GREMLIN Database
ALDH3 - Probable aldehyde dehydrogenase AldX
UniProt: P46329 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 445 (429)
Sequences: 35673 (21409)
Seq/√Len: 1033.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
258_K357_E5.0591.00
202_T206_K3.9731.00
258_K355_N3.1781.00
230_M267_I3.1261.00
261_Q355_N2.9231.00
319_V328_S2.8041.00
225_S257_K2.7501.00
336_T339_M2.7101.00
294_D298_N2.6211.00
234_K271_V2.5781.00
153_I156_K2.5611.00
306_D340_K2.5411.00
305_D309_E2.5101.00
265_A353_M2.4971.00
225_S259_D2.4431.00
45_H48_E2.4101.00
43_I77_R2.4101.00
17_K186_D2.3321.00
379_S385_I2.3081.00
282_T285_R2.2581.00
304_F327_I2.2541.00
159_R164_E2.1901.00
46_E70_E2.1551.00
38_F158_I2.1291.00
301_K305_D2.1081.00
41_S160_D2.0751.00
359_I384_L2.0641.00
5_V8_D2.0491.00
301_K320_F2.0301.00
313_E334_N2.0221.00
178_T182_D2.0151.00
370_D418_T2.0111.00
306_D310_R2.0011.00
146_F293_N2.0001.00
107_E437_K1.9921.00
182_D203_A1.9691.00
269_Q273_N1.9531.00
291_I300_V1.9491.00
221_T236_I1.9391.00
387_N391_H1.9221.00
106_Y431_K1.8971.00
315_V333_K1.8891.00
301_K327_I1.8891.00
48_E153_I1.8771.00
263_R267_I1.8731.00
308_I314_V1.8711.00
10_Q179_E1.8481.00
226_E384_L1.8161.00
199_I202_T1.8151.00
41_S161_A1.8091.00
198_K418_T1.7961.00
255_F365_Y1.7851.00
34_K162_F1.7751.00
47_E66_K1.7681.00
359_I387_N1.7581.00
45_H160_D1.7521.00
41_S44_A1.7491.00
393_T417_N1.7491.00
106_Y434_S1.7251.00
342_M354_M1.7241.00
257_K356_Y1.6841.00
41_S157_V1.6691.00
337_P365_Y1.6671.00
255_F362_V1.6501.00
269_Q315_V1.6491.00
332_L341_I1.6431.00
313_E333_K1.6351.00
10_Q14_Q1.6311.00
272_V331_V1.6221.00
155_A169_I1.6211.00
361_E364_D1.6141.00
52_A153_I1.6081.00
36_Q77_R1.6021.00
261_Q265_A1.5751.00
76_I130_A1.5741.00
20_Q24_R1.5731.00
236_I264_F1.5731.00
241_F272_V1.5711.00
27_T30_Q1.5621.00
266_G270_T1.5601.00
357_E361_E1.5591.00
340_K344_E1.5571.00
138_S166_E1.5551.00
43_I73_K1.5521.00
229_L267_I1.5401.00
302_D340_K1.5341.00
10_Q183_Q1.5181.00
294_D325_R1.5181.00
254_L351_L1.5171.00
40_D44_A1.5121.00
267_I270_T1.5051.00
262_D355_N1.4931.00
37_R40_D1.4801.00
314_V332_L1.4581.00
233_A267_I1.4571.00
30_Q33_E1.4571.00
360_D391_H1.4561.00
255_F356_Y1.4401.00
156_K160_D1.4381.00
224_D384_L1.4361.00
36_Q84_E1.4351.00
235_K378_F1.4281.00
261_Q333_K1.4251.00
51_E55_K1.4211.00
225_S384_L1.4201.00
25_A391_H1.4141.00
256_I264_F1.4131.00
375_L394_S1.4061.00
47_E51_E1.4031.00
271_V274_A1.3981.00
39_L77_R1.3941.00
361_E365_Y1.3901.00
263_R266_G1.3841.00
105_M390_Q1.3841.00
236_I254_L1.3801.00
8_D11_R1.3791.00
40_D77_R1.3781.00
76_I126_M1.3781.00
114_I139_A1.3721.00
82_N85_Q1.3691.00
13_F183_Q1.3661.00
26_S30_Q1.3611.00
300_V348_A1.3491.00
201_M421_I1.3391.00
305_D308_I1.3381.00
