GREMLIN Database
ARSC - Protein ArsC
UniProt: P45947 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 139 (127)
Sequences: 7721 (5277)
Seq/√Len: 468.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
27_Y132_K3.3151.00
21_E25_K2.7471.00
5_I33_K2.7161.00
27_Y128_G2.1621.00
104_D126_E2.0831.00
128_G132_K2.0681.00
52_M59_I2.0541.00
54_E121_Q2.0031.00
55_V124_R1.9031.00
50_K117_W1.8851.00
26_Q30_D1.8671.00
11_T85_A1.8401.00
83_G102_G1.8161.00
55_V128_G1.8031.00
8_F24_A1.6741.00
51_A124_R1.6651.00
19_M48_A1.6651.00
25_K34_V1.6581.00
115_E119_F1.6561.00
19_M52_M1.6541.00
7_Y37_A1.5831.00
80_T89_C1.5821.00
67_I89_C1.5491.00
24_A34_V1.5441.00
122_R126_E1.5101.00
117_W121_Q1.5091.00
94_P101_W1.4971.00
51_A121_Q1.4901.00
88_K92_T1.4721.00
22_G57_I1.4591.00
6_I24_A1.4371.00
44_L49_V1.4011.00
35_Y65_D1.3841.00
98_R101_W1.3691.00
41_A66_I1.3641.00
55_V125_D1.3631.00
80_T86_A1.3381.00
11_T40_E1.3311.00
23_W55_V1.3171.00
28_L32_W1.3101.00
119_F122_R1.3041.00
51_A54_E1.2971.00
23_W124_R1.2911.00
44_L62_Q1.2851.00
116_K119_F1.2491.00
23_W127_I1.2321.00
35_Y75_A1.2241.00
22_G59_I1.2151.00
70_D74_N1.2151.00
23_W131_L1.2121.00
50_K54_E1.1611.00
47_N117_W1.1491.00
19_M124_R1.1441.00
12_G107_A1.1341.00
39_I88_K1.1251.00
54_E117_W1.1231.00
47_N50_K1.1191.00
5_I35_Y1.0951.00
7_Y75_A1.0941.00
95_H98_R1.0881.00
27_Y131_L1.0861.00
48_A120_F1.0861.00
86_A90_P1.0821.00
33_K74_N1.0671.00
47_N116_K1.0581.00
88_K93_P1.0581.00
4_K77_L1.0571.00
90_P93_P1.0511.00
24_A131_L1.0411.00
133_E136_E1.0281.00
8_F131_L1.0251.00
28_L34_V1.0161.00
49_V59_I1.0151.00
49_V53_K1.0061.00
65_D71_I1.0011.00
5_I75_A0.9991.00
94_P100_H0.9921.00
51_A117_W0.9691.00
121_Q125_D0.9481.00
57_I128_G0.9471.00
94_P97_K0.9461.00
5_I74_N0.9441.00
79_V134_F0.9421.00
45_N120_F0.9391.00
8_F20_A0.9371.00
88_K91_M0.9331.00
51_A55_V0.9241.00
23_W128_G0.9191.00
77_L134_F0.9171.00
23_W57_I0.9131.00
104_D122_R0.9101.00
22_G62_Q0.9071.00
94_P99_E0.9021.00
44_L59_I0.8971.00
28_L135_A0.8871.00
22_G25_K0.8761.00
57_I124_R0.8661.00
37_A67_I0.8611.00
87_D90_P0.8391.00
59_I62_Q0.8361.00
72_L78_V0.8321.00
37_A65_D0.8261.00
11_T84_D0.8151.00
27_Y135_A0.8141.00
43_G64_S0.8121.00
103_F123_V0.8111.00
24_A28_L0.8091.00
103_F126_E0.8081.00
101_W130_R0.8051.00
84_D88_K0.7971.00
18_Q44_L0.7901.00
52_M57_I0.7881.00
20_A127_I0.7831.00
24_A32_W0.7791.00
20_A81_L0.7791.00
46_P50_K0.7781.00
23_W52_M0.7761.00
48_A51_A0.7751.00
96_V99_E0.7521.00
22_G44_L0.7451.00
35_Y74_N0.7401.00
89_C93_P0.7331.00
97_K100_H0.7321.00
26_Q57_I0.7241.00
125_D129_N0.7211.00
72_L75_A0.7191.00
95_H101_W0.7171.00
103_F127_I0.7131.00
119_F123_V0.7121.00
69_S92_T0.7121.00
94_P98_R0.7091.00
68_D71_I0.7061.00
127_I131_L0.6971.00
123_V127_I0.6951.00
129_N133_E0.6951.00
8_F81_L0.6911.00
82_C85_A0.6891.00
11_T82_C0.6811.00
70_D73_N0.6791.00
124_R128_G0.6741.00
53_K59_I0.6711.00
25_K33_K0.6691.00
71_I75_A0.6611.00
40_E66_I0.6601.00
50_K53_K0.6521.00
81_L85_A0.6461.00
126_E130_R0.6431.00
118_A122_R0.6300.99
96_V101_W0.6270.99
58_D61_N0.6260.99
15_C120_F0.6220.99
23_W27_Y0.6180.99
7_Y78_V0.6140.99
55_V121_Q0.6010.99
132_K136_E0.5950.99
19_M123_V0.5920.99
95_H100_H0.5860.99
81_L103_F0.5850.99
6_I77_L0.5800.99
26_Q128_G0.5790.99
12_G40_E0.5740.99
96_V100_H0.5690.99
83_G87_D0.5610.99
67_I72_L0.5590.99
123_V126_E0.5580.99
39_I85_A0.5520.99
83_G86_A0.5500.99
20_A131_L0.5490.99
40_E88_K0.5490.99
97_K101_W0.5480.99
22_G60_S0.5460.99
11_T88_K0.5440.99
45_N48_A0.5420.98
12_G15_C0.5410.98
42_H64_S0.5400.98
104_D123_V0.5400.98
7_Y67_I0.5390.98
8_F134_F0.5360.98
108_R116_K0.5330.98
53_K58_D0.5320.98
8_F79_V0.5320.98
19_M51_A0.5260.98
68_D74_N0.5230.98
26_Q29_G0.5200.98
27_Y30_D0.5160.98
69_S73_N0.5090.98
72_L93_P0.5070.98
14_S120_F0.5040.98
13_N17_S0.5020.98
47_N108_R0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1jl3A 1 0.9856 100 0.116 Contact Map
1jf8A 1 0.9353 100 0.124 Contact Map
3rh0A 1 0.9209 100 0.136 Contact Map
3t38A 2 0.8993 100 0.152 Contact Map
1p8aA 1 0.9496 100 0.157 Contact Map
2l17A 1 0.9353 100 0.16 Contact Map
3jviA 1 0.9209 100 0.16 Contact Map
4picA 2 0.9353 100 0.161 Contact Map
4lrqA 2 0.9424 100 0.163 Contact Map
2cwdA 1 0.9496 100 0.169 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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