GREMLIN Database
GABP - GABA permease
UniProt: P46349 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 469 (423)
Sequences: 24708 (15895)
Seq/√Len: 772.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_T339_T4.3761.00
321_R333_Q4.2811.00
381_K385_K3.3131.00
53_G244_I3.2901.00
373_L409_I3.0881.00
324_K333_Q3.0621.00
230_E234_K3.0301.00
77_S315_R2.9161.00
13_K226_S2.8631.00
225_T231_S2.7721.00
93_G312_L2.7401.00
168_G253_I2.6751.00
313_A323_M2.6251.00
227_N230_E2.6081.00
129_L343_Y2.5891.00
18_T238_S2.5731.00
223_G314_E2.5431.00
326_S332_V2.4881.00
166_I170_A2.4671.00
281_A285_I2.4471.00
65_E383_R2.4121.00
14_T238_S2.3941.00
321_R324_K2.3651.00
376_A408_T2.2881.00
336_V340_F2.2741.00
224_E307_R2.2561.00
81_H89_G2.2151.00
137_L141_Y2.1971.00
14_T18_T2.1741.00
435_I439_V2.1621.00
310_Y314_E2.1601.00
136_T335_I2.1361.00
14_T231_S2.1201.00
144_K148_E2.1091.00
406_Y410_I2.0771.00
272_A275_E2.0651.00
17_M225_T2.0631.00
133_I343_Y2.0611.00
84_I381_K2.0051.00
18_T242_R1.9981.00
140_V332_V1.9871.00
97_W338_G1.9841.00
234_K238_S1.9741.00
441_I445_V1.9711.00
8_L325_L1.9601.00
128_S346_V1.9461.00
129_L346_V1.9361.00
316_N320_R1.9251.00
62_M376_A1.9191.00
13_K16_H1.9191.00
54_L58_F1.9101.00
155_L159_V1.9091.00
326_S330_V1.8871.00
81_H86_P1.8801.00
259_P262_S1.8691.00
322_F337_A1.8541.00
84_I377_V1.8461.00
377_V409_I1.8121.00
139_N299_N1.7911.00
262_S276_H1.7601.00
410_I414_G1.7571.00
237_R241_W1.7541.00
227_N231_S1.7121.00
445_V449_R1.7091.00
16_H151_Y1.7071.00
44_G201_V1.7071.00
21_S239_V1.7061.00
48_S204_G1.6921.00
272_A276_H1.6901.00
80_A92_I1.6871.00
92_I374_V1.6851.00
433_G437_G1.6801.00
85_G88_A1.6791.00
159_V163_A1.6761.00
12_L16_H1.6751.00
133_I339_T1.6671.00
403_F407_L1.6631.00
140_V336_V1.6541.00
55_L411_A1.6451.00
439_V443_Y1.6431.00
37_V45_A1.6401.00
394_L397_K1.6351.00
108_A298_L1.6341.00
158_V162_I1.6331.00
241_W245_V1.6161.00
381_K384_K1.6111.00
132_T342_S1.6101.00
328_K332_V1.5781.00
115_I127_T1.5571.00
104_I342_S1.5491.00
227_N234_K1.5481.00
309_L334_A1.5201.00
333_Q337_A1.5161.00
58_F407_L1.4991.00
437_G441_I1.4951.00
221_A303_Y1.4841.00
52_A208_V1.4781.00
94_W439_V1.4771.00
9_K329_G1.4621.00
141_Y328_K1.4571.00
160_T289_I1.4501.00
394_L398_M1.4501.00
169_F253_I1.4491.00
73_S223_G1.4361.00
54_L407_L1.4251.00
60_M240_V1.4241.00
84_I88_A1.4211.00
12_L17_M1.4151.00
310_Y325_L1.4151.00
111_G291_L1.4131.00
8_L310_Y1.4071.00
305_T338_G1.4001.00
129_L133_I1.3971.00
108_A132_T1.3961.00
377_V381_K1.3961.00
275_E283_A1.3881.00
396_I399_W1.3861.00
183_G186_N1.3801.00
228_P233_T1.3781.00
320_R323_M1.3751.00
430_L434_V1.3701.00
44_G194_F1.3651.00
132_T339_T1.3581.00
80_A374_V1.3571.00