303_L346_I1.3371.00
45_H153_I1.3351.00
187_H212_T1.3271.00
51_E281_H1.3251.00
276_F285_R1.3251.00
54_R64_V1.3221.00
262_D266_G1.3161.00
297_F327_I1.3011.00
224_D356_Y1.2981.00
178_T203_A1.2961.00
297_F301_K1.2931.00
356_Y365_Y1.2881.00
125_T141_V1.2881.00
310_R340_K1.2731.00
297_F320_F1.2671.00
20_Q138_S1.2661.00
298_N302_D1.2631.00
270_T273_N1.2521.00
155_A167_V1.2391.00
182_D206_K1.2391.00
224_D388_V1.2371.00
265_A269_Q1.2371.00
145_D174_V1.2341.00
363_I388_V1.2331.00
273_N316_F1.2321.00
158_I167_V1.2301.00
294_D297_F1.2251.00
61_Y66_K1.2201.00
39_L43_I1.2181.00
222_I362_V1.2171.00
9_I176_V1.2161.00
178_T199_I1.2161.00
257_K358_D1.2141.00
145_D173_E1.2101.00
428_Y431_K1.2091.00
257_K260_V1.2081.00
54_R280_D1.1991.00
338_D343_Q1.1971.00
358_D361_E1.1931.00
260_V263_R1.1811.00
106_Y436_E1.1751.00
165_K168_A1.1671.00
267_I271_V1.1641.00
103_I386_D1.1631.00
51_E61_Y1.1631.00
276_F287_K1.1621.00
427_V431_K1.1601.00
6_K179_E1.1591.00
15_L168_A1.1581.00
268_L351_L1.1581.00
270_T274_A1.1571.00
337_P368_D1.1541.00
14_Q18_K1.1541.00
26_S34_K1.1451.00
307_A332_L1.1441.00
13_F185_F1.1421.00
49_I153_I1.1411.00
302_D306_D1.1371.00
375_L397_A1.1361.00
37_R41_S1.1291.00
312_A332_L1.1281.00
264_F268_L1.1261.00
389_L439_V1.1261.00
278_E286_S1.1241.00
360_D387_N1.1191.00
265_A315_V1.1191.00
385_I399_I1.1171.00
196_V199_I1.1141.00
265_A333_K1.1081.00
179_E183_Q1.1051.00
38_F157_V1.1051.00
199_I203_A1.1051.00
109_K187_H1.1041.00
221_T251_P1.0991.00
129_L167_V1.0961.00
275_G288_F1.0871.00
152_N171_E1.0851.00
46_E66_K1.0841.00
38_F76_I1.0831.00
114_I189_F1.0801.00
195_N199_I1.0791.00
343_Q368_D1.0791.00
113_L180_L1.0731.00
343_Q370_D1.0711.00
201_M211_V1.0661.00
359_I388_V1.0651.00
269_Q316_F1.0611.00
38_F162_F1.0571.00
222_I388_V1.0561.00
360_D364_D1.0551.00
89_P427_V1.0521.00
36_Q81_N1.0501.00
273_N328_S1.0471.00
428_Y436_E1.0451.00
363_I391_H1.0421.00
113_L185_F1.0401.00
228_D380_K1.0401.00
279_D282_T1.0351.00
22_A26_S1.0301.00
222_I366_V1.0281.00
297_F325_R1.0271.00
381_N384_L1.0261.00
414_G423_S1.0251.00
129_L139_A1.0241.00
32_R84_E1.0231.00
310_R339_M1.0201.00
120_Y247_T1.0201.00
198_K208_L1.0081.00
317_G330_T1.0071.00
19_Q138_S1.0071.00
356_Y362_V1.0031.00
423_S435_H1.0021.00
218_K252_D1.0011.00
89_P428_Y0.9991.00
228_D231_D0.9991.00
44_A160_D0.9981.00
45_H157_V0.9971.00
152_N169_I0.9951.00
49_I157_V0.9931.00
300_V350_I0.9841.00
105_M439_V0.9801.00
72_T126_M0.9721.00
21_K364_D0.9711.00
201_M205_A0.9691.00
317_G328_S0.9631.00
21_K393_T0.9601.00
416_V435_H0.9581.00
156_K159_R0.9571.00
17_K21_K0.9561.00
262_D265_A0.9561.00
111_V138_S0.9491.00
303_L306_D0.9491.00
45_H156_K0.9481.00
335_V339_M0.9411.00
376_Y402_V0.9411.00
