GREMLIN Database
IOLS - Protein IolS
UniProt: P46336 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 310 (262)
Sequences: 32261 (20449)
Seq/√Len: 1263.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_E287_I3.1931.00
108_D148_K2.9761.00
34_E69_E2.9321.00
72_R115_N2.8101.00
255_H301_D2.7811.00
298_S301_D2.5001.00
107_V143_M2.4871.00
38_K73_E2.4741.00
104_K142_E2.4271.00
5_K12_Q2.3881.00
104_K146_A2.3831.00
43_E47_N2.3181.00
254_K304_F2.2071.00
141_N145_K2.1061.00
249_A253_E2.0601.00
38_K69_E2.0491.00
269_A302_I2.0131.00
254_K301_D2.0021.00
118_Y150_R1.9901.00
109_E113_R1.9571.00
142_E146_A1.9461.00
192_Y196_H1.9441.00
299_Q303_S1.9221.00
283_A287_I1.9151.00
75_N78_D1.9111.00
250_P304_F1.8951.00
193_T200_F1.8561.00
43_E283_A1.8441.00
17_G51_M1.8401.00
100_P142_E1.8141.00
62_R65_E1.8081.00
163_K167_K1.7601.00
47_N287_I1.7591.00
123_Y173_V1.7491.00
142_E145_K1.7441.00
257_V295_V1.7361.00
270_R306_D1.7171.00
81_I116_T1.7141.00
65_E113_R1.6851.00
83_T119_I1.6591.00
247_K250_P1.6391.00
199_S275_I1.6311.00
100_P104_K1.6301.00
258_D288_D1.6301.00
47_N290_I1.6291.00
44_A49_V1.6211.00
163_K192_Y1.6171.00
85_A122_F1.6131.00
38_K42_R1.6031.00
265_A295_V1.5971.00
33_N36_T1.5961.00
83_T110_S1.5941.00
38_K70_V1.5831.00
291_K294_D1.5661.00
43_E46_R1.5651.00
104_K108_D1.5651.00
107_V122_F1.5631.00
42_R73_E1.5541.00
139_A142_E1.5531.00
85_A103_L1.5431.00
303_S307_K1.5381.00
82_A123_Y1.5161.00
20_T52_L1.4821.00
105_K109_E1.4531.00
11_L151_S1.4461.00
56_Y106_S1.4381.00
257_V261_H1.4221.00
123_Y201_I1.4091.00
45_I79_V1.4011.00
36_T39_E1.3951.00
119_I149_I1.3931.00
191_P195_E1.3911.00
108_D112_K1.3901.00
188_T191_P1.3831.00
41_V70_V1.3801.00
158_S161_Q1.3781.00
194_K271_P1.3671.00
166_N196_H1.3641.00
34_E38_K1.3591.00
287_I291_K1.3421.00
166_N192_Y1.3361.00
176_G200_F1.3081.00
100_P138_N1.2971.00
265_A269_A1.2911.00
11_L80_V1.2841.00
42_R46_R1.2771.00
104_K139_A1.2751.00
39_E43_E1.2691.00
257_V262_I1.2631.00
151_S172_D1.2611.00
250_P254_K1.2561.00
109_E112_K1.2551.00
149_I152_I1.2531.00
159_L192_Y1.2521.00
247_K304_F1.2511.00
143_M149_I1.2511.00
304_F307_K1.2491.00
280_A285_Q1.2371.00
100_P139_A1.2241.00
64_E110_S1.2031.00
114_L119_I1.1971.00
52_L67_I1.1961.00
68_G115_N1.1951.00
69_E115_N1.1931.00
80_V121_L1.1931.00
258_D261_H1.1871.00
190_F194_K1.1811.00
35_E39_E1.1791.00
280_A286_L1.1681.00
251_I262_I1.1661.00
127_P161_Q1.1501.00
163_K195_E1.1491.00
121_L173_V1.1491.00
249_A259_I1.1471.00
76_R116_T1.1441.00
65_E69_E1.1431.00
135_E138_N1.1421.00
76_R118_Y1.1371.00
107_V119_I1.1341.00
284_D287_I1.1311.00
163_K196_H1.1151.00
102_F105_K1.1081.00
101_D105_K1.1081.00
42_R74_F1.1031.00
178_Y270_R1.0941.00
141_N169_G1.0931.00
144_K172_D1.0921.00
141_N144_K1.0901.00
51_M201_I1.0861.00
246_N250_P1.0811.00
140_L152_I1.0791.00
51_M82_A1.0691.00
9_S151_S1.0681.00
