GREMLIN Database
YXBB - Uncharacterized protein YxbB
UniProt: P46326 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 244 (201)
Sequences: 14919 (10518)
Seq/√Len: 741.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_V61_H3.1741.00
128_Y188_I2.7801.00
126_E129_R2.7191.00
69_P92_L2.6961.00
45_T64_A2.6831.00
51_S62_V2.5701.00
63_H105_A2.5681.00
127_C137_I2.5391.00
56_K82_S2.4751.00
100_Y105_A2.4101.00
106_D132_A2.3651.00
121_V185_D2.3391.00
44_G113_C2.3311.00
75_A90_F2.3301.00
65_V93_E2.3271.00
38_K107_F2.3261.00
72_H90_F2.2751.00
61_H89_S2.0911.00
74_I77_E2.0691.00
72_H76_Q2.0641.00
69_P73_E2.0621.00
108_I127_C2.0591.00
52_I79_A2.0421.00
41_I105_A1.9561.00
126_E130_V1.9101.00
39_V63_H1.9071.00
63_H91_D1.8941.00
121_V125_K1.8861.00
131_L137_I1.8681.00
40_I54_L1.8491.00
108_I131_L1.8131.00
72_H92_L1.8051.00
79_A90_F1.7721.00
119_D122_K1.7401.00
52_I78_E1.7321.00
175_S178_D1.7301.00
120_V182_F1.7251.00
121_V182_F1.7251.00
43_M127_C1.7231.00
180_H184_Q1.6761.00
45_T51_S1.6701.00
66_D72_H1.6141.00
27_A53_Q1.5861.00
131_L135_G1.5481.00
122_K125_K1.5071.00
93_E99_S1.4771.00
131_L188_I1.4681.00
113_C117_W1.4531.00
77_E81_K1.4411.00
39_V132_A1.4391.00
43_M95_V1.4361.00
64_A90_F1.4101.00
27_A31_R1.4051.00
65_V98_L1.4001.00
117_W123_G1.3971.00
67_I94_D1.3821.00
73_E76_Q1.3791.00
99_S126_E1.3521.00
202_D206_S1.3441.00
63_H89_S1.3401.00
41_I108_I1.3341.00
70_A73_E1.3281.00
80_K85_S1.3251.00
110_S113_C1.3051.00
102_D129_R1.3021.00
51_S64_A1.2771.00
29_L138_V1.2741.00
39_V105_A1.2641.00
181_Q185_D1.2451.00
94_D97_H1.2411.00
124_L183_V1.2331.00
28_R194_E1.2041.00
53_Q57_R1.1991.00
101_A104_Y1.1951.00
53_Q56_K1.1951.00
44_G110_S1.1951.00
108_I130_V1.1941.00
40_I107_F1.1931.00
91_D100_Y1.1721.00
52_I82_S1.1711.00
123_G127_C1.1401.00
181_Q184_Q1.1341.00
95_V113_C1.1271.00
14_V17_Y1.1081.00
48_G75_A1.1051.00
28_R32_M1.0981.00
45_T75_A1.0961.00
74_I78_E1.0941.00
65_V91_D1.0941.00
112_S116_H1.0921.00
77_E80_K1.0861.00
98_L130_V1.0811.00
55_A87_L1.0701.00
66_D71_M1.0651.00
121_V186_A1.0601.00
39_V104_Y1.0521.00
127_C131_L1.0501.00
32_M194_E1.0491.00
180_H193_L1.0451.00
76_Q80_K1.0411.00
64_A75_A1.0231.00
78_E82_S1.0191.00
42_D64_A1.0181.00
27_A57_R1.0161.00
38_K60_A1.0101.00
14_V18_Q1.0071.00
112_S115_H1.0061.00
78_E81_K1.0031.00
79_A88_I1.0021.00
51_S88_I1.0001.00
178_D181_Q0.9921.00
176_F195_T0.9791.00
128_Y186_A0.9691.00
47_P71_M0.9631.00
95_V117_W0.9591.00
50_L111_Y0.9461.00
98_L126_E0.9451.00
114_L141_D0.9441.00
52_I56_K0.9441.00
125_K186_A0.9411.00
115_H141_D0.9361.00
40_I62_V0.9221.00
73_E77_E0.9201.00
35_P38_K0.9191.00
48_G90_F0.9171.00
41_I130_V0.9121.00
125_K129_R0.9101.00
37_N60_A0.9011.00
31_R57_R0.8971.00
107_F135_G0.8751.00
38_K106_D0.8701.00
45_T66_D0.8641.00
28_R31_R0.8641.00
97_H122_K0.8561.00
158_K162_Y0.8541.00
114_L117_W0.8531.00
63_H100_Y0.8521.00
51_S90_F0.8481.00
56_K84_V0.8471.00
32_M192_S0.8461.00
54_L109_V0.8441.00
11_K68_N0.8431.00
68_N71_M0.8291.00
160_P164_R0.8201.00
152_I155_K0.8131.00
50_L109_V0.8031.00
182_F186_A0.8031.00
104_Y130_V0.7881.00
114_L124_L0.7841.00
112_S140_L0.7811.00
190_N193_L0.7811.00
18_Q47_P0.7801.00
10_Y18_Q0.7791.00
9_T12_E0.7791.00
55_A88_I0.7771.00
122_K126_E0.7751.00
42_D116_H0.7741.00
40_I109_V0.7721.00
124_L179_I0.7701.00