230_M263_R0.9381.00
220_P375_L0.9371.00
231_D235_K0.9351.00
48_E51_E0.9331.00
109_K210_S0.9311.00
364_D368_D0.9311.00
83_L134_A0.9251.00
306_D309_E0.9241.00
111_V185_F0.9181.00
186_D393_T0.9171.00
239_G251_P0.9161.00
21_K25_A0.9111.00
36_Q80_M0.9091.00
237_A271_V0.9081.00
57_V147_T0.9071.00
112_T187_H0.9061.00
59_K68_E0.9051.00
102_G411_L0.9021.00
6_K175_E0.8981.00
107_E390_Q0.8981.00
41_S45_H0.8971.00
302_D305_D0.8911.00
240_K252_D0.8901.00
6_K10_Q0.8901.00
33_E37_R0.8881.00
221_T378_F0.8871.00
55_K281_H0.8841.00
198_K202_T0.8821.00
24_R393_T0.8811.00
300_V346_I0.8801.00
354_M365_Y0.8801.00
386_D390_Q0.8801.00
233_A268_L0.8791.00
303_L340_K0.8781.00
39_L80_M0.8751.00
32_R36_Q0.8741.00
318_G330_T0.8741.00
229_L233_A0.8681.00
411_L438_G0.8681.00
224_D359_I0.8671.00
28_A32_R0.8671.00
15_L165_K0.8651.00
308_I332_L0.8651.00
146_F295_R0.8641.00
210_S435_H0.8631.00
261_Q353_M0.8631.00
375_L392_T0.8591.00
298_N301_K0.8591.00
9_I113_L0.8571.00
193_S196_V0.8561.00
311_G339_M0.8541.00
233_A271_V0.8531.00
32_R80_M0.8521.00
172_G176_V0.8521.00
107_E416_V0.8511.00
155_A159_R0.8511.00
72_T122_F0.8501.00
312_A339_M0.8501.00
25_A390_Q0.8471.00
201_M204_A0.8451.00
11_R15_L0.8441.00
152_N156_K0.8441.00
362_V365_Y0.8431.00
42_V72_T0.8421.00
337_P354_M0.8411.00
224_D379_S0.8371.00
377_V388_V0.8301.00
356_Y361_E0.8281.00
188_I200_V0.8271.00
7_D11_R0.8271.00
109_K435_H0.8261.00
223_I264_F0.8261.00
188_I204_A0.8241.00
109_K137_N0.8231.00
92_V95_S0.8211.00
7_D10_Q0.8201.00
19_Q166_E0.8151.00
233_A264_F0.8131.00
232_A236_I0.8131.00
307_A346_I0.8121.00
37_R161_A0.8101.00
363_I367_N0.8081.00
304_F350_I0.8041.00
14_Q17_K0.7991.00
300_V327_I0.7971.00
266_G269_Q0.7961.00
131_A429_G0.7941.00
22_A25_A0.7931.00
141_V151_S0.7921.00
197_G215_L0.7921.00
135_A434_S0.7891.00
261_Q334_N0.7891.00
16_Q168_A0.7891.00
174_V178_T0.7881.00
132_S139_A0.7871.00
113_L177_A0.7861.00
201_M208_L0.7851.00
42_V73_K0.7851.00
35_L134_A0.7841.00
382_Q385_I0.7821.00
11_R14_Q0.7821.00
54_R61_Y0.7821.00
34_K161_A0.7791.00
55_K149_N0.7791.00
333_K355_N0.7741.00
177_A181_L0.7731.00
18_K21_K0.7731.00
162_F167_V0.7721.00
61_Y281_H0.7711.00
125_T129_L0.7701.00
197_G213_L0.7671.00
126_M154_A0.7661.00
36_Q40_D0.7661.00
394_S397_A0.7651.00
62_H287_K0.7651.00
23_L166_E0.7611.00
268_L331_V0.7591.00
114_I128_P0.7571.00
181_L188_I0.7561.00
29_E84_E0.7561.00
219_S252_D0.7551.00
232_A264_F0.7551.00
275_G287_K0.7531.00
57_V292_V0.7511.00
181_L200_V0.7511.00
190_F196_V0.7461.00
233_A237_A0.7451.00
220_P366_V0.7441.00
50_I61_Y0.7441.00
194_T418_T0.7411.00
50_I54_R0.7371.00
122_F150_T0.7351.00
181_L203_A0.7341.00
198_K206_K0.7341.00
204_A211_V0.7311.00
303_L344_E0.7311.00
50_I66_K0.7301.00
