GREMLIN Database
YEAB - Uncharacterized transporter YeaB
UniProt: P46348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 290 (275)
Sequences: 10379 (7263)
Seq/√Len: 438.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
178_W182_V3.3641.00
193_K197_D3.1671.00
247_V282_V2.8761.00
232_K248_V2.8291.00
222_I247_V2.8081.00
219_K223_E2.6821.00
31_I121_T2.4881.00
221_T274_E2.3991.00
221_T275_H2.3751.00
100_F104_E2.3651.00
29_L44_G2.3091.00
99_L185_F2.2521.00
225_I270_R2.2161.00
222_I267_I2.2031.00
69_D76_H2.1881.00
171_A179_I2.1301.00
88_S199_F2.1241.00
140_A149_L2.0691.00
200_K204_H2.0301.00
216_S220_Q2.0021.00
79_A207_T1.9991.00
211_D214_D1.9971.00
120_W124_G1.9921.00
229_S252_S1.9701.00
32_G41_T1.9501.00
269_R273_E1.9441.00
99_L188_G1.9171.00
170_V174_F1.9151.00
256_N259_E1.8901.00
253_A258_T1.8861.00
11_E65_Q1.8641.00
225_I267_I1.8621.00
72_H76_H1.7881.00
78_R208_D1.7791.00
119_A166_F1.7671.00
104_E108_S1.7461.00
221_T270_R1.7401.00
249_V267_I1.7201.00
204_H209_G1.7111.00
217_A274_E1.7021.00
261_H283_H1.6981.00
30_I34_L1.6921.00
196_W200_K1.6901.00
215_I236_A1.6721.00
15_L19_A1.6611.00
225_I266_E1.6511.00
96_L100_F1.6391.00
259_E262_D1.6301.00
230_R250_E1.6201.00
257_I260_S1.6121.00
262_D266_E1.5801.00
98_V184_A1.5681.00
138_R142_K1.5641.00
168_G183_T1.5611.00
137_K141_K1.5591.00
119_A173_Q1.5381.00
103_G107_F1.5221.00
11_E62_R1.5151.00
189_L193_K1.5111.00
185_F189_L1.5071.00
55_V59_I1.5021.00
29_L33_Y1.4911.00
260_S284_M1.4841.00
15_L58_L1.4511.00
102_A184_A1.4441.00
116_M120_W1.4391.00
270_R274_E1.4281.00
46_N154_D1.4231.00
149_L201_E1.4031.00
130_L134_R1.4011.00
170_V173_Q1.4001.00
74_Y246_D1.3881.00
22_L51_I1.3881.00
266_E270_R1.3791.00
119_A170_V1.3751.00
164_G183_T1.3721.00
236_A245_V1.3721.00
217_A221_T1.3671.00
137_K152_A1.3631.00
232_K285_E1.3611.00
123_A127_V1.3541.00
197_D200_K1.3511.00
20_A128_L1.3441.00
220_Q224_K1.3381.00
178_W181_T1.2721.00
16_V135_Y1.2701.00
69_D72_H1.2511.00
35_F118_A1.2311.00
123_A166_F1.2281.00
251_V257_I1.2251.00
60_G83_A1.2241.00
264_A268_E1.2231.00
223_E230_R1.2221.00
215_I219_K1.2181.00
95_G192_C1.2071.00
127_V131_I1.2071.00
97_Q100_F1.2041.00
251_V263_I1.2031.00
131_I134_R1.1961.00
126_A166_F1.1901.00
28_K47_N1.1891.00
38_E102_A1.1881.00
106_I181_T1.1851.00
134_R138_R1.1761.00
216_S219_K1.1641.00
32_G44_G1.1611.00
25_S48_T1.1601.00
217_A275_H1.1601.00
234_I247_V1.1561.00
63_I79_A1.1541.00
258_T262_D1.1441.00
264_A283_H1.1421.00
92_M195_A1.1401.00
248_V285_E1.1371.00
227_G259_E1.1341.00
119_A169_I1.1241.00
77_F242_T1.1231.00
268_E272_K1.1211.00
208_D244_H1.1101.00
20_A132_V1.1021.00
225_I263_I1.0981.00
257_I284_M1.0851.00
19_A23_V1.0841.00
176_L179_I1.0831.00
71_D76_H1.0781.00
235_K279_Y1.0761.00
106_I178_W1.0751.00
224_K270_R1.0691.00
72_H204_H1.0681.00
261_H264_A1.0651.00
139_L142_K1.0641.00
264_A284_M1.0611.00
56_A83_A1.0571.00
62_R65_Q1.0501.00
24_L28_K1.0481.00
217_A220_Q1.0451.00
232_K250_E1.0401.00
120_W123_A1.0401.00
