ALDH3 - BACSU - GREMLIN Contacts

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ALDH3 - Probable aldehyde dehydrogenase AldX

UniProt:	P46329	Sequences: MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIAHEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANGILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRDAFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGKSPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGFMEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKNVTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHTTSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	445 (429)
Sequences:	35673 (21409)
Seq/√Len:	1033.6

ECOLI - GABD PUUC BETB ABDH ALDB FEAB ALDA ASTD SAD EUTE PUTA PAAZ PROA ADHE
BACSU - ALDH3 ROCA2 ROCA ALDH4 ALDH1 ALDH5 IOLA GABD ALDY BETB ALDH2 PROA
HALSA - Q9HMJ6 Q9HQZ2 Q9HR91 Q9HRB5
SULSO - Q97YT9 Q97XS9 KGSDH GAPN Q97XA5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
258_K	357_E	5.059	1.00
202_T	206_K	3.973	1.00
258_K	355_N	3.178	1.00
230_M	267_I	3.126	1.00
261_Q	355_N	2.923	1.00
319_V	328_S	2.804	1.00
225_S	257_K	2.750	1.00
336_T	339_M	2.710	1.00
294_D	298_N	2.621	1.00
234_K	271_V	2.578	1.00
153_I	156_K	2.561	1.00
306_D	340_K	2.541	1.00
305_D	309_E	2.510	1.00
265_A	353_M	2.497	1.00
225_S	259_D	2.443	1.00
45_H	48_E	2.410	1.00
43_I	77_R	2.410	1.00
17_K	186_D	2.332	1.00
379_S	385_I	2.308	1.00
282_T	285_R	2.258	1.00
304_F	327_I	2.254	1.00
159_R	164_E	2.190	1.00
46_E	70_E	2.155	1.00
38_F	158_I	2.129	1.00
301_K	305_D	2.108	1.00
41_S	160_D	2.075	1.00
359_I	384_L	2.064	1.00
5_V	8_D	2.049	1.00
301_K	320_F	2.030	1.00
313_E	334_N	2.022	1.00
178_T	182_D	2.015	1.00
370_D	418_T	2.011	1.00
306_D	310_R	2.001	1.00
146_F	293_N	2.000	1.00
107_E	437_K	1.992	1.00
182_D	203_A	1.969	1.00
269_Q	273_N	1.953	1.00
291_I	300_V	1.949	1.00
221_T	236_I	1.939	1.00
387_N	391_H	1.922	1.00
106_Y	431_K	1.897	1.00
315_V	333_K	1.889	1.00
301_K	327_I	1.889	1.00
48_E	153_I	1.877	1.00
263_R	267_I	1.873	1.00
308_I	314_V	1.871	1.00
10_Q	179_E	1.848	1.00
226_E	384_L	1.816	1.00
199_I	202_T	1.815	1.00
41_S	161_A	1.809	1.00
198_K	418_T	1.796	1.00
255_F	365_Y	1.785	1.00
34_K	162_F	1.775	1.00
47_E	66_K	1.768	1.00
359_I	387_N	1.758	1.00
45_H	160_D	1.752	1.00
41_S	44_A	1.749	1.00
393_T	417_N	1.749	1.00
106_Y	434_S	1.725	1.00