43_I46_E0.7301.00
113_L188_I0.7291.00
272_V316_F0.7291.00
21_K24_R0.7271.00
257_K359_I0.7241.00
43_I70_E0.7221.00
102_G438_G0.7201.00
230_M271_V0.7201.00
295_R298_N0.7201.00
229_L260_V0.7181.00
282_T286_S0.7161.00
146_F292_V0.7161.00
237_A268_L0.7151.00
128_P424_Y0.7151.00
179_E182_D0.7131.00
174_V199_I0.7121.00
52_A149_N0.7111.00
256_I260_V0.7081.00
380_K383_D0.7051.00
141_V167_V0.7041.00
269_Q272_V0.7021.00
16_Q138_S0.7021.00
143_L171_E0.6981.00
66_K70_E0.6951.00
224_D257_K0.6941.00
23_L34_K0.6931.00
137_N434_S0.6921.00
53_I56_D0.6921.00
125_T151_S0.6921.00
9_I179_E0.6911.00
272_V275_G0.6901.00
48_E156_K0.6891.00
47_E61_Y0.6891.00
109_K186_D0.6861.00
116_G125_T0.6851.00
28_A83_L0.6841.00
254_L264_F0.6821.00
19_Q22_A0.6821.00
202_T205_A0.6801.00
255_F342_M0.6801.00
17_K20_Q0.6791.00
296_N299_R0.6791.00
175_E178_T0.6791.00
308_I319_V0.6781.00
158_I162_F0.6741.00
9_I13_F0.6731.00
365_Y368_D0.6721.00
358_D364_D0.6711.00
327_I330_T0.6701.00
101_N386_D0.6671.00
316_F331_V0.6661.00
293_N296_N0.6641.00
172_G177_A0.6641.00
382_Q386_D0.6641.00
59_K63_E0.6631.00
359_I363_I0.6631.00
244_A288_F0.6621.00
140_I168_A0.6621.00
277_M288_F0.6601.00
299_R302_D0.6591.00
385_I389_L0.6591.00
223_I232_A0.6581.00
24_R391_H0.6581.00
335_V341_I0.6581.00
145_D299_R0.6581.00
431_K436_E0.6571.00
294_D320_F0.6561.00
304_F332_L0.6561.00
203_A206_K0.6561.00
301_K304_F0.6561.00
337_P342_M0.6561.00
237_A275_G0.6541.00
23_L133_L0.6541.00
125_T154_A0.6521.00
69_I73_K0.6521.00
335_V342_M0.6511.00
255_F337_P0.6511.00
40_D43_I0.6501.00
318_G328_S0.6491.00
226_E379_S0.6491.00
15_L164_E0.6481.00
210_S432_E0.6481.00
102_G440_F0.6451.00
173_E176_V0.6441.00
332_L335_V0.6441.00
393_T416_V0.6441.00
229_L263_R0.6431.00
49_I122_F0.6421.00
389_L399_I0.6411.00
145_D199_I0.6411.00
236_I268_L0.6401.00
39_L73_K0.6401.00
279_D286_S0.6351.00
128_P189_F0.6351.00
153_I157_V0.6341.00
212_T432_E0.6331.00
295_R299_R0.6331.00
24_R107_E0.6321.00
12_V170_F0.6311.00
431_K434_S0.6311.00
95_S98_P0.6301.00
268_L353_M0.6271.00
30_Q34_K0.6261.00
105_M437_K0.6261.00
291_I296_N0.6251.00
363_I387_N0.6241.00
53_I64_V0.6231.00
59_K120_Y0.6221.00
46_E50_I0.6201.00
21_K391_H0.6191.00
231_D234_K0.6161.00
24_R108_P0.6161.00
278_E282_T0.6151.00
314_V330_T0.6141.00
231_D380_K0.6141.00
51_E54_R0.6131.00
6_K182_D0.6131.00
53_I68_E0.6131.00
383_D386_D0.6121.00
129_L141_V0.6121.00
379_S384_L0.6101.00
239_G402_V0.6071.00
201_M213_L0.6061.00
103_I439_V0.6031.00
86_W434_S0.6031.00
320_F328_S0.6021.00
138_S168_A0.6021.00
53_I150_T0.5971.00
346_I350_I0.5971.00
310_R338_D0.5971.00
269_Q331_V0.5961.00
54_R281_H0.5951.00
363_I392_T0.5941.00
221_T254_L0.5931.00
181_L207_H0.5931.00
377_V385_I0.5931.00
78_D82_N0.5921.00
