GREMLIN Database
PGSA - CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase
UniProt: P46322 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 193 (175)
Sequences: 4396 (2909)
Seq/√Len: 219.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
63_Y67_L3.3051.00
73_F77_L3.2481.00
131_N180_E2.9481.00
94_V104_V2.9101.00
8_I56_T2.8381.00
20_M92_I2.4021.00
140_A173_F2.3571.00
51_I146_S2.2981.00
19_F89_A2.2621.00
133_L176_V2.2441.00
3_N71_T2.1961.00
20_M88_A2.1411.00
16_I84_L2.1181.00
22_I49_L2.1071.00
113_A182_F2.0931.00
41_V45_A2.0521.00
144_A170_A2.0491.00
132_M136_I2.0421.00
54_S142_I1.9161.00
179_W183_S1.9131.00
72_N75_K1.8841.00
3_N69_L1.8751.00
183_S186_W1.8721.00
23_M92_I1.8351.00
70_V75_K1.8281.00
62_Y66_K1.8101.00
55_T58_W1.8051.00
103_M168_W1.8021.00
22_I45_A1.7581.00
15_L49_L1.7531.00
140_A169_V1.6911.00
2_F7_K1.6521.00
53_A85_L1.6341.00
136_I139_W1.6121.00
141_Q174_T1.6061.00
44_L48_I1.6051.00
9_T77_L1.6021.00
148_L163_A1.5261.00
5_P69_L1.5051.00
103_M171_V1.5001.00
47_A146_S1.4851.00
147_A166_A1.4621.00
180_E184_K1.4611.00
23_M96_F1.4571.00
8_I59_V1.4561.00
107_I174_T1.4231.00
55_T59_V1.4121.00
161_P165_L1.4071.00
63_Y69_L1.4021.00
148_L167_L1.3961.00
13_I81_A1.3961.00
10_L14_A1.3431.00
58_W62_Y1.3391.00
147_A163_A1.3311.00
15_L52_I1.3191.00
139_W143_I1.3161.00
47_A150_L1.3111.00
138_T142_I1.3021.00
18_I22_I1.3021.00
121_L128_V1.2661.00
175_V179_W1.2461.00
13_I84_L1.2421.00
48_I52_I1.2291.00
2_F10_L1.2221.00
43_H98_L1.2181.00
114_V182_F1.2151.00
133_L180_E1.2131.00
4_L7_K1.1891.00
18_I49_L1.1841.00
7_K11_A1.1841.00
118_R137_K1.1831.00
144_A167_L1.1731.00
15_L18_I1.1691.00
8_I55_T1.1551.00
121_L185_N1.1481.00
22_I42_A1.1461.00
89_A145_V1.1301.00
22_I46_G1.1291.00
24_L92_I1.1281.00
19_F49_L1.1171.00
27_F41_V1.1171.00
5_P63_Y1.1011.00
106_V175_V1.0901.00
99_A167_L1.0801.00
106_V171_V1.0661.00
101_A105_I1.0631.00
90_L145_V1.0591.00
87_S108_I1.0201.00
105_I109_S1.0191.00
87_S91_I1.0151.00
131_N184_K1.0061.00
174_T178_G0.9911.00
59_V63_Y0.9771.00
139_W142_I0.9771.00
165_L169_V0.9711.00
86_V145_V0.9651.00
94_V101_A0.9631.00
114_V178_G0.9571.00
136_I173_F0.9571.00
103_M167_L0.9561.00
66_K70_V0.9511.00
5_P8_I0.9511.00
88_A92_I0.9471.00
51_I55_T0.9280.99
134_G177_S0.9240.99
44_L150_L0.9220.99
23_M149_L0.9220.99
134_G137_K0.9190.99
21_I25_A0.9110.99
144_A166_A0.9080.99
86_V90_L0.9070.99
51_I143_I0.9040.99
144_A163_A0.9000.99
14_A17_P0.8990.99
50_F85_L0.8900.99
75_K129_A0.8850.99
75_K127_V0.8820.99
172_F176_V0.8790.99
7_K10_L0.8710.99
131_N134_G0.8700.99
176_V180_E0.8650.99
164_D168_W0.8610.99
158_V162_F0.8570.99
14_A18_I0.8480.99
45_A49_L0.8460.99
11_A56_T0.8350.99
110_R177_S0.8280.99
8_I11_A0.8280.99
11_A52_I0.8260.99
151_H163_A0.8260.99
158_V161_P0.8260.99
160_F164_D0.8210.99
161_P164_D0.8130.99
54_S85_L0.8060.99
133_L177_S0.8030.99
79_P138_T0.8020.99
15_L19_F0.8010.99
141_Q170_A0.7900.98
76_F119_L0.7810.98