342_M	354_M	1.724	1.00
257_K	356_Y	1.684	1.00
41_S	157_V	1.669	1.00
337_P	365_Y	1.667	1.00
255_F	362_V	1.650	1.00
269_Q	315_V	1.649	1.00
332_L	341_I	1.643	1.00
313_E	333_K	1.635	1.00
10_Q	14_Q	1.631	1.00
272_V	331_V	1.622	1.00
155_A	169_I	1.621	1.00
361_E	364_D	1.614	1.00
52_A	153_I	1.608	1.00
36_Q	77_R	1.602	1.00
261_Q	265_A	1.575	1.00
76_I	130_A	1.574	1.00
20_Q	24_R	1.573	1.00
236_I	264_F	1.573	1.00
241_F	272_V	1.571	1.00
27_T	30_Q	1.562	1.00
266_G	270_T	1.560	1.00
357_E	361_E	1.559	1.00
340_K	344_E	1.557	1.00
138_S	166_E	1.555	1.00
43_I	73_K	1.552	1.00
229_L	267_I	1.540	1.00
302_D	340_K	1.534	1.00
10_Q	183_Q	1.518	1.00
294_D	325_R	1.518	1.00
254_L	351_L	1.517	1.00
40_D	44_A	1.512	1.00
267_I	270_T	1.505	1.00
262_D	355_N	1.493	1.00
37_R	40_D	1.480	1.00
314_V	332_L	1.458	1.00
233_A	267_I	1.457	1.00
30_Q	33_E	1.457	1.00
360_D	391_H	1.456	1.00
255_F	356_Y	1.440	1.00
156_K	160_D	1.438	1.00
224_D	384_L	1.436	1.00
36_Q	84_E	1.435	1.00
235_K	378_F	1.428	1.00
261_Q	333_K	1.425	1.00
51_E	55_K	1.421	1.00
225_S	384_L	1.420	1.00
25_A	391_H	1.414	1.00
256_I	264_F	1.413	1.00
375_L	394_S	1.406	1.00
47_E	51_E	1.403	1.00
271_V	274_A	1.398	1.00
39_L	77_R	1.394	1.00
361_E	365_Y	1.390	1.00
263_R	266_G	1.384	1.00
105_M	390_Q	1.384	1.00
236_I	254_L	1.380	1.00
8_D	11_R	1.379	1.00
40_D	77_R	1.378	1.00
76_I	126_M	1.378	1.00
114_I	139_A	1.372	1.00
82_N	85_Q	1.369	1.00
13_F	183_Q	1.366	1.00
26_S	30_Q	1.361	1.00
300_V	348_A	1.349	1.00
201_M	421_I	1.339	1.00
305_D	308_I	1.338	1.00
303_L	346_I	1.337	1.00
45_H	153_I	1.335	1.00
187_H	212_T	1.327	1.00
51_E	281_H	1.325	1.00
276_F	285_R	1.325	1.00
54_R	64_V	1.322	1.00
262_D	266_G	1.316	1.00
297_F	327_I	1.301	1.00
224_D	356_Y	1.298	1.00
178_T	203_A	1.296	1.00
297_F	301_K	1.293	1.00
356_Y	365_Y	1.288	1.00
125_T	141_V	1.288	1.00
310_R	340_K	1.273	1.00
297_F	320_F	1.267	1.00
20_Q	138_S	1.266	1.00
298_N	302_D	1.263	1.00
270_T	273_N	1.252	1.00
155_A	167_V	1.239	1.00
182_D	206_K	1.239	1.00
224_D	388_V	1.237	1.00
265_A	269_Q	1.237	1.00
145_D	174_V	1.234	1.00
363_I	388_V	1.233	1.00
273_N	316_F	1.232	1.00
158_I	167_V	1.230	1.00
294_D	297_F	1.225	1.00
61_Y	66_K	1.220	1.00
39_L	43_I	1.218	1.00
222_I	362_V	1.217	1.00
9_I	176_V	1.216	1.00
178_T	199_I	1.216	1.00
257_K	358_D	1.214	1.00
145_D	173_E	1.210	1.00
428_Y	431_K	1.209	1.00
