GREMLIN Database
YVRN - Uncharacterized ABC transporter permease YvrN
UniProt: P46324 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 409 (359)
Sequences: 37489 (32144)
Seq/√Len: 1696.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_E192_K3.5371.00
177_S184_P3.4961.00
317_I334_F3.3001.00
177_S186_K3.2721.00
179_E184_P3.1111.00
161_E165_D2.9811.00
313_R337_E2.6901.00
157_V210_L2.6801.00
156_V186_K2.6231.00
156_V188_V2.6151.00
401_Q404_D2.5711.00
138_R192_K2.5061.00
164_R190_V2.4591.00
158_M189_G2.4381.00
173_A176_K2.4241.00
172_E176_K2.4201.00
86_A89_T2.4111.00
321_K327_R2.3501.00
13_F16_K2.3151.00
346_G379_L2.2931.00
243_G247_A2.2901.00
326_K329_V2.2751.00
391_L395_I2.2041.00
238_H241_E2.1961.00
159_I164_R2.1521.00
90_V94_K2.1491.00
395_I399_K2.1311.00
91_K94_K2.0911.00
338_A390_G2.0911.00
157_V185_F2.0611.00
155_Q216_V2.0251.00
158_M191_F2.0021.00
27_I348_L1.9991.00
342_T386_G1.9771.00
268_D271_E1.9751.00
98_M245_M1.9671.00
143_R188_V1.9631.00
100_K234_D1.9611.00
349_G353_G1.9431.00
163_V167_L1.9391.00
139_I144_K1.8721.00
371_S374_A1.8651.00
23_M27_I1.8631.00
98_M234_D1.8511.00
87_E91_K1.8341.00
313_R316_E1.8191.00
157_V212_V1.7941.00
34_I353_G1.7931.00
213_P216_V1.7721.00
172_E187_V1.7601.00
215_K218_P1.7511.00
233_A242_A1.7511.00
241_E245_M1.7331.00
100_K232_Q1.7201.00
91_K95_S1.7151.00
159_I163_V1.7031.00
185_F216_V1.7011.00
212_V217_W1.6981.00
331_L395_I1.6901.00
92_A95_S1.6861.00
141_E172_E1.6761.00
244_V247_A1.6501.00
127_V131_Y1.6371.00
31_A352_A1.6291.00
160_N191_F1.5811.00
143_R156_V1.5601.00
159_I210_L1.5531.00
27_I352_A1.5411.00
240_Q243_G1.5401.00
162_A193_E1.5361.00
45_E49_Q1.5241.00
10_Q13_F1.5161.00
23_M345_G1.5071.00
159_I187_V1.5061.00
157_V178_I1.5041.00
174_L190_V1.5021.00
239_I243_G1.4991.00
329_V332_F1.4891.00
214_K218_P1.4821.00
345_G349_G1.4681.00
88_E92_A1.4641.00
153_T156_V1.4481.00
11_S337_E1.4461.00
328_R332_F1.4401.00
355_G359_L1.4291.00
144_K158_M1.4261.00
89_T92_A1.4261.00
179_E182_G1.4141.00
158_M188_V1.4131.00
18_R312_E1.4131.00
30_I349_G1.4031.00
162_A165_D1.4001.00
92_A96_D1.3921.00
327_R398_S1.3851.00
212_V216_V1.3821.00
317_I330_I1.3821.00
372_I376_V1.3801.00
235_S238_H1.3791.00
244_V248_D1.3761.00
140_T161_E1.3741.00
240_Q244_V1.3581.00
245_M248_D1.3551.00
155_Q183_V1.3551.00
342_T346_G1.3541.00
26_V345_G1.3521.00
314_T405_A1.3441.00
145_L188_V1.3261.00
41_K371_S1.3231.00
389_F393_P1.3211.00
394_S398_S1.3181.00
373_P377_G1.3181.00
351_L355_G1.3051.00
12_I19_S1.3011.00
98_M242_A1.2841.00
318_G405_A1.2801.00
96_D245_M1.2711.00
325_A329_V1.2701.00
376_V380_I1.2661.00
101_G232_Q1.2651.00
145_L158_M1.2581.00
141_E173_A1.2441.00
288_G292_S1.2381.00
27_I31_A1.2361.00
8_S336_T1.2261.00
318_G322_A1.2221.00
355_G358_K1.2191.00
88_E91_K1.2151.00
347_I351_L1.2151.00
316_E320_K1.2121.00
38_S357_A1.2111.00
159_I190_V1.2101.00
140_T192_K1.2031.00
