GREMLIN Database
LICH - Probable 6-phospho-beta-glucosidase
UniProt: P46320 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 442 (422)
Sequences: 1746 (1004)
Seq/√Len: 48.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
75_R138_E5.6141.00
78_L140_C4.0931.00
83_F327_Y4.0871.00
74_R135_D3.8561.00
192_R212_D3.6211.00
105_K424_E3.4961.00
136_I145_L3.4601.00
52_G70_L3.3121.00
399_Y423_D3.2831.00
360_T365_K3.2451.00
73_D76_K3.1111.00
208_D215_S3.0801.00
45_E49_N3.0061.00
403_L422_L2.9921.00
75_R135_D2.9581.00
136_I165_L2.9421.00
325_S332_D2.9371.00
35_E67_D2.9031.00
137_E163_S2.8781.00
336_V359_M2.8531.00
108_V421_I2.8211.00
35_E69_H2.7681.00
214_V219_Q2.7051.00
345_A371_D2.6061.00
109_I267_L2.6021.00
52_G56_K2.5761.00
6_K37_W2.5351.00
343_A353_V2.5041.00
372_L380_V2.4881.00
402_A422_L2.4651.00
169_V364_P2.3741.00
396_T401_T2.3541.00
189_D192_R2.3441.00
49_N53_T2.3251.00
90_V128_V2.2771.00
37_W69_H2.2651.00
136_I140_C2.2021.00
133_A159_L2.1881.00
119_L390_A2.1871.00
137_E165_L2.1861.00
211_L216_V2.1791.00
245_F248_A2.1641.00
134_K137_E2.1571.00
161_R392_E2.1491.00
336_V357_C2.1471.00
106_Y420_Q2.1361.00
131_E134_K2.1201.00
341_N349_D2.1031.00
108_V116_P2.0761.00
106_Y424_E2.0761.00
222_E226_D2.0701.00
347_I380_V2.0511.00
346_S377_R2.0121.00
278_G285_Q1.9810.99
289_K293_E1.9800.99
216_V219_Q1.9660.99
30_E324_S1.9500.99
126_I158_A1.9360.99
49_N52_G1.8990.99
160_L339_I1.8320.99
75_R139_L1.8200.99
342_G349_D1.8190.99
59_V68_I1.8120.99
144_W167_K1.8060.99
21_V36_L1.8050.99
392_E396_T1.7880.99
37_W71_T1.7840.99
192_R211_L1.7790.99
130_L158_A1.7520.99
98_K428_A1.7360.99
392_E401_T1.7330.99
76_K79_K1.7290.99
126_I154_M1.7230.98
358_V367_I1.7060.98
6_K35_E1.6980.98
398_D401_T1.6970.98
326_I329_D1.6940.98
83_F326_I1.6530.98
324_S328_N1.6520.98
296_K300_L1.6110.98
401_T404_L1.6030.98
196_Q208_D1.5930.97
142_N167_K1.5830.97
331_H360_T1.5810.97
162_Y395_V1.5800.97
205_F261_F1.5770.97
82_D142_N1.5680.97
31_L323_I1.5670.97
125_T128_V1.5550.97
129_I159_L1.5400.97
186_L220_V1.5170.97
290_E306_Q1.5150.97
114_N383_I1.5110.96
94_Q97_A1.5050.96
53_T56_K1.5010.96
13_G40_D1.5000.96
346_S370_G1.4890.96
159_L168_V1.4870.96
116_P412_V1.4780.96
241_W245_F1.4720.96
69_H76_K1.4680.96
8_V81_A1.4650.96
360_T363_G1.4640.96
42_P45_E1.4580.96
377_R381_Q1.4510.96
119_L386_F1.4410.95
244_D248_A1.4370.95
345_A370_G1.4360.95
333_I358_V1.4310.95
394_A397_G1.4210.95
219_Q223_A1.4010.95
133_A136_I1.3960.94
393_A402_A1.3740.94
237_S260_Y1.3660.94
106_Y421_I1.3580.94
360_T364_P1.3480.93
8_V37_W1.3400.93
71_T77_A1.3190.93
345_A349_D1.3110.92
79_K139_L1.3090.92
247_K250_N1.3070.92
126_I394_A1.3020.92
406_M425_M1.2980.92
