GREMLIN Database
CINA - Putative competence-damage inducible protein
UniProt: P46323 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 416 (406)
Sequences: 1600 (1264)
Seq/√Len: 62.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
325_T339_E4.1351.00
337_A357_T3.3391.00
203_D250_R3.1891.00
322_K339_E3.1751.00
407_H411_K3.1551.00
268_S302_L3.1261.00
355_S376_G2.9381.00
92_P126_E2.8751.00
50_P87_N2.8661.00
279_S350_S2.7711.00
32_Q35_E2.7161.00
323_K327_D2.6821.00
8_E63_R2.6481.00
334_K338_S2.5701.00
289_F356_F2.5591.00
407_H410_L2.5331.00
7_A38_V2.4931.00
342_K383_E2.4921.00
68_I153_L2.4861.00
338_S385_V2.4611.00
292_W402_A2.3721.00
50_P84_T2.3671.00
70_S160_L2.2731.00
22_A27_Q2.2721.00
322_K325_T2.2681.00
276_I352_I2.2271.00
312_N331_A2.1831.00
325_T336_C2.1761.00
272_K301_K2.1721.00
54_K87_N2.1521.00
233_E237_E2.1351.00
95_L123_L2.1151.00
329_F335_E2.1151.00
91_R127_G2.1001.00
326_L331_A2.0611.00
316_Q323_K2.0551.00
264_V292_W2.0391.00
32_Q165_E2.0361.00
345_Q378_S2.0291.00
185_T241_K1.9941.00
94_V126_E1.9901.00
278_I409_I1.9781.00
11_A45_A1.9601.00
134_H167_E1.9451.00
23_N26_A1.9341.00
142_L171_L1.9171.00
344_V353_G1.9041.00
359_V369_E1.8871.00
28_F165_E1.8861.00
185_T244_E1.8761.00
276_I351_D1.8691.00
83_E120_K1.8541.00
286_G294_T1.8511.00
318_V347_L1.8081.00
305_G348_T1.8011.00
304_A350_S1.7971.00
309_C314_V1.7941.00
309_C340_L1.7831.00
365_Q368_H1.7120.99
230_H236_T1.6870.99
96_N99_A1.6770.99
246_V249_E1.6760.99
374_F385_V1.6720.99
297_S363_D1.6620.99
354_I409_I1.6310.99
290_S308_V1.6230.99
248_L255_F1.6210.99
42_Y59_I1.6080.99
23_N43_H1.6070.99
118_N195_S1.5990.99
101_Q104_E1.5910.99
57_I88_T1.5860.99
378_S383_E1.5680.99
30_S43_H1.5660.99
97_D101_Q1.5430.99
278_I293_L1.5350.99
364_A369_E1.5340.99
288_L402_A1.5300.99
134_H166_N1.5270.99
364_A370_P1.5230.99
124_V130_V1.5230.99
279_S344_V1.5150.98
151_M168_A1.5140.98
291_E295_D1.5000.98
365_Q370_P1.4910.98
321_V343_G1.4880.98
390_F404_Y1.4870.98
38_V172_L1.4850.98
314_V348_T1.4780.98
291_E398_R1.4480.98
334_K385_V1.4420.98
8_E44_T1.4380.98
104_E119_R1.4370.98
8_E60_A1.4340.98
338_S342_K1.4320.98
268_S296_H1.4240.98
365_Q369_E1.4180.98
280_A303_F1.4140.98
116_P119_R1.4100.98
61_E150_Y1.4030.97
299_A302_L1.3980.97
351_D380_N1.3930.97
61_E148_R1.3900.97
366_E369_E1.3880.97
210_N239_L1.3840.97
334_K387_E1.3780.97
345_Q380_N1.3780.97
104_E108_K1.3730.97
85_I152_L1.3730.97
95_L100_F1.3700.97
356_F405_G1.3700.97
49_N52_R1.3700.97
244_E248_L1.3600.97
29_I164_F1.3550.97
215_P224_L1.3490.97
304_A313_D1.3410.97
57_I69_F1.3220.96
301_K363_D1.3180.96
