GREMLIN Database
IOLR - HTH-type transcriptional regulator IolR
UniProt: P46337 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 251 (245)
Sequences: 7685 (5687)
Seq/√Len: 363.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_D166_K3.2121.00
83_Y86_R3.0831.00
105_I204_L3.0211.00
135_N142_N2.7141.00
167_A198_A2.5661.00
12_Y27_V2.3521.00
195_S219_A2.2261.00
97_D191_K2.2081.00
107_D127_A2.1961.00
207_H230_S2.1851.00
160_D193_R2.1271.00
89_E92_D2.0851.00
12_Y16_H2.0761.00
202_Y226_C2.0731.00
8_E11_E2.0421.00
166_K202_Y2.0341.00
195_S201_V1.9981.00
82_H108_T1.9941.00
78_T104_S1.9751.00
95_F164_I1.9561.00
217_T220_P1.9281.00
157_A160_D1.9011.00
233_L238_T1.8931.00
166_K200_E1.8781.00
90_D113_K1.8451.00
96_I102_T1.8411.00
95_F194_I1.8181.00
200_E226_C1.7901.00
238_T242_N1.7741.00
104_S107_D1.7641.00
118_L164_I1.7181.00
220_P223_R1.6731.00
157_A161_K1.6411.00
164_I194_I1.6341.00
84_A168_F1.6181.00
84_A204_L1.6171.00
193_R196_E1.6031.00
156_P189_E1.5951.00
125_I138_I1.5871.00
138_I150_F1.5841.00
165_N199_K1.5571.00
105_I168_F1.5491.00
73_H208_S1.5351.00
18_T56_T1.5311.00
139_I158_M1.5141.00
180_L203_L1.5061.00
160_D196_E1.5041.00
117_I128_A1.4931.00
180_L224_L1.4901.00
85_S108_T1.4861.00
73_H76_E1.4721.00
24_L35_V1.4701.00
30_V35_V1.4691.00
6_I45_K1.4571.00
139_I150_F1.4351.00
155_D190_I1.4341.00
14_L57_S1.4231.00
78_T108_T1.4211.00
81_A108_T1.4201.00
39_I55_V1.4181.00
16_H23_E1.4091.00
8_E12_Y1.4071.00
12_Y19_V1.4061.00
87_F228_V1.4031.00
239_Q243_E1.3961.00
49_E58_I1.3961.00
193_R197_K1.3951.00
98_S149_S1.3771.00
9_M24_L1.3761.00
203_L224_L1.3761.00
87_F202_Y1.3711.00
7_Q11_E1.3631.00
90_D112_A1.3531.00
92_D165_N1.3481.00
117_I134_I1.3481.00
143_Y150_F1.3451.00
207_H232_P1.3421.00
76_E230_S1.3191.00
88_I109_L1.3151.00
20_S23_E1.3141.00
10_E47_A1.3131.00
6_I41_K1.3121.00
74_Q104_S1.3121.00
90_D114_N1.3101.00
22_D32_K1.3081.00
142_N186_L1.3071.00
139_I155_D1.2881.00
174_T210_F1.2811.00
219_A223_R1.2761.00
234_D237_Y1.2721.00
51_V54_G1.2711.00
200_E225_H1.2621.00
235_D239_Q1.2501.00
77_K100_T1.2361.00
78_T107_D1.2341.00
95_F197_K1.2341.00
13_I48_I1.2321.00
91_H114_N1.2301.00
8_E28_F1.2281.00
116_T137_I1.2251.00
83_Y87_F1.2071.00
106_L128_A1.1931.00
13_I57_S1.1921.00
8_E27_V1.1861.00
40_N44_E1.1781.00
210_F233_L1.1771.00
168_F202_Y1.1701.00
239_Q242_N1.1671.00
171_A205_A1.1611.00
74_Q78_T1.1611.00
196_E223_R1.1581.00
33_N37_R1.1481.00
175_T178_H1.1421.00
226_C247_G1.1381.00
75_D78_T1.1271.00
10_E13_I1.1201.00
173_G181_T1.1191.00
201_V224_L1.1171.00
76_E207_H1.1161.00
116_T135_N1.1121.00
154_D158_M1.1111.00
49_E56_T1.1061.00
11_E15_S1.0971.00
156_P190_I1.0961.00