434_V438_I1.3381.00
136_T336_V1.3341.00
401_F405_T1.3331.00
306_S335_I1.3321.00
32_V110_A1.3321.00
320_R324_K1.3201.00
444_L448_K1.3131.00
184_F187_L1.3111.00
231_S234_K1.3101.00
60_M236_T1.3051.00
16_H147_G1.2991.00
172_I256_A1.2911.00
284_Q288_F1.2891.00
83_A378_S1.2791.00
442_S446_F1.2781.00
59_I376_A1.2771.00
414_G418_S1.2771.00
111_G131_L1.2761.00
87_W446_F1.2751.00
309_L318_A1.2701.00
386_L389_T1.2681.00
439_V442_S1.2671.00
25_V243_I1.2641.00
61_R237_R1.2591.00
70_N82_D1.2521.00
245_V249_G1.2511.00
324_K332_V1.2421.00
14_T234_K1.2381.00
107_E297_C1.2311.00
165_L249_G1.2261.00
443_Y447_R1.2161.00
62_M405_T1.2121.00
275_E280_P1.2111.00
12_L147_G1.2111.00
400_L404_L1.2101.00
46_V252_A1.2081.00
21_S218_V1.2021.00
125_W129_L1.1801.00
380_L406_Y1.1761.00
126_L130_I1.1721.00
78_Q82_D1.1711.00
138_T149_F1.1661.00
38_I45_A1.1621.00
168_G257_L1.1531.00
97_W309_L1.1501.00
15_R19_M1.1481.00
395_K398_M1.1471.00
417_V421_F1.1471.00
135_L298_L1.1451.00
442_S445_V1.1451.00
413_C417_V1.1431.00
170_A175_F1.1421.00
90_F94_W1.1361.00
445_V448_K1.1341.00
226_S231_S1.1311.00
77_S311_S1.1301.00
20_I221_A1.1291.00
63_L76_F1.1281.00
163_A167_V1.1261.00
434_V437_G1.1241.00
373_L413_C1.1221.00
17_M235_A1.1211.00
164_F168_G1.1141.00
123_P126_L1.1111.00
333_Q336_V1.1091.00
149_F153_F1.1061.00
140_V330_V1.1021.00
260_W263_A1.1021.00
197_G200_S1.0981.00
429_L432_T1.0951.00
150_E299_N1.0921.00
72_T78_Q1.0921.00
387_E394_L1.0911.00
325_L329_G1.0851.00
408_T419_M1.0801.00
65_E68_A1.0781.00
384_K387_E1.0721.00
389_T394_L1.0711.00
169_F173_F1.0681.00
130_I134_V1.0671.00
11_E226_S1.0651.00
67_S79_Y1.0651.00
268_S272_A1.0651.00
22_I242_R1.0611.00
82_D386_L1.0531.00
440_L444_L1.0481.00
394_L399_W1.0441.00
162_I166_I1.0341.00
340_F344_I1.0341.00
69_V394_L1.0311.00
403_F406_Y1.0301.00
408_T411_A1.0241.00
438_I442_S1.0191.00
222_A232_V1.0181.00
266_L272_A1.0181.00
148_E152_W1.0181.00
80_A88_A1.0111.00
50_A248_V1.0111.00
383_R387_E1.0091.00
379_Q405_T1.0081.00
431_L434_V1.0041.00
259_P276_H1.0001.00
143_V303_Y0.9961.00
158_V246_F0.9941.00
140_V326_S0.9941.00
409_I413_C0.9921.00
278_G282_A0.9921.00
428_E432_T0.9921.00
202_L414_G0.9891.00
22_I243_I0.9881.00
279_V282_A0.9871.00
136_T140_V0.9851.00
216_E220_I0.9791.00
401_F404_L0.9791.00
112_A127_T0.9741.00
115_I119_F0.9741.00
194_F201_V0.9741.00
157_K293_A0.9661.00
213_M368_A0.9651.00
373_L377_V0.9651.00
133_I137_L0.9631.00
112_A128_S0.9631.00
402_P406_Y0.9571.00
121_D124_L0.9551.00
326_S329_G0.9511.00
72_T82_D0.9471.00
429_L433_G0.9451.00
416_L419_M0.9451.00
428_E435_I0.9421.00
314_E323_M0.9391.00
268_S271_V0.9371.00
53_G212_F0.9331.00
182_V185_S0.9311.00