261_T265_K1.3170.96
187_L244_E1.3140.96
61_E88_T1.3130.96
204_I247_I1.3000.96
65_D148_R1.2950.96
270_A410_L1.2930.96
100_F104_E1.2920.96
91_R126_E1.2860.96
107_F118_N1.2770.96
280_A290_S1.2610.95
279_S348_T1.2590.95
192_I197_L1.2570.95
156_P162_P1.2490.95
226_L240_L1.2380.95
210_N228_A1.2340.95
374_F387_E1.2340.95
232_D235_E1.2270.94
95_L119_R1.2260.94
264_V295_D1.2230.94
261_T269_I1.2210.94
100_F119_R1.2180.94
364_A367_G1.2110.94
131_L142_L1.2090.94
184_S227_T1.2080.94
189_F251_V1.2060.94
50_P54_K1.2000.94
284_F365_Q1.1940.94
366_E370_P1.1930.94
6_K39_N1.1910.94
57_I67_I1.1850.93
91_R145_H1.1790.93
69_F152_L1.1790.93
290_S303_F1.1760.93
39_N229_K1.1750.93
121_Q137_M1.1720.93
291_E402_A1.1700.93
36_I169_K1.1690.93
241_K245_A1.1630.93
320_G347_L1.1610.93
359_V366_E1.1590.93
345_Q353_G1.1570.93
140_G163_M1.1560.93
226_L244_E1.1560.93
307_V344_V1.1540.92
198_E202_E1.1530.92
313_D317_N1.1520.92
107_F114_M1.1500.92
187_L255_F1.1490.92
53_L84_T1.1480.92
354_I377_I1.1470.92
280_A306_G1.1460.92
321_V325_T1.1460.92
54_K58_R1.1280.92
342_K345_Q1.1220.91
338_S383_E1.1220.91
131_L168_A1.1200.91
103_I122_A1.1170.91
96_N124_V1.1120.91
288_L291_E1.1120.91
294_T299_A1.1060.91
392_G397_I1.1060.91
337_A355_S1.1020.91
101_Q105_D1.1010.91
8_E64_S1.0980.90
125_I141_M1.0920.90
312_N369_E1.0900.90
359_V364_A1.0880.90
268_S299_A1.0860.90
197_L251_V1.0850.90
248_L258_Y1.0840.90
58_R88_T1.0840.90
51_E55_Q1.0830.90
196_Q200_D1.0830.90
257_G261_T1.0770.90
243_T246_V1.0770.90
330_G369_E1.0740.89
289_F405_G1.0720.89
277_T304_A1.0700.89
352_I379_A1.0690.89
305_G314_V1.0680.89
30_S40_V1.0680.89
261_T266_E1.0680.89
28_F164_F1.0600.89
167_E171_L1.0590.89
267_L410_L1.0560.89
124_V139_P1.0560.89
192_I254_F1.0540.89
188_R221_E1.0530.89
326_L336_C1.0470.88
16_L21_I1.0460.88
295_D398_R1.0350.88
280_A289_F1.0320.87
152_L156_P1.0300.87
342_K346_K1.0260.87
288_L398_R1.0240.87
201_L247_I1.0190.87
310_Y315_K1.0170.87
44_T63_R1.0170.87
58_R62_E1.0120.86
377_I412_L1.0060.86
77_K202_E1.0030.86
33_L68_I0.9910.85
21_I27_Q0.9840.85
359_V370_P0.9800.85
352_I409_I0.9780.85
353_G378_S0.9770.84
267_L270_A0.9750.84
384_E412_L0.9720.84
345_Q379_A0.9640.84
317_N349_G0.9630.84
279_S353_G0.9620.84
164_F169_K0.9610.83
49_N212_T0.9550.83
189_F197_L0.9540.83
292_W403_K0.9530.83
334_K374_F0.9510.83
144_E147_S0.9490.83
375_I388_F0.9480.83
267_L406_C0.9470.83
132_A167_E0.9450.82
237_E241_K0.9440.82
153_L160_L0.9440.82
124_V141_M0.9430.82
67_I148_R0.9430.82
307_V314_V0.9390.82
284_F356_F0.9370.82
377_I408_L0.9320.82
312_N330_G0.9220.81
153_L168_A0.9210.81