137_I142_N1.0961.00
171_A218_Y1.0921.00
48_I55_V1.0841.00
89_E166_K1.0801.00
87_F226_C1.0641.00
16_H27_V1.0581.00
84_A105_I1.0511.00
41_K45_K1.0501.00
174_T205_A1.0471.00
66_F100_T1.0401.00
85_S88_I1.0361.00
81_A85_S1.0341.00
118_L162_Y1.0311.00
210_F227_I1.0251.00
237_Y240_Y1.0181.00
202_Y228_V1.0151.00
21_L39_I1.0141.00
139_I159_L1.0121.00
88_I168_F1.0011.00
76_E80_I0.9971.00
25_C32_K0.9831.00
96_I105_I0.9801.00
12_Y15_S0.9801.00
4_M8_E0.9791.00
99_G102_T0.9781.00
85_S105_I0.9751.00
156_P193_R0.9651.00
105_I108_T0.9651.00
172_T182_N0.9481.00
106_L127_A0.9481.00
154_D162_Y0.9451.00
222_D244_H0.9441.00
189_E192_K0.9441.00
167_A194_I0.9331.00
102_T124_I0.9201.00
123_D148_R0.9181.00
171_A203_L0.9171.00
73_H206_D0.9161.00
19_V55_V0.9141.00
78_T82_H0.9131.00
175_T213_S0.9131.00
40_N43_T0.9081.00
23_E27_V0.9061.00
161_K192_K0.9041.00
19_V24_L0.9001.00
136_L143_Y0.8971.00
41_K44_E0.8971.00
101_T206_D0.8901.00
163_N178_H0.8891.00
25_C35_V0.8871.00
154_D161_K0.8861.00
80_I101_T0.8801.00
188_Y216_L0.8761.00
81_A105_I0.8681.00
102_T105_I0.8671.00
10_E14_L0.8621.00
168_F204_L0.8601.00
147_T172_T0.8601.00
110_D131_L0.8541.00
77_K101_T0.8531.00
163_N199_K0.8521.00
129_S148_R0.8501.00
106_L124_I0.8491.00
77_K209_K0.8471.00
162_Y185_L0.8471.00
121_S124_I0.8451.00
199_K213_S0.8401.00
81_A104_S0.8401.00
42_L47_A0.8381.00
84_A228_V0.8301.00
4_M7_Q0.8261.00
159_L193_R0.8191.00
101_T209_K0.8151.00
240_Y243_E0.8151.00
163_N217_T0.8101.00
79_K82_H0.8081.00
163_N213_S0.8061.00
96_I106_L0.8051.00
159_L194_I0.8041.00
182_N188_Y0.8041.00
11_E14_L0.8031.00
201_V225_H0.8021.00
4_M18_T0.8001.00
178_H213_S0.7941.00
185_L216_L0.7911.00
112_A115_V0.7901.00
40_N50_K0.7861.00
110_D127_A0.7851.00
102_T204_L0.7791.00
103_K127_A0.7731.00
171_A180_L0.7711.00
163_N197_K0.7681.00
95_F159_L0.7671.00
73_H207_H0.7591.00
114_N133_N0.7571.00
126_N148_R0.7561.00
96_I117_I0.7481.00
17_G57_S0.7481.00
195_S218_Y0.7451.00
75_D79_K0.7441.00
161_K217_T0.7431.00
23_E26_Q0.7411.00
181_T213_S0.7361.00
164_I198_A0.7361.00
144_K151_V0.7281.00
174_T180_L0.7221.00
180_L218_Y0.7180.99
6_I10_E0.7160.99
205_A227_I0.7150.99
51_V56_T0.7150.99
192_K196_E0.7150.99
144_K187_E0.7150.99
110_D113_K0.7130.99
233_L237_Y0.7130.99
100_T209_K0.7070.99
140_G158_M0.7050.99
80_I204_L0.7010.99
236_E240_Y0.6990.99
10_E42_L0.6980.99
240_Y244_H0.6970.99
125_I150_F0.6920.99
174_T221_F0.6920.99
22_D26_Q0.6890.99
125_I143_Y0.6870.99
65_P68_N0.6860.99
202_Y225_H0.6830.99
69_R172_T0.6830.99
98_S147_T0.6810.99
167_A201_V0.6800.99
182_N218_Y0.6770.99
79_K83_Y0.6750.99
39_I50_K0.6750.99
160_D197_K0.6750.99
104_S108_T0.6750.99
70_T103_K0.6740.99
153_M189_E0.6720.99
