GREMLIN Database
PUNA - Purine nucleoside phosphorylase 1
UniProt: P46354 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 271 (241)
Sequences: 3877 (2299)
Seq/√Len: 148.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_D224_R4.2981.00
167_E179_K3.5351.00
183_T199_L3.1411.00
198_F202_M3.0891.00
125_M206_A2.9961.00
183_T204_S2.9951.00
166_A226_L2.8171.00
116_N205_D2.5831.00
185_V199_L2.5811.00
42_K62_Q2.5791.00
65_L74_I2.5641.00
21_K104_E2.5001.00
161_D224_R2.4991.00
39_N67_T2.4241.00
265_A268_A2.3591.00
166_A266_I2.3001.00
157_A215_V2.2901.00
172_D269_Q2.2881.00
137_N189_S2.2811.00
120_R123_D2.1571.00
21_K72_S2.1521.00
92_T217_V2.1321.00
134_M184_A1.9881.00
131_I204_S1.9161.00
67_T72_S1.9141.00
168_K269_Q1.9001.00
44_K62_Q1.8781.00
172_D265_A1.8621.00
62_Q77_Q1.8611.00
21_K71_V1.8501.00
250_E254_K1.8391.00
117_T200_R1.8231.00
37_I75_A1.7691.00
23_G98_M1.7591.00
128_T179_K1.7531.00
206_A231_I1.7481.00
105_A224_R1.7441.00
123_D178_Q1.7251.00
182_Y208_G1.7151.00
38_E67_T1.6751.00
164_S168_K1.6621.00
169_I265_A1.6611.00
169_I173_L1.6421.00
126_I167_E1.6181.00
69_E268_A1.6111.00
25_I95_V1.5851.00
114_G231_I1.5731.00
143_N220_H1.5661.00
99_K221_A1.5341.00
106_L223_M1.5091.00
173_L261_K1.5081.00
126_I163_S1.5071.00
126_I177_I1.4951.00
63_L74_I1.4931.00
246_D250_E1.4841.00
191_E233_N1.4711.00
36_E264_K1.4541.00
87_S90_K1.4481.00
173_L265_A1.4431.00
25_I108_V1.4341.00
69_E264_K1.4211.00
196_V233_N1.4071.00
110_N229_S1.3961.00
170_A177_I1.3831.00
67_T70_G1.3821.00
116_N119_F1.3761.00
108_V215_V1.3631.00
156_S160_K1.3441.00
122_G251_V1.3251.00
158_Y211_T1.3231.00
251_V254_K1.3221.00
196_V235_A1.3141.00
156_S193_P1.3121.00
140_I186_T1.3001.00
115_V196_V1.2981.00
63_L97_V1.2941.00
163_S167_E1.2911.00
197_R201_T1.2801.00
48_I96_R1.2801.00
175_I258_G1.2571.00
127_I227_G1.2561.00
96_R100_A1.2501.00
125_M231_I1.2471.00
169_I269_Q1.2441.00
190_Y248_V1.2411.00
46_E51_F1.2411.00
253_E256_K1.2201.00
32_I260_L1.2101.00
99_K104_E1.2071.00
199_L204_S1.1981.00
82_F88_M1.1971.00
95_V221_A1.1961.00
196_V237_G1.1901.00
99_K223_M1.1631.00
135_G186_T1.1621.00
61_G79_R1.1581.00
131_I183_T1.1571.00
251_V255_V1.1481.00
105_A162_L1.1471.00
60_A77_Q1.1411.00
121_A234_A1.1401.00
241_Q247_E1.1340.99
130_H158_Y1.1240.99
244_S247_E1.1150.99
33_L68_L1.1070.99
189_S216_I1.1040.99
254_K258_G1.0960.99
100_A147_F1.0780.99
119_F231_I1.0670.99
230_C255_V1.0670.99
265_A269_Q1.0620.99
108_V227_G1.0600.99
165_L269_Q1.0580.99
119_F178_Q1.0550.99
120_R234_A1.0540.99
95_V106_L1.0530.99
22_I267_V1.0440.99
44_K51_F1.0380.99
245_H249_M1.0340.99
169_I266_I1.0070.99
226_L266_I1.0040.99
196_V238_I0.9840.99