180_L305_I1.0661.00
267_Y276_L1.0621.00
99_S102_F1.0621.00
177_E182_N1.0601.00
20_T67_I1.0591.00
145_K168_D1.0561.00
108_D146_A1.0541.00
40_L286_L1.0541.00
248_L259_I1.0521.00
124_I140_L1.0331.00
246_N249_A1.0301.00
159_L163_K1.0251.00
42_R70_V1.0251.00
8_K172_D1.0241.00
50_T80_V1.0241.00
250_P253_E1.0191.00
98_N124_I1.0171.00
39_E283_A1.0161.00
143_M148_K1.0081.00
5_K10_D1.0031.00
261_H291_K1.0011.00
268_L292_T0.9951.00
144_K169_G0.9821.00
100_P135_E0.9781.00
180_L263_V0.9781.00
71_L79_V0.9721.00
194_K272_E0.9621.00
14_F50_T0.9571.00
154_V171_V0.9571.00
138_N142_E0.9521.00
187_K191_P0.9481.00
134_D164_E0.9471.00
173_V201_I0.9471.00
69_E73_E0.9431.00
201_I275_I0.9421.00
191_P194_K0.9331.00
261_H288_D0.9301.00
15_P268_L0.9251.00
120_D150_R0.9251.00
9_S172_D0.9211.00
286_L290_I0.9191.00
64_E113_R0.9111.00
65_E112_K0.9091.00
288_D291_K0.9061.00
152_I171_V0.9061.00
143_M146_A0.9031.00
14_F49_V0.9011.00
154_V162_L0.8991.00
41_V52_L0.8961.00
284_D288_D0.8961.00
104_K107_V0.8951.00
56_Y89_K0.8861.00
39_E42_R0.8781.00
139_A143_M0.8761.00
174_L193_T0.8731.00
15_P293_A0.8711.00
105_K108_D0.8681.00
269_A296_T0.8671.00
282_R285_Q0.8641.00
88_R97_D0.8611.00
82_A201_I0.8571.00
104_K143_M0.8571.00
56_Y102_F0.8541.00
300_E303_S0.8541.00
141_N152_I0.8531.00
138_N141_N0.8501.00
300_E304_F0.8501.00
264_L292_T0.8461.00
254_K298_S0.8411.00
303_S306_D0.8361.00
251_I255_H0.8301.00
82_A121_L0.8271.00
141_N168_D0.8241.00
270_R302_I0.8231.00
45_I75_N0.8211.00
255_H298_S0.8201.00
9_S144_K0.8051.00
192_Y195_E0.8051.00
34_E62_R0.8041.00
199_S274_D0.8021.00
164_E167_K0.7981.00
18_L44_A0.7861.00
190_F200_F0.7841.00
162_L198_I0.7811.00
263_V267_Y0.7811.00
56_Y113_R0.7791.00
183_R306_D0.7781.00
156_N203_Y0.7731.00
178_Y190_F0.7681.00
20_T63_S0.7631.00
269_A299_Q0.7611.00
47_N291_K0.7591.00
111_L148_K0.7591.00
216_T249_A0.7501.00
18_L23_V0.7471.00
83_T122_F0.7421.00
43_E286_L0.7421.00
137_V165_A0.7401.00
159_L189_F0.7391.00
45_I74_F0.7341.00
54_T67_I0.7321.00
111_L116_T0.7311.00
126_F156_N0.7271.00
56_Y109_E0.7241.00
205_P278_P0.7221.00
35_E38_K0.7201.00
297_L302_I0.7121.00
137_V171_V0.7091.00
202_P276_L0.7021.00
181_L245_V0.7001.00
265_A292_T0.6991.00
189_F193_T0.6981.00
77_E118_Y0.6961.00
17_G278_P0.6961.00
257_V294_D0.6951.00
45_I52_L0.6941.00
37_G66_L0.6931.00
154_V157_F0.6921.00
16_I268_L0.6911.00
159_L188_T0.6911.00
137_V152_I0.6881.00
183_R187_K0.6871.00
253_E256_N0.6871.00
49_V290_I0.6871.00
42_R75_N0.6861.00
202_P205_P0.6861.00
193_T198_I0.6841.00
281_K285_Q0.6841.00
107_V148_K0.6781.00
98_N136_A0.6771.00
251_I301_D0.6771.00
106_S109_E0.6771.00
242_I246_N0.6721.00
266_W306_D0.6721.00
183_R186_E0.6691.00
103_L136_A0.6681.00
186_E191_P0.6631.00
103_L143_M0.6631.00
50_T78_D0.6601.00
257_V291_K0.6571.00
255_H262_I0.6551.00
40_L283_A0.6551.00
243_R246_N0.6531.00
