GREMLIN Database
YXBC - Uncharacterized protein YxbC
UniProt: P46327 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 330 (264)
Sequences: 1212 (862)
Seq/√Len: 53.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
159_E211_T7.8661.00
161_T207_I5.0571.00
20_E24_E3.7041.00
264_E267_V3.6721.00
17_T20_E3.3211.00
164_L222_L3.2981.00
138_N230_Q3.1191.00
163_K225_S3.0531.00
141_G225_S2.9871.00
24_E29_K2.8351.00
79_D87_E2.8131.00
261_R264_E2.6571.00
262_F267_V2.5571.00
102_F105_L2.4151.00
163_K207_I2.3991.00
118_K122_R2.3291.00
262_F266_A2.2091.00
40_F156_I2.1931.00
289_Q293_E2.1881.00
32_V208_V2.1531.00
267_V270_Q2.1471.00
161_T229_D2.1331.00
153_I226_T2.0651.00
19_S23_E2.0071.00
262_F265_L1.9120.99
159_E229_D1.9120.99
154_F215_M1.8850.99
36_E215_M1.8740.99
51_T55_V1.8720.99
145_H224_H1.8410.99
277_K283_Y1.8330.99
285_E292_S1.8330.99
146_F223_W1.8180.99
25_Y31_L1.8010.99
133_V235_L1.7830.99
145_H160_K1.7480.99
159_E230_Q1.7150.99
135_A233_L1.7120.99
32_V210_L1.7080.99
156_I235_L1.7010.99
132_I149_Y1.7000.99
126_G238_T1.6970.99
290_T293_E1.6540.98
33_A215_M1.6410.98
154_F237_I1.6370.98
16_V31_L1.6280.98
265_L270_Q1.6190.98
159_E209_N1.6070.98
132_I236_N1.6020.98
103_T133_V1.5890.98
161_T209_N1.5630.98
153_I234_A1.5440.98
25_Y28_V1.5410.98
285_E293_E1.5210.97
288_I291_L1.5210.97
166_K205_A1.5110.97
34_R211_T1.4900.97
278_S281_N1.4850.97
160_K232_T1.4730.97
164_L218_L1.4670.97
25_Y29_K1.4630.97
281_N285_E1.4550.97
126_G149_Y1.4530.97
13_I17_T1.4420.96
280_L288_I1.4340.96
210_L215_M1.4280.96
163_K227_K1.4140.96
276_S281_N1.4040.96
147_D224_H1.3770.95
261_R267_V1.3700.95
160_K224_H1.3640.95
134_Y236_N1.3500.95
279_E288_I1.3260.94
16_V25_Y1.3140.94
148_A221_G1.3000.94
280_L285_E1.2990.94
286_S290_T1.2910.93
97_A141_G1.2870.93
46_F157_Q1.2860.93
43_I115_E1.2630.93
264_E269_H1.2430.92
40_F154_F1.2430.92
140_G143_K1.2300.92
19_S278_S1.2250.91
283_Y287_L1.2250.91
294_N297_T1.2030.91
132_I142_F1.1980.90
292_S296_E1.1910.90
292_S295_A1.1710.89
134_Y160_K1.1670.89
132_I238_T1.1560.89
95_G221_G1.1500.89
288_I294_N1.1420.88
288_I292_S1.1400.88
126_G236_N1.1370.88
288_I297_T1.1340.88
285_E289_Q1.1200.87
285_E294_N1.1170.87
142_F149_Y1.0950.86
99_E149_Y1.0940.86
34_R210_L1.0930.86
41_T278_S1.0850.85
276_S288_I1.0810.85
270_Q273_H1.0790.85
149_Y238_T1.0780.85
152_L217_Y1.0720.85
205_A222_L1.0690.85
251_A254_K1.0660.84
134_Y149_Y1.0630.84
277_K280_L1.0570.84
289_Q292_S1.0430.83
99_E134_Y1.0360.83
166_K222_L1.0350.83
146_F168_E1.0340.83
103_T235_L1.0310.82
276_S295_A1.0300.82
15_P18_M1.0290.82
138_N231_A1.0200.82
150_T217_Y1.0170.82
57_A60_N1.0130.81
40_F43_I1.0130.81
280_L283_Y1.0110.81
264_E274_E1.0040.81
147_D160_K0.9970.80
198_P202_L0.9950.80
20_E23_E0.9940.80
55_V63_V0.9940.80
284_L287_L0.9910.80
46_F50_R0.9860.79
136_A234_A0.9850.79
265_L274_E0.9810.79
136_A140_G0.9700.78
266_A269_H0.9640.78