76_Q89_S0.7651.00
152_I156_Q0.7641.00
43_M108_I0.7631.00
111_Y140_L0.7631.00
124_L186_A0.7611.00
47_P78_E0.7591.00
39_V106_D0.7581.00
34_S136_K0.7571.00
49_Y53_Q0.7561.00
137_I183_V0.7531.00
79_A84_V0.7501.00
42_D62_V0.7451.00
201_E205_E0.7441.00
98_L105_A0.7431.00
30_S54_L0.7321.00
96_H119_D0.7311.00
71_M112_S0.7281.00
64_A88_I0.7251.00
96_H117_W0.7241.00
30_S53_Q0.7191.00
110_S117_W0.7131.00
18_Q78_E0.7101.00
72_H75_A0.7081.00
107_F136_K0.7071.00
13_F17_Y0.7041.00
20_Y23_P0.6991.00
202_D205_E0.6991.00
69_P76_Q0.6951.00
29_L111_Y0.6941.00
24_L27_A0.6941.00
104_Y132_A0.6891.00
102_D126_E0.6881.00
114_L123_G0.6871.00
52_I55_A0.6861.00
33_Y138_V0.6851.00
153_M157_I0.6851.00
128_Y187_G0.6831.00
79_A83_G0.6741.00
55_A84_V0.6731.00
105_A130_V0.6721.00
203_F206_S0.6701.00
61_H87_L0.6691.00
116_H141_D0.6681.00
50_L54_L0.6631.00
12_E16_L0.6611.00
10_Y14_V0.6581.00
16_L20_Y0.6541.00
144_N175_S0.6481.00
43_M65_V0.6451.00
139_I183_V0.6441.00
26_G50_L0.6421.00
30_S57_R0.6411.00
103_Q132_A0.6351.00
141_D179_I0.6351.00
153_M156_Q0.6281.00
17_Y21_L0.6281.00
176_F193_L0.6251.00
35_P60_A0.6241.00
76_Q90_F0.6221.00
183_V186_A0.6191.00
102_D130_V0.6181.00
16_L19_S0.6171.00
19_S22_Y0.6151.00
137_I188_I0.6141.00
112_S142_T0.6131.00
47_P74_I0.6121.00
70_A74_I0.6111.00
45_T65_V0.6101.00
11_K70_A0.6101.00
11_K14_V0.6081.00
14_V19_S0.6071.00
114_L139_I0.6051.00
168_E171_E0.6041.00
99_S130_V0.6031.00
100_Y104_Y0.5991.00
103_Q133_P0.5991.00
114_L179_I0.5991.00
104_Y129_R0.5961.00
7_C14_V0.5951.00
19_S23_P0.5941.00
150_L153_M0.5941.00
59_N87_L0.5931.00
38_K136_K0.5921.00
18_Q22_Y0.5921.00
93_E98_L0.5911.00
167_R170_F0.5911.00
84_V88_I0.5881.00
154_R157_I0.5881.00
166_V169_A0.5881.00
182_F185_D0.5851.00
26_G30_S0.5821.00
177_E181_Q0.5761.00
30_S33_Y0.5751.00
55_A62_V0.5751.00
197_H200_P0.5741.00
26_G49_Y0.5721.00
42_D45_T0.5681.00
176_F180_H0.5651.00
49_Y78_E0.5621.00
115_H142_T0.5621.00
139_I179_I0.5571.00
66_D92_L0.5561.00
150_L154_R0.5551.00
110_S139_I0.5521.00
151_E155_K0.5521.00
44_G67_I0.5501.00
144_N178_D0.5491.00
176_F179_I0.5491.00
96_H122_K0.5481.00
18_Q21_L0.5461.00
200_P203_F0.5451.00
165_F168_E0.5431.00
51_S55_A0.5391.00
97_H126_E0.5391.00
152_I157_I0.5381.00
129_R132_A0.5351.00
136_K139_I0.5341.00
35_P107_F0.5241.00
111_Y115_H0.5241.00
24_L28_R0.5241.00
149_H153_M0.5211.00
67_I92_L0.5211.00
151_E154_R0.5201.00
146_Q177_E0.5161.00
30_S58_T0.5141.00
196_F203_F0.5131.00
95_V123_G0.5121.00
35_P58_T0.5121.00
45_T90_F0.5111.00
52_I88_I0.5101.00
42_D109_V0.5091.00
71_M111_Y0.5081.00
177_E180_H0.5071.00
125_K128_Y0.5061.00
37_N107_F0.5041.00
164_R167_R0.5041.00
100_Y130_V0.5031.00
25_L28_R0.5031.00
153_M158_K0.5021.00
180_H191_Y0.5021.00
164_R168_E0.5011.00
178_D182_F0.5001.00
33_Y107_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o57A 2 0.959 100 0.407 Contact Map
4pneA 2 0.9467 100 0.412 Contact Map
4obxA 2 0.8402 100 0.42 Contact Map
3busA 1 0.8975 100 0.423 Contact Map
1vl5A 1 0.8648 100 0.432 Contact Map
3bkxA 2 0.9836 100 0.432 Contact Map
2fk8A 1 0.959 100 0.435 Contact Map
4ineA 2 0.959 100 0.437 Contact Map
3ujcA 1 0.9221 100 0.44 Contact Map
3hemA 2 0.9795 100 0.44 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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