190_F270_R0.6531.00
57_I86_A0.6501.00
41_V45_I0.6461.00
260_P288_D0.6461.00
11_L150_R0.6451.00
267_Y272_E0.6431.00
154_V174_L0.6381.00
110_S122_F0.6361.00
248_L305_I0.6351.00
262_I297_L0.6351.00
23_V40_L0.6341.00
248_L263_V0.6331.00
178_Y267_Y0.6321.00
163_K166_N0.6301.00
47_N286_L0.6301.00
123_Y153_G0.6281.00
243_R247_K0.6191.00
262_I295_V0.6191.00
107_V111_L0.6161.00
247_K308_L0.6161.00
285_Q288_D0.6151.00
161_Q164_E0.6141.00
70_V74_F0.6141.00
144_K151_S0.6121.00
141_N170_L0.6121.00
136_A139_A0.6111.00
257_V265_A0.6091.00
40_L280_A0.6081.00
205_P267_Y0.6071.00
144_K149_I0.6071.00
217_E246_N0.6051.00
140_L144_K0.6041.00
190_F272_E0.6031.00
132_P135_E0.6011.00
133_K136_A0.6001.00
21_N204_F0.5991.00
36_T283_A0.5991.00
252_A262_I0.5971.00
85_A98_N0.5941.00
242_I245_V0.5941.00
178_Y200_F0.5941.00
75_N79_V0.5931.00
251_I304_F0.5911.00
103_L139_A0.5911.00
119_I122_F0.5911.00
252_A259_I0.5881.00
104_K148_K0.5871.00
301_D304_F0.5871.00
13_V275_I0.5861.00
17_G275_I0.5811.00
46_R283_A0.5791.00
297_L301_D0.5781.00
134_D138_N0.5771.00
111_L119_I0.5771.00
22_A208_S0.5751.00
45_I50_T0.5731.00
262_I301_D0.5731.00
212_A215_Y0.5711.00
25_G66_L0.5691.00
245_V249_A0.5671.00
213_G216_T0.5641.00
216_T246_N0.5631.00
166_N198_I0.5611.00
62_R66_L0.5591.00
53_D175_Q0.5581.00
23_V37_G0.5581.00
204_F208_S0.5571.00
89_K102_F0.5541.00
45_I78_D0.5541.00
41_V67_I0.5541.00
268_L276_L0.5531.00
252_A255_H0.5521.00
124_I136_A0.5491.00
97_D102_F0.5481.00
99_S136_A0.5461.00
122_F149_I0.5451.00
248_L252_A0.5441.00
111_L118_Y0.5401.00
160_E163_K0.5401.00
8_K197_N0.5371.00
178_Y183_R0.5371.00
6_L199_S0.5371.00
262_I305_I0.5361.00
122_F140_L0.5361.00
13_V51_M0.5341.00
54_T63_S0.5331.00
85_A106_S0.5331.00
176_G189_F0.5321.00
261_H295_V0.5301.00
178_Y272_E0.5301.00
111_L117_D0.5261.00
128_D131_T0.5261.00
154_V165_A0.5251.00
45_I70_V0.5251.00
52_L71_L0.5231.00
18_L40_L0.5211.00
56_Y86_A0.5201.00
17_G277_I0.5191.00
107_V139_A0.5191.00
34_E66_L0.5191.00
87_H98_N0.5191.00
180_L266_W0.5181.00
255_H295_V0.5171.00
6_L9_S0.5171.00
59_G62_R0.5151.00
87_H126_F0.5131.00
251_I308_L0.5101.00
165_A171_V0.5081.00
127_P157_F0.5071.00
100_P103_L0.5071.00
133_K161_Q0.5061.00
283_A286_L0.5061.00
251_I254_K0.5051.00
64_E83_T0.5021.00
265_A296_T0.5011.00
84_K125_H0.5001.00
51_M80_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pyfA 1 0.9968 100 0.054 Contact Map
1pz1A 1 0.9968 100 0.069 Contact Map
3v0sA 1 0.871 100 0.078 Contact Map
3n2tA 1 0.9903 100 0.079 Contact Map
4xk2A 5 0.9194 100 0.086 Contact Map
3erpA 6 0.9226 100 0.109 Contact Map
1lqaA 2 0.9806 100 0.111 Contact Map
3eauA 3 0.9742 100 0.114 Contact Map
3n6qA 5 0.9226 100 0.117 Contact Map
3lutA 3 0.971 100 0.119 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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