245_V280_S1.0381.00
151_A154_D1.0381.00
18_I51_I1.0381.00
63_I66_K1.0371.00
118_A169_I1.0351.00
140_A143_V1.0301.00
92_M96_L1.0291.00
99_L103_G1.0251.00
25_S29_L1.0241.00
25_S44_G1.0241.00
245_V277_I1.0221.00
131_I135_Y1.0211.00
268_E283_H1.0211.00
101_S104_E1.0151.00
29_L41_T1.0121.00
81_T205_S1.0091.00
88_S198_I1.0061.00
12_S16_V1.0051.00
221_T225_I1.0041.00
221_T224_K1.0001.00
92_M196_W0.9911.00
115_D173_Q0.9881.00
254_D258_T0.9881.00
152_A156_K0.9871.00
260_S264_A0.9841.00
92_M192_C0.9831.00
122_A166_F0.9711.00
24_L128_L0.9711.00
134_R137_K0.9681.00
261_H286_P0.9651.00
17_S132_V0.9591.00
218_Y271_M0.9501.00
163_I167_I0.9471.00
139_L143_V0.9461.00
43_D162_S0.9461.00
271_M277_I0.9451.00
38_E105_S0.9411.00
106_I185_F0.9391.00
38_E184_A0.9371.00
218_Y236_A0.9351.00
102_A185_F0.9251.00
18_I58_L0.9251.00
33_Y41_T0.9231.00
57_V147_A0.9191.00
133_Y152_A0.9131.00
18_I55_V0.9111.00
223_E231_L0.9101.00
43_D46_N0.9081.00
265_N269_R0.9071.00
133_Y137_K0.9061.00
101_S105_S0.9041.00
112_E115_D0.9021.00
82_I207_T0.8961.00
89_F93_V0.8951.00
231_L234_I0.8941.00
26_A30_I0.8941.00
208_D239_L0.8901.00
57_V150_A0.8871.00
227_G263_I0.8831.00
251_V260_S0.8821.00
251_V284_M0.8721.00
59_I63_I0.8711.00
103_G185_F0.8691.00
233_D279_Y0.8591.00
220_Q223_E0.8531.00
228_V249_V0.8501.00
239_L244_H0.8481.00
168_G179_I0.8431.00
214_D243_V0.8421.00
104_E107_F0.8421.00
210_F214_D0.8411.00
117_I120_W0.8291.00
13_G135_Y0.8281.00
141_K144_K0.8281.00
116_M173_Q0.8281.00
233_D248_V0.8271.00
182_V186_V0.8261.00
125_G129_M0.8221.00
227_G266_E0.8171.00
260_S263_I0.8171.00
222_I231_L0.8151.00
109_A112_E0.8151.00
272_K278_D0.8121.00
205_S238_Y0.8091.00
132_V155_N0.8081.00
271_M280_S0.8081.00
270_R273_E0.8041.00
140_A152_A0.8021.00
130_L156_K0.8011.00
27_I124_G0.7991.00
208_D237_R0.7921.00
264_A282_V0.7881.00
46_N50_D0.7881.00
80_E145_S0.7861.00
93_V97_Q0.7851.00
231_L247_V0.7821.00
38_E101_S0.7781.00
22_L26_A0.7761.00
104_E110_K0.7761.00
212_I216_S0.7731.00
21_Y47_N0.7651.00
266_E269_R0.7641.00
97_Q101_S0.7601.00
228_V231_L0.7601.00
218_Y245_V0.7591.00
49_T94_V0.7591.00
219_K231_L0.7571.00
210_F243_V0.7531.00
179_I183_T0.7531.00
74_Y237_R0.7471.00
29_L48_T0.7411.00
238_Y243_V0.7401.00
61_L147_A0.7391.00
78_R237_R0.7381.00
129_M132_V0.7361.00
119_A123_A0.7351.00
85_L89_F0.7331.00
265_N268_E0.7321.00
126_A163_I0.7321.00
85_L202_S0.7301.00
85_L199_F0.7281.00
261_H285_E0.7271.00
28_K44_G0.7261.00
11_E58_L0.7251.00
268_E280_S0.7191.00
154_D158_D0.7191.00
157_S194_T0.7191.00
59_I62_R0.7171.00
110_K113_T0.7171.00
27_I121_T0.7151.00
13_G139_L0.7151.00
133_Y156_K0.7131.00
235_K246_D0.7111.00
190_L194_T0.7101.00
260_S286_P0.7061.00
146_Q205_S0.7051.00
13_G138_R0.7001.00
25_S47_N0.7001.00
82_I203_S0.6981.00
263_I267_I0.6941.00
135_Y139_L0.6941.00
33_Y44_G0.6921.00
183_T187_I0.6921.00
37_S180_D0.6901.00
25_S51_I0.6861.00
272_K280_S0.6851.00
11_E15_L0.6851.00
210_F236_A0.6851.00
93_V100_F0.6851.00