69_V389_T0.9211.00
46_V255_V0.9171.00
96_Y100_W0.9131.00
134_V295_L0.9101.00
165_L253_I0.9061.00
185_S188_T0.9041.00
74_G78_Q0.9041.00
238_S242_R0.9031.00
26_I29_G0.9031.00
135_L299_N0.8991.00
432_T436_T0.8981.00
153_F296_S0.8901.00
50_A54_L0.8891.00
8_L224_E0.8861.00
8_L307_R0.8851.00
183_G187_L0.8831.00
302_L339_T0.8801.00
186_N189_G0.8801.00
430_L433_G0.8781.00
244_I248_V0.8751.00
164_F274_L0.8711.00
127_T130_I0.8711.00
115_I291_L0.8661.00
332_V336_V0.8651.00
19_M151_Y0.8651.00
380_L405_T0.8641.00
438_I441_I0.8631.00
58_F404_L0.8601.00
170_A174_G0.8571.00
446_F449_R0.8571.00
435_I438_I0.8541.00
443_Y448_K0.8531.00
109_I360_L0.8521.00
122_I126_L0.8501.00
15_R151_Y0.8481.00
16_H148_E0.8481.00
169_F249_G0.8461.00
414_G417_V0.8451.00
373_L412_I0.8441.00
393_A397_K0.8431.00
172_I175_F0.8421.00
106_I210_F0.8421.00
26_I157_K0.8421.00
106_I361_V0.8401.00
252_A256_A0.8401.00
443_Y449_R0.8391.00
74_G77_S0.8391.00
137_L140_V0.8361.00
80_A378_S0.8341.00
395_K399_W0.8311.00
81_H315_R0.8311.00
125_W346_V0.8261.00
322_F333_Q0.8231.00
213_M372_Y0.8211.00
165_L169_F0.8201.00
376_A409_I0.8181.00
57_I61_R0.8181.00
94_W318_A0.8171.00
415_I419_M0.8161.00
58_F62_M0.8121.00
186_N190_K0.8111.00
11_E144_K0.8101.00
57_I237_R0.8071.00
14_T235_A0.8031.00
68_A395_K0.8011.00
227_N233_T0.7991.00
257_L273_V0.7991.00
318_A322_F0.7971.00
47_V201_V0.7961.00
87_W91_T0.7961.00
428_E431_L0.7961.00
217_I304_T0.7931.00
111_G295_L0.7921.00
203_L207_V0.7891.00
433_G436_T0.7871.00
85_G447_R0.7851.00
432_T435_I0.7851.00
148_E151_Y0.7831.00
339_T343_Y0.7831.00
400_L403_F0.7781.00
384_K402_P0.7771.00
135_L302_L0.7671.00
441_I444_L0.7641.00
140_V328_K0.7581.00
88_A374_V0.7571.00
363_S367_I0.7541.00
69_V387_E0.7531.00
105_A360_L0.7531.00
62_M398_M0.7521.00
170_A173_F0.7521.00
280_P284_Q0.7521.00
432_T439_V0.7511.00
25_V239_V0.7491.00
18_T235_A0.7471.00
405_T419_M0.7461.00
85_G89_G0.7461.00
198_I201_V0.7451.00
172_I253_I0.7451.00
436_T440_L0.7451.00
132_T346_V0.7451.00
11_E143_V0.7421.00
399_W403_F0.7391.00
111_G294_V0.7371.00
393_A396_I0.7361.00
340_F343_Y0.7331.00
103_V364_S0.7331.00
165_L250_S0.7321.00
37_V41_T0.7311.00
443_Y446_F0.7291.00
309_L337_A0.7251.00
233_T236_T0.7241.00
47_V50_A0.7221.00
30_L250_S0.7221.00
379_Q383_R0.7211.00
66_M379_Q0.7211.00
302_L306_S0.7211.00
139_N335_I0.7201.00
184_F256_A0.7191.00
26_I246_F0.7191.00
380_L384_K0.7161.00
429_L442_S0.7101.00
141_Y145_S0.7071.00
331_P334_A0.7061.00
388_K394_L0.7031.00
435_I442_S0.7021.00
125_W128_S0.7021.00
139_N303_Y0.7021.00
66_M79_Y0.7001.00
321_R337_A0.6951.00
77_S81_H0.6921.00
59_I412_I0.6921.00
232_V236_T0.6911.00
83_A381_K0.6911.00
429_L443_Y0.6901.00
