GREMLIN Database
PHOL - PhoH-like protein
UniProt: P46343 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 319 (305)
Sequences: 3599 (1947)
Seq/√Len: 111.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
126_A293_S6.8441.00
233_Y261_I4.4661.00
299_Q313_E4.3231.00
244_P281_V3.5031.00
283_K296_E3.4401.00
161_K231_D3.3871.00
254_L260_M3.2761.00
283_K294_M3.2751.00
132_L307_L3.2731.00
145_Y200_D3.2171.00
165_L194_L3.1321.00
291_G310_K3.0841.00
21_L70_I2.8181.00
130_N293_S2.7981.00
60_D64_G2.7321.00
269_I280_A2.7001.00
153_H157_N2.6611.00
128_K150_K2.5621.00
231_D257_G2.4051.00
119_G297_L2.4001.00
136_I283_K2.3911.00
121_R125_A2.3901.00
131_D259_K2.3801.00
234_V258_S2.3631.00
130_N291_G2.3401.00
27_S78_E2.2291.00
287_K296_E2.2061.00
236_L250_F2.2051.00
38_L59_A2.2031.00
38_L49_V2.1631.00
132_L262_I2.1531.00
306_P310_K2.1401.00
126_A295_I2.1091.00
134_F294_M2.0711.00
52_D55_S2.0561.00
266_V280_A2.0141.00
31_L82_I1.9951.00
49_V60_D1.9851.00
234_V260_M1.9381.00
36_L59_A1.9351.00
183_L223_Y1.9011.00
132_L292_I1.8971.00
154_A159_H1.8951.00
123_Y135_G1.8761.00
102_E128_K1.8521.00
182_D185_E1.8281.00
66_L84_A1.8111.00
125_A129_R1.7771.00
289_I310_K1.7291.00
127_M233_Y1.7131.00
127_M150_K1.7061.00
155_L215_I1.7041.00
199_H207_T1.6931.00
276_K284_E1.6911.00
77_S80_D1.6861.00
310_K313_E1.6751.00
135_G297_L1.6501.00
124_V150_K1.6481.00
66_L81_V1.5881.00
36_L85_I1.5721.00
281_V285_M1.5691.00
96_F100_Y1.5611.00
35_D85_I1.5561.00
49_V56_F1.5551.00
148_V235_I1.5541.00
57_Q60_D1.5501.00
14_N17_E1.5421.00
136_I294_M1.4821.00
22_F42_T1.4801.00
208_E212_E1.4791.00
49_V59_A1.4681.00
17_E70_I1.4641.00
26_D30_K1.4621.00
149_V201_V1.4591.00
92_E95_Y1.4541.00
17_E71_R1.4371.00
210_L215_I1.4031.00
136_I296_E1.4031.00
115_V121_R1.3871.00
20_S70_I1.3751.00
127_M135_G1.3731.00
115_V124_V1.3701.00
290_D310_K1.3551.00
32_M62_L1.3531.00
174_E246_Q1.3311.00
127_M261_I1.3261.00
96_F99_M1.3171.00
18_A22_F1.3141.00
110_G124_V1.2910.99
62_L84_A1.2770.99
136_I266_V1.2490.99
59_A62_L1.2470.99
194_L235_I1.2430.99
32_M85_I1.2310.99
151_A233_Y1.2300.99
64_G68_A1.2250.99
136_I267_S1.2080.99
122_E125_A1.2030.99
116_K256_F1.2010.99
231_D256_F1.1930.99
166_T219_A1.1850.99
17_E67_L1.1830.99
51_G56_F1.1750.99
127_M259_K1.1740.99
66_L70_I1.1640.99
162_K232_A1.1600.99
94_E98_S1.1600.99
130_N154_A1.1520.99
41_I50_S1.1460.99
12_L67_L1.1380.99
206_H209_R1.1330.99
79_R83_Y1.1150.98
