GREMLIN Database
PTJB - Lichenan-specific phosphotransferase enzyme IIB component
UniProt: P46318 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 102 (96)
Sequences: 1191 (844)
Seq/√Len: 86.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_L65_K3.5031.00
27_Q93_K3.4371.00
79_N94_S2.3521.00
2_N32_T2.2951.00
82_H87_N2.0651.00
89_A93_K2.0411.00
41_V64_L1.9881.00
18_S21_E1.9681.00
42_Q67_L1.9111.00
50_V98_L1.8471.00
16_L91_V1.8421.00
17_V33_I1.8061.00
79_N82_H1.7721.00
18_S22_K1.7721.00
29_K96_E1.7551.00
82_H90_E1.6711.00
4_L48_A1.6041.00
65_K69_E1.5691.00
4_L36_V1.5441.00
23_S27_Q1.5211.00
20_M33_I1.4880.99
22_K26_E1.4640.99
27_Q89_A1.4150.99
62_P65_K1.4140.99
94_S97_Q1.4090.99
31_Y96_E1.3630.99
22_K25_Q1.3440.99
23_S26_E1.3310.99
76_D98_L1.2960.99
15_L18_S1.2890.98
87_N90_E1.2820.98
11_M14_S1.2270.98
93_K97_Q1.2020.98
60_M63_Q1.1770.97
6_V41_V1.1700.97
52_L76_D1.1700.97
23_S89_A1.1660.97
66_K69_E1.1610.97
23_S88_G1.1470.97
21_E25_Q1.1250.96
15_L86_C1.1240.96
82_H94_S1.1190.96
82_H91_V1.1080.96
76_D94_S1.1010.96
46_D71_K1.0910.96
38_G60_M1.0900.96
90_E93_K1.0880.96
5_L13_T1.0860.96
4_L34_W1.0620.95
27_Q96_E1.0400.94
64_L75_V1.0370.94
24_A33_I1.0360.94
45_I68_G1.0360.94
61_L76_D1.0310.94
92_L96_E1.0110.94
44_H47_K0.9960.93
34_W48_A0.9890.93
29_K92_L0.9850.93
3_I31_Y0.9770.92
63_Q66_K0.9670.92
69_E72_G0.9620.92
51_L73_V0.9610.92
26_E89_A0.9580.92
9_A37_S0.9560.91
68_G71_K0.9520.91
61_L75_V0.9510.91
6_V36_V0.9380.91
24_A31_Y0.9350.91
51_L68_G0.9320.90
21_E32_T0.9240.90
41_V48_A0.9230.90
53_L57_V0.9140.90
3_I95_A0.9130.90
20_M95_A0.9040.89
64_L68_G0.8910.88
16_L78_I0.8680.87
23_S92_L0.8670.87
61_L77_V0.8580.86
13_T54_G0.8560.86
2_N34_W0.8460.86
51_L64_L0.8340.85
50_V95_A0.8040.83
6_V51_L0.8030.83
85_T90_E0.7640.79
34_W44_H0.7500.78
53_L61_L0.7400.77
53_L77_V0.7330.76
36_V48_A0.7310.76
95_A98_L0.7270.76
78_I91_V0.7140.75
19_K22_K0.7090.74
2_N48_A0.7070.74
41_V51_L0.6920.72
88_G91_V0.6810.71
24_A92_L0.6720.70
15_L19_K0.6710.70
38_G64_L0.6670.69
18_S25_Q0.6610.69
7_C10_G0.6360.66
81_V87_N0.6320.65
52_L94_S0.6260.65
8_A37_S0.6160.63
12_S83_Y0.6150.63
36_V44_H0.6100.63
93_K96_E0.6070.62
39_D60_M0.6040.62
4_L68_G0.5950.61
17_V20_M0.5940.61
68_G72_G0.5920.60
11_M15_L0.5880.60
40_S43_N0.5850.59
43_N47_K0.5790.59
62_P66_K0.5780.58
36_V40_S0.5750.58
57_V60_M0.5750.58
13_T20_M0.5740.58
86_C91_V0.5740.58
76_D79_N0.5680.57
6_V64_L0.5670.57
6_V57_V0.5600.56
2_N47_K0.5600.56
38_G44_H0.5560.56
6_V40_S0.5560.56
8_A38_G0.5550.55
25_Q30_D0.5530.55
69_E75_V0.5490.55
38_G57_V0.5480.54
5_L20_M0.5390.53
20_M91_V0.5350.53
53_L92_L0.5350.53
7_C35_A0.5320.52
69_E74_P0.5300.52
39_D57_V0.5270.52
81_V85_T0.5250.51
24_A29_K0.5230.51
45_I69_E0.5180.50
7_C13_T0.5160.50
43_N46_D0.5130.50
4_L51_L0.5120.50
12_S84_G0.5090.49
8_A56_Q0.5060.49
31_Y59_Y0.5040.49
71_K75_V0.5010.48
17_V23_S0.5000.48
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nbmA 1 0.9706 99.9 0.334 Contact Map
4mgeA 3 1 99.9 0.343 Contact Map
2l2qA 1 1 99.9 0.377 Contact Map
1e2bA 1 0.9804 99.9 0.399 Contact Map
2kyrA 1 0.9314 99.9 0.429 Contact Map
4tn5A 2 0.9314 99.9 0.432 Contact Map
2r4qA 1 0.9118 99.9 0.436 Contact Map
2m1zA 1 0.9314 99.9 0.442 Contact Map
1tvmA 1 0.8824 99.6 0.587 Contact Map
3czcA 1 0.8824 99.3 0.647 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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