386_H408_L0.9170.80
69_F85_I0.9170.80
131_L167_E0.9150.80
46_V56_V0.9110.80
281_A319_L0.9100.80
67_I150_Y0.9090.80
189_F255_F0.9090.80
102_S132_A0.9080.80
10_I56_V0.9060.80
316_Q326_L0.9040.80
284_F331_A0.9040.80
118_N121_Q0.8970.79
367_G370_P0.8970.79
255_F258_Y0.8940.79
341_A378_S0.8920.79
312_N365_Q0.8920.79
356_F401_G0.8890.78
373_V397_I0.8890.78
379_A382_K0.8850.78
117_N199_A0.8850.78
66_F151_M0.8830.78
14_S52_R0.8790.78
228_A239_L0.8760.77
115_S199_A0.8690.77
300_S315_K0.8680.77
307_V348_T0.8670.77
10_I60_A0.8620.76
269_I272_K0.8610.76
300_S310_Y0.8600.76
325_T335_E0.8600.76
205_I213_I0.8590.76
189_F192_I0.8580.76
330_G359_V0.8550.76
197_L224_L0.8540.76
97_D104_E0.8490.75
221_E256_Y0.8480.75
164_F168_A0.8430.75
283_S315_K0.8420.74
27_Q30_S0.8420.74
151_M171_L0.8420.74
244_E258_Y0.8410.74
162_P166_N0.8370.74
54_K84_T0.8370.74
269_I273_E0.8370.74
283_S310_Y0.8360.74
188_R223_T0.8360.74
55_Q62_E0.8350.74
372_H387_E0.8350.74
359_V365_Q0.8340.74
7_A66_F0.8330.74
105_D109_R0.8320.74
93_L123_L0.8260.73
214_A225_R0.8260.73
189_F254_F0.8240.73
135_F162_P0.8230.73
54_K88_T0.8230.73
8_E42_Y0.8230.73
370_P397_I0.8230.73
23_N45_A0.8210.73
20_Q216_L0.8200.73
91_R125_I0.8200.73
262_S265_K0.8170.72
314_V318_V0.8170.72
364_A368_H0.8160.72
293_L296_H0.8160.72
277_T350_S0.8150.72
343_G347_L0.8150.72
40_V43_H0.8120.72
205_I208_Q0.8100.72
47_G52_R0.8080.71
240_L244_E0.8070.71
60_A63_R0.8040.71
89_L143_T0.7990.71
12_V53_L0.7990.71
284_F373_V0.7980.70
141_M152_L0.7970.70
89_L125_I0.7950.70
182_I229_K0.7950.70
284_F364_A0.7940.70
376_G385_V0.7880.69
44_T56_V0.7870.69
226_L243_T0.7840.69
149_Y171_L0.7830.69
55_Q59_I0.7820.69
312_N366_E0.7790.69
52_R212_T0.7760.68
208_Q213_I0.7740.68
106_Y110_T0.7740.68
134_H162_P0.7720.68
190_F404_Y0.7710.68
12_V69_F0.7710.68
289_F402_A0.7690.68
395_T398_R0.7660.67
310_Y362_P0.7660.67
288_L292_W0.7640.67
312_N359_V0.7640.67
289_F406_C0.7530.66
264_V296_H0.7520.66
266_E269_I0.7510.66
388_F404_Y0.7460.65
114_M119_R0.7450.65
142_L151_M0.7430.65
32_Q169_K0.7430.65
388_F408_L0.7430.65
28_F161_R0.7410.65
14_S217_A0.7390.65
242_E246_V0.7380.64
9_I33_L0.7370.64
312_N364_A0.7370.64
315_K362_P0.7360.64
270_A273_E0.7360.64
129_D144_E0.7360.64
294_T303_F0.7340.64
142_L149_Y0.7280.63
153_L156_P0.7270.63
335_E339_E0.7270.63
129_D171_L0.7260.63
397_I401_G0.7250.63
276_I380_N0.7250.63
18_L34_A0.7240.63
41_F52_R0.7240.63
131_L171_L0.7180.62
18_L225_R0.7170.62
315_K361_G0.7170.62
396_G400_R0.7150.62
270_A274_K0.7140.62
99_A124_V0.7120.62
190_F263_L0.7100.61
393_S396_G0.7050.61
200_D250_R0.7050.61