108_V417_V1.2910.92
59_V66_I1.2760.91
362_T365_K1.2750.91
97_A281_A1.2730.91
334_Q359_M1.2730.91
194_E210_F1.2700.91
137_E164_N1.2690.91
188_V211_L1.2670.91
84_V136_I1.2650.91
8_V78_L1.2630.91
421_I425_M1.2580.91
98_K429_H1.2460.90
130_L395_V1.2450.90
50_I296_K1.2440.90
102_I428_A1.2430.90
80_D142_N1.2420.90
286_K290_E1.2360.90
86_T129_I1.2290.90
42_P92_L1.2170.89
127_P394_A1.2130.89
7_I31_L1.2090.89
374_V385_S1.1990.89
305_P308_E1.1930.88
97_A101_R1.1930.88
427_E430_K1.1920.88
198_A207_L1.1880.88
30_E330_K1.1880.88
84_V143_A1.1770.88
198_A372_L1.1660.87
346_S381_Q1.1530.86
49_N70_L1.1530.86
34_R67_D1.1510.86
99_D124_R1.1280.85
203_M383_I1.1230.85
134_K163_S1.1160.85
238_G241_W1.1140.85
264_K417_V1.1080.84
399_Y422_L1.0990.84
343_A355_V1.0960.84
375_S404_L1.0910.83
39_V77_A1.0880.83
294_L306_Q1.0880.83
406_M418_A1.0860.83
45_E72_L1.0850.83
129_I155_V1.0800.83
5_L327_Y1.0790.83
108_V413_P1.0780.83
56_K60_E1.0740.82
329_D361_K1.0710.82
94_Q288_E1.0680.82
264_K268_E1.0670.82
10_I145_L1.0650.82
157_E388_R1.0570.81
345_A368_A1.0530.81
89_R96_R1.0510.81
55_A68_I1.0500.81
120_F426_L1.0440.80
386_F406_M1.0430.80
203_M379_L1.0420.80
42_P46_E1.0420.80
333_I367_I1.0360.80
103_P106_Y1.0350.80
399_Y419_K1.0310.80
407_T415_D1.0290.79
215_S218_E1.0290.79
403_L418_A1.0250.79
179_K195_V1.0240.79
95_A98_K1.0240.79
264_K414_S1.0180.79
103_P425_M1.0180.79
293_E296_K1.0160.79
403_L419_K1.0150.79
88_F152_A1.0100.78
358_V365_K1.0080.78
48_L70_L1.0060.78
402_A426_L1.0050.78
135_D139_L1.0030.78
94_Q98_K1.0010.78
8_V39_V0.9990.77
96_R100_E0.9960.77
344_I353_V0.9950.77
252_I255_G0.9940.77
177_G181_G0.9920.77
78_L139_L0.9890.77
338_T357_C0.9860.76
243_P247_K0.9830.76
161_R388_R0.9830.76
88_F132_I0.9820.76
244_D247_K0.9810.76
83_F323_I0.9800.76
385_S388_R0.9780.76
399_Y426_L0.9780.76
10_I132_I0.9740.76
208_D217_K0.9640.75
172_C202_H0.9610.75
281_A284_V0.9580.74
118_G124_R0.9560.74
338_T359_M0.9560.74
241_W244_D0.9530.74
412_V418_A0.9530.74
119_L406_M0.9470.74
169_V326_I0.9410.73
197_F206_G0.9410.73
351_S384_K0.9390.73
413_P417_V0.9370.73
333_I356_N0.9310.72
153_G387_E0.9300.72
283_V287_V0.9260.72
110_G117_G0.9250.72
266_M270_E0.9250.72
397_G435_Q0.9250.72
120_F429_H0.9230.72
245_F251_V0.9150.71
113_T118_G0.9120.71
155_V158_A0.9050.70
78_L84_V0.8980.69
197_F204_V0.8950.69
194_E333_I0.8910.69
116_P406_M0.8910.69
103_P421_I0.8870.69
131_E135_D0.8860.68
218_E250_N0.8850.68
81_A140_C0.8800.68
407_T418_A0.8770.68
180_M190_V0.8770.68
122_G126_I0.8750.67
406_M421_I0.8740.67
321_N332_D0.8700.67
238_G242_E0.8650.67
294_L297_D0.8640.66
134_K162_Y0.8620.66
282_E286_K0.8620.66
104_L267_L0.8590.66