116_K166_T1.1130.98
103_E114_R1.0970.98
203_G207_T1.0920.98
24_N27_S1.0810.98
64_G67_L1.0800.98
151_A163_I1.0760.98
111_K231_D1.0750.98
196_D227_R1.0730.98
110_G153_H1.0700.98
187_V203_G1.0670.98
58_I89_K1.0640.98
32_M63_L1.0640.98
47_I63_L1.0620.98
299_Q316_D1.0560.98
127_M133_V1.0560.98
123_Y146_L1.0500.98
199_H208_E1.0450.97
205_D209_R1.0370.97
22_F47_I1.0360.97
84_A87_M1.0330.97
39_N50_S1.0290.97
33_E36_L1.0290.97
93_L96_F1.0280.97
266_V283_K1.0140.97
69_L74_I1.0130.97
254_L307_L1.0060.97
194_L263_T1.0020.97
59_A63_L0.9950.97
127_M154_A0.9940.97
163_I194_L0.9930.97
57_Q61_R0.9830.96
98_S101_E0.9820.96
20_S75_E0.9810.96
245_A275_V0.9780.96
40_I63_L0.9770.96
12_L18_A0.9770.96
133_V295_I0.9760.96
133_V293_S0.9650.96
72_K76_I0.9600.96
178_F191_L0.9570.96
63_L70_I0.9570.96
244_P276_K0.9500.96
40_I49_V0.9430.95
63_L67_L0.9430.95
151_A165_L0.9380.95
80_D84_A0.9370.95
198_L216_I0.9330.95
62_L81_V0.9250.95
281_V284_E0.9240.95
65_S69_L0.9230.95
76_I80_D0.9220.95
26_D206_H0.9180.95
190_Y222_A0.9170.95
133_V185_E0.9160.95
276_K281_V0.9150.95
207_T211_M0.9140.95
42_T47_I0.9130.94
150_K154_A0.9100.94
25_Q28_F0.9100.94
33_E209_R0.9100.94
53_D57_Q0.9090.94
286_L292_I0.9060.94
147_A263_T0.9030.94
204_A208_E0.9020.94
118_M121_R0.9010.94
35_D89_K0.8990.94
37_N55_S0.8950.94
283_K287_K0.8940.94
280_A284_E0.8940.94
176_L190_Y0.8930.94
113_I201_V0.8900.94
126_A130_N0.8890.94
67_L71_R0.8810.93
154_A233_Y0.8800.93
154_A157_N0.8790.93
152_V201_V0.8710.93
148_V197_A0.8700.93
126_A133_V0.8690.93
61_R65_S0.8680.93
125_A128_K0.8660.93
12_L17_E0.8650.93
22_F29_L0.8620.93
117_T297_L0.8550.92
168_P221_L0.8540.92
61_R93_L0.8540.92
224_M246_Q0.8540.92
131_D291_G0.8540.92
282_A315_Y0.8460.92
171_E222_A0.8430.92
58_I88_A0.8390.92
131_D290_D0.8370.92
202_L210_L0.8340.91
33_E38_L0.8300.91
195_Y199_H0.8250.91
234_V254_L0.8240.91
39_N65_S0.8230.91
148_V202_L0.8200.91
230_D256_F0.8150.90
65_S68_A0.8110.90
95_Y98_S0.8040.90
168_P220_P0.7990.90
81_V85_I0.7990.90
183_L220_P0.7990.90
84_A88_A0.7940.89
282_A285_M0.7860.89
166_T309_A0.7850.89
92_E96_F0.7830.89
26_D42_T0.7800.88
94_E97_E0.7800.88
81_V84_A0.7760.88
61_R64_G0.7750.88
24_N30_K0.7750.88
25_Q42_T0.7720.88
119_G122_E0.7710.88
152_V198_L0.7670.88
62_L88_A0.7670.88
264_G279_L0.7640.87
144_T307_L0.7630.87
269_I274_G0.7610.87
72_K97_E0.7610.87
162_K199_H0.7490.86
70_I76_I0.7470.86
287_K310_K0.7430.86
118_M122_E0.7420.86
87_M118_M0.7390.86
