GREMLIN Database
DEOB - Phosphopentomutase
UniProt: P46353 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (382)
Sequences: 1414 (858)
Seq/√Len: 43.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
273_G317_K4.6451.00
266_D310_R3.5301.00
121_R184_E3.3581.00
128_G137_I3.2161.00
112_D116_Q3.1591.00
136_A139_D3.1561.00
118_L161_L2.9941.00
228_N250_E2.9841.00
268_V282_A2.9051.00
106_F191_Y2.8561.00
38_H41_E2.7831.00
118_L182_A2.7021.00
254_S274_E2.7001.00
143_Q147_E2.6981.00
146_M208_F2.6641.00
128_G141_L2.6241.00
338_G342_T2.5491.00
119_E125_K2.5231.00
310_R313_E2.5041.00
130_K140_E2.4911.00
144_E150_A2.4901.00
231_K253_T2.4201.00
220_K250_E2.4051.00
34_H37_G2.3901.00
230_L378_F2.3831.00
34_H60_E2.3451.00
94_I370_I2.2881.00
262_M266_D2.2761.00
87_T246_I2.1791.00
117_E120_K2.1681.00
137_I141_L2.1681.00
117_E121_R2.1501.00
143_Q208_F2.1501.00
127_I144_E2.1311.00
146_M169_V2.1311.00
77_K363_L2.1100.99
125_K150_A2.0890.99
224_R232_D2.0750.99
26_A31_E2.0550.99
145_H201_F2.0200.99
364_A369_D1.9840.99
88_M218_A1.9590.99
121_R181_T1.9300.99
136_A140_E1.9100.99
174_E177_R1.9000.99
350_A389_F1.8950.99
265_M314_V1.8770.99
50_N53_K1.8650.99
240_I271_T1.8630.99
144_E147_E1.8350.99
115_L126_I1.8260.99
226_V375_A1.7950.98
10_F280_S1.7870.98
295_R342_T1.7840.98
76_G362_P1.7700.98
352_S355_H1.7670.98
177_R180_E1.7650.98
215_H257_R1.7590.98
139_D206_G1.7500.98
48_M304_L1.7370.98
204_E207_Q1.7360.98
180_E217_Y1.7230.98
151_L178_I1.7200.98
137_I140_E1.7080.98
262_M310_R1.6980.98
78_M348_I1.6900.98
143_Q205_P1.6890.97
38_H335_I1.6870.97
23_P345_Y1.6850.97
74_Y355_H1.6820.97
114_L191_Y1.6810.97
132_A137_I1.6750.97
267_K270_D1.6750.97
244_S249_G1.6680.97
291_F303_A1.6530.97
365_D387_K1.6530.97
336_H342_T1.6520.97
167_E213_N1.6520.97
172_L213_N1.6460.97
321_D354_K1.6450.97
53_K72_L1.6380.97
297_P335_I1.6300.97
263_D267_K1.6300.97
272_L314_V1.6190.97
376_D388_S1.6110.97
33_A336_H1.5910.96
295_R336_H1.5880.96
40_A64_G1.5770.96
50_N312_P1.5690.96
224_R229_E1.5550.96
132_A141_L1.5460.96
262_M306_E1.5240.95
228_N231_K1.5190.95
161_L186_T1.5110.95
124_R174_E1.5080.95
295_R338_G1.5040.95
77_K345_Y1.5020.95
220_K248_D1.4960.95
128_G132_A1.4950.95
239_S252_I1.4700.94
79_Q365_D1.4690.94
115_L119_E1.4670.94
48_M56_L1.4660.94
177_R181_T1.4660.94
132_A140_E1.4520.94
79_Q345_Y1.4510.94
364_A389_F1.4450.94
296_D302_R1.4430.94
116_Q120_K1.4430.94
127_I150_A1.4270.93