353_G357_A1.1991.00
168_F172_E1.1931.00
396_K399_K1.1901.00
58_A62_V1.1881.00
85_V89_T1.1861.00
31_A356_I1.1811.00
31_A353_G1.1801.00
139_I189_G1.1771.00
160_N208_P1.1741.00
160_N163_V1.1741.00
31_A349_G1.1701.00
34_I378_A1.1611.00
174_L188_V1.1531.00
359_L362_V1.1491.00
132_F144_K1.1381.00
167_L172_E1.1321.00
332_F336_T1.1321.00
314_T400_L1.1271.00
285_L289_G1.1231.00
99_V102_L1.1181.00
55_G58_A1.1171.00
233_A239_I1.1131.00
320_K333_Q1.1131.00
145_L156_V1.0971.00
17_L20_I1.0951.00
44_S48_K1.0801.00
320_K325_A1.0781.00
105_Y228_Q1.0771.00
162_A166_E1.0741.00
29_G291_A1.0711.00
45_E369_I1.0671.00
19_S341_L1.0631.00
243_G268_D1.0561.00
245_M249_L1.0541.00
395_I398_S1.0531.00
373_P376_V1.0531.00
274_Q278_S1.0521.00
41_K44_S1.0481.00
306_M338_A1.0471.00
143_R146_T1.0461.00
50_S53_G1.0441.00
44_S284_A1.0421.00
229_I233_A1.0391.00
45_E48_K1.0361.00
23_M348_L1.0281.00
87_E90_V1.0281.00
49_Q52_I1.0271.00
49_Q53_G1.0241.00
216_V219_L1.0231.00
233_A236_S1.0231.00
342_T382_S1.0211.00
369_I372_I1.0161.00
299_G389_F1.0131.00
161_E193_E1.0091.00
101_G134_M1.0081.00
348_L351_L1.0081.00
168_F173_A1.0001.00
23_M344_I0.9871.00
20_I24_L0.9771.00
217_W221_E0.9731.00
294_S301_G0.9671.00
346_G382_S0.9661.00
241_E244_V0.9641.00
27_I30_I0.9601.00
41_K374_A0.9591.00
15_H312_E0.9581.00
370_V375_V0.9531.00
141_E174_L0.9481.00
229_I232_Q0.9481.00
400_L404_D0.9471.00
103_S128_D0.9461.00
338_A342_T0.9441.00
89_T93_I0.9401.00
154_H215_K0.9341.00
101_G133_D0.9301.00
9_F13_F0.9301.00
234_D237_E0.9251.00
314_T318_G0.9231.00
261_K264_Y0.9221.00
331_L391_L0.9221.00
41_K45_E0.9201.00
90_V104_L0.9201.00
394_S397_A0.9191.00
130_D133_D0.9191.00
15_H18_R0.9191.00
299_G385_V0.9151.00
350_V375_V0.9131.00
277_E281_Q0.9111.00
94_K102_L0.9071.00
160_N207_N0.9051.00
106_Y217_W0.9031.00
303_M307_L0.8991.00
27_I345_G0.8981.00
90_V102_L0.8971.00
325_A330_I0.8891.00
38_S42_G0.8881.00
154_H213_P0.8861.00
392_L395_I0.8861.00
281_Q285_L0.8851.00
26_V30_I0.8821.00
237_E241_E0.8791.00
313_R334_F0.8781.00
339_V387_I0.8761.00
54_M58_A0.8701.00
396_K400_L0.8681.00
327_R399_K0.8671.00
380_I384_A0.8621.00
382_S386_G0.8611.00
111_A124_V0.8591.00
321_K402_P0.8581.00
400_L405_A0.8551.00
92_A249_L0.8531.00
246_A249_L0.8531.00
93_I246_A0.8501.00
141_E190_V0.8501.00
48_K52_I0.8481.00
358_K362_V0.8461.00
124_V212_V0.8461.00
168_F176_K0.8451.00
56_N59_I0.8391.00
278_S281_Q0.8341.00
327_R331_L0.8301.00
265_S268_D0.8291.00
133_D144_K0.8291.00
128_D131_Y0.8281.00
237_E242_A0.8271.00
377_G380_I0.8251.00
402_P405_A0.8241.00
93_I96_D0.8221.00
104_L128_D0.8181.00
99_V231_V0.8171.00
378_A382_S0.8171.00
384_A388_I0.8161.00
120_S166_E0.8151.00
134_M232_Q0.8131.00
30_I382_S0.8121.00
11_S313_R0.8121.00
242_A246_A0.8121.00
126_G217_W0.8101.00
60_N63_Y0.8091.00
242_A245_M0.8091.00
310_V317_I0.8071.00
234_D238_H0.8021.00
25_G29_G0.8011.00