11_A26_A0.7040.61
284_F294_T0.7040.61
311_T369_E0.7040.61
319_L340_L0.7030.61
89_L145_H0.7020.61
186_V223_T0.6990.60
280_A354_I0.6990.60
105_D108_K0.6950.60
207_A246_V0.6940.60
128_S143_T0.6940.60
307_V318_V0.6910.59
324_E328_R0.6890.59
315_K360_A0.6890.59
352_I380_N0.6880.59
345_Q381_G0.6880.59
107_F193_G0.6840.59
235_E238_R0.6830.58
14_S212_T0.6830.58
131_L140_G0.6810.58
45_A215_P0.6800.58
361_G371_G0.6800.58
310_Y394_R0.6780.58
36_I164_F0.6770.58
293_L303_F0.6770.58
265_K269_I0.6760.58
68_I130_V0.6750.58
310_Y332_V0.6700.57
60_A64_S0.6690.57
337_A374_F0.6690.57
60_A67_I0.6670.57
125_I152_L0.6670.57
344_V348_T0.6660.57
180_E229_K0.6630.56
310_Y360_A0.6630.56
85_I150_Y0.6620.56
156_P160_L0.6620.56
86_A93_L0.6610.56
183_V237_E0.6610.56
357_T374_F0.6590.56
44_T60_A0.6590.56
25_N156_P0.6580.56
305_G318_V0.6570.56
153_L163_M0.6570.56
100_F114_M0.6550.55
204_I250_R0.6540.55
310_Y358_G0.6530.55
315_K358_G0.6530.55
77_K205_I0.6520.55
12_V216_L0.6500.55
17_L216_L0.6490.55
317_N347_L0.6490.55
358_G371_G0.6480.54
379_A412_L0.6480.54
284_F359_V0.6470.54
291_E395_T0.6460.54
29_I169_K0.6460.54
25_N160_L0.6450.54
331_A365_Q0.6450.54
28_F32_Q0.6440.54
283_S300_S0.6420.54
331_A366_E0.6420.54
339_E343_G0.6420.54
184_S212_T0.6420.54
91_R143_T0.6410.54
156_P217_A0.6400.54
82_K141_M0.6400.54
189_F221_E0.6390.53
266_E410_L0.6390.53
102_S106_Y0.6370.53
29_I68_I0.6360.53
310_Y361_G0.6340.53
315_K394_R0.6340.53
133_N138_A0.6320.53
283_S362_P0.6310.53
246_V250_R0.6310.53
311_T314_V0.6300.52
358_G362_P0.6290.52
268_S293_L0.6290.52
300_S362_P0.6280.52
130_V139_P0.6280.52
408_L412_L0.6280.52
373_V390_F0.6270.52
43_H47_G0.6270.52
198_E215_P0.6260.52
358_G394_R0.6250.52
218_A223_T0.6250.52
52_R211_P0.6250.52
193_G196_Q0.6240.52
56_V59_I0.6200.51
283_S358_G0.6200.51
27_Q161_R0.6200.51
193_G222_V0.6200.51
82_K216_L0.6190.51
312_N370_P0.6190.51
131_L163_M0.6180.51
77_K206_D0.6160.51
238_R242_E0.6150.51
368_H387_E0.6140.51
56_V60_A0.6120.50
169_K173_L0.6120.50
362_P371_G0.6110.50
283_S360_A0.6110.50
183_V240_L0.6100.50
331_A364_A0.6100.50
300_S360_A0.6070.50
331_A359_V0.6070.50
298_G310_Y0.6050.50
357_T376_G0.6050.50
121_Q195_S0.6040.49
298_G315_K0.6040.49
92_P346_K0.6030.49
80_L120_K0.6020.49
14_S215_P0.6010.49
201_L205_I0.6000.49
343_G346_K0.6000.49
331_A369_E0.5980.49
215_P222_V0.5970.49
185_T258_Y0.5950.48
300_S394_R0.5940.48
211_P239_L0.5940.48
331_A343_G0.5930.48
310_Y371_G0.5930.48
77_K215_P0.5920.48
342_K378_S0.5910.48
228_A236_T0.5900.48
17_L214_A0.5900.48
283_S361_G0.5890.48
331_A370_P0.5870.48
23_N152_L0.5870.48
