GREMLIN Database
XERD - Tyrosine recombinase XerD
UniProt: P46352 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (268)
Sequences: 37774 (30299)
Seq/√Len: 1850.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
249_A266_L5.0981.00
50_T53_H3.2481.00
156_T192_M3.2471.00
176_R267_G3.2031.00
240_T243_T2.7751.00
141_L241_P2.7721.00
145_G248_F2.7711.00
148_V242_H2.7111.00
248_F265_M2.5951.00
61_L74_H2.5511.00
44_T53_H2.4751.00
155_K216_Q2.2301.00
155_K207_A2.2291.00
141_L151_M2.1821.00
268_H274_T2.1661.00
167_R177_I2.1491.00
164_G185_A2.1171.00
246_H279_H2.1121.00
136_A191_Y2.0631.00
113_A116_E2.0441.00
155_K206_D2.0091.00
29_D73_R1.9381.00
258_D261_A1.9331.00
58_L75_L1.9261.00
253_L262_V1.9181.00
143_A181_G1.9181.00
150_E176_R1.9141.00
185_A189_E1.9131.00
260_R263_Q1.8661.00
84_F88_E1.8141.00
165_F177_I1.7891.00
27_E31_K1.7811.00
160_H163_M1.7471.00
32_S74_H1.7371.00
174_K269_A1.7171.00
29_D77_S1.7081.00
134_D225_N1.6681.00
252_L257_A1.6671.00
179_P265_M1.6641.00
54_I96_S1.6501.00
266_L274_T1.6401.00
254_E284_R1.6291.00
272_S275_Q1.6161.00
146_I151_M1.6111.00
9_I27_E1.6011.00
114_L251_H1.5891.00
45_D48_H1.5131.00
81_F85_L1.5111.00
248_F252_L1.5101.00
135_K139_E1.4971.00
142_Y251_H1.4841.00
253_L278_T1.4751.00
180_I185_A1.4741.00
139_E187_A1.4681.00
49_V82_H1.4621.00
156_T208_L1.4541.00
69_K73_R1.4521.00
137_M222_F1.4461.00
148_V152_I1.4351.00
161_L189_E1.4331.00
155_K158_D1.4171.00
148_V219_R1.4161.00
252_L262_V1.4141.00
250_T279_H1.4081.00
263_Q271_I1.4031.00
112_L247_S1.3811.00
160_H165_F1.3801.00
21_N24_V1.3761.00
22_T26_Y1.3711.00
273_T276_I1.3641.00
57_Y74_H1.3521.00
117_V142_Y1.3421.00
116_E119_R1.3381.00
143_A184_A1.3341.00
125_K135_K1.3241.00
20_Q24_V1.3191.00
260_R264_E1.3181.00
124_P229_I1.3131.00
207_A216_Q1.2931.00
57_Y61_L1.2901.00
136_A190_E1.2851.00
149_S153_E1.2621.00
157_A206_D1.2511.00
219_R223_W1.2451.00
62_K71_S1.2421.00
117_V251_H1.2401.00
121_L139_E1.2381.00
112_L239_L1.2281.00
8_F80_S1.2261.00
58_L62_K1.2221.00
137_M151_M1.2161.00
249_A262_V1.2071.00
247_S251_H1.1931.00
263_Q274_T1.1921.00
24_V28_R1.1911.00
147_R242_H1.1901.00
75_L79_R1.1891.00
142_Y244_L1.1801.00
72_A102_Q1.1721.00
118_E122_D1.1721.00
70_T74_H1.1721.00
136_A187_A1.1671.00
220_Q223_W1.1621.00
148_V223_W1.1621.00
254_E281_T1.1531.00
19_S169_F1.1501.00
9_I23_I1.1501.00
13_M23_I1.1421.00
83_Q97_V1.1371.00
137_M209_F1.1271.00
225_N228_K1.1191.00
164_G182_E1.1191.00
230_A239_L1.1161.00
55_I59_K1.1131.00
218_S221_G1.1121.00
157_A205_S1.0991.00
86_L91_T1.0961.00
111_V247_S1.0891.00
169_F175_E1.0891.00
226_L230_A1.0881.00
270_D275_Q1.0871.00
221_G224_K1.0851.00
223_W227_K1.0781.00
270_D273_T1.0771.00
23_I27_E1.0771.00
67_S70_T1.0751.00
248_F266_L1.0671.00
119_R123_T1.0651.00
182_E186_S1.0631.00
123_T232_E1.0601.00
154_L166_I1.0581.00
112_L120_L1.0561.00
142_Y247_S1.0501.00
40_T60_H1.0441.00