48_Y53_D0.7380.85
31_L34_K0.7310.85
58_I61_R0.7270.85
89_K95_Y0.7270.85
83_Y87_M0.7260.85
184_K260_M0.7230.84
313_E316_D0.7230.84
25_Q32_M0.7220.84
97_E100_Y0.7170.84
74_I80_D0.7150.84
175_S297_L0.7150.84
11_K45_E0.7150.84
76_I82_I0.7140.84
174_E224_M0.7130.83
105_T153_H0.7110.83
11_K14_N0.7090.83
189_P252_T0.7070.83
60_D67_L0.7040.83
309_A313_E0.6970.82
90_K300_T0.6900.81
78_E81_V0.6890.81
41_I48_Y0.6890.81
147_A261_I0.6870.81
114_R210_L0.6860.81
55_S58_I0.6850.81
66_L76_I0.6840.81
148_V207_T0.6830.81
145_Y197_A0.6830.81
18_A42_T0.6810.81
68_A97_E0.6800.80
99_M102_E0.6770.80
19_L45_E0.6760.80
60_D63_L0.6720.80
16_D19_L0.6710.80
295_I298_D0.6700.79
168_P265_D0.6690.79
166_T203_G0.6690.79
96_F103_E0.6680.79
285_M289_I0.6680.79
115_V156_K0.6670.79
61_R88_A0.6660.79
247_M251_L0.6650.79
147_A176_L0.6640.79
91_N94_E0.6620.79
195_Y222_A0.6600.78
96_F102_E0.6560.78
182_D203_G0.6550.78
247_M262_I0.6550.78
166_T170_V0.6550.78
87_M92_E0.6550.78
106_K153_H0.6540.78
280_A283_K0.6490.77
87_M90_K0.6490.77
180_P189_P0.6480.77
290_D306_P0.6470.77
184_K188_D0.6420.77
113_I116_K0.6410.76
102_E121_R0.6400.76
284_E287_K0.6400.76
200_D230_D0.6380.76
27_S75_E0.6350.76
141_T312_I0.6330.76
34_K290_D0.6330.76
293_S296_E0.6310.75
58_I101_E0.6310.75
169_A191_L0.6300.75
88_A93_L0.6300.75
91_N97_E0.6300.75
275_V316_D0.6290.75
26_D41_I0.6280.75
130_N159_H0.6270.75
34_K82_I0.6260.75
119_G156_K0.6260.75
121_R124_V0.6240.74
107_N110_G0.6230.74
68_A71_R0.6230.74
302_V312_I0.6220.74
199_H214_G0.6210.74
79_R82_I0.6200.74
129_R293_S0.6160.74
225_R270_D0.6140.73
62_L85_I0.6130.73
30_K33_E0.6120.73
173_G217_E0.6110.73
116_K231_D0.6080.73
109_K161_K0.6070.72
86_K117_T0.6070.72
245_A267_S0.6050.72
124_V128_K0.6050.72
82_I86_K0.6030.72
22_F112_S0.6020.72
110_G297_L0.5990.71
114_R154_A0.5980.71
83_Y116_K0.5950.71
94_E101_E0.5950.71
158_G231_D0.5940.71
27_S31_L0.5930.71
58_I63_L0.5900.70
297_L300_T0.5890.70
273_K276_K0.5890.70
141_T262_I0.5890.70
291_G306_P0.5890.70
19_L39_N0.5880.70
119_G298_D0.5880.70
280_A297_L0.5870.70
65_S84_A0.5870.70
48_Y55_S0.5870.70
251_L282_A0.5850.70
244_P312_I0.5840.70
92_E98_S0.5830.69
86_K90_K0.5830.69
106_K112_S0.5830.69
134_F242_T0.5820.69
43_R194_L0.5820.69
284_E296_E0.5810.69
201_V211_M0.5800.69
128_K153_H0.5800.69
38_L55_S0.5790.69
269_I272_P0.5780.69
281_V315_Y0.5780.69
266_V282_A0.5770.69
65_S95_Y0.5750.68
243_T246_Q0.5740.68
222_A229_L0.5740.68