134_K138_E0.8540.66
157_E161_R0.8500.65
245_F249_L0.8490.65
179_K206_G0.8370.64
265_E268_E0.8370.64
95_A429_H0.8240.63
399_Y403_L0.8240.63
244_D250_N0.8240.63
130_L162_Y0.8230.63
122_G352_A0.8210.63
346_S353_V0.8210.63
351_S388_R0.8190.62
114_N409_N0.8170.62
5_L34_R0.8160.62
389_V404_L0.8130.62
357_C366_P0.8120.62
174_V255_G0.8110.62
103_P117_G0.8090.61
248_A404_L0.8080.61
189_D211_L0.8080.61
89_R100_E0.8060.61
152_A175_P0.8050.61
56_K67_D0.8020.61
280_R284_V0.7990.60
157_E384_K0.7980.60
425_M428_A0.7960.60
426_L430_K0.7950.60
383_I409_N0.7950.60
242_E245_F0.7950.60
420_Q423_D0.7950.60
244_D419_K0.7930.60
16_Y87_Q0.7910.60
222_E247_K0.7860.59
302_I305_P0.7860.59
128_V131_E0.7840.59
144_W326_I0.7840.59
6_K81_A0.7830.59
196_Q369_V0.7820.59
9_T85_T0.7800.59
74_R78_L0.7790.58
94_Q285_Q0.7780.58
46_E349_D0.7770.58
188_V192_R0.7760.58
56_K76_K0.7760.58
148_F319_A0.7740.58
165_L168_V0.7720.58
254_C257_H0.7680.57
104_L270_E0.7680.57
90_V125_T0.7660.57
99_D118_G0.7630.57
120_F425_M0.7600.57
397_G434_P0.7540.56
121_K260_Y0.7540.56
378_G385_S0.7530.56
420_Q424_E0.7470.55
113_T256_Y0.7460.55
98_K102_I0.7450.55
49_N365_K0.7450.55
402_A434_P0.7440.55
262_K265_E0.7440.55
324_S330_K0.7430.55
55_A59_V0.7420.55
12_G418_A0.7410.55
431_A434_P0.7360.54
103_P120_F0.7330.54
51_V55_A0.7330.54
159_L163_S0.7310.54
145_L159_L0.7310.54
198_A369_V0.7310.54
248_A251_V0.7280.53
238_G247_K0.7280.53
382_Q408_I0.7260.53
237_S250_N0.7240.53
223_A227_P0.7220.53
335_P356_N0.7210.53
383_I387_E0.7190.52
291_L295_Y0.7190.52
113_T154_M0.7170.52
112_E121_K0.7170.52
38_L55_A0.7150.52
145_L168_V0.7140.52
359_M364_P0.7120.52
249_L261_F0.7100.52
346_S371_D0.7100.52
162_Y392_E0.7100.52
81_A84_V0.7090.51
138_E226_D0.7080.51
182_V209_V0.7070.51
288_E292_F0.7060.51
172_C201_N0.7060.51
74_R131_E0.7030.51
178_I204_V0.7030.51
61_K301_A0.7010.51
146_V323_I0.7000.51
113_T260_Y0.7000.51
158_A394_A0.6990.50
46_E49_N0.6990.50
176_I322_L0.6990.50
114_N260_Y0.6990.50
390_A406_M0.6970.50
156_T170_G0.6960.50
116_P421_I0.6930.50
148_F153_G0.6920.50
344_I370_G0.6920.50
242_E248_A0.6920.50
110_G387_E0.6910.50
69_H138_E0.6910.50
240_E245_F0.6870.49
119_L402_A0.6860.49
150_N201_N0.6850.49
197_F335_P0.6840.49
51_V70_L0.6830.49
10_I78_L0.6830.49
17_T87_Q0.6810.49
160_L168_V0.6810.49
71_T76_K0.6800.48
36_L66_I0.6800.48
194_E208_D0.6800.48
240_E243_P0.6790.48
120_F140_C0.6760.48
217_K221_I0.6750.48
266_M414_S0.6730.48
14_S19_E0.6730.48
71_T254_C0.6720.48
94_Q431_A0.6720.48
325_S334_Q0.6700.47
7_I24_F0.6690.47
78_L135_D0.6690.47
288_E291_L0.6690.47
403_L406_M0.6680.47
263_T267_L0.6680.47
280_R291_L0.6660.47
23_G156_T0.6660.47
57_R303_K0.6640.47