257_K	260_V	1.208	1.00
54_R	280_D	1.199	1.00
338_D	343_Q	1.197	1.00
358_D	361_E	1.193	1.00
260_V	263_R	1.181	1.00
106_Y	436_E	1.175	1.00
165_K	168_A	1.167	1.00
267_I	271_V	1.164	1.00
103_I	386_D	1.163	1.00
51_E	61_Y	1.163	1.00
276_F	287_K	1.162	1.00
427_V	431_K	1.160	1.00
6_K	179_E	1.159	1.00
15_L	168_A	1.158	1.00
268_L	351_L	1.158	1.00
270_T	274_A	1.157	1.00
337_P	368_D	1.154	1.00
14_Q	18_K	1.154	1.00
26_S	34_K	1.145	1.00
307_A	332_L	1.144	1.00
13_F	185_F	1.142	1.00
49_I	153_I	1.141	1.00
302_D	306_D	1.137	1.00
375_L	397_A	1.136	1.00
37_R	41_S	1.129	1.00
312_A	332_L	1.128	1.00
264_F	268_L	1.126	1.00
389_L	439_V	1.126	1.00
278_E	286_S	1.124	1.00
360_D	387_N	1.119	1.00
265_A	315_V	1.119	1.00
385_I	399_I	1.117	1.00
196_V	199_I	1.114	1.00
265_A	333_K	1.108	1.00
179_E	183_Q	1.105	1.00
38_F	157_V	1.105	1.00
199_I	203_A	1.105	1.00
109_K	187_H	1.104	1.00
221_T	251_P	1.099	1.00
129_L	167_V	1.096	1.00
275_G	288_F	1.087	1.00
152_N	171_E	1.085	1.00
46_E	66_K	1.084	1.00
38_F	76_I	1.083	1.00
114_I	189_F	1.080	1.00
195_N	199_I	1.079	1.00
343_Q	368_D	1.079	1.00
113_L	180_L	1.073	1.00
343_Q	370_D	1.071	1.00
201_M	211_V	1.066	1.00
359_I	388_V	1.065	1.00
269_Q	316_F	1.061	1.00
38_F	162_F	1.057	1.00
222_I	388_V	1.056	1.00
360_D	364_D	1.055	1.00
89_P	427_V	1.052	1.00
36_Q	81_N	1.050	1.00
273_N	328_S	1.047	1.00
428_Y	436_E	1.045	1.00
363_I	391_H	1.042	1.00
113_L	185_F	1.040	1.00
228_D	380_K	1.040	1.00
279_D	282_T	1.035	1.00
22_A	26_S	1.030	1.00
222_I	366_V	1.028	1.00
297_F	325_R	1.027	1.00
381_N	384_L	1.026	1.00
414_G	423_S	1.025	1.00
129_L	139_A	1.024	1.00
32_R	84_E	1.023	1.00
310_R	339_M	1.020	1.00
120_Y	247_T	1.020	1.00
198_K	208_L	1.008	1.00
317_G	330_T	1.007	1.00
19_Q	138_S	1.007	1.00
356_Y	362_V	1.003	1.00
423_S	435_H	1.002	1.00
218_K	252_D	1.001	1.00
89_P	428_Y	0.999	1.00
228_D	231_D	0.999	1.00
44_A	160_D	0.998	1.00
45_H	157_V	0.997	1.00
152_N	169_I	0.995	1.00
49_I	157_V	0.993	1.00
300_V	350_I	0.984	1.00
105_M	439_V	0.980	1.00
72_T	126_M	0.972	1.00
21_K	364_D	0.971	1.00
201_M	205_A	0.969	1.00
317_G	328_S	0.963	1.00
21_K	393_T	0.960	1.00
416_V	435_H	0.958	1.00
156_K	159_R	0.957	1.00
17_K	21_K	0.956	1.00
262_D	265_A	0.956	1.00
111_V	138_S	0.949	1.00
303_L	306_D	0.949	1.00
45_H	156_K	0.948	1.00
335_V	339_M	0.941	1.00
376_Y	402_V	0.941	1.00
230_M	263_R	0.938	1.00