228_N232_D1.4240.93
21_E32_G1.4230.93
151_L170_V1.4130.93
146_M205_P1.4130.93
43_M301_G1.4030.93
377_N390_L1.4020.93
126_I153_V1.3880.92
325_I350_A1.3530.91
97_L222_F1.3460.91
265_M312_P1.3270.91
33_A338_G1.3230.91
78_M370_I1.3140.90
320_E353_K1.3060.90
276_F280_S1.3000.90
78_M364_A1.2990.90
369_D389_F1.2960.90
372_A383_P1.2820.89
6_Y377_N1.2750.89
265_M284_L1.2740.89
22_A79_Q1.2610.88
230_L235_L1.2520.88
10_F272_L1.2400.87
54_L73_A1.2350.87
33_A342_T1.2330.87
17_V304_L1.2330.87
235_L277_T1.2250.87
324_L351_Y1.2240.87
226_V383_P1.2220.87
119_E126_I1.2200.87
269_I272_L1.2190.86
78_M346_V1.2150.86
265_M310_R1.2130.86
27_D83_N1.1910.85
166_H203_G1.1880.85
298_E302_R1.1880.85
205_P208_F1.1850.85
186_T196_I1.1840.85
323_L377_N1.1810.85
43_M298_E1.1740.84
262_M265_M1.1630.84
295_R337_H1.1560.83
58_L71_P1.1550.83
266_D313_E1.1520.83
52_A66_E1.1490.83
174_E178_I1.1440.83
227_M252_I1.1410.83
25_A33_A1.1340.82
122_S151_L1.1320.82
236_D254_S1.1290.82
76_G389_F1.1210.81
346_V370_I1.1180.81
52_A58_L1.1170.81
11_L94_I1.1150.81
235_L278_G1.1080.81
350_A361_L1.1020.80
209_K290_L1.1010.80
233_C380_T1.0860.79
16_S300_Y1.0770.79
262_M313_E1.0730.79
168_E204_E1.0730.79
240_I282_A1.0720.78
325_I348_I1.0650.78
52_A65_V1.0600.78
145_H151_L1.0590.78
74_Y352_S1.0580.78
114_L185_L1.0470.77
48_M305_E1.0440.77
202_V209_K1.0430.77
95_M371_G1.0410.76
97_L223_D1.0370.76
230_L380_T1.0330.76
54_L315_F1.0250.75
127_I141_L1.0200.75
124_R151_L1.0190.75
52_A57_G1.0160.75
21_E345_Y1.0100.74
89_T103_F1.0060.74
261_N306_E1.0050.74
22_A345_Y1.0030.74
260_S290_L1.0020.74
41_E63_K0.9940.73
325_I370_I0.9930.73
244_S255_S0.9910.73
170_V178_I0.9880.72
119_E124_R0.9820.72
14_M326_I0.9800.72
118_L153_V0.9780.72
94_I247_Y0.9730.71
7_N277_T0.9690.71
239_S244_S0.9660.71
74_Y361_L0.9640.71
256_R271_T0.9570.70
11_L370_I0.9540.70
302_R306_E0.9540.70
17_V36_L0.9530.70
11_L95_M0.9460.69
28_F83_N0.9430.69
247_Y281_F0.9390.69
44_N298_E0.9390.69
219_L222_F0.9380.69
6_Y355_H0.9350.68
80_E367_F0.9350.68
27_D379_Q0.9320.68
240_I268_V0.9300.68
225_T228_N0.9290.68
46_L305_E0.9280.68
238_I271_T0.9250.67
258_T264_G0.9240.67
36_L56_L0.9230.67
9_V377_N0.9220.67
122_S181_T0.9180.67
132_A136_A0.9170.67
104_K193_V0.9160.67
275_D278_G0.9150.67
237_V253_T0.9100.66
74_Y358_A0.9080.66
118_L178_I0.9070.66
8_R319_R0.9060.66
21_E336_H0.9030.66
238_I276_F0.8970.65
114_L186_T0.8940.65
36_L48_M0.8920.65
229_E383_P0.8920.65