36_L423_D0.6640.47
349_D371_D0.6630.47
122_G158_A0.6610.47
85_T167_K0.6600.46
422_L426_L0.6590.46
114_N203_M0.6590.46
114_N386_F0.6580.46
100_E110_G0.6580.46
132_I145_L0.6570.46
125_T394_A0.6550.46
39_V78_L0.6550.46
116_P233_M0.6540.46
348_P351_S0.6540.46
247_K251_V0.6520.46
315_Y387_E0.6500.45
133_A165_L0.6480.45
105_K420_Q0.6480.45
381_Q385_S0.6480.45
244_D249_L0.6470.45
356_N373_P0.6470.45
205_F404_L0.6460.45
11_G14_S0.6460.45
304_P307_L0.6440.45
256_Y259_Y0.6430.45
384_K387_E0.6430.45
89_R387_E0.6420.45
173_N315_Y0.6410.45
12_G52_G0.6390.44
227_P247_K0.6390.44
203_M409_N0.6380.44
290_E294_L0.6380.44
100_E112_E0.6380.44
242_E249_L0.6350.44
284_V291_L0.6340.44
265_E364_P0.6330.44
48_L72_L0.6320.44
146_V169_V0.6310.44
185_A220_V0.6310.44
416_T420_Q0.6300.43
191_D214_V0.6290.43
16_Y93_L0.6280.43
84_V140_C0.6270.43
148_F318_A0.6270.43
102_I424_E0.6260.43
89_R110_G0.6240.43
183_A188_V0.6240.43
101_R279_T0.6230.43
210_F215_S0.6230.43
46_E342_G0.6230.43
303_K307_L0.6220.43
258_R269_H0.6220.43
20_L315_Y0.6220.43
242_E419_K0.6210.43
331_H358_V0.6190.42
304_P310_R0.6180.42
36_L214_V0.6180.42
17_T20_L0.6180.42
58_M143_A0.6180.42
38_L68_I0.6170.42
243_P251_V0.6170.42
101_R282_E0.6160.42
56_K142_N0.6160.42
56_K69_H0.6150.42
211_L214_V0.6140.42
346_S372_L0.6130.42
227_P230_A0.6130.42
25_I325_S0.6110.42
136_I163_S0.6110.42
171_L254_C0.6080.41
28_Y65_P0.6080.41
245_F250_N0.6070.41
119_L122_G0.6070.41
153_G203_M0.6070.41
374_V381_Q0.6060.41
113_T124_R0.6060.41
283_V286_K0.6050.41
292_F296_K0.6050.41
45_E138_E0.6050.41
26_K317_D0.6040.41
406_M412_V0.6040.41
150_N202_H0.6030.41
10_I41_I0.6030.41
89_R121_K0.6020.41
186_L219_Q0.6000.40
195_V206_G0.5990.40
53_T70_L0.5980.40
16_Y19_E0.5970.40
180_M184_K0.5970.40
423_D427_E0.5970.40
59_V65_P0.5960.40
37_W188_V0.5940.40
7_I107_G0.5940.40
100_E111_Q0.5920.40
125_T155_V0.5910.40
79_K134_K0.5910.40
168_V352_A0.5890.39
241_W249_L0.5890.39
153_G383_I0.5890.39
24_F173_N0.5870.39
398_D435_Q0.5870.39
370_G377_R0.5860.39
96_R113_T0.5860.39
30_E323_I0.5860.39
6_K34_R0.5850.39
219_Q222_E0.5850.39
326_I330_K0.5840.39
121_K125_T0.5810.39
57_R304_P0.5810.39
110_G152_A0.5810.39
18_P280_R0.5810.39
207_L371_D0.5800.39
150_N172_C0.5800.39
58_M62_A0.5790.38
380_V404_L0.5790.38
307_L311_G0.5770.38
237_S240_E0.5760.38
179_K209_V0.5760.38
255_G270_E0.5740.38
28_Y324_S0.5730.38
253_P257_H0.5730.38
186_L211_L0.5730.38
254_C261_F0.5730.38
267_L270_E0.5710.38
196_Q207_L0.5710.38
373_P376_V0.5710.38
13_G41_I0.5710.38
421_I424_E0.5710.38
55_A87_Q0.5690.37
205_F245_F0.5690.37
331_H361_K0.5670.37
174_V204_V0.5660.37
419_K423_D0.5660.37
6_K80_D0.5650.37
218_E222_E0.5650.37