220_P	375_L	0.937	1.00
231_D	235_K	0.935	1.00
48_E	51_E	0.933	1.00
109_K	210_S	0.931	1.00
364_D	368_D	0.931	1.00
83_L	134_A	0.925	1.00
306_D	309_E	0.924	1.00
111_V	185_F	0.918	1.00
186_D	393_T	0.917	1.00
239_G	251_P	0.916	1.00
21_K	25_A	0.911	1.00
36_Q	80_M	0.909	1.00
237_A	271_V	0.908	1.00
57_V	147_T	0.907	1.00
112_T	187_H	0.906	1.00
59_K	68_E	0.905	1.00
102_G	411_L	0.902	1.00
6_K	175_E	0.898	1.00
107_E	390_Q	0.898	1.00
41_S	45_H	0.897	1.00
302_D	305_D	0.891	1.00
240_K	252_D	0.890	1.00
6_K	10_Q	0.890	1.00
33_E	37_R	0.888	1.00
221_T	378_F	0.887	1.00
55_K	281_H	0.884	1.00
198_K	202_T	0.882	1.00
24_R	393_T	0.881	1.00
300_V	346_I	0.880	1.00
354_M	365_Y	0.880	1.00
386_D	390_Q	0.880	1.00
233_A	268_L	0.879	1.00
303_L	340_K	0.878	1.00
39_L	80_M	0.875	1.00
32_R	36_Q	0.874	1.00
318_G	330_T	0.874	1.00
229_L	233_A	0.868	1.00
411_L	438_G	0.868	1.00
224_D	359_I	0.867	1.00
28_A	32_R	0.867	1.00
15_L	165_K	0.865	1.00
308_I	332_L	0.865	1.00
146_F	295_R	0.864	1.00
210_S	435_H	0.863	1.00
261_Q	353_M	0.863	1.00
375_L	392_T	0.859	1.00
298_N	301_K	0.859	1.00
9_I	113_L	0.857	1.00
193_S	196_V	0.856	1.00
311_G	339_M	0.854	1.00
233_A	271_V	0.853	1.00
32_R	80_M	0.852	1.00
172_G	176_V	0.852	1.00
107_E	416_V	0.851	1.00
155_A	159_R	0.851	1.00
72_T	122_F	0.850	1.00
312_A	339_M	0.850	1.00
25_A	390_Q	0.847	1.00
201_M	204_A	0.845	1.00
11_R	15_L	0.844	1.00
152_N	156_K	0.844	1.00
362_V	365_Y	0.843	1.00
42_V	72_T	0.842	1.00
337_P	354_M	0.841	1.00
224_D	379_S	0.837	1.00
377_V	388_V	0.830	1.00
356_Y	361_E	0.828	1.00
188_I	200_V	0.827	1.00
7_D	11_R	0.827	1.00
109_K	435_H	0.826	1.00
223_I	264_F	0.826	1.00
188_I	204_A	0.824	1.00
109_K	137_N	0.823	1.00
92_V	95_S	0.821	1.00
7_D	10_Q	0.820	1.00
19_Q	166_E	0.815	1.00
233_A	264_F	0.813	1.00
232_A	236_I	0.813	1.00
307_A	346_I	0.812	1.00
37_R	161_A	0.810	1.00
363_I	367_N	0.808	1.00
304_F	350_I	0.804	1.00
14_Q	17_K	0.799	1.00
300_V	327_I	0.797	1.00
266_G	269_Q	0.796	1.00
131_A	429_G	0.794	1.00
22_A	25_A	0.793	1.00
141_V	151_S	0.792	1.00
197_G	215_L	0.792	1.00
135_A	434_S	0.789	1.00
261_Q	334_N	0.789	1.00
16_Q	168_A	0.789	1.00
174_V	178_T	0.788	1.00
132_S	139_A	0.787	1.00
113_L	177_A	0.786	1.00
201_M	208_L	0.785	1.00
42_V	73_K	0.785	1.00
35_L	134_A	0.784	1.00
382_Q	385_I	0.782	1.00
11_R	14_Q	0.782	1.00
54_R	61_Y	0.782	1.00
34_K	161_A	0.779	1.00