66_K74_H1.0441.00
123_T233_A1.0431.00
89_K93_K1.0321.00
250_T278_T1.0271.00
29_D74_H1.0271.00
114_L255_N1.0231.00
181_G184_A1.0231.00
25_S28_R1.0191.00
249_A278_T1.0161.00
25_S29_D1.0151.00
146_I168_C1.0111.00
167_R175_E1.0091.00
82_H91_T0.9981.00
135_K187_A0.9961.00
143_A183_A0.9851.00
284_R287_D0.9841.00
140_L209_F0.9841.00
156_T195_A0.9781.00
28_R32_S0.9721.00
139_E183_A0.9651.00
21_N25_S0.9651.00
51_R55_I0.9611.00
227_K238_E0.9591.00
251_H254_E0.9551.00
124_P138_L0.9521.00
18_L23_I0.9481.00
191_Y195_A0.9481.00
114_L118_E0.9451.00
55_I88_E0.9411.00
60_H64_S0.9401.00
152_I219_R0.9401.00
85_L90_V0.9391.00
62_K68_G0.9281.00
207_A210_L0.9271.00
61_L66_K0.9091.00
261_A288_V0.9081.00
12_V18_L0.9031.00
249_A253_L0.8961.00
114_L254_E0.8951.00
112_L116_E0.8951.00
264_E285_L0.8891.00
26_Y77_S0.8881.00
132_Y190_E0.8871.00
79_R83_Q0.8861.00
183_A186_S0.8831.00
246_H276_I0.8821.00
169_F173_R0.8801.00
170_G176_R0.8801.00
44_T48_H0.8791.00
6_K10_H0.8771.00
228_K232_E0.8751.00
19_S22_T0.8751.00
257_A261_A0.8731.00
83_Q94_D0.8731.00
132_Y194_K0.8721.00
73_R76_A0.8691.00
82_H95_P0.8681.00
51_R87_R0.8671.00
18_L26_Y0.8631.00
7_D11_Y0.8631.00
223_W241_P0.8601.00
111_V279_H0.8561.00
87_R100_E0.8561.00
140_L166_I0.8541.00
259_L275_Q0.8531.00
227_K231_L0.8511.00
263_Q275_Q0.8501.00
160_H167_R0.8491.00
148_V222_F0.8471.00
161_L185_A0.8461.00
9_I13_M0.8451.00
110_K243_T0.8431.00
66_K70_T0.8411.00
7_D90_V0.8381.00
229_I232_E0.8381.00
25_S73_R0.8371.00
8_F12_V0.8371.00
86_L94_D0.8361.00
56_Q60_H0.8321.00
154_L159_V0.8281.00
61_L71_S0.8261.00
140_L184_A0.8251.00
283_T287_D0.8201.00
20_Q23_I0.8201.00
53_H56_Q0.8111.00
87_R98_H0.8081.00
144_T178_V0.8071.00
82_H96_S0.8021.00
152_I222_F0.7961.00
136_A209_F0.7891.00
33_Y82_H0.7881.00
132_Y136_A0.7791.00
254_E283_T0.7771.00
94_D97_V0.7761.00
184_A187_A0.7721.00
224_K228_K0.7711.00
211_N215_K0.7681.00
140_L151_M0.7671.00
190_E194_K0.7661.00
145_G266_L0.7651.00
148_V241_P0.7641.00
59_K62_K0.7561.00
132_Y135_K0.7541.00
120_L230_A0.7521.00
57_Y60_H0.7521.00
81_F84_F0.7501.00
271_I274_T0.7491.00
66_K71_S0.7491.00
249_A274_T0.7481.00
150_E170_G0.7411.00
180_I184_A0.7391.00
75_L96_S0.7381.00
12_V16_R0.7371.00
156_T196_R0.7341.00
112_L243_T0.7291.00
271_I275_Q0.7281.00
55_I58_L0.7261.00
154_L208_L0.7181.00
51_R89_K0.7171.00
270_D274_T0.7171.00
10_H13_M0.7161.00
123_T229_I0.7151.00
259_L271_I0.7091.00
6_K27_E0.7091.00
189_E193_T0.7081.00
192_M196_R0.7041.00
249_A268_H0.7041.00
69_K72_A0.7041.00
124_P135_K0.7031.00
265_M285_L0.7031.00
253_L281_T0.7001.00
225_N229_I0.6981.00
226_L241_P0.6981.00
226_L244_L0.6951.00
227_K230_A0.6941.00
6_K38_T0.6921.00
220_Q227_K0.6921.00
141_L148_V0.6901.00
134_D229_I0.6871.00
160_H164_G0.6861.00
85_L91_T0.6851.00
140_L146_I0.6831.00
189_E192_M0.6811.00
195_A210_L0.6801.00
192_M195_A0.6741.00
54_I78_I0.6741.00
28_R31_K0.6731.00