115_T118_R0.7810.98
87_S111_E0.7740.98
90_L107_I0.7710.98
119_L122_A0.7680.98
4_L67_L0.7660.98
16_I88_A0.7630.98
25_A42_A0.7600.98
43_H96_F0.7550.98
2_F6_N0.7420.98
95_Q101_A0.7370.97
62_Y67_L0.7340.97
97_D101_A0.7260.97
88_A105_I0.7240.97
27_F42_A0.7210.97
113_A116_G0.7210.97
111_E174_T0.7200.97
17_P79_P0.7190.97
121_L124_T0.7190.97
133_L136_I0.7160.97
70_V130_A0.7140.97
111_E115_T0.7120.97
17_P81_A0.7050.97
19_F46_G0.7020.97
169_V173_F0.6970.96
110_R137_K0.6900.96
170_A174_T0.6810.96
47_A149_L0.6800.96
91_I104_V0.6790.96
86_V142_I0.6780.96
45_A48_I0.6720.96
91_I94_V0.6680.95
84_L109_S0.6660.95
117_L137_K0.6640.95
4_L63_Y0.6620.95
83_K141_Q0.6610.95
111_E137_K0.6600.95
5_P67_L0.6600.95
100_P103_M0.6570.95
46_G53_A0.6530.95
11_A15_L0.6480.95
23_M43_H0.6480.95
104_V108_I0.6440.95
8_I77_L0.6440.95
8_I63_Y0.6440.95
130_A133_L0.6360.94
46_G92_I0.6320.94
47_A51_I0.6290.94
137_K177_S0.6260.94
19_F92_I0.6240.94
15_L53_A0.6240.94
93_L98_L0.6230.93
65_R134_G0.6190.93
110_R114_V0.6190.93
132_M139_W0.6180.93
137_K173_F0.6170.93
20_M105_I0.6140.93
136_I140_A0.6010.92
121_L125_G0.6000.92
148_L164_D0.6000.92
90_L170_A0.5980.92
183_S187_E0.5970.92
147_A162_F0.5960.92
166_A170_A0.5930.92
143_I147_A0.5930.92
13_I77_L0.5930.92
86_V141_Q0.5920.92
87_S112_F0.5910.92
103_M164_D0.5900.92
140_A166_A0.5890.91
20_M24_L0.5870.91
92_I96_F0.5870.91
115_T137_K0.5810.91
161_P166_A0.5780.91
54_S58_W0.5760.91
4_L69_L0.5760.91
143_I166_A0.5750.90
121_L126_E0.5710.90
98_L152_N0.5690.90
83_K174_T0.5610.89
72_N124_T0.5600.89
159_S163_A0.5600.89
83_K130_A0.5590.89
157_L161_P0.5560.89
90_L141_Q0.5520.89
9_T13_I0.5510.89
182_F186_W0.5510.89
24_L95_Q0.5490.88
67_L71_T0.5450.88
75_K130_A0.5440.88
55_T159_S0.5430.88
130_A134_G0.5410.88
110_R141_Q0.5410.88
108_I112_F0.5340.87
118_R125_G0.5310.87
137_K141_Q0.5310.87
116_G120_V0.5310.87
58_W139_W0.5300.87
115_T122_A0.5280.86
152_N160_F0.5270.86
42_A45_A0.5270.86
155_F159_S0.5250.86
97_D100_P0.5240.86
43_H151_H0.5210.86
83_K111_E0.5170.85
44_L47_A0.5160.85
143_I146_S0.5160.85
80_L116_G0.5160.85
152_N155_F0.5140.85
141_Q178_G0.5130.85
86_V115_T0.5130.85
184_K188_A0.5120.85
172_F175_V0.5100.84
184_K187_E0.5100.84
115_T178_G0.5090.84
27_F40_P0.5070.84
99_A106_V0.5060.84
185_N188_A0.5060.84
50_F54_S0.5050.84
152_N163_A0.5030.84
112_F116_G0.5020.84
63_Y66_K0.5010.83
130_A137_K0.5000.83
108_I111_E0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4mndA 2 0.8601 100 0.409 Contact Map
4o6mA 2 0.8653 99.9 0.456 Contact Map
3tx3A 2 0.7668 14.3 0.942 Contact Map
1vryA 1 0.3161 6.4 0.951 Contact Map
3j08A 2 0.3264 5.7 0.952 Contact Map
1oedE 1 0.4767 4.5 0.954 Contact Map
1oedC 1 0.4767 4.3 0.954 Contact Map
1oedB 1 0.4611 3.9 0.955 Contact Map
1oedA 1 0.4611 3.1 0.957 Contact Map
3wu2J 1 0.2021 2.7 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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