GREMLIN Database
ARSR - Arsenical resistance operon repressor
UniProt: P45949 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 105 (88)
Sequences: 4772 (3201)
Seq/√Len: 341.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
36_K69_E4.0271.00
68_K75_S3.1641.00
67_T78_D2.9371.00
67_T80_N2.4481.00
70_T75_S2.3551.00
18_A63_A1.9721.00
61_L68_K1.8821.00
58_K62_D1.8421.00
10_R22_Q1.8371.00
36_K78_D1.7731.00
14_Q62_D1.7561.00
48_V53_L1.7211.00
48_V52_K1.7061.00
13_E22_Q1.6031.00
42_L53_L1.5851.00
28_M65_L1.5801.00
57_L66_I1.5741.00
30_E45_I1.5581.00
86_G90_E1.4451.00
31_L66_I1.4271.00
30_E37_T1.4211.00
27_I42_L1.3211.00
39_V57_L1.3201.00
18_A59_I1.3151.00
38_C74_W1.3011.00
37_T41_D1.2971.00
57_L61_L1.2941.00
43_T50_Q1.2941.00
52_K55_Y1.2941.00
21_D55_Y1.2801.00
89_S93_C1.2621.00
49_T52_K1.2611.00
16_F87_L1.2601.00
59_I63_A1.2021.00
28_M79_L1.1931.00
36_K76_Y1.1921.00
12_Y91_E1.1711.00
8_L96_F1.1661.00
23_K53_L1.1071.00
46_F53_L1.0941.00
38_C41_D1.0881.00
36_K71_K1.0741.00
40_C74_W1.0471.00
60_L66_I1.0171.00
23_K48_V1.0041.00
43_T53_L1.0021.00
15_K87_L0.9981.00
8_L11_K0.9931.00
61_L75_S0.9851.00
70_T73_T0.9811.00
55_Y73_T0.9781.00
83_E94_C0.9521.00
27_I31_L0.9511.00
9_L29_Y0.9481.00
32_C89_S0.9351.00
16_F19_L0.9281.00
82_E85_N0.9171.00
16_F20_A0.9111.00
85_N89_S0.9101.00
55_Y58_K0.9051.00
13_E25_L0.9011.00
52_K56_H0.8961.00
32_C85_N0.8921.00
64_N80_N0.8881.00
31_L37_T0.8871.00
37_T45_I0.8771.00
15_K65_L0.8751.00
90_E93_C0.8691.00
37_T42_L0.8581.00
67_T81_D0.8531.00
11_K64_N0.8511.00
39_V61_L0.8191.00
10_R14_Q0.8011.00
58_K61_L0.8011.00
12_Y92_L0.7811.00
83_E86_G0.7741.00
71_K74_W0.7631.00
41_D44_E0.7591.00
20_A56_H0.7471.00
49_T55_Y0.7340.99
59_I62_D0.7300.99
17_K20_A0.7180.99
18_A60_L0.7110.99
23_K26_E0.7080.99
86_G89_S0.7010.99
13_E20_A0.6920.99
28_M88_L0.6860.99
71_K76_Y0.6760.99
61_L66_I0.6640.99
16_F25_L0.6560.99
19_L22_Q0.6540.99
90_E94_C0.6520.99
80_N83_E0.6430.99
86_G93_C0.6390.99
26_E29_Y0.6250.98
21_D49_T0.6200.98
34_R37_T0.6020.98
84_V94_C0.6010.98
15_K83_E0.5990.98
22_Q26_E0.5970.98
81_D84_V0.5970.98
9_L12_Y0.5890.97
21_D52_K0.5860.97
29_Y32_C0.5850.97
83_E87_L0.5810.97
39_V52_K0.5790.97
19_L28_M0.5710.97
92_L95_I0.5640.97
30_E42_L0.5620.97
11_K86_G0.5610.97
30_E46_F0.5610.97
55_Y59_I0.5600.97
17_K52_K0.5540.96
11_K14_Q0.5510.96
52_K73_T0.5460.96
21_D73_T0.5460.96
46_F51_S0.5450.96
11_K22_Q0.5400.96
12_Y16_F0.5350.96
43_T49_T0.5340.96
39_V50_Q0.5330.95
40_C44_E0.5280.95
51_S55_Y0.5280.95
81_D94_C0.5280.95
49_T56_H0.5220.95
10_R89_S0.5150.95
35_G81_D0.5150.95
42_L45_I0.5120.94
93_C96_F0.5100.94
81_D85_N0.5040.94
23_K70_T0.5010.94
19_L87_L0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1r1tA 2 0.9238 99.7 0.486 Contact Map
1u2wA 2 0.9429 99.7 0.508 Contact Map
2kkoA 2 0.9905 99.7 0.515 Contact Map
1r1uA 2 0.9333 99.7 0.516 Contact Map
2jscA 2 0.8952 99.7 0.518 Contact Map
2zkzA 2 0.8476 99.6 0.53 Contact Map
3pqkA 2 0.9524 99.6 0.532 Contact Map
4k2eA 2 0.8952 99.6 0.545 Contact Map
3f6vA 2 0.8762 99.6 0.55 Contact Map
2vxzA 1 0.8476 99.6 0.551 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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