351_L354_F0.8011.00
25_G301_G0.7991.00
22_T25_G0.7961.00
161_E164_R0.7951.00
86_A90_V0.7931.00
375_V379_L0.7881.00
122_P210_L0.7871.00
321_K330_I0.7841.00
377_G381_F0.7811.00
359_L363_I0.7791.00
339_V386_G0.7781.00
266_V269_L0.7761.00
393_P397_A0.7751.00
403_V406_L0.7711.00
160_N209_V0.7691.00
124_V210_L0.7691.00
59_I243_G0.7681.00
311_T314_T0.7671.00
292_S296_L0.7671.00
309_S337_E0.7661.00
16_K20_I0.7661.00
381_F384_A0.7621.00
90_V93_I0.7611.00
173_A190_V0.7601.00
304_N308_V0.7571.00
160_N193_E0.7571.00
233_A237_E0.7561.00
267_M271_E0.7561.00
214_K217_W0.7491.00
354_F370_V0.7481.00
57_N61_V0.7431.00
142_G145_L0.7431.00
352_A355_G0.7421.00
137_I191_F0.7401.00
11_S316_E0.7371.00
33_I37_V0.7371.00
90_V229_I0.7361.00
180_M185_F0.7351.00
338_A393_P0.7341.00
191_F211_Y0.7341.00
242_A249_L0.7331.00
291_A295_L0.7321.00
247_A266_V0.7311.00
208_P211_Y0.7301.00
346_G386_G0.7301.00
357_A361_T0.7301.00
25_G304_N0.7291.00
263_E266_V0.7291.00
358_K368_F0.7271.00
335_L387_I0.7271.00
309_S313_R0.7261.00
331_L398_S0.7261.00
230_A233_A0.7261.00
271_E274_Q0.7251.00
191_F195_N0.7251.00
102_L105_Y0.7251.00
280_N284_A0.7241.00
139_I191_F0.7241.00
122_P163_V0.7241.00
357_A368_F0.7231.00
100_K104_L0.7221.00
346_G350_V0.7211.00
381_F385_V0.7211.00
7_I11_S0.7201.00
344_I347_I0.7201.00
379_L383_M0.7201.00
105_Y108_S0.7191.00
270_Q274_Q0.7181.00
346_G383_M0.7181.00
159_I178_I0.7161.00
35_A356_I0.7111.00
374_A377_G0.7101.00
174_L189_G0.7081.00
159_I172_E0.7061.00
46_Q50_S0.7061.00
96_D249_L0.7011.00
350_V379_L0.7001.00
126_G214_K0.6991.00
102_L231_V0.6991.00
374_A378_A0.6991.00
139_I143_R0.6981.00
278_S282_S0.6971.00
35_A353_G0.6951.00
38_S353_G0.6951.00
319_I322_A0.6951.00
301_G304_N0.6941.00
318_G402_P0.6921.00
392_L396_K0.6921.00
390_G394_S0.6911.00
338_A386_G0.6911.00
114_F179_E0.6891.00
303_M389_F0.6891.00
298_G301_G0.6891.00
178_I185_F0.6881.00
105_Y230_A0.6871.00
155_Q186_K0.6871.00
123_Q126_G0.6861.00
22_T305_I0.6861.00
7_I320_K0.6841.00
336_T339_V0.6821.00
331_L394_S0.6801.00
209_V213_P0.6801.00
56_N60_N0.6791.00
275_E278_S0.6771.00
315_R319_I0.6751.00
227_T231_V0.6721.00
185_F212_V0.6691.00
7_I333_Q0.6681.00
139_I158_M0.6671.00
158_M211_Y0.6671.00
316_E337_E0.6671.00
96_D242_A0.6651.00
336_T340_V0.6651.00
338_A394_S0.6631.00
122_P125_Y0.6631.00
113_V122_P0.6621.00
94_K101_G0.6611.00
101_G130_D0.6601.00
100_K103_S0.6591.00
260_E263_E0.6591.00
141_E164_R0.6581.00
282_S286_L0.6561.00
319_I323_L0.6531.00
175_H186_K0.6501.00
140_T191_F0.6501.00
305_I309_S0.6501.00
354_F358_K0.6481.00
183_V219_L0.6461.00
62_V267_M0.6441.00
172_E178_I0.6401.00
393_P398_S0.6391.00
306_M309_S0.6361.00
139_I145_L0.6351.00
337_E340_V0.6331.00
8_S333_Q0.6331.00
37_V41_K0.6321.00
331_L335_L0.6311.00
198_E206_A0.6311.00
273_A277_E0.6301.00
343_S383_M0.6271.00
322_A402_P0.6261.00
34_I349_G0.6251.00
59_I231_V0.6251.00
124_V127_V0.6231.00