215_H244_S0.8920.65
104_K189_P0.8920.65
124_R150_A0.8910.64
87_T300_Y0.8880.64
11_L279_L0.8880.64
44_N64_G0.8870.64
128_G140_E0.8860.64
46_L301_G0.8830.64
122_S178_I0.8810.64
76_G361_L0.8780.63
54_L72_L0.8780.63
286_D289_A0.8770.63
269_I313_E0.8770.63
181_T184_E0.8690.63
185_L190_K0.8690.63
161_L196_I0.8670.62
21_E31_E0.8510.61
38_H342_T0.8500.61
323_L350_A0.8430.60
239_S255_S0.8360.60
74_Y359_Q0.8350.59
146_M166_H0.8340.59
366_T387_K0.8340.59
306_E309_A0.8310.59
10_F318_M0.8290.59
57_G65_V0.8280.59
374_I378_F0.8280.59
81_A98_Y0.8200.58
73_A349_L0.8170.58
40_A46_L0.8110.57
7_N377_N0.8020.56
42_H298_E0.7980.56
19_I60_E0.7960.56
61_D67_K0.7910.55
236_D253_T0.7890.55
261_N303_A0.7830.55
143_Q146_M0.7790.54
142_G208_F0.7770.54
368_A385_Y0.7760.54
58_L67_K0.7760.54
231_K237_V0.7760.54
23_P79_Q0.7750.54
229_E372_A0.7740.54
19_I59_I0.7700.53
153_V161_L0.7700.53
17_V48_M0.7700.53
213_N259_V0.7690.53
7_N321_D0.7680.53
226_V371_G0.7670.53
165_A175_L0.7660.53
145_H170_V0.7660.53
89_T99_I0.7650.53
312_P316_E0.7650.53
48_M51_M0.7630.53
272_L317_K0.7610.52
47_H305_E0.7610.52
237_V252_I0.7590.52
170_V174_E0.7580.52
39_I297_P0.7580.52
112_D120_K0.7580.52
170_V201_F0.7580.52
269_I310_R0.7570.52
13_V327_T0.7570.52
107_P131_P0.7560.52
168_E202_V0.7540.52
48_M52_A0.7520.52
244_S252_I0.7500.51
29_N337_H0.7490.51
183_R189_P0.7490.51
138_L205_P0.7470.51
97_L225_T0.7470.51
33_A295_R0.7450.51
376_D390_L0.7400.50
298_E301_G0.7390.50
289_A332_N0.7370.50
17_V326_I0.7360.50
229_E380_T0.7330.50
113_E190_K0.7320.50
348_I361_L0.7320.50
264_G284_L0.7300.49
247_Y371_G0.7300.49
106_F159_S0.7280.49
88_M248_D0.7270.49
62_I77_K0.7250.49
161_L362_P0.7250.49
180_E257_R0.7220.49
260_S286_D0.7220.49
116_Q119_E0.7200.48
375_A380_T0.7200.48
235_L378_F0.7180.48
121_R185_L0.7170.48
305_E309_A0.7140.48
272_L318_M0.7140.48
104_K248_D0.7140.48
94_I346_V0.7130.48
240_I247_Y0.7100.48
146_M204_E0.7090.47
121_R182_A0.7090.47
88_M104_K0.7080.47
76_G348_I0.7080.47
315_F324_L0.7040.47
11_L281_F0.7030.47
14_M307_F0.6990.46
11_L374_I0.6990.46
265_M272_L0.6970.46
104_K191_Y0.6940.46
124_R170_V0.6940.46
115_L125_K0.6940.46
78_M369_D0.6930.46
244_S257_R0.6930.46
227_M239_S0.6920.46
68_T71_P0.6890.46
39_I300_Y0.6890.46
268_V280_S0.6890.46
72_L351_Y0.6880.45
373_T389_F0.6840.45
79_Q363_L0.6840.45
259_V263_D0.6820.45
52_A349_L0.6760.44
291_F306_E0.6750.44
11_L325_I0.6740.44
113_E191_Y0.6740.44