103_V223_M0.9830.99
114_G119_F0.9790.98
124_L230_C0.9670.98
165_L168_K0.9660.98
133_F183_T0.9650.98
86_Y90_K0.9630.98
175_I262_L0.9590.98
74_I98_M0.9500.98
136_T140_I0.9460.98
42_K79_R0.9380.98
184_A212_V0.9360.98
23_G103_V0.9280.98
190_Y245_H0.9280.98
163_S179_K0.9170.98
84_E87_S0.9100.98
199_L207_V0.9060.98
197_R200_R0.9030.97
128_T163_S0.8970.97
96_R220_H0.8970.97
156_S159_D0.8920.97
184_A213_P0.8890.97
196_V236_A0.8870.97
43_L65_L0.8840.97
136_T186_T0.8790.97
230_C259_F0.8770.97
249_M253_E0.8760.97
132_N135_G0.8760.97
154_M216_I0.8750.97
107_I263_V0.8730.97
232_S252_T0.8730.97
124_L228_I0.8670.97
191_E196_V0.8660.97
211_T227_G0.8640.97
123_D176_P0.8630.97
185_V233_N0.8610.97
131_I198_F0.8570.97
169_I172_D0.8530.96
200_R238_I0.8480.96
112_A206_A0.8450.96
257_A261_K0.8450.96
197_R205_D0.8400.96
110_N211_T0.8350.96
153_D243_L0.8350.96
118_E178_Q0.8320.96
63_L101_L0.8240.96
48_I63_L0.8230.96
236_A243_L0.8230.96
112_A231_I0.8190.95
88_M91_V0.8180.95
238_I243_L0.8170.95
82_F186_T0.8160.95
135_G139_L0.8140.95
76_M98_M0.8120.95
156_S219_N0.8120.95
44_K47_D0.8120.95
84_E143_N0.8090.95
255_V258_G0.8060.95
143_N148_G0.8000.95
167_E171_K0.7970.95
74_I103_V0.7970.95
162_L226_L0.7950.95
115_V199_L0.7940.95
127_I206_A0.7910.95
168_K171_K0.7870.94
114_G234_A0.7870.94
126_I166_A0.7860.94
170_A262_L0.7850.94
177_I262_L0.7850.94
93_F97_V0.7830.94
42_K64_V0.7830.94
107_I266_I0.7750.94
245_H248_V0.7750.94
36_E260_L0.7680.94
165_L266_I0.7670.94
233_N238_I0.7660.94
159_D219_N0.7660.94
165_L169_I0.7590.93
42_K77_Q0.7570.93
130_H154_M0.7560.93
139_L216_I0.7510.93
228_I262_L0.7500.93
137_N140_I0.7490.93
50_E93_F0.7470.93
215_V225_V0.7400.92
20_P65_L0.7370.92
193_P236_A0.7370.92
105_A159_D0.7360.92
132_N137_N0.7360.92
120_R176_P0.7340.92
237_G243_L0.7330.92
239_L242_P0.7330.92
99_K222_G0.7320.92
119_F125_M0.7310.92
82_F136_T0.7300.92
88_M213_P0.7280.92
258_G261_K0.7280.92
233_N237_G0.7270.92
185_V191_E0.7270.92
37_I66_G0.7210.91
185_V196_V0.7190.91
160_K164_S0.7190.91
129_D157_A0.7180.91
247_E250_E0.7160.91
134_M186_T0.7150.91
128_T180_G0.7110.91
129_D181_V0.7070.91
157_A192_T0.7030.90
130_H192_T0.7030.90
138_P143_N0.7000.90
126_I228_I0.6950.90
196_V243_L0.6950.90
212_V215_V0.6920.90
47_D97_V0.6880.89
139_L212_V0.6880.89
155_S236_A0.6780.89
107_I226_L0.6770.89
197_R238_I0.6770.89
43_L101_L0.6760.89
133_F199_L0.6690.88
22_I71_V0.6670.88
261_K264_K0.6650.88
74_I101_L0.6630.88
193_P233_N0.6620.88
123_D258_G0.6620.88
198_F201_T0.6590.87
130_H212_V0.6590.87
137_N186_T0.6580.87
28_S245_H0.6580.87
252_T256_K0.6580.87
88_M92_T0.6550.87
21_K105_A0.6500.87
154_M157_A0.6480.86
