GREMLIN Database
PTJC - Lichenan permease IIC component
UniProt: P46317 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 452 (416)
Sequences: 2134 (1546)
Seq/√Len: 75.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_F107_G4.8421.00
304_T336_N4.3701.00
375_V406_M4.3301.00
365_L413_V3.8341.00
306_A414_S3.7941.00
308_V339_I3.0001.00
276_A284_P2.9681.00
249_A352_L2.9231.00
376_A400_K2.9031.00
401_V405_V2.8471.00
362_T414_S2.8231.00
91_I153_M2.8061.00
315_A426_D2.7561.00
361_V417_V2.7031.00
84_G152_A2.5021.00
362_T410_N2.4531.00
365_L406_M2.4031.00
272_A285_K2.3941.00
207_V218_I2.3531.00
427_K431_K2.3051.00
202_A206_I2.2791.00
99_Y164_R2.2691.00
412_A416_V2.2541.00
358_T361_V2.2531.00
24_H95_L2.2021.00
358_T417_V2.1661.00
88_A110_S2.1351.00
166_I195_A2.1351.00
397_T403_G2.1091.00
234_L364_T2.0891.00
314_R419_Y2.0811.00
23_R99_Y2.0721.00
361_V413_V2.0671.00
366_T370_M2.0661.00
99_Y161_E2.0371.00
96_A106_A2.0331.00
429_K432_E2.0211.00
252_L257_I1.9941.00
376_A402_S1.9901.00
309_V411_I1.9801.00
431_K435_D1.9631.00
409_I413_V1.9511.00
277_F283_L1.9361.00
238_L360_L1.9201.00
394_Y404_A1.9131.00
242_A360_L1.8831.00
24_H161_E1.8821.00
317_S426_D1.8641.00
406_M410_N1.8601.00
351_L425_W1.8601.00
393_G407_Q1.8501.00
92_A106_A1.8471.00
369_G374_L1.8441.00
315_A422_F1.8171.00
232_G285_K1.8161.00
368_I372_T1.7871.00
430_L434_N1.7741.00
366_T410_N1.7661.00
369_G406_M1.7511.00
304_T331_A1.7321.00
276_A283_L1.7121.00
161_E164_R1.7071.00
393_G403_G1.6881.00
369_G375_V1.6811.00
345_I351_L1.6731.00
390_I404_A1.6711.00
102_D185_K1.6671.00
310_T415_F1.6661.00
374_L402_S1.6401.00
164_R168_Q1.6381.00
264_P268_G1.6361.00
358_T414_S1.6161.00
234_L238_L1.6131.00
23_R98_K1.6121.00
306_A415_F1.6031.00
303_A362_T1.5790.99
117_A155_I1.5730.99
156_A160_T1.5680.99
92_A107_G1.5650.99
9_E14_P1.5610.99
246_L250_C1.5600.99
238_L364_T1.5570.99
425_W429_K1.5400.99
366_T406_M1.5350.99
176_P179_V1.5250.99
320_M425_W1.5220.99
416_V419_Y1.5200.99
44_F48_I1.5190.99
310_T422_F1.5150.99
392_S407_Q1.5130.99
65_G68_W1.5100.99
306_A411_I1.5030.99
93_Y104_L1.5000.99
374_L406_M1.4970.99
275_I279_A1.4960.99
89_F111_L1.4910.99
310_T313_L1.4870.99
165_L169_R1.4820.99
28_L157_M1.4710.99
95_L161_E1.4680.99
402_S405_V1.4540.99
242_A246_L1.4530.99
255_A301_S1.4520.99
319_Q429_K1.4430.99
7_I11_K1.4430.99
310_T419_Y1.4180.99
214_S217_N1.4010.99
60_M68_W1.3980.99
22_Q161_E1.3950.99
113_A200_I1.3900.99
408_A412_A1.3820.99
31_G90_G1.3820.99
158_V199_L1.3740.98
321_K325_K1.3700.98
271_D275_I1.3680.98
248_W254_G1.3660.98
166_I171_L1.3640.98
305_L411_I1.3570.98
352_L356_I1.3510.98
92_A110_S1.3440.98