437_G440_L0.6901.00
400_L405_T0.6881.00
306_S334_A0.6881.00
56_V215_T0.6871.00
61_R404_L0.6861.00
432_T437_G0.6851.00
430_L439_V0.6851.00
47_V51_L0.6841.00
87_W440_L0.6841.00
15_R148_E0.6821.00
262_S265_I0.6821.00
11_E15_R0.6801.00
101_V341_F0.6801.00
327_K332_V0.6761.00
108_A112_A0.6751.00
184_F188_T0.6731.00
412_I415_I0.6731.00
129_L347_V0.6701.00
242_R246_F0.6701.00
147_G151_Y0.6691.00
24_G300_S0.6691.00
307_R310_Y0.6671.00
27_G247_Y0.6651.00
77_S93_G0.6641.00
281_A284_Q0.6631.00
116_Q120_H0.6611.00
436_T439_V0.6601.00
147_G299_N0.6601.00
442_S448_K0.6591.00
219_A236_T0.6571.00
408_T422_I0.6561.00
45_A251_I0.6551.00
402_P405_T0.6551.00
99_F368_A0.6531.00
135_L295_L0.6481.00
213_M216_E0.6461.00
46_V248_V0.6451.00
140_V335_I0.6441.00
24_G301_G0.6431.00
405_T409_I0.6411.00
143_V221_A0.6401.00
384_K388_K0.6401.00
49_Y211_S0.6401.00
63_L375_I0.6391.00
131_L298_L0.6391.00
398_M401_F0.6381.00
117_Y287_N0.6371.00
366_A432_T0.6341.00
224_E331_P0.6321.00
411_A415_I0.6321.00
417_V420_A0.6291.00
156_I160_T0.6281.00
73_S310_Y0.6271.00
202_L418_S0.6241.00
191_G194_F0.6241.00
66_M83_A0.6221.00
118_W288_F0.6221.00
238_S241_W0.6201.00
60_M215_T0.6201.00
95_L371_V0.6181.00
249_G253_I0.6171.00
34_S251_I0.6161.00
223_G310_Y0.6151.00
145_S148_E0.6151.00
43_P255_V0.6151.00
133_I136_T0.6141.00
60_M64_G0.6121.00
269_P274_L0.6121.00
378_S382_M0.6121.00
322_F334_A0.6111.00
132_T343_Y0.6101.00
76_F216_E0.6081.00
388_K393_A0.6071.00
46_V50_A0.6061.00
242_R245_V0.6031.00
134_V138_T0.6021.00
380_L409_I0.6021.00
189_G192_G0.6021.00
115_I131_L0.6001.00
23_A154_S0.6001.00
30_L33_G0.5991.00
269_P277_I0.5951.00
305_T309_L0.5951.00
186_N192_G0.5941.00
15_R18_T0.5941.00
433_G439_V0.5931.00
84_I378_S0.5931.00
367_I371_V0.5921.00
112_A115_I0.5921.00
83_A382_M0.5921.00
253_I256_A0.5911.00
136_T302_L0.5891.00
156_I289_I0.5891.00
439_V447_R0.5891.00
439_V446_F0.5881.00
313_A322_F0.5861.00
167_V171_F0.5861.00
432_T441_I0.5851.00
103_V106_I0.5841.00
95_L370_L0.5841.00
77_S89_G0.5841.00
430_L443_Y0.5831.00
142_S145_S0.5831.00
293_A296_S0.5811.00
64_G68_A0.5811.00
100_W301_G0.5801.00
18_T21_S0.5801.00
398_M404_L0.5801.00
416_L429_L0.5801.00
408_T412_I0.5801.00
266_L269_P0.5781.00
444_L447_R0.5771.00
337_A341_F0.5751.00
151_Y155_L0.5751.00
76_F220_I0.5751.00
44_G193_F0.5731.00
67_S219_A0.5731.00
107_E298_L0.5721.00
405_T408_T0.5711.00
200_S203_L0.5701.00
52_A212_F0.5701.00
107_E110_A0.5681.00
52_A209_I0.5671.00
130_I133_I0.5671.00
75_S219_A0.5671.00
405_T422_I0.5661.00
67_S232_V0.5661.00
33_G361_V0.5661.00
429_L436_T0.5641.00
225_T232_V0.5641.00
325_L328_K0.5631.00
250_S254_V0.5631.00
51_L205_I0.5621.00
8_L11_E0.5621.00
59_I216_E0.5611.00