27_I349_G0.6191.00
114_F119_V0.6161.00
125_Y211_Y0.6151.00
297_V301_G0.6141.00
209_V212_V0.6141.00
26_V302_V0.6121.00
161_E190_V0.6121.00
85_V88_E0.6111.00
127_V132_F0.6111.00
128_D214_K0.6111.00
29_G301_G0.6101.00
354_F375_V0.6091.00
316_E319_I0.6081.00
121_Y124_V0.6071.00
306_M390_G0.6071.00
115_H118_N0.6061.00
17_L21_L0.6041.00
316_E333_Q0.6041.00
102_L229_I0.6041.00
365_P369_I0.6031.00
9_F340_V0.6021.00
134_M137_I0.6011.00
284_A288_G0.6011.00
46_Q49_Q0.5981.00
21_L25_G0.5961.00
140_T190_V0.5951.00
342_T390_G0.5941.00
114_F117_T0.5941.00
40_L284_A0.5931.00
243_G271_E0.5921.00
310_V334_F0.5911.00
233_A238_H0.5881.00
310_V397_A0.5871.00
44_S47_L0.5861.00
97_P100_K0.5841.00
267_M272_I0.5841.00
155_Q185_F0.5841.00
154_H216_V0.5811.00
164_R173_A0.5811.00
111_A115_H0.5801.00
58_A64_Q0.5791.00
54_M57_N0.5751.00
372_I375_V0.5741.00
29_G32_A0.5731.00
311_T396_K0.5731.00
100_K233_A0.5731.00
335_L391_L0.5721.00
34_I38_S0.5701.00
235_S239_I0.5691.00
103_S134_M0.5661.00
16_K19_S0.5661.00
164_R167_L0.5661.00
31_A35_A0.5651.00
386_G389_F0.5631.00
47_L51_M0.5631.00
299_G303_M0.5611.00
18_R301_G0.5611.00
41_K373_P0.5611.00
59_I233_A0.5601.00
139_I192_K0.5591.00
314_T396_K0.5581.00
369_I373_P0.5561.00
175_H178_I0.5561.00
334_F338_A0.5551.00
32_A334_F0.5551.00
118_N121_Y0.5551.00
157_V187_V0.5541.00
194_K197_Q0.5531.00
267_M270_Q0.5531.00
226_P229_I0.5511.00
142_G189_G0.5511.00
286_L290_I0.5501.00
135_F138_R0.5501.00
386_G390_G0.5481.00
206_A209_V0.5481.00
385_V389_F0.5471.00
302_V342_T0.5461.00
143_R147_E0.5451.00
60_N267_M0.5451.00
243_G266_V0.5451.00
96_D99_V0.5431.00
43_Q46_Q0.5431.00
156_V213_P0.5421.00
11_S15_H0.5421.00
22_T26_V0.5421.00
187_V190_V0.5411.00
94_K97_P0.5401.00
127_V211_Y0.5401.00
333_Q336_T0.5391.00
57_N60_N0.5381.00
195_N207_N0.5371.00
294_S298_G0.5371.00
133_D136_P0.5331.00
228_Q231_V0.5321.00
347_I350_V0.5281.00
388_I392_L0.5271.00
287_L291_A0.5261.00
338_A389_F0.5231.00
358_K361_T0.5221.00
164_R174_L0.5201.00
164_R187_V0.5171.00
90_V96_D0.5171.00
350_V354_F0.5161.00
228_Q232_Q0.5141.00
191_F194_K0.5131.00
283_F287_L0.5131.00
335_L339_V0.5101.00
185_F220_I0.5101.00
22_T304_N0.5101.00
129_D132_F0.5091.00
333_Q337_E0.5061.00
174_L187_V0.5051.00
173_A187_V0.5041.00
135_F230_A0.5041.00
321_K405_A0.5041.00
103_S106_Y0.5031.00
11_S18_R0.5031.00
376_V379_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ftjA 1 0.5183 99.6 0.682 Contact Map
3is6A 2 0.5355 99.2 0.745 Contact Map
4av3A 2 0.2641 35.8 0.935 Contact Map
3w9iA 3 0.8313 22.4 0.941 Contact Map
4dx5A 3 0.8337 17.7 0.944 Contact Map
4mt1A 3 0.8533 16.2 0.945 Contact Map
4k0jA 3 0.8289 14.5 0.946 Contact Map
4pl0A 2 0.2298 12.3 0.948 Contact Map
4a01A 2 0.3178 10.3 0.95 Contact Map
4gycB 2 0.1394 8.1 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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