82_I86_I0.6761.00
277_I280_S0.6731.00
238_Y241_S0.6721.00
15_L18_I0.6711.00
39_A183_T0.6701.00
64_S80_E0.6671.00
153_A156_K0.6651.00
150_A198_I0.6611.00
84_S147_A0.6611.00
96_L192_C0.6601.00
102_A188_G0.6571.00
53_A90_I0.6541.00
53_A57_V0.6530.99
222_I249_V0.6530.99
71_D204_H0.6520.99
227_G252_S0.6480.99
141_K149_L0.6470.99
136_N151_A0.6460.99
267_I270_R0.6460.99
138_R141_K0.6460.99
30_I33_Y0.6440.99
146_Q201_E0.6410.99
48_T52_I0.6400.99
95_G195_A0.6400.99
267_I282_V0.6390.99
149_L153_A0.6380.99
21_Y50_D0.6370.99
17_S136_N0.6350.99
132_V136_N0.6350.99
28_K43_D0.6340.99
58_L62_R0.6300.99
129_M136_N0.6290.99
193_K196_W0.6260.99
249_V284_M0.6240.99
186_V190_L0.6220.99
259_E266_E0.6210.99
261_H265_N0.6210.99
114_P117_I0.6210.99
46_N91_M0.6210.99
222_I225_I0.6190.99
19_A22_L0.6190.99
73_P235_K0.6170.99
234_I245_V0.6150.99
108_S111_Q0.6150.99
17_S155_N0.6100.99
35_F117_I0.6100.99
84_S198_I0.6090.99
246_D279_Y0.6040.99
128_L132_V0.6040.99
32_G35_F0.6020.99
88_S202_S0.5970.99
132_V135_Y0.5930.99
130_L159_A0.5930.99
105_S110_K0.5920.99
14_A57_V0.5920.99
85_L206_L0.5890.99
160_F163_I0.5860.99
171_A174_F0.5860.99
154_D157_S0.5840.99
156_K160_F0.5810.99
271_M282_V0.5800.99
66_K76_H0.5790.99
31_I117_I0.5770.99
133_Y155_N0.5750.99
269_R272_K0.5750.99
183_T186_V0.5750.99
124_G128_L0.5720.99
264_A267_I0.5720.99
94_V97_Q0.5720.99
222_I228_V0.5690.99
17_S54_S0.5650.99
137_K156_K0.5640.99
84_S202_S0.5620.98
137_K140_A0.5610.98
209_G212_I0.5600.98
54_S151_A0.5590.98
139_L148_L0.5560.98
16_V19_A0.5520.98
21_Y51_I0.5510.98
111_Q177_A0.5510.98
52_I55_V0.5480.98
122_A125_G0.5470.98
53_A154_D0.5460.98
203_S207_T0.5460.98
165_T168_G0.5450.98
161_V164_G0.5450.98
74_Y235_K0.5450.98
85_L203_S0.5450.98
283_H286_P0.5450.98
79_A83_A0.5440.98
214_D217_A0.5390.98
126_A130_L0.5390.98
175_H178_W0.5380.98
161_V165_T0.5360.98
190_L193_K0.5360.98
164_G187_I0.5350.98
14_A18_I0.5340.98
118_A172_A0.5340.98
38_E41_T0.5340.98
149_L152_A0.5330.98
272_K279_Y0.5290.98
101_S185_F0.5290.98
24_L27_I0.5280.98
129_M155_N0.5260.98
120_W127_V0.5240.98
245_V278_D0.5240.98
16_V20_A0.5220.98
218_Y275_H0.5210.98
62_R66_K0.5200.98
102_A181_T0.5180.97
56_A86_I0.5170.97
67_P76_H0.5160.97
136_N155_N0.5150.97
157_S198_I0.5150.97
25_S45_L0.5130.97
254_D259_E0.5110.97
229_S251_V0.5110.97
17_S151_A0.5090.97
83_A147_A0.5090.97
40_L122_A0.5080.97
201_E204_H0.5050.97
226_S266_E0.5050.97
18_I54_S0.5040.97
262_D265_N0.5020.97
225_I282_V0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3j1zP 8 1 100 0.108 Contact Map
3h90A 3 0.9724 100 0.119 Contact Map
2zztA 2 0.2724 99.5 0.758 Contact Map
3bypA 2 0.2724 99.5 0.761 Contact Map
3w61A 2 0.2724 99.4 0.772 Contact Map
3cq1A 2 0.2621 29 0.949 Contact Map
3lnoA 1 0.2828 27.4 0.95 Contact Map
3ne5A 3 0.431 24.5 0.951 Contact Map
3w9iA 3 0.3897 22.2 0.952 Contact Map
4mt1A 3 0.3862 21.3 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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