120_L138_L0.6721.00
89_K98_H0.6721.00
257_A288_V0.6711.00
52_I88_E0.6711.00
281_T284_R0.6691.00
261_A265_M0.6691.00
222_F241_P0.6691.00
242_H246_H0.6681.00
61_L64_S0.6661.00
72_A76_A0.6661.00
221_G225_N0.6641.00
239_L243_T0.6611.00
186_S190_E0.6611.00
32_S57_Y0.6601.00
139_E184_A0.6581.00
117_V121_L0.6561.00
52_I56_Q0.6551.00
144_T181_G0.6501.00
86_L97_V0.6491.00
58_L71_S0.6481.00
13_M27_E0.6411.00
133_R191_Y0.6411.00
125_K139_E0.6391.00
282_K285_L0.6381.00
158_D169_F0.6361.00
186_S189_E0.6351.00
12_V26_Y0.6341.00
136_A140_L0.6341.00
79_R96_S0.6341.00
49_V54_I0.6321.00
83_Q86_L0.6261.00
170_G175_E0.6221.00
115_N119_R0.6201.00
119_R122_D0.6161.00
138_L244_L0.6141.00
33_Y78_I0.6131.00
146_I150_E0.6121.00
40_T56_Q0.6111.00
260_R275_Q0.6111.00
79_R101_T0.6091.00
187_A190_E0.6081.00
253_L260_R0.6071.00
33_Y64_S0.6071.00
253_L258_D0.6071.00
30_L38_T0.6071.00
30_L34_S0.6061.00
57_Y78_I0.6061.00
114_L247_S0.6051.00
84_F90_V0.6041.00
109_P240_T0.6041.00
68_G72_A0.6041.00
30_L81_F0.6041.00
121_L135_K0.6041.00
82_H86_L0.6021.00
30_L77_S0.6021.00
139_E143_A0.6011.00
115_N118_E0.6001.00
283_T286_K0.5991.00
257_A262_V0.5981.00
243_T246_H0.5971.00
111_V250_T0.5951.00
136_A184_A0.5951.00
147_R169_F0.5951.00
117_V247_S0.5921.00
188_I208_L0.5911.00
9_I12_V0.5881.00
253_L259_L0.5871.00
7_D10_H0.5871.00
153_E216_Q0.5821.00
263_Q273_T0.5821.00
259_L274_T0.5801.00
262_V278_T0.5801.00
33_Y57_Y0.5801.00
86_L89_K0.5791.00
60_H63_D0.5781.00
26_Y29_D0.5691.00
136_A188_I0.5691.00
59_K63_D0.5661.00
80_S83_Q0.5621.00
269_A273_T0.5611.00
229_I233_A0.5591.00
31_K34_S0.5561.00
46_W85_L0.5551.00
159_V188_I0.5511.00
190_E193_T0.5491.00
51_R98_H0.5481.00
141_L244_L0.5471.00
191_Y194_K0.5461.00
96_S99_I0.5441.00
133_R136_A0.5441.00
80_S84_F0.5381.00
138_L226_L0.5371.00
156_T188_I0.5331.00
78_I96_S0.5311.00
86_L93_K0.5311.00
72_A101_T0.5301.00
263_Q266_L0.5291.00
79_R97_V0.5281.00
150_E267_G0.5261.00
106_R276_I0.5261.00
86_L98_H0.5261.00
112_L117_V0.5241.00
252_L265_M0.5241.00
73_R77_S0.5231.00
140_L188_I0.5231.00
253_L280_V0.5211.00
51_R88_E0.5201.00
155_K205_S0.5191.00
18_L22_T0.5171.00
161_L180_I0.5151.00
260_R271_I0.5141.00
159_V208_L0.5141.00
75_L99_I0.5121.00
109_P246_H0.5091.00
220_Q224_K0.5091.00
146_I154_L0.5081.00
263_Q270_D0.5061.00
11_Y84_F0.5051.00
82_H94_D0.5011.00
7_D84_F0.5011.00
131_G135_K0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.9088 100 0.148 Contact Map
2a3vA 3 0.9392 100 0.212 Contact Map
1z1bA 3 0.9257 100 0.213 Contact Map
1z19A 3 0.9358 100 0.222 Contact Map
1xo0A 3 0.9662 100 0.228 Contact Map
4a8eA 2 0.8851 100 0.245 Contact Map
3nkhA 2 0.6453 100 0.396 Contact Map
1ae9A 4 0.5676 100 0.465 Contact Map
1aihA 2 0.5541 99.9 0.515 Contact Map
4e0gA 2 0.9122 99.9 0.552 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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