43_M297_P0.6730.44
345_Y363_L0.6730.44
373_T386_G0.6720.44
238_I254_S0.6720.44
117_E181_T0.6710.44
173_E180_E0.6700.44
263_D266_D0.6690.44
169_V204_E0.6660.43
212_P260_S0.6650.43
52_A68_T0.6640.43
106_F114_L0.6640.43
192_M219_L0.6620.43
45_G297_P0.6620.43
295_R332_N0.6600.43
226_V229_E0.6600.43
271_T280_S0.6590.43
270_D274_E0.6590.43
271_T274_E0.6580.43
75_Y360_M0.6530.42
75_Y349_L0.6510.42
44_N63_K0.6500.42
124_R178_I0.6490.42
60_E360_M0.6490.42
17_V56_L0.6480.42
132_A138_L0.6470.42
104_K192_M0.6450.41
328_A347_P0.6440.41
75_Y358_A0.6430.41
265_M307_F0.6420.41
260_S263_D0.6410.41
135_T294_R0.6410.41
7_N319_R0.6400.41
81_A385_Y0.6390.41
10_F314_V0.6390.41
127_I151_L0.6380.41
118_L186_T0.6380.41
324_L349_L0.6360.41
223_D384_K0.6350.40
240_I269_I0.6330.40
9_V374_I0.6330.40
210_R294_R0.6320.40
314_V318_M0.6310.40
115_L153_V0.6280.40
22_A346_V0.6280.40
220_K228_N0.6260.40
100_D385_Y0.6260.40
24_D343_R0.6230.39
311_L324_L0.6230.39
28_F338_G0.6220.39
139_D207_Q0.6210.39
192_M218_A0.6200.39
38_H338_G0.6190.39
265_M313_E0.6180.39
12_I284_L0.6180.39
352_S377_N0.6180.39
13_V346_V0.6180.39
224_R250_E0.6170.39
371_G382_K0.6160.39
328_A346_V0.6150.39
76_G364_A0.6150.39
190_K193_V0.6140.39
76_G161_L0.6140.39
258_T267_K0.6130.38
33_A337_H0.6130.38
323_L390_L0.6130.38
40_A57_G0.6120.38
134_G210_R0.6110.38
227_M237_V0.6110.38
315_F351_Y0.6100.38
378_F383_P0.6100.38
215_H255_S0.6090.38
269_I317_K0.6070.38
301_G305_E0.6050.38
166_H204_E0.6050.38
192_M222_F0.6040.38
146_M213_N0.6000.37
52_A64_G0.6000.37
265_M311_L0.5990.37
36_L304_L0.5990.37
28_F295_R0.5970.37
189_P192_M0.5970.37
103_F375_A0.5950.37
118_L185_L0.5940.37
118_L122_S0.5940.37
21_E59_I0.5940.37
10_F322_D0.5930.37
57_G64_G0.5930.37
286_D290_L0.5930.37
94_I374_I0.5930.37
70_H379_Q0.5920.37
167_E211_T0.5910.36
104_K218_A0.5900.36
6_Y9_V0.5900.36
134_G294_R0.5900.36
94_I97_L0.5890.36
120_K365_D0.5880.36
19_I56_L0.5870.36
145_H148_T0.5820.36
78_M366_T0.5810.36
356_K359_Q0.5800.35
10_F282_A0.5800.35
165_A170_V0.5790.35
112_D147_E0.5770.35
265_M269_I0.5770.35
372_A384_K0.5750.35
132_A139_D0.5740.35
323_L352_S0.5730.35
76_G360_M0.5730.35
279_L371_G0.5710.35
109_G129_N0.5710.35
215_H218_A0.5700.35
235_L279_L0.5680.34
371_G384_K0.5680.34
369_D372_A0.5670.34
180_E184_E0.5670.34
22_A25_A0.5660.34
59_I77_K0.5650.34
8_R322_D0.5620.34
375_A383_P0.5620.34
99_I218_A0.5620.34
141_L144_E0.5610.34
254_S271_T0.5600.34