31_L81_V0.5740.68
30_K156_K0.5730.68
83_Y309_A0.5720.68
138_P174_E0.5720.68
188_D219_A0.5710.68
178_F182_D0.5700.68
244_P285_M0.5690.68
93_L115_V0.5660.67
223_Y299_Q0.5650.67
199_H245_A0.5640.67
50_S57_Q0.5640.67
290_D300_T0.5630.67
207_T210_L0.5630.67
229_L232_A0.5620.67
155_L218_I0.5610.67
16_D54_E0.5600.66
12_L47_I0.5600.66
57_Q99_M0.5590.66
127_M151_A0.5580.66
64_G129_R0.5570.66
233_Y258_S0.5560.66
203_G223_Y0.5530.65
187_V190_Y0.5530.65
141_T302_V0.5520.65
171_E190_Y0.5500.65
19_L214_G0.5490.65
16_D67_L0.5490.65
90_K95_Y0.5480.65
86_K273_K0.5470.65
182_D220_P0.5470.65
22_F153_H0.5470.65
29_L189_P0.5420.64
224_M236_L0.5410.64
115_V118_M0.5410.64
53_D56_F0.5390.63
82_I85_I0.5380.63
267_S316_D0.5380.63
115_V146_L0.5350.63
138_P224_M0.5340.63
68_A77_S0.5330.63
25_Q46_T0.5320.62
145_Y149_V0.5320.62
65_S105_T0.5300.62
61_R276_K0.5290.62
171_E174_E0.5290.62
102_E290_D0.5270.62
43_R200_D0.5260.62
32_M35_D0.5250.61
75_E99_M0.5250.61
266_V284_E0.5250.61
236_L246_Q0.5240.61
246_Q277_S0.5240.61
175_S184_K0.5240.61
174_E222_A0.5230.61
94_E99_M0.5230.61
183_L217_E0.5220.61
154_A160_I0.5210.61
168_P192_R0.5210.61
11_K46_T0.5210.61
167_R227_R0.5210.61
37_N122_E0.5210.61
211_M218_I0.5200.61
51_G314_A0.5190.61
84_A187_V0.5190.61
188_D228_T0.5190.61
78_E95_Y0.5180.60
31_L35_D0.5160.60
64_G94_E0.5160.60
192_R217_E0.5160.60
127_M146_L0.5160.60
145_Y201_V0.5130.60
26_D114_R0.5130.60
117_T166_T0.5130.60
262_I282_A0.5130.60
169_A222_A0.5120.60
26_D119_G0.5120.60
153_H156_K0.5110.59
106_K113_I0.5090.59
285_M312_I0.5090.59
57_Q77_S0.5090.59
62_L65_S0.5080.59
244_P275_V0.5080.59
21_L49_V0.5070.59
164_I232_A0.5060.59
82_I213_R0.5060.59
20_S39_N0.5060.59
69_L80_D0.5060.59
134_F171_E0.5030.58
117_T200_D0.5030.58
174_E277_S0.5020.58
45_E300_T0.5020.58
61_R98_S0.5020.58
98_S121_R0.5010.58
179_L227_R0.5010.58
24_N42_T0.5000.58
124_V146_L0.5000.58
262_I293_S0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b85A 3 0.5893 100 0.736 Contact Map
3upuA 1 0.5893 99.7 0.836 Contact Map
3e1sA 1 0.8276 99.6 0.851 Contact Map
3lfuA 1 0.6395 99.6 0.851 Contact Map
4c2uA 1 0.6458 99.6 0.852 Contact Map
1w36D 1 0.906 99.5 0.865 Contact Map
4c2tA 1 0.652 99.5 0.865 Contact Map
2wjyA 1 0.9498 99.5 0.866 Contact Map
2gk6A 1 0.931 99.4 0.868 Contact Map
4pj3A 1 0.9091 99.4 0.868 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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