113_A196_V1.3420.98
317_S433_E1.3410.98
295_W370_M1.3380.98
95_L99_Y1.3300.98
88_A156_A1.3160.98
390_I408_A1.3130.98
364_T368_I1.3110.98
24_H157_M1.3110.98
365_L369_G1.3020.98
296_V363_V1.3000.98
88_A152_A1.2900.98
112_A197_I1.2870.98
288_T379_A1.2820.98
172_V188_V1.2800.98
340_I355_F1.2670.97
320_M429_K1.2630.97
31_G94_R1.2580.97
389_P411_I1.2570.97
311_M324_G1.2460.97
367_Y371_S1.2420.97
171_L195_A1.2410.97
221_V225_T1.2410.97
331_A336_N1.2350.97
431_K434_N1.2270.97
38_L86_V1.2220.97
241_E363_V1.2210.97
289_Q293_D1.2200.97
76_V81_E1.2150.97
118_T216_H1.2130.97
6_Q10_E1.2090.97
87_A149_L1.2020.96
365_L410_N1.2020.96
88_A92_A1.2000.96
317_S430_L1.1980.96
68_W72_L1.1940.96
308_V311_M1.1910.96
45_F75_P1.1900.96
54_P58_E1.1830.96
34_L90_G1.1820.96
210_T213_E1.1820.96
7_I14_P1.1770.96
50_N73_A1.1770.96
400_K403_G1.1730.96
162_I196_V1.1700.96
350_M424_M1.1660.96
274_R278_Q1.1660.96
142_S147_K1.1640.96
299_G305_L1.1570.96
322_Q325_K1.1560.96
35_T90_G1.1540.95
310_T324_G1.1530.95
88_A107_G1.1510.95
311_M422_F1.1490.95
152_A156_A1.1440.95
309_V415_F1.1410.95
277_F380_G1.1320.95
56_Y60_M1.1290.95
323_L327_A1.1280.95
283_L380_G1.1240.95
276_A282_E1.1200.95
318_K322_Q1.1190.95
387_M395_L1.1180.95
269_A285_K1.1100.94
42_G79_T1.1100.94
151_V216_H1.1080.94
64_F68_W1.1060.94
175_M179_V1.1060.94
40_I190_L1.1030.94
75_P201_W1.0960.94
31_G156_A1.0880.94
23_R161_E1.0760.93
276_A281_E1.0730.93
85_L115_L1.0700.93
423_R426_D1.0700.93
389_P407_Q1.0680.93
275_I278_Q1.0670.93
390_I407_Q1.0510.93
235_G239_V1.0500.93
8_L14_P1.0460.92
308_V324_G1.0460.92
8_L424_M1.0450.92
175_M178_G1.0390.92
311_M343_M1.0330.92
355_F418_Y1.0290.92
94_R97_E1.0270.92
336_N340_I1.0250.92
299_G302_G1.0250.92
410_N414_S1.0220.92
357_I361_V1.0220.92
272_A276_A1.0160.91
295_W397_T1.0150.91
95_L160_T1.0150.91
101_V164_R1.0090.91
302_G336_N1.0060.91
155_I200_I1.0040.91
312_F324_G1.0020.91
300_G304_T1.0000.91
235_G238_L1.0000.91
313_L426_D1.0000.91
324_G422_F1.0000.91
271_D274_R0.9940.90
298_I303_A0.9900.90
60_M64_F0.9890.90
114_F152_A0.9860.90
276_A280_G0.9840.90
77_D81_E0.9840.90
240_A262_M0.9800.90
314_R415_F0.9760.90
32_I87_A0.9750.89
426_D433_E0.9730.89
358_T362_T0.9730.89
158_V200_I0.9720.89
97_E103_A0.9710.89
101_V167_I0.9680.89
241_E296_V0.9650.89
312_F328_V0.9640.89
24_H99_Y0.9630.89
93_Y103_A0.9620.89
109_I193_G0.9610.89
306_A309_V0.9580.89
390_I393_G0.9560.89
49_G73_A0.9550.88
263_A289_Q0.9490.88
27_A98_K0.9470.88
135_V138_G0.9460.88
303_A306_A0.9460.88
310_T314_R0.9460.88
276_A279_A0.9400.88
340_I345_I0.9390.88
31_G91_I0.9380.88
49_G72_L0.9360.87
89_F104_L0.9300.87