18_K22_A0.5921.00
28_A134_A0.5901.00
42_V122_F0.5901.00
383_D387_N0.5901.00
226_E381_N0.5891.00
334_N355_N0.5891.00
256_I353_M0.5851.00
226_E380_K0.5841.00
184_P370_D0.5831.00
122_F154_A0.5791.00
39_L76_I0.5781.00
69_I122_F0.5761.00
247_T250_A0.5751.00
42_V154_A0.5741.00
187_H432_E0.5741.00
42_V76_I0.5741.00
249_I406_F0.5731.00
229_L264_F0.5701.00
194_T198_K0.5691.00
154_A158_I0.5691.00
227_Y232_A0.5681.00
221_T376_Y0.5671.00
277_M287_K0.5661.00
17_K111_V0.5661.00
86_W430_F0.5651.00
337_P364_D0.5651.00
112_T137_N0.5631.00
362_V366_V0.5601.00
145_D195_N0.5591.00
38_F41_S0.5591.00
66_K284_D0.5581.00
359_I391_H0.5581.00
133_L162_F0.5581.00
377_V399_I0.5581.00
314_V317_G0.5571.00
34_K38_F0.5561.00
112_T139_A0.5551.00
135_A430_F0.5541.00
12_V168_A0.5521.00
16_Q111_V0.5521.00
225_S356_Y0.5501.00
393_T435_H0.5491.00
123_M127_A0.5491.00
398_A401_D0.5481.00
230_M270_T0.5471.00
229_L232_A0.5461.00
301_K308_I0.5461.00
50_I69_I0.5461.00
308_I311_G0.5451.00
240_K351_L0.5441.00
366_V392_T0.5431.00
29_E33_E0.5431.00
258_K261_Q0.5431.00
114_I129_L0.5401.00
16_Q140_I0.5391.00
254_L353_M0.5381.00
57_V243_N0.5381.00
133_L167_V0.5371.00
304_F330_T0.5371.00
388_V392_T0.5371.00
111_V186_D0.5361.00
397_A437_K0.5351.00
79_N131_A0.5341.00
81_N84_E0.5341.00
241_F275_G0.5331.00
49_I69_I0.5331.00
17_K183_Q0.5331.00
219_S374_A0.5331.00
195_N295_R0.5311.00
211_V421_I0.5301.00
307_A340_K0.5291.00
33_E36_Q0.5291.00
251_P376_Y0.5291.00
42_V49_I0.5291.00
310_R336_T0.5291.00
159_R165_K0.5291.00
233_A260_V0.5281.00
70_E73_K0.5281.00
15_L19_Q0.5281.00
50_I64_V0.5271.00
291_I327_I0.5261.00
22_A138_S0.5251.00
341_I346_I0.5251.00
392_T397_A0.5221.00
342_M365_Y0.5221.00
107_E393_T0.5211.00
205_A208_L0.5191.00
46_E73_K0.5191.00
71_G123_M0.5191.00
268_L272_V0.5171.00
256_I261_Q0.5151.00
140_I170_F0.5141.00
315_V334_N0.5131.00
337_P343_Q0.5131.00
374_A398_A0.5121.00
178_T181_L0.5111.00
364_D391_H0.5101.00
290_Q326_T0.5081.00
314_V318_G0.5081.00
220_P394_S0.5071.00
113_L181_L0.5071.00
276_F282_T0.5061.00
113_L140_I0.5041.00
299_R303_L0.5031.00
148_M171_E0.5031.00
342_M352_P0.5031.00
119_N347_F0.5011.00
100_A401_D0.5011.00
234_K238_V0.5001.00
303_L341_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a4sA 4 0.9843 100 0.031 Contact Map
1wndA 4 0.9843 100 0.034 Contact Map
3ek1A 5 0.9843 100 0.034 Contact Map
4o5hA 4 0.991 100 0.035 Contact Map
4qf6A 4 0.9843 100 0.035 Contact Map
4yweA 5 0.9798 100 0.035 Contact Map
4pxlA 4 0.9865 100 0.037 Contact Map
4pz2A 4 0.9865 100 0.038 Contact Map
2d4eA 4 0.982 100 0.038 Contact Map
4qtoA 4 0.9865 100 0.039 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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