.662	0.88
198_F	201_T	0.659	0.87
130_H	212_V	0.659	0.87
137_N	186_T	0.658	0.87
28_S	245_H	0.658	0.87
252_T	256_K	0.658	0.87
88_M	92_T	0.655	0.87
21_K	105_A	0.650	0.87
154_M	157_A	0.648	0.86
131_I	202_M	0.648	0.86
173_L	262_L	0.646	0.86
128_T	181_V	0.646	0.86
24_L	267_V	0.645	0.86
171_K	176_P	0.644	0.86
49_P	96_R	0.642	0.86
87_S	143_N	0.642	0.86
25_I	106_L	0.641	0.86
22_I	105_A	0.640	0.86
219_N	222_G	0.639	0.86
64_V	79_R	0.638	0.86
105_A	161_D	0.634	0.85
166_A	262_L	0.634	0.85
110_N	208_G	0.629	0.85
183_T	202_M	0.627	0.85
28_S	190_Y	0.625	0.84
88_M	136_T	0.625	0.84
134_M	185_V	0.625	0.84
133_F	185_V	0.624	0.84
166_A	228_I	0.618	0.84
68_L	267_V	0.618	0.84
31_G	77_Q	0.617	0.84
158_Y	227_G	0.617	0.84
119_F	123_D	0.613	0.83
120_R	178_Q	0.612	0.83
128_T	193_P	0.610	0.83
32_I	256_K	0.607	0.83
157_A	193_P	0.605	0.82
238_I	242_P	0.605	0.82
261_K	265_A	0.605	0.82
63_L	98_M	0.601	0.82
228_I	263_V	0.599	0.82
31_G	75_A	0.595	0.81
182_Y	211_T	0.595	0.81
218_A	225_V	0.595	0.81
51_F	97_V	0.593	0.81
212_V	216_I	0.592	0.81
169_I	226_L	0.589	0.81
134_M	213_P	0.589	0.81
32_I	35_D	0.588	0.81
116_N	234_A	0.588	0.81
132_N	184_A	0.587	0.80
129_D	155_S	0.587	0.80
88_M	134_M	0.585	0.80
257_A	260_L	0.585	0.80
108_V	225_V	0.583	0.80
115_V	237_G	0.581	0.80
198_F	204_S	0.578	0.79
236_A	239_L	0.576	0.79
193_P	243_L	0.575	0.79
115_V	200_R	0.574	0.79
218_A	223_M	0.569	0.78
68_L	71_V	0.568	0.78
256_K	260_L	0.565	0.78
124_L	259_F	0.561	0.77
106_L	218_A	0.559	0.77
133_F	202_M	0.559	0.77
90_K	93_F	0.558	0.77
234_A	239_L	0.557	0.77
25_I	98_M	0.557	0.77
49_P	84_E	0.554	0.77
234_A	238_I	0.553	0.76
156_S	242_P	0.553	0.76
96_R	217_V	0.553	0.76
160_K	163_S	0.549	0.76
119_F	206_A	0.549	0.76
112_A	232_S	0.548	0.76
29_G	81_H	0.546	0.76
254_K	257_A	0.545	0.75
104_E	224_R	0.544	0.75
157_A	219_N	0.543	0.75
81_H	111_A	0.542	0.75
33_L	36_E	0.541	0.75
20_P	74_I	0.541	0.75
156_S	163_S	0.540	0.75
71_V	268_A	0.538	0.74
148_G	220_H	0.538	0.74
127_I	211_T	0.538	0.74
128_T	197_R	0.537	0.74
108_V	211_T	0.536	0.74
82_F	140_I	0.531	0.74
213_P	217_V	0.530	0.73
130_H	211_T	0.530	0.73
185_V	236_A	0.526	0.73
110_N	227_G	0.523	0.72
115_V	183_T	0.522	0.72
117_T	234_A	0.520	0.72
138_P	216_I	0.520	0.72
91_V	213_P	0.520	0.72
164_S	167_E	0.519	0.72
193_P	239_L	0.519	0.72
63_L	93_F	0.518	0.72
158_Y	163_S	0.517	0.72
96_R	221_A	0.511	0.71
39_N	66_G	0.510	0.71
65_L	72_S	0.509	0.70
119_F	205_D	0.508	0.70
19_S	72_S	0.508	0.70
95_V	98_M	0.507	0.70
19_S	103_V	0.507	0.70
111_A	248_V	0.506	0.70
235_A	243_L	0.506	0.70
71_V	267_V	0.504	0.70
233_N	240_D	0.504	0.70
115_V	233_N	0.504	0.70
185_V	207_V	0.504	0.70
117_T	238_I	0.502	0.69
173_L	176_P	0.500	0.69

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2p4sA	3	1	100	0.248	Contact Map
3la8A	1	0.9077	100	0.256	Contact Map
1vmkA	3	0.9262	100	0.267	Contact Map
4earA	3	0.9963	100	0.271	Contact Map
4m1eA	5	1	100	0.271	Contact Map
1tcvA	3	0.9889	100	0.278	Contact Map
1g2oA	3	0.9557	100	0.281	Contact Map
3khsA	3	0.9594	100	0.283	Contact Map
3odgA	3	1	100	0.286	Contact Map
4nsnA	3	0.9926	100	0.287	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0095 seconds.