167_N221_G0.9610.78
151_N217_Y0.9580.77
157_Q231_A0.9580.77
99_E150_T0.9560.77
218_L222_L0.9550.77
168_E172_N0.9540.77
276_S283_Y0.9510.77
127_T235_L0.9490.77
101_D238_T0.9460.77
264_E273_H0.9450.76
153_I236_N0.9420.76
138_N229_D0.9420.76
136_A141_G0.9380.76
63_V98_L0.9320.75
15_P39_R0.9280.75
95_G139_G0.9270.75
110_V235_L0.9230.75
132_I160_K0.9190.74
133_V156_I0.9170.74
276_S279_E0.9090.74
126_G132_I0.9050.73
174_M177_Y0.9000.73
99_E126_G0.8850.72
101_D149_Y0.8830.71
52_L83_V0.8730.71
253_R256_L0.8680.70
283_Y286_S0.8660.70
220_R236_N0.8650.70
285_E288_I0.8640.70
277_K281_N0.8620.70
168_E223_W0.8610.70
276_S287_L0.8580.69
261_R284_L0.8550.69
209_N229_D0.8550.69
34_R215_M0.8550.69
146_F167_N0.8450.68
158_G219_P0.8410.68
126_G134_Y0.8400.68
53_E88_A0.8390.68
282_G286_S0.8350.67
26_W123_L0.8340.67
251_A256_L0.8300.67
21_F217_Y0.8300.67
142_F226_T0.8290.67
132_I220_R0.8270.66
266_A270_Q0.8250.66
52_L60_N0.8200.66
64_M141_G0.8170.65
20_E25_Y0.8160.65
152_L238_T0.8140.65
84_S87_E0.8120.65
49_V75_E0.8120.65
173_P221_G0.8110.65
288_I295_A0.8110.65
42_S206_E0.8100.65
141_G163_K0.8080.65
99_E238_T0.8080.65
284_L294_N0.8060.64
293_E297_T0.8040.64
91_W133_V0.8020.64
178_D181_E0.7950.63
50_R100_F0.7920.63
46_F233_L0.7910.63
97_A136_A0.7890.63
140_G236_N0.7870.63
50_R85_P0.7860.62
210_L232_T0.7800.62
149_Y236_N0.7790.62
99_E103_T0.7770.62
223_W236_N0.7750.61
141_G232_T0.7740.61
285_E291_L0.7740.61
204_D207_I0.7730.61
103_T110_V0.7700.61
261_R265_L0.7660.60
132_I234_A0.7660.60
258_S284_L0.7640.60
164_L208_V0.7630.60
276_S280_L0.7610.60
277_K282_G0.7610.60
44_P106_F0.7580.60
24_E163_K0.7580.60
34_R214_T0.7560.59
275_S281_N0.7540.59
272_L275_S0.7520.59
150_T218_L0.7520.59
108_P208_V0.7520.59
97_A137_K0.7500.59
134_Y238_T0.7480.59
159_E212_P0.7470.59
26_W30_P0.7470.59
40_F235_L0.7460.58
277_K292_S0.7440.58
142_F236_N0.7420.58
149_Y240_G0.7410.58
97_A125_A0.7410.58
13_I96_A0.7300.57
99_E124_P0.7260.56
112_R289_Q0.7230.56
281_N284_L0.7230.56
61_N96_A0.7190.56
62_P134_Y0.7180.56
132_I226_T0.7170.55
265_L269_H0.7150.55
214_T217_Y0.7120.55
275_S285_E0.7100.55
144_A237_I0.7090.55
220_R234_A0.7060.54
279_E292_S0.7060.54
121_L127_T0.7060.54
87_E93_E0.7030.54
48_K51_T0.7010.54
146_F169_N0.6990.54
64_M149_Y0.6950.53
91_W94_K0.6930.53
289_Q294_N0.6910.53
166_K221_G0.6870.52
53_E87_E0.6850.52
101_D126_G0.6830.52
47_E51_T0.6830.52
132_I240_G0.6810.52
110_V227_K0.6810.52
37_V116_K0.6800.52
62_P91_W0.6800.52
204_D225_S0.6790.51
169_N223_W0.6720.51
64_M99_E0.6700.50
144_A223_W0.6700.50
254_K292_S0.6700.50
134_Y234_A0.6700.50
134_Y142_F0.6660.50
21_F152_L0.6650.50
209_N222_L0.6650.50
262_F291_L0.6620.50
236_N242_P0.6610.50
114_I127_T0.6590.49
213_G219_P0.6550.49
101_D142_F0.6530.49
279_E283_Y0.6520.49
101_D132_I0.6520.49
26_W138_N0.6510.48
19_S249_L0.6480.48
282_G295_A0.6440.48
150_T238_T0.6430.48
262_F273_H0.6430.48