160_T164_R0.9280.87
314_R422_F0.9270.87
232_G269_A0.9270.87
6_Q11_K0.9270.87
369_G372_T0.9240.87
82_I86_V0.9240.87
313_L419_Y0.9230.87
217_N221_V0.9200.87
412_A415_F0.9170.86
191_I195_A0.9160.86
60_M65_G0.9150.86
139_I144_M0.9120.86
50_N386_T0.9110.86
85_L144_M0.9090.86
109_I196_V0.9080.86
240_A258_V0.9070.86
428_Q431_K0.9040.86
369_G373_G0.9040.86
368_I371_S0.9020.85
84_G88_A0.9010.85
8_L79_T0.9000.85
36_M39_I0.8980.85
274_R380_G0.8950.85
260_G264_P0.8940.85
31_G157_M0.8790.84
277_F284_P0.8790.84
339_I345_I0.8790.84
365_L409_I0.8790.84
158_V162_I0.8760.84
375_V402_S0.8720.83
35_T87_A0.8570.82
204_R208_E0.8530.82
106_A163_Y0.8470.82
426_D430_L0.8440.81
331_A339_I0.8430.81
46_L80_F0.8370.81
103_A107_G0.8360.81
97_E100_G0.8360.81
270_M290_Q0.8330.81
299_G303_A0.8330.81
312_F325_K0.8300.80
230_L239_V0.8300.80
334_N385_W0.8280.80
113_A159_S0.8280.80
19_I25_L0.8250.80
162_I199_L0.8240.80
401_V404_A0.8240.80
248_W253_H0.8240.80
87_A91_I0.8220.80
295_W366_T0.8160.79
419_Y422_F0.8160.79
180_P226_P0.8150.79
53_I56_Y0.8130.79
300_G336_N0.8120.79
307_L418_Y0.8110.79
173_F179_V0.8060.78
269_A272_A0.8060.78
155_I159_S0.8060.78
237_S363_V0.8050.78
30_D182_A0.8040.78
253_H337_E0.8020.78
422_F426_D0.8020.78
180_P338_P0.7990.78
405_V409_I0.7950.77
122_V138_G0.7940.77
383_V396_A0.7920.77
375_V403_G0.7910.77
404_A407_Q0.7900.77
307_L422_F0.7900.77
162_I195_A0.7890.77
173_F176_P0.7870.77
299_G336_N0.7860.77
30_D98_K0.7850.77
59_F63_T0.7850.77
337_E341_F0.7840.76
184_S188_V0.7820.76
430_L433_E0.7810.76
406_M409_I0.7760.76
286_I370_M0.7750.76
115_L144_M0.7740.76
114_F144_M0.7740.76
159_S200_I0.7730.75
302_G355_F0.7730.75
25_L347_M0.7710.75
245_M297_N0.7700.75
154_I219_V0.7690.75
311_M331_A0.7660.75
314_R321_K0.7650.75
167_I172_V0.7630.74
350_M428_Q0.7630.74
10_E14_P0.7610.74
245_M301_S0.7600.74
313_L324_G0.7590.74
199_L202_A0.7590.74
238_L242_A0.7570.74
226_P338_P0.7560.74
306_A416_V0.7550.74
205_L209_A0.7530.74
424_M428_Q0.7520.73
78_A115_L0.7510.73
161_E165_L0.7500.73
15_I19_I0.7420.72
369_G409_I0.7410.72
302_G418_Y0.7400.72
410_N413_V0.7400.72
143_L217_N0.7380.72
295_W375_V0.7380.72
358_T413_V0.7370.72
262_M266_W0.7350.72
170_N174_K0.7320.71
22_Q99_Y0.7310.71
375_V400_K0.7270.71
159_S196_V0.7260.71
223_L247_L0.7240.71
311_M339_I0.7240.71
101_V168_Q0.7200.70
49_G75_P0.7180.70
359_P418_Y0.7160.70
286_I291_F0.7160.70
14_P17_G0.7120.69
308_V331_A0.7110.69
291_F366_T0.7100.69
281_E284_P0.7080.69
315_A320_M0.7080.69
30_D94_R0.7070.69
411_I415_F0.7060.69
270_M382_A0.7050.69
371_S376_A0.7050.69
267_Y271_D0.7050.69
206_I210_T0.7050.69
106_A160_T0.7040.68
409_I412_A0.7020.68