93_L118_L0.6720.99
152_G155_D0.6710.99
94_V117_I0.6690.99
43_T48_I0.6660.99
122_L150_F0.6660.99
13_I19_V0.6650.99
63_L69_R0.6640.99
113_K133_N0.6640.99
153_M157_A0.6630.99
120_N194_I0.6610.99
21_L35_V0.6600.99
127_A130_A0.6560.99
235_D238_T0.6520.99
43_T50_K0.6510.99
94_V166_K0.6490.99
82_H86_R0.6490.99
182_N187_E0.6450.99
157_A189_E0.6440.99
172_T214_T0.6390.99
24_L39_I0.6380.99
30_V33_N0.6300.99
162_Y216_L0.6300.99
3_L6_I0.6300.99
206_D209_K0.6280.99
88_I105_I0.6270.99
155_D158_M0.6250.99
140_G155_D0.6220.99
103_K123_D0.6190.99
122_L138_I0.6160.98
237_Y241_C0.6120.98
186_L189_E0.6120.98
123_D126_N0.6120.98
200_E247_G0.6110.98
118_L215_L0.6050.98
169_M198_A0.6050.98
76_E232_P0.6030.98
122_L126_N0.6020.98
198_A201_V0.5990.98
219_A224_L0.5970.98
169_M195_S0.5960.98
28_F35_V0.5920.98
114_N135_N0.5910.98
188_Y218_Y0.5910.98
144_K184_D0.5860.98
118_L137_I0.5840.98
5_R38_D0.5810.98
156_P160_D0.5780.98
173_G214_T0.5770.98
183_S214_T0.5760.98
154_D157_A0.5750.98
33_N121_S0.5740.98
153_M156_P0.5730.98
190_I193_R0.5730.98
33_N172_T0.5730.98
79_K231_Q0.5720.98
180_L219_A0.5710.97
119_T125_I0.5710.97
131_L134_I0.5690.97
170_S182_N0.5690.97
176_L240_Y0.5690.97
169_M218_Y0.5670.97
172_T183_S0.5660.97
97_D102_T0.5640.97
93_L215_L0.5640.97
94_V168_F0.5610.97
210_F229_T0.5610.97
95_F167_A0.5590.97
63_L144_K0.5580.97
99_G170_S0.5560.97
232_P238_T0.5530.97
96_I124_I0.5530.97
175_T181_T0.5510.97
173_G212_K0.5510.97
242_N247_G0.5490.97
150_F158_M0.5450.97
153_M186_L0.5430.97
169_M201_V0.5430.97
235_D242_N0.5420.97
207_H233_L0.5410.97
172_T187_E0.5390.96
70_T104_S0.5390.96
96_I109_L0.5360.96
149_S187_E0.5360.96
191_K218_Y0.5340.96
157_A192_K0.5330.96
95_F118_L0.5300.96
201_V223_R0.5300.96
21_L25_C0.5280.96
227_I241_C0.5280.96
67_E70_T0.5280.96
176_L237_Y0.5280.96
207_H231_Q0.5260.96
37_R174_T0.5240.96
238_T241_C0.5240.96
172_T191_K0.5240.96
69_R187_E0.5200.96
76_E79_K0.5200.96
121_S187_E0.5180.96
39_I43_T0.5180.96
21_L52_Y0.5160.95
154_D185_L0.5140.95
94_V105_I0.5140.95
25_C31_S0.5120.95
125_I136_L0.5070.95
26_Q29_N0.5060.95
129_S143_Y0.5020.95
135_N145_R0.5010.95
126_N129_S0.5000.95
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1stzA 3 0.9402 100 0.508 Contact Map
3rrlB 1 0.6932 100 0.523 Contact Map
2w48A 3 0.9363 100 0.573 Contact Map
3l7oA 2 0.6016 100 0.603 Contact Map
1o8bA 2 0.5896 100 0.609 Contact Map
1m0sA 2 0.6135 100 0.614 Contact Map
1uj6A 2 0.6096 100 0.616 Contact Map
2o0mA 1 0.7052 100 0.617 Contact Map
1lk5A 4 0.6096 100 0.617 Contact Map
3uw1A 2 0.6215 100 0.623 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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