GREMLIN Database
YBEY - Endoribonuclease YbeY
UniProt: P46347 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 157 (133)
Sequences: 3746 (2648)
Seq/√Len: 229.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_H62_D3.1671.00
48_N97_S3.1341.00
48_N103_E2.5581.00
142_F145_Q2.4201.00
33_E144_K2.4111.00
52_H63_A2.3161.00
100_R103_E2.2521.00
53_Q57_E2.2461.00
48_N100_R2.1591.00
56_K62_D2.1491.00
52_H56_K2.0891.00
45_I98_A2.0691.00
48_N99_D1.9431.00
66_D104_Q1.7891.00
44_T95_I1.7151.00
133_M137_E1.7031.00
22_V43_V1.6841.00
134_T137_E1.6731.00
28_F151_A1.6561.00
52_H64_P1.6491.00
46_V50_D1.6181.00
26_L124_F1.5971.00
46_V51_I1.5731.00
54_I95_I1.5551.00
101_T119_L1.5521.00
146_K150_D1.5451.00
114_R154_L1.5321.00
54_I68_I1.4991.00
96_I120_A1.4821.00
102_R112_F1.4801.00
101_T116_L1.4761.00
138_E142_F1.4601.00
144_K147_E1.4521.00
143_T147_E1.4351.00
50_D53_Q1.4341.00
46_V95_I1.4141.00
66_D115_E1.4091.00
51_I64_P1.4081.00
32_R147_E1.4031.00
96_I101_T1.3991.00
32_R151_A1.3771.00
104_Q115_E1.3511.00
22_V120_A1.3491.00
118_F138_E1.3001.00
117_G154_L1.2841.00
21_E113_K1.2561.00
30_A124_F1.2501.00
73_E89_P1.2461.00
23_E27_Q1.2401.00
97_S100_R1.2241.00
118_F145_Q1.2221.00
71_A74_E1.2101.00
29_A121_V1.2071.00
101_T112_F1.2061.00
19_L23_E1.1841.00
42_S93_D1.1841.00
98_A102_R1.1771.00
44_T50_D1.1621.00
111_S114_R1.1491.00
67_V94_I1.1431.00
102_R106_E1.1291.00
47_S50_D1.1111.00
103_E107_E1.0691.00
69_S92_G1.0211.00
55_N59_R1.0201.00
139_E143_T1.0201.00
61_K68_I1.0111.00
104_Q110_H1.0071.00
140_E144_K0.9861.00
26_L120_A0.9731.00
72_L90_V0.9591.00
21_E24_N0.9551.00
130_Y144_K0.9521.00
121_V148_L0.9481.00
147_E151_A0.9461.00
118_F142_F0.9391.00
21_E25_L0.9381.00
135_K139_E0.9371.00
98_A116_L0.9371.00
20_K24_N0.9361.00
27_Q31_E0.9301.00
64_P97_S0.9241.00
55_N61_K0.9221.00
41_V124_F0.9010.99
25_L117_G0.8970.99
28_F152_Y0.8830.99
29_A124_F0.8800.99
45_I116_L0.8780.99
43_V94_I0.8770.99
69_S127_L0.8750.99
43_V120_A0.8710.99
24_N28_F0.8700.99
52_H61_K0.8590.99
26_L30_A0.8570.99
25_L152_Y0.8560.99
110_H115_E0.8470.99
75_E78_G0.8420.99
28_F32_R0.8400.99
71_A75_E0.8400.99
64_P100_R0.8370.99
48_N64_P0.8370.99
130_Y140_E0.8350.99
21_E117_G0.8290.99
66_D110_H0.8270.99
44_T93_D0.8210.99
40_E90_V0.8150.99
59_R68_I0.8130.99
112_F116_L0.8110.99
138_E145_Q0.8070.99
47_S99_D0.8060.99
59_R63_A0.8030.99
115_E118_F0.7980.99
32_R148_L0.7930.99
91_L128_L0.7880.99
71_A123_G0.7820.98
71_A93_D0.7800.98
67_V123_G0.7790.98
92_G127_L0.7750.98
102_R105_A0.7710.98
114_R153_G0.7590.98
69_S91_L0.7550.98
124_F128_L0.7530.98
135_K138_E0.7480.98
51_I97_S0.7460.98
54_I58_Y0.7460.98
51_I65_T0.7450.98
66_D142_F0.7330.98
22_V116_L0.7320.98
68_I71_A0.7290.98
66_D118_F0.7180.97
104_Q118_F0.7180.97
33_E148_L0.7130.97
33_E130_Y0.7120.97
143_T146_K0.7080.97
51_I94_I0.7080.97
58_Y70_F0.7070.97
118_F146_K0.7050.97
28_F31_E0.7020.97
67_V119_L0.6980.97
51_I63_A0.6960.97
26_L43_V0.6940.97
55_N62_D0.6900.97
110_H118_F0.6880.97
46_V97_S0.6820.96
120_A124_F0.6770.96
114_R118_F0.6720.96
51_I95_I0.6560.96
39_A89_P0.6550.96
18_M21_E0.6460.95
33_E128_L0.6430.95
66_D146_K0.6420.95
146_K149_L0.6420.95
121_V149_L0.6400.95
125_L148_L0.6330.95
72_L91_L0.6270.94
144_K148_L0.6250.94
51_I100_R0.6240.94
94_I123_G0.6230.94
106_E112_F0.6200.94
125_L141_M0.6150.94
121_V125_L0.6080.93
67_V101_T0.6070.93
53_Q56_K0.6050.93
147_E150_D0.5990.93
22_V45_I0.5980.93
24_N113_K0.5970.93
110_H114_R0.5960.93
55_N68_I0.5960.93
26_L41_V0.5940.93
149_L154_L0.5910.92
56_K63_A0.5910.92
72_L127_L0.5900.92
105_A111_S0.5800.92
35_V39_A0.5730.91
106_E109_N0.5720.91
113_K154_L0.5690.91
90_V95_I0.5660.91
29_A33_E0.5600.90
134_T139_E0.5500.90
42_S90_V0.5440.89
22_V25_L0.5400.89
29_A148_L0.5310.88
75_E89_P0.5270.87
136_E139_E0.5270.87
118_F149_L0.5250.87
59_R132_H0.5200.87
61_K132_H0.5200.87
137_E140_E0.5190.87
119_L132_H0.5180.87
25_L121_V0.5170.86
51_I96_I0.5160.86
104_Q119_L0.5140.86
13_S16_E0.5130.86
71_A133_M0.5100.86
71_A91_L0.5080.85
25_L120_A0.5070.85
28_F148_L0.5050.85
54_I94_I0.5040.85
139_E142_F0.5000.85
63_A100_R0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xm5A 1 0.9363 100 0.14 Contact Map
1xaxA 1 0.9045 100 0.14 Contact Map
1oz9A 1 0.8917 100 0.161 Contact Map
1tviA 1 0.8662 100 0.195 Contact Map
1lmlA 1 0.8535 67.2 0.913 Contact Map
1hv5A 2 0.8535 61.4 0.916 Contact Map
3ayuA 1 0.8471 56.7 0.918 Contact Map
4in9A 1 0.8471 51.8 0.921 Contact Map
1g9kA 3 0.8344 51 0.921 Contact Map
1k7iA 1 0.879 50.1 0.922 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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