17_G21_G0.6990.68
8_L12_V0.6960.68
46_L76_V0.6960.68
394_Y398_G0.6950.67
175_M187_F0.6920.67
21_G108_A0.6920.67
287_F367_Y0.6920.67
31_G87_A0.6910.67
96_A160_T0.6890.67
180_P187_F0.6880.67
9_E13_M0.6870.67
298_I305_L0.6840.66
248_W347_M0.6840.66
323_L339_I0.6830.66
299_G307_L0.6830.66
25_L266_W0.6820.66
277_F280_G0.6820.66
314_R325_K0.6810.66
151_V155_I0.6790.66
305_L332_I0.6770.65
23_R27_A0.6770.65
290_Q379_A0.6760.65
19_I364_T0.6760.65
234_L368_I0.6750.65
25_L29_R0.6720.65
111_L144_M0.6710.65
167_I170_N0.6710.65
305_L331_A0.6710.65
58_E62_K0.6700.65
327_A339_I0.6690.64
82_I85_L0.6680.64
432_E435_D0.6680.64
85_L111_L0.6650.64
306_A310_T0.6650.64
114_F118_T0.6640.64
390_I411_I0.6640.64
413_V417_V0.6630.64
156_A159_S0.6630.64
239_V311_M0.6610.64
269_A288_T0.6610.64
238_L363_V0.6600.63
32_I47_I0.6560.63
376_A404_A0.6520.62
245_M355_F0.6520.62
320_M351_L0.6520.62
303_A414_S0.6520.62
11_K316_R0.6500.62
178_G329_G0.6480.62
188_V191_I0.6470.62
317_S324_G0.6470.62
210_T218_I0.6470.62
74_Y204_R0.6460.62
29_R102_D0.6450.62
374_L409_I0.6430.61
308_V422_F0.6430.61
27_A31_G0.6420.61
357_I417_V0.6390.61
253_H341_F0.6370.61
300_G418_Y0.6360.61
393_G404_A0.6360.61
415_F419_Y0.6360.61
362_T366_T0.6340.60
237_S292_F0.6340.60
183_V384_P0.6330.60
180_P183_V0.6320.60
317_S320_M0.6310.60
46_L49_G0.6310.60
309_V353_L0.6310.60
171_L191_I0.6290.60
230_L331_A0.6290.60
397_T400_K0.6270.59
320_M324_G0.6270.59
357_I360_L0.6270.59
419_Y423_R0.6270.59
340_I346_V0.6270.59
33_I364_T0.6260.59
40_I384_P0.6260.59
301_S355_F0.6260.59
89_F92_A0.6250.59
22_Q95_L0.6230.59
236_G250_C0.6200.59
50_N53_I0.6190.59
10_E242_A0.6190.59
413_V416_V0.6180.58
55_G58_E0.6160.58
186_S190_L0.6160.58
354_P421_F0.6150.58
101_V160_T0.6150.58
27_A95_L0.6130.58
5_N352_L0.6130.58
114_F145_G0.6100.57
106_A159_S0.6090.57
319_Q426_D0.6080.57
63_T68_W0.6070.57
236_G249_A0.6050.57
206_I209_A0.6050.57
86_V112_A0.6050.57
253_H256_N0.6050.57
174_K177_D0.6050.57
58_E61_A0.6040.57
177_D181_P0.6030.57
351_L418_Y0.6010.56
304_T327_A0.5980.56
51_L56_Y0.5970.56
16_A22_Q0.5960.56
92_A96_A0.5960.56
8_L11_K0.5920.55
286_I367_Y0.5920.55
73_A76_V0.5910.55
26_Q29_R0.5900.55
324_G327_A0.5890.55
92_A160_T0.5890.55
308_V328_V0.5880.55
423_R430_L0.5820.54
71_K201_W0.5820.54
248_W337_E0.5800.54
327_A331_A0.5790.54
185_K188_V0.5790.54
72_L201_W0.5780.53
424_M427_K0.5770.53
311_M320_M0.5760.53
295_W403_G0.5750.53
345_I355_F0.5740.53
91_I157_M0.5730.53
176_P180_P0.5730.53
309_V332_I0.5690.52
78_A116_L0.5690.52
302_G307_L0.5690.52
22_Q27_A0.5680.52
308_V312_F0.5680.52
180_P264_P0.5670.52
328_V332_I0.5660.52