55_K	149_N	0.779	1.00
333_K	355_N	0.774	1.00
177_A	181_L	0.773	1.00
18_K	21_K	0.773	1.00
162_F	167_V	0.772	1.00
61_Y	281_H	0.771	1.00
125_T	129_L	0.770	1.00
197_G	213_L	0.767	1.00
126_M	154_A	0.766	1.00
36_Q	40_D	0.766	1.00
394_S	397_A	0.765	1.00
62_H	287_K	0.765	1.00
23_L	166_E	0.761	1.00
268_L	331_V	0.759	1.00
114_I	128_P	0.757	1.00
181_L	188_I	0.756	1.00
29_E	84_E	0.756	1.00
219_S	252_D	0.755	1.00
232_A	264_F	0.755	1.00
275_G	287_K	0.753	1.00
57_V	292_V	0.751	1.00
181_L	200_V	0.751	1.00
190_F	196_V	0.746	1.00
233_A	237_A	0.745	1.00
220_P	366_V	0.744	1.00
50_I	61_Y	0.744	1.00
194_T	418_T	0.741	1.00
50_I	54_R	0.737	1.00
122_F	150_T	0.735	1.00
181_L	203_A	0.734	1.00
198_K	206_K	0.734	1.00
204_A	211_V	0.731	1.00
303_L	344_E	0.731	1.00
50_I	66_K	0.730	1.00
43_I	46_E	0.730	1.00
113_L	188_I	0.729	1.00
272_V	316_F	0.729	1.00
21_K	24_R	0.727	1.00
257_K	359_I	0.724	1.00
43_I	70_E	0.722	1.00
102_G	438_G	0.720	1.00
230_M	271_V	0.720	1.00
295_R	298_N	0.720	1.00
229_L	260_V	0.718	1.00
282_T	286_S	0.716	1.00
146_F	292_V	0.716	1.00
237_A	268_L	0.715	1.00
128_P	424_Y	0.715	1.00
179_E	182_D	0.713	1.00
174_V	199_I	0.712	1.00
52_A	149_N	0.711	1.00
256_I	260_V	0.708	1.00
380_K	383_D	0.705	1.00
141_V	167_V	0.704	1.00
269_Q	272_V	0.702	1.00
16_Q	138_S	0.702	1.00
143_L	171_E	0.698	1.00
66_K	70_E	0.695	1.00
224_D	257_K	0.694	1.00
23_L	34_K	0.693	1.00
137_N	434_S	0.692	1.00
53_I	56_D	0.692	1.00
125_T	151_S	0.692	1.00
9_I	179_E	0.691	1.00
272_V	275_G	0.690	1.00
48_E	156_K	0.689	1.00
47_E	61_Y	0.689	1.00
109_K	186_D	0.686	1.00
116_G	125_T	0.685	1.00
28_A	83_L	0.684	1.00
254_L	264_F	0.682	1.00
19_Q	22_A	0.682	1.00
202_T	205_A	0.680	1.00
255_F	342_M	0.680	1.00
17_K	20_Q	0.679	1.00
296_N	299_R	0.679	1.00
175_E	178_T	0.679	1.00
308_I	319_V	0.678	1.00
158_I	162_F	0.674	1.00
9_I	13_F	0.673	1.00
365_Y	368_D	0.672	1.00
358_D	364_D	0.671	1.00
327_I	330_T	0.670	1.00
101_N	386_D	0.667	1.00
316_F	331_V	0.666	1.00
293_N	296_N	0.664	1.00
172_G	177_A	0.664	1.00
382_Q	386_D	0.664	1.00
59_K	63_E	0.663	1.00
359_I	363_I	0.663	1.00
244_A	288_F	0.662	1.00
140_I	168_A	0.662	1.00
277_M	288_F	0.660	1.00
299_R	302_D	0.659	1.00
385_I	389_L	0.659	1.00
223_I	232_A	0.658	1.00
24_R	391_H	0.658	1.00
335_V	341_I	0.658	1.00
145_D	299_R	0.658	1.00
431_K	436_E	0.657	1.00
294_D	320_F	0.656	1.00