305_G309_C0.5860.47
57_I85_I0.5860.47
156_P215_P0.5860.47
96_N130_V0.5850.47
268_S272_K0.5840.47
205_I215_P0.5830.47
373_V401_G0.5820.47
290_S306_G0.5820.47
101_Q381_G0.5800.47
26_A43_H0.5790.47
360_A394_R0.5790.47
27_Q31_K0.5770.46
358_G361_G0.5730.46
320_G343_G0.5730.46
211_P226_L0.5730.46
210_N227_T0.5720.46
315_K340_L0.5720.46
354_I405_G0.5700.46
386_H411_K0.5690.45
362_P394_R0.5680.45
163_M167_E0.5680.45
315_K371_G0.5660.45
283_S394_R0.5650.45
82_K214_A0.5640.45
292_W295_D0.5640.45
77_K198_E0.5620.45
180_E232_D0.5620.45
311_T330_G0.5620.45
292_W399_K0.5600.44
214_A227_T0.5590.44
291_E294_T0.5590.44
200_D253_E0.5590.44
188_R257_G0.5580.44
192_I251_V0.5580.44
283_S340_L0.5570.44
75_P118_N0.5560.44
120_K123_L0.5560.44
85_I143_T0.5550.44
275_G301_K0.5550.44
99_A128_S0.5540.44
12_V156_P0.5530.44
300_S361_G0.5530.44
283_S332_V0.5510.43
50_P354_I0.5500.43
245_A249_E0.5470.43
18_L52_R0.5450.43
18_L184_S0.5450.43
307_V347_L0.5440.43
29_I160_L0.5430.43
129_D174_K0.5420.42
254_F411_K0.5410.42
10_I69_F0.5410.42
360_A371_G0.5410.42
49_N211_P0.5410.42
310_Y340_L0.5400.42
312_N326_L0.5390.42
293_L299_A0.5390.42
239_L243_T0.5380.42
201_L224_L0.5370.42
350_S353_G0.5360.42
181_K230_H0.5360.42
284_F312_N0.5350.42
376_G386_H0.5340.41
144_E149_Y0.5330.41
188_R256_Y0.5330.41
321_V332_V0.5320.41
398_R402_A0.5320.41
280_A344_V0.5320.41
300_S358_G0.5290.41
257_G260_D0.5290.41
141_M156_P0.5290.41
185_T240_L0.5280.41
18_L214_A0.5260.41
101_Q108_K0.5250.40
251_V255_F0.5240.40
312_N343_G0.5240.40
99_A102_S0.5230.40
160_L164_F0.5220.40
77_K82_K0.5210.40
99_A103_I0.5200.40
121_Q138_A0.5200.40
86_A92_P0.5180.40
402_A405_G0.5180.40
298_G394_R0.5180.40
133_N136_G0.5180.40
312_N321_V0.5170.40
14_S41_F0.5150.39
268_S271_C0.5140.39
276_I379_A0.5140.39
375_I405_G0.5130.39
32_Q164_F0.5120.39
320_G339_E0.5090.39
304_A351_D0.5080.39
352_I412_L0.5070.39
257_G262_S0.5060.38
392_G400_R0.5060.38
135_F158_S0.5060.38
156_P164_F0.5040.38
55_Q58_R0.5030.38
31_K161_R0.5020.38
361_G394_R0.5010.38
162_P167_E0.5000.38
267_L409_I0.5000.38
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4uuwA 2 0.9447 100 0.245 Contact Map
2a9sA 2 0.3918 100 0.651 Contact Map
3kbqA 2 0.4087 100 0.702 Contact Map
1y5eA 4 0.3798 100 0.784 Contact Map
2is8A 3 0.3822 100 0.785 Contact Map
3iwtA 4 0.3726 100 0.788 Contact Map
2g2cA 1 0.3558 100 0.788 Contact Map
3pzyA 3 0.3582 100 0.791 Contact Map
3rfqA 5 0.3726 100 0.791 Contact Map
1mkzA 2 0.3942 100 0.792 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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