103_V107_E0.5591.00
22_I154_S0.5581.00
114_I290_V0.5581.00
62_M408_T0.5571.00
102_I363_S0.5571.00
133_I336_V0.5571.00
261_N265_I0.5561.00
32_V35_G0.5551.00
218_V232_V0.5551.00
406_Y409_I0.5551.00
228_P231_S0.5551.00
95_L99_F0.5531.00
40_S203_L0.5521.00
183_G256_A0.5521.00
190_K195_P0.5511.00
347_V350_Y0.5511.00
65_E69_V0.5511.00
145_S149_F0.5511.00
220_I304_T0.5511.00
26_I31_F0.5501.00
288_F292_T0.5481.00
382_M387_E0.5481.00
167_V279_V0.5481.00
285_I289_I0.5461.00
194_F197_G0.5451.00
46_V49_Y0.5451.00
152_W155_L0.5441.00
431_L437_G0.5441.00
105_A342_S0.5431.00
92_I371_V0.5421.00
36_S358_L0.5421.00
434_V439_V0.5411.00
189_G193_F0.5401.00
431_L443_Y0.5401.00
430_L447_R0.5381.00
182_V186_N0.5381.00
427_D430_L0.5351.00
411_A419_M0.5351.00
146_F303_Y0.5351.00
58_F408_T0.5341.00
274_L279_V0.5331.00
229_I393_A0.5331.00
105_A108_A0.5331.00
31_F157_K0.5321.00
172_I257_L0.5321.00
49_Y251_I0.5311.00
107_E294_V0.5311.00
432_T446_F0.5311.00
213_M364_S0.5311.00
225_T235_A0.5291.00
307_R325_L0.5291.00
37_V204_G0.5291.00
117_Y120_H0.5281.00
114_I271_V0.5281.00
358_L361_V0.5271.00
150_E296_S0.5261.00
411_A414_G0.5261.00
435_I440_L0.5251.00
302_L335_I0.5251.00
389_T395_K0.5241.00
269_P273_V0.5231.00
48_S201_V0.5231.00
401_F408_T0.5231.00
110_A114_I0.5231.00
65_E397_K0.5211.00
118_W287_N0.5211.00
397_K402_P0.5211.00
211_S247_Y0.5201.00
216_E372_Y0.5201.00
230_E233_T0.5191.00
19_M154_S0.5191.00
430_L435_I0.5181.00
43_P46_V0.5171.00
190_K193_F0.5161.00
402_P419_M0.5161.00
37_V208_V0.5161.00
194_F198_I0.5151.00
224_E325_L0.5151.00
307_R331_P0.5141.00
429_L441_I0.5141.00
168_G172_I0.5131.00
159_V162_I0.5131.00
409_I412_I0.5121.00
242_R249_G0.5121.00
309_L313_A0.5111.00
344_I347_V0.5111.00
131_L295_L0.5101.00
250_S270_F0.5101.00
105_A345_A0.5101.00
427_D431_L0.5101.00
27_G157_K0.5101.00
27_G31_F0.5091.00
108_A135_L0.5091.00
274_L277_I0.5081.00
57_I241_W0.5081.00
419_M422_I0.5071.00
435_I443_Y0.5061.00
100_W304_T0.5051.00
72_T223_G0.5051.00
22_I25_V0.5051.00
119_F122_I0.5041.00
36_S39_H0.5021.00
427_D432_T0.5021.00
192_G195_P0.5021.00
436_T443_Y0.5021.00
412_I416_L0.5011.00
154_S157_K0.5011.00
241_W244_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.8891 100 0.303 Contact Map
3giaA 1 0.9083 100 0.362 Contact Map
4djkA 2 0.8827 100 0.366 Contact Map
3dh4A 3 0.9211 99.2 0.844 Contact Map
2xq2A 2 0.9211 99.1 0.849 Contact Map
2jlnA 1 0.8763 99 0.858 Contact Map
2a65A 2 0.9147 97.9 0.897 Contact Map
4xp4A 1 0.9296 97.8 0.9 Contact Map
4wgvA 2 0.791 97.8 0.901 Contact Map
4us3A 1 0.8401 96.4 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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