69_S73_A0.5650.52
6_Q9_E0.5650.52
194_F198_F0.5640.52
270_M288_T0.5630.52
320_M343_M0.5620.51
38_L395_L0.5610.51
241_E292_F0.5600.51
151_V219_V0.5590.51
244_K297_N0.5590.51
248_W301_S0.5590.51
117_A200_I0.5580.51
117_A215_L0.5580.51
225_T229_I0.5550.51
183_V186_S0.5550.51
76_V80_F0.5540.50
222_L405_V0.5520.50
90_G94_R0.5520.50
11_K15_I0.5510.50
360_L364_T0.5500.50
11_K14_P0.5500.50
215_L218_I0.5490.50
228_S236_G0.5490.50
60_M403_G0.5490.50
336_N355_F0.5440.49
316_R423_R0.5430.49
302_G359_P0.5420.49
193_G197_I0.5420.49
178_G318_K0.5400.49
313_L325_K0.5400.49
248_W341_F0.5400.49
423_R427_K0.5390.49
398_G404_A0.5390.49
318_K321_K0.5380.48
249_A349_P0.5380.48
376_A403_G0.5380.48
315_A319_Q0.5380.48
143_L216_H0.5380.48
380_G398_G0.5370.48
387_M393_G0.5360.48
157_M161_E0.5360.48
42_G189_A0.5350.48
379_A397_T0.5350.48
29_R33_I0.5340.48
116_L197_I0.5340.48
48_I199_L0.5340.48
166_I170_N0.5340.48
313_L415_F0.5330.48
145_G148_G0.5330.48
172_V185_K0.5330.48
306_A418_Y0.5320.48
361_V365_L0.5320.48
23_R40_I0.5320.48
334_N386_T0.5320.48
82_I115_L0.5310.47
244_K255_A0.5290.47
162_I200_I0.5290.47
254_G355_F0.5280.47
100_G281_E0.5280.47
20_A25_L0.5270.47
57_A61_A0.5260.47
84_G145_G0.5260.47
7_I10_E0.5250.47
12_V387_M0.5240.47
95_L164_R0.5240.47
320_M422_F0.5240.47
355_F359_P0.5230.46
375_V384_P0.5230.46
246_L311_M0.5220.46
254_G359_P0.5210.46
404_A408_A0.5200.46
27_A157_M0.5200.46
311_M323_L0.5200.46
21_G26_Q0.5200.46
370_M375_V0.5200.46
8_L332_I0.5200.46
219_V225_T0.5190.46
237_S287_F0.5180.46
270_M351_L0.5180.46
385_W389_P0.5170.46
299_G304_T0.5170.46
28_L149_L0.5160.46
56_Y65_G0.5150.45
383_V395_L0.5150.45
230_L236_G0.5140.45
114_F162_I0.5140.45
253_H346_V0.5130.45
78_A112_A0.5120.45
153_M264_P0.5120.45
117_A204_R0.5110.45
110_S113_A0.5100.45
176_P347_M0.5100.45
158_V353_L0.5100.45
31_G92_A0.5090.45
190_L384_P0.5090.45
308_V314_R0.5080.45
381_I384_P0.5080.45
50_N418_Y0.5070.44
389_P404_A0.5060.44
370_M403_G0.5050.44
324_G423_R0.5050.44
207_V215_L0.5050.44
329_G352_L0.5050.44
256_N263_A0.5050.44
290_Q383_V0.5020.44
291_F370_M0.5020.44
84_G156_A0.5020.44
290_Q293_D0.5000.44
383_V387_M0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3qnqA 2 0.9602 100 0.304 Contact Map
2kluA 1 0.1305 13.9 0.977 Contact Map
4lz6A 1 0.3429 13.5 0.978 Contact Map
3mktA 1 0.3717 11.9 0.978 Contact Map
3ne5A 3 0.3473 10.8 0.978 Contact Map
3wo6A 1 0.1881 10.1 0.979 Contact Map
2rddB 1 0.0819 9.4 0.979 Contact Map
4ldsA 2 0.4204 8.6 0.979 Contact Map
2l16A 1 0.0796 8.2 0.98 Contact Map
3wy9C 1 0.0398 8.2 0.98 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0117 seconds.