GREMLIN Database
PTJA - Lichenan-specific phosphotransferase enzyme IIA component
UniProt: P46319 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 110 (100)
Sequences: 1388 (1035)
Seq/√Len: 103.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_R100_E4.4581.00
29_A34_D3.1981.00
34_D37_E3.0381.00
31_K94_E3.0021.00
31_K97_E2.9841.00
23_A45_A2.7261.00
62_N67_E2.6171.00
29_A41_K2.2801.00
22_S44_D2.1991.00
15_H48_E2.1871.00
27_I92_A2.1361.00
46_A89_K1.9151.00
95_I98_L1.9111.00
18_N48_E1.7871.00
29_A37_E1.7761.00
28_A94_E1.5931.00
56_Q79_Q1.5521.00
37_E41_K1.5321.00
37_E40_K1.5321.00
46_A93_A1.5021.00
10_F14_L1.4981.00
14_L18_N1.4711.00
42_L96_I1.4671.00
71_M76_V1.4501.00
40_K44_D1.3550.99
25_E41_K1.3440.99
35_A103_T1.3440.99
22_S41_K1.3420.99
98_L102_I1.3290.99
41_K44_D1.2960.99
43_Q47_E1.2880.99
58_E62_N1.2860.99
63_E66_G1.2670.99
95_I99_Y1.2450.99
51_K54_H1.1940.99
39_R43_Q1.1560.98
40_K43_Q1.1430.98
27_I95_I1.1360.98
57_T79_Q1.1280.98
59_L75_M1.1240.98
89_K93_A1.1210.98
33_G101_K1.1140.98
43_Q46_A1.1060.98
35_A100_E1.0920.98
9_I75_M1.0880.98
29_A32_S1.0820.97
47_E51_K1.0410.97
30_A96_I1.0360.97
16_G52_A1.0280.96
61_Q65_G1.0090.96
56_Q86_M0.9990.96
24_M88_V0.9840.95
75_M78_A0.9760.95
50_S54_H0.9530.95
24_M90_D0.9360.94
44_D47_E0.9320.94
13_I78_A0.9230.94
62_N69_T0.9220.94
4_E7_Q0.9210.94
21_S25_E0.9110.93
9_I73_L0.8890.92
84_N88_V0.8730.92
20_R90_D0.8660.91
27_I91_M0.8650.91
6_E74_L0.8640.91
81_H86_M0.8490.91
23_A85_A0.8460.90
9_I74_L0.8340.90
83_M87_T0.8330.90
48_E51_K0.8250.89
30_A99_Y0.7980.88
30_A35_A0.7910.87
55_Y58_E0.7690.86
24_M92_A0.7690.86
81_H90_D0.7650.85
23_A42_L0.7630.85
62_N65_G0.7560.85
23_A89_K0.7520.84
79_Q86_M0.7470.84
16_G85_A0.7450.84
88_V92_A0.7390.83
11_Q15_H0.7380.83
79_Q84_N0.7340.83
7_Q11_Q0.7140.81
56_Q84_N0.7080.81
5_M75_M0.7060.80
76_V79_Q0.7050.80
21_S24_M0.7000.80
31_K99_Y0.6980.80
60_I64_A0.6880.79
45_A89_K0.6870.79
56_Q81_H0.6850.78
15_H51_K0.6840.78
24_M87_T0.6790.78
23_A92_A0.6640.76
22_S48_E0.6620.76
63_E72_T0.6610.76
18_N22_S0.6580.76
31_K101_K0.6580.76
59_L73_L0.6460.74
16_G81_H0.6440.74
40_K47_E0.6420.74
39_R93_A0.6360.73
76_V81_H0.6340.73
87_T90_D0.6330.73
60_I73_L0.6310.72
20_R87_T0.6290.72
45_A49_L0.6230.72
9_I14_L0.6130.70
63_E74_L0.6090.70
88_V91_M0.6080.70
36_E40_K0.6050.69
34_D40_K0.6050.69
44_D48_E0.5840.67
47_E50_S0.5840.67
15_H18_N0.5780.66
32_S36_E0.5760.66
20_R84_N0.5720.65
16_G87_T0.5680.64
42_L93_A0.5640.64
60_I76_V0.5640.64
84_N87_T0.5570.63
11_Q51_K0.5500.62
45_A90_D0.5490.62
27_I31_K0.5450.61
18_N81_H0.5430.61
49_L86_M0.5410.61
31_K98_L0.5400.61
87_T92_A0.5400.61
72_T75_M0.5390.60
51_K55_Y0.5390.60
12_I16_G0.5380.60
26_A30_A0.5370.60
28_A31_K0.5370.60
60_I78_A0.5360.60
86_M89_K0.5340.60
36_E43_Q0.5270.59
54_H93_A0.5230.58
30_A38_A0.5230.58
6_E78_A0.5190.58
8_I58_E0.5170.57
38_A92_A0.5160.57
33_G99_Y0.5160.57
23_A38_A0.5160.57
85_A88_V0.5110.56
36_E39_R0.5110.56
61_Q64_A0.5070.56
5_M70_E0.5070.56
10_F66_G0.5050.56
96_I99_Y0.5000.55
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2e2aA 3 0.9364 100 0.089 Contact Map
3l8rA 3 0.9182 100 0.094 Contact Map
1wcrA 3 0.9364 100 0.098 Contact Map
3k1sA 6 0.9636 100 0.102 Contact Map
3h87C 3 0.2455 12.4 0.928 Contact Map
4udxX 2 0.9091 7.6 0.935 Contact Map
1z96A 1 0.3455 6.5 0.937 Contact Map
3ieeA 1 0.9818 4.8 0.941 Contact Map
3shgA 1 0.4455 4.7 0.941 Contact Map
4m0mA 1 0.4091 4.5 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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