114_L137_I0.5590.34
185_L286_D0.5580.34
52_A67_K0.5560.33
56_L349_L0.5550.33
321_D353_K0.5550.33
73_A352_S0.5550.33
172_L175_L0.5530.33
99_I222_F0.5530.33
10_F159_S0.5530.33
238_I256_R0.5520.33
12_I307_F0.5510.33
373_T390_L0.5510.33
17_V300_Y0.5510.33
272_L324_L0.5500.33
22_A48_M0.5500.33
186_T189_P0.5490.33
61_D73_A0.5490.33
25_A31_E0.5480.33
130_K136_A0.5470.33
193_V197_I0.5470.33
151_L174_E0.5460.33
58_L68_T0.5460.33
230_L279_L0.5460.33
309_A312_P0.5460.33
226_V279_L0.5430.32
268_V314_V0.5430.32
145_H164_A0.5430.32
321_D324_L0.5410.32
10_F276_F0.5410.32
16_S246_I0.5400.32
313_E316_E0.5400.32
36_L326_I0.5390.32
136_A206_G0.5390.32
122_S174_E0.5380.32
287_F307_F0.5370.32
348_I389_F0.5370.32
23_P363_L0.5360.32
6_Y378_F0.5350.32
145_H178_I0.5340.32
166_H369_D0.5340.32
81_A366_T0.5330.31
269_I273_G0.5320.31
48_M64_G0.5320.31
50_N315_F0.5320.31
112_D274_E0.5310.31
14_M328_A0.5310.31
226_V325_I0.5310.31
94_I297_P0.5300.31
118_L151_L0.5300.31
130_K137_I0.5280.31
321_D374_I0.5280.31
135_T340_D0.5270.31
151_L280_S0.5260.31
89_T98_Y0.5250.31
193_V203_G0.5250.31
97_L228_N0.5250.31
202_V213_N0.5230.31
321_D377_N0.5230.31
256_R267_K0.5210.30
272_L316_E0.5200.30
143_Q206_G0.5200.30
71_P358_A0.5190.30
124_R149_G0.5180.30
314_V324_L0.5170.30
236_D276_F0.5170.30
228_N247_Y0.5150.30
360_M363_L0.5150.30
8_R234_G0.5140.30
297_P301_G0.5140.30
47_H232_D0.5140.30
352_S356_K0.5140.30
272_L282_A0.5140.30
118_L181_T0.5130.30
145_H165_A0.5130.30
194_G218_A0.5130.30
197_I200_P0.5120.30
268_V332_N0.5120.30
240_I349_L0.5120.30
79_Q387_K0.5110.30
31_E337_H0.5110.30
28_F336_H0.5100.30
172_L201_F0.5100.30
154_Y214_R0.5100.30
95_M226_V0.5060.29
114_L117_E0.5050.29
144_E148_T0.5050.29
12_I324_L0.5050.29
94_I225_T0.5040.29
43_M302_R0.5040.29
182_A193_V0.5040.29
73_A387_K0.5020.29
70_H73_A0.5020.29
58_L70_H0.5010.29
52_A75_Y0.5010.29
151_L201_F0.5000.29
249_G255_S0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3m7vA 1 0.9848 100 0.337 Contact Map
3ot9A 1 0.9898 100 0.339 Contact Map
3kd8A 1 0.8223 100 0.778 Contact Map
2zktA 3 0.8426 100 0.84 Contact Map
1zedA 2 0.8655 100 0.845 Contact Map
2x98A 4 0.8147 99.9 0.855 Contact Map
1o98A 1 0.9467 99.9 0.857 Contact Map
1k7hA 2 0.8604 99.9 0.858 Contact Map
3igzB 1 0.967 99.9 0.858 Contact Map
3a52A 2 0.7665 99.9 0.865 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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