304_F	332_L	0.656	1.00
203_A	206_K	0.656	1.00
301_K	304_F	0.656	1.00
337_P	342_M	0.656	1.00
237_A	275_G	0.654	1.00
23_L	133_L	0.654	1.00
125_T	154_A	0.652	1.00
69_I	73_K	0.652	1.00
335_V	342_M	0.651	1.00
255_F	337_P	0.651	1.00
40_D	43_I	0.650	1.00
318_G	328_S	0.649	1.00
226_E	379_S	0.649	1.00
15_L	164_E	0.648	1.00
210_S	432_E	0.648	1.00
102_G	440_F	0.645	1.00
173_E	176_V	0.644	1.00
332_L	335_V	0.644	1.00
393_T	416_V	0.644	1.00
229_L	263_R	0.643	1.00
49_I	122_F	0.642	1.00
389_L	399_I	0.641	1.00
145_D	199_I	0.641	1.00
236_I	268_L	0.640	1.00
39_L	73_K	0.640	1.00
279_D	286_S	0.635	1.00
128_P	189_F	0.635	1.00
153_I	157_V	0.634	1.00
212_T	432_E	0.633	1.00
295_R	299_R	0.633	1.00
24_R	107_E	0.632	1.00
12_V	170_F	0.631	1.00
431_K	434_S	0.631	1.00
95_S	98_P	0.630	1.00
268_L	353_M	0.627	1.00
30_Q	34_K	0.626	1.00
105_M	437_K	0.626	1.00
291_I	296_N	0.625	1.00
363_I	387_N	0.624	1.00
53_I	64_V	0.623	1.00
59_K	120_Y	0.622	1.00
46_E	50_I	0.620	1.00
21_K	391_H	0.619	1.00
231_D	234_K	0.616	1.00
24_R	108_P	0.616	1.00
278_E	282_T	0.615	1.00
314_V	330_T	0.614	1.00
231_D	380_K	0.614	1.00
51_E	54_R	0.613	1.00
6_K	182_D	0.613	1.00
53_I	68_E	0.613	1.00
383_D	386_D	0.612	1.00
129_L	141_V	0.612	1.00
379_S	384_L	0.610	1.00
239_G	402_V	0.607	1.00
201_M	213_L	0.606	1.00
103_I	439_V	0.603	1.00
86_W	434_S	0.603	1.00
320_F	328_S	0.602	1.00
138_S	168_A	0.602	1.00
53_I	150_T	0.597	1.00
346_I	350_I	0.597	1.00
310_R	338_D	0.597	1.00
269_Q	331_V	0.596	1.00
54_R	281_H	0.595	1.00
363_I	392_T	0.594	1.00
221_T	254_L	0.593	1.00
181_L	207_H	0.593	1.00
377_V	385_I	0.593	1.00
78_D	82_N	0.592	1.00
18_K	22_A	0.592	1.00
28_A	134_A	0.590	1.00
42_V	122_F	0.590	1.00
383_D	387_N	0.590	1.00
226_E	381_N	0.589	1.00
334_N	355_N	0.589	1.00
256_I	353_M	0.585	1.00
226_E	380_K	0.584	1.00
184_P	370_D	0.583	1.00
122_F	154_A	0.579	1.00
39_L	76_I	0.578	1.00
69_I	122_F	0.576	1.00
247_T	250_A	0.575	1.00
42_V	154_A	0.574	1.00
187_H	432_E	0.574	1.00
42_V	76_I	0.574	1.00
249_I	406_F	0.573	1.00
229_L	264_F	0.570	1.00
194_T	198_K	0.569	1.00
154_A	158_I	0.569	1.00
227_Y	232_A	0.568	1.00
221_T	376_Y	0.567	1.00
277_M	287_K	0.566	1.00
17_K	111_V	0.566	1.00
86_W	430_F	0.565	1.00
337_P	364_D	0.565	1.00
112_T	137_N	0.563	1.00
362_V	366_V	0.560	1.00
145_D	195_N	0.559	1.00
38_F	41_S	0.559	1.00
66_K	284_D	0.558	1.00