114_N154_M0.5640.37
76_K427_E0.5640.37
10_I74_R0.5640.37
293_E299_N0.5630.37
76_K265_E0.5630.37
160_L337_N0.5610.37
207_L373_P0.5610.37
241_W248_A0.5600.37
386_F390_A0.5600.37
194_E371_D0.5590.37
175_P335_P0.5580.36
64_V68_I0.5570.36
174_V178_I0.5560.36
324_S357_C0.5560.36
54_L196_Q0.5560.36
10_I39_V0.5550.36
343_A350_D0.5540.36
79_K341_N0.5540.36
99_D115_G0.5520.36
154_M329_D0.5520.36
133_A337_N0.5520.36
54_L402_A0.5520.36
183_A205_F0.5510.36
27_R320_C0.5510.36
111_Q387_E0.5480.36
60_E193_V0.5480.36
377_R388_R0.5480.36
76_K293_E0.5460.35
341_N366_P0.5460.35
7_I323_I0.5460.35
182_V252_I0.5460.35
86_T145_L0.5460.35
93_L281_A0.5460.35
96_R256_Y0.5450.35
116_P160_L0.5440.35
96_R429_H0.5440.35
337_N352_A0.5430.35
189_D308_E0.5430.35
323_I370_G0.5430.35
328_N344_I0.5430.35
353_V356_N0.5390.35
382_Q385_S0.5390.35
106_Y116_P0.5380.35
65_P404_L0.5380.35
155_V394_A0.5370.35
174_V318_A0.5360.34
115_G124_R0.5360.34
149_T432_Y0.5350.34
350_D368_A0.5350.34
101_R276_T0.5350.34
8_V79_K0.5350.34
241_W419_K0.5340.34
15_S292_F0.5340.34
144_W169_V0.5340.34
36_L177_G0.5340.34
394_A433_L0.5330.34
291_L294_L0.5330.34
350_D394_A0.5320.34
34_R65_P0.5310.34
205_F253_P0.5300.34
200_L383_I0.5290.34
96_R280_R0.5290.34
170_G410_P0.5280.34
187_D214_V0.5260.34
162_Y396_T0.5260.34
19_E315_Y0.5230.33
47_K256_Y0.5220.33
17_T24_F0.5220.33
205_F260_Y0.5210.33
8_V69_H0.5200.33
20_L100_E0.5190.33
297_D302_I0.5170.33
386_F409_N0.5170.33
282_E288_E0.5160.33
222_E268_E0.5160.33
24_F323_I0.5150.33
400_Q404_L0.5150.33
179_K193_V0.5140.32
255_G258_R0.5140.32
19_E23_G0.5140.32
183_A193_V0.5130.32
78_L114_N0.5130.32
379_L383_I0.5120.32
96_R110_G0.5120.32
91_G95_A0.5120.32
86_T149_T0.5120.32
230_A277_E0.5110.32
297_D306_Q0.5110.32
17_T96_R0.5100.32
113_T121_K0.5100.32
329_D360_T0.5100.32
54_L61_K0.5090.32
130_L134_K0.5090.32
19_E316_S0.5080.32
42_P142_N0.5080.32
359_M424_E0.5080.32
193_V211_L0.5080.32
34_R285_Q0.5070.32
90_V132_I0.5060.32
86_T168_V0.5060.32
100_E387_E0.5040.32
355_V369_V0.5030.31
341_N368_A0.5030.31
355_V366_P0.5020.31
159_L164_N0.5010.31
32_P327_Y0.5010.31
9_T20_L0.5010.31
104_L278_G0.5000.31
7_I36_L0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1s6yA 1 0.9367 100 0.335 Contact Map
1u8xX 1 0.9593 100 0.354 Contact Map
1obbA 2 0.9706 100 0.358 Contact Map
1up7A 3 0.9344 100 0.359 Contact Map
3u95A 2 0.9683 100 0.422 Contact Map
3fefA 3 0.9186 100 0.426 Contact Map
1pzgA 4 0.7127 100 0.713 Contact Map
4rorA 4 0.7081 100 0.722 Contact Map
3p7mA 4 0.6991 100 0.722 Contact Map
4plzA 4 0.6584 100 0.724 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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