61_N149_Y0.6410.47
58_I94_K0.6400.47
270_Q274_E0.6380.47
99_E132_I0.6340.47
96_A101_D0.6340.47
151_N214_T0.6310.46
145_H162_W0.6270.46
262_F270_Q0.6260.46
45_G157_Q0.6250.46
140_G226_T0.6250.46
134_Y145_H0.6240.46
244_W287_L0.6240.46
167_N172_N0.6210.45
114_I125_A0.6210.45
144_A233_L0.6200.45
123_L238_T0.6180.45
244_W247_L0.6180.45
51_T98_L0.6170.45
158_G213_G0.6150.45
126_G240_G0.6140.45
54_N85_P0.6130.44
283_Y289_Q0.6110.44
92_Y95_G0.6090.44
260_N263_R0.6080.44
32_V97_A0.6070.44
259_D289_Q0.6030.43
48_K107_I0.6010.43
167_N222_L0.5980.43
99_E236_N0.5970.43
27_P150_T0.5930.42
262_F280_L0.5920.42
32_V120_E0.5920.42
167_N248_M0.5920.42
264_E272_L0.5910.42
28_V31_L0.5910.42
278_S286_S0.5900.42
285_E295_A0.5890.42
267_V272_L0.5880.42
151_N238_T0.5870.42
44_P111_R0.5860.42
236_N240_G0.5850.42
23_E34_R0.5820.41
136_A232_T0.5820.41
40_F215_M0.5790.41
51_T85_P0.5780.41
150_T240_G0.5760.41
32_V174_M0.5750.41
293_E296_E0.5750.41
46_F156_I0.5730.40
226_T236_N0.5710.40
60_N101_D0.5700.40
35_G38_E0.5680.40
137_K157_Q0.5670.40
13_I253_R0.5660.40
27_P217_Y0.5650.40
162_W224_H0.5650.40
251_A255_K0.5630.39
162_W219_P0.5630.39
151_N236_N0.5620.39
99_E142_F0.5600.39
63_V97_A0.5580.39
275_S279_E0.5570.39
39_R73_E0.5570.39
157_Q230_Q0.5560.39
141_G175_Q0.5530.38
217_Y226_T0.5510.38
155_Q219_P0.5510.38
198_P207_I0.5480.38
261_R269_H0.5470.38
27_P134_Y0.5470.38
136_A236_N0.5450.38
86_A90_E0.5430.37
288_I296_E0.5430.37
101_D104_D0.5420.37
251_A263_R0.5380.37
42_S156_I0.5380.37
204_D221_G0.5380.37
84_S112_R0.5380.37
261_R270_Q0.5350.37
101_D150_T0.5350.37
121_L247_L0.5340.36
275_S280_L0.5340.36
87_E90_E0.5340.36
117_L226_T0.5330.36
59_Y102_F0.5330.36
136_A160_K0.5300.36
33_A113_W0.5270.36
19_S171_S0.5260.36
81_F144_A0.5260.36
163_K196_D0.5260.36
35_G39_R0.5250.36
158_G162_W0.5230.35
178_D228_S0.5220.35
26_W140_G0.5220.35
112_R243_A0.5200.35
24_E259_D0.5170.35
38_E282_G0.5140.35
252_L291_L0.5140.35
137_K164_L0.5140.35
155_Q158_G0.5130.34
176_H179_L0.5110.34
160_K234_A0.5100.34
103_T126_G0.5100.34
104_D246_D0.5070.34
93_E278_S0.5060.34
59_Y78_T0.5050.34
81_F240_G0.5050.34
217_Y238_T0.5050.34
20_E28_V0.5050.34
104_D245_L0.5040.34
87_E200_E0.5030.33
280_L291_L0.5020.33
241_Q246_D0.5020.33
277_K295_A0.5020.33
151_N240_G0.5010.33
199_K242_P0.5010.33
43_I112_R0.5010.33
285_E290_T0.5000.33
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vrbA 2 0.9636 100 0.336 Contact Map
4bxfA 2 0.9273 100 0.428 Contact Map
4ccjA 3 0.9394 100 0.442 Contact Map
4cswA 2 0.903 100 0.538 Contact Map
4litA 2 0.8364 100 0.547 Contact Map
4qszA 2 0.7515 99.9 0.687 Contact Map
3al5A 2 0.8515 99.9 0.692 Contact Map
3k2oA 2 0.8121 99.9 0.701 Contact Map
3kv5D 2 0.9061 99.9 0.704 Contact Map
4gjzA 1 0.6242 99.9 0.712 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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