359_I	391_H	0.558	1.00
133_L	162_F	0.558	1.00
377_V	399_I	0.558	1.00
314_V	317_G	0.557	1.00
34_K	38_F	0.556	1.00
112_T	139_A	0.555	1.00
135_A	430_F	0.554	1.00
12_V	168_A	0.552	1.00
16_Q	111_V	0.552	1.00
225_S	356_Y	0.550	1.00
393_T	435_H	0.549	1.00
123_M	127_A	0.549	1.00
398_A	401_D	0.548	1.00
230_M	270_T	0.547	1.00
229_L	232_A	0.546	1.00
301_K	308_I	0.546	1.00
50_I	69_I	0.546	1.00
308_I	311_G	0.545	1.00
240_K	351_L	0.544	1.00
366_V	392_T	0.543	1.00
29_E	33_E	0.543	1.00
258_K	261_Q	0.543	1.00
114_I	129_L	0.540	1.00
16_Q	140_I	0.539	1.00
254_L	353_M	0.538	1.00
57_V	243_N	0.538	1.00
133_L	167_V	0.537	1.00
304_F	330_T	0.537	1.00
388_V	392_T	0.537	1.00
111_V	186_D	0.536	1.00
397_A	437_K	0.535	1.00
79_N	131_A	0.534	1.00
81_N	84_E	0.534	1.00
241_F	275_G	0.533	1.00
49_I	69_I	0.533	1.00
17_K	183_Q	0.533	1.00
219_S	374_A	0.533	1.00
195_N	295_R	0.531	1.00
211_V	421_I	0.530	1.00
307_A	340_K	0.529	1.00
33_E	36_Q	0.529	1.00
251_P	376_Y	0.529	1.00
42_V	49_I	0.529	1.00
310_R	336_T	0.529	1.00
159_R	165_K	0.529	1.00
233_A	260_V	0.528	1.00
70_E	73_K	0.528	1.00
15_L	19_Q	0.528	1.00
50_I	64_V	0.527	1.00
291_I	327_I	0.526	1.00
22_A	138_S	0.525	1.00
341_I	346_I	0.525	1.00
392_T	397_A	0.522	1.00
342_M	365_Y	0.522	1.00
107_E	393_T	0.521	1.00
205_A	208_L	0.519	1.00
46_E	73_K	0.519	1.00
71_G	123_M	0.519	1.00
268_L	272_V	0.517	1.00
256_I	261_Q	0.515	1.00
140_I	170_F	0.514	1.00
315_V	334_N	0.513	1.00
337_P	343_Q	0.513	1.00
374_A	398_A	0.512	1.00
178_T	181_L	0.511	1.00
364_D	391_H	0.510	1.00
290_Q	326_T	0.508	1.00
314_V	318_G	0.508	1.00
220_P	394_S	0.507	1.00
113_L	181_L	0.507	1.00
276_F	282_T	0.506	1.00
113_L	140_I	0.504	1.00
299_R	303_L	0.503	1.00
148_M	171_E	0.503	1.00
342_M	352_P	0.503	1.00
119_N	347_F	0.501	1.00
100_A	401_D	0.501	1.00
234_K	238_V	0.500	1.00
303_L	341_I	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1a4sA	4	0.9843	100	0.031	Contact Map
1wndA	4	0.9843	100	0.034	Contact Map
3ek1A	5	0.9843	100	0.034	Contact Map
4o5hA	4	0.991	100	0.035	Contact Map
4qf6A	4	0.9843	100	0.035	Contact Map
4yweA	5	0.9798	100	0.035	Contact Map
4pxlA	4	0.9865	100	0.037	Contact Map
4pz2A	4	0.9865	100	0.038	Contact Map
2d4eA	4	0.982	100	0.038	Contact Map
4qtoA	4	0.9865	100	0.039	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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