131_I202_M0.6480.86
173_L262_L0.6460.86
128_T181_V0.6460.86
24_L267_V0.6450.86
171_K176_P0.6440.86
49_P96_R0.6420.86
87_S143_N0.6420.86
25_I106_L0.6410.86
22_I105_A0.6400.86
219_N222_G0.6390.86
64_V79_R0.6380.86
105_A161_D0.6340.85
166_A262_L0.6340.85
110_N208_G0.6290.85
183_T202_M0.6270.85
28_S190_Y0.6250.84
88_M136_T0.6250.84
134_M185_V0.6250.84
133_F185_V0.6240.84
166_A228_I0.6180.84
68_L267_V0.6180.84
31_G77_Q0.6170.84
158_Y227_G0.6170.84
119_F123_D0.6130.83
120_R178_Q0.6120.83
128_T193_P0.6100.83
32_I256_K0.6070.83
157_A193_P0.6050.82
238_I242_P0.6050.82
261_K265_A0.6050.82
63_L98_M0.6010.82
228_I263_V0.5990.82
31_G75_A0.5950.81
182_Y211_T0.5950.81
218_A225_V0.5950.81
51_F97_V0.5930.81
212_V216_I0.5920.81
169_I226_L0.5890.81
134_M213_P0.5890.81
32_I35_D0.5880.81
116_N234_A0.5880.81
132_N184_A0.5870.80
129_D155_S0.5870.80
88_M134_M0.5850.80
257_A260_L0.5850.80
108_V225_V0.5830.80
115_V237_G0.5810.80
198_F204_S0.5780.79
236_A239_L0.5760.79
193_P243_L0.5750.79
115_V200_R0.5740.79
218_A223_M0.5690.78
68_L71_V0.5680.78
256_K260_L0.5650.78
124_L259_F0.5610.77
106_L218_A0.5590.77
133_F202_M0.5590.77
90_K93_F0.5580.77
234_A239_L0.5570.77
25_I98_M0.5570.77
49_P84_E0.5540.77
234_A238_I0.5530.76
156_S242_P0.5530.76
96_R217_V0.5530.76
160_K163_S0.5490.76
119_F206_A0.5490.76
112_A232_S0.5480.76
29_G81_H0.5460.76
254_K257_A0.5450.75
104_E224_R0.5440.75
157_A219_N0.5430.75
81_H111_A0.5420.75
33_L36_E0.5410.75
20_P74_I0.5410.75
156_S163_S0.5400.75
71_V268_A0.5380.74
148_G220_H0.5380.74
127_I211_T0.5380.74
128_T197_R0.5370.74
108_V211_T0.5360.74
82_F140_I0.5310.74
213_P217_V0.5300.73
130_H211_T0.5300.73
185_V236_A0.5260.73
110_N227_G0.5230.72
115_V183_T0.5220.72
117_T234_A0.5200.72
138_P216_I0.5200.72
91_V213_P0.5200.72
164_S167_E0.5190.72
193_P239_L0.5190.72
63_L93_F0.5180.72
158_Y163_S0.5170.72
96_R221_A0.5110.71
39_N66_G0.5100.71
65_L72_S0.5090.70
119_F205_D0.5080.70
19_S72_S0.5080.70
95_V98_M0.5070.70
19_S103_V0.5070.70
111_A248_V0.5060.70
235_A243_L0.5060.70
71_V267_V0.5040.70
233_N240_D0.5040.70
115_V233_N0.5040.70
185_V207_V0.5040.70
117_T238_I0.5020.69
173_L176_P0.5000.69
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2p4sA 3 1 100 0.248 Contact Map
3la8A 1 0.9077 100 0.256 Contact Map
1vmkA 3 0.9262 100 0.267 Contact Map
4earA 3 0.9963 100 0.271 Contact Map
4m1eA 5 1 100 0.271 Contact Map
1tcvA 3 0.9889 100 0.278 Contact Map
1g2oA 3 0.9557 100 0.281 Contact Map
3khsA 3 0.9594 100 0.283 Contact Map
3odgA 3 1 100 0.286 Contact Map
4nsnA 3 0.9926 100 0.287 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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