ARSB - BACSU - GREMLIN Contacts

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ARSB - Arsenite resistance protein ArsB

UniProt:	P45946	Sequences: MKRLSFLDRYLTIWIFLAMALGIGLGFIFPSFVGGLNKLQVGTTSIPLAIGLVLMMYPPLAKVRYEEIGRVFKDIKVLILSLVQNWIIGPTLMFILAIIFLPDKPEYMIGLIMIGLARCIAMVIVWNDLSKGDTEYAAGLVAFNSIFQMLFFSVYAYIFVTVIPQWLGMEGAVVNITMAEVAKSVFIYLGVPFIAGMVTRYIFVKVKGKEWYEKVFIPKISPITLIALLFTIIVMFSLKGDVIVSLPLDVVRVAIPLLIYFVLMFFVSFFLGKKIGANYAVTTTLAFTAGSNNFELAIAVAVGVFGIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	346 (301)
Sequences:	5907 (3387)
Seq/√Len:	195.2

ECOLI - YFEH
BACSU - ARSB YOCS YBAS

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
133_D	281_V	7.770	1.00
57_Y	199_T	7.228	1.00
270_F	274_K	3.751	1.00
279_Y	283_T	3.344	1.00
69_G	73_K	3.280	1.00
177_T	180_E	3.262	1.00
57_Y	195_A	3.050	1.00
127_N	132_G	3.044	1.00
278_N	281_V	3.011	1.00
273_K	282_T	2.838	1.00
111_L	256_P	2.804	1.00
85_N	119_C	2.738	1.00
297_A	315_A	2.624	1.00
272_G	282_T	2.591	1.00
272_G	285_L	2.521	1.00
92_L	263_L	2.449	1.00
261_F	325_V	2.385	1.00
113_M	301_A	2.376	1.00
83_V	87_I	2.252	1.00
116_L	155_Y	2.234	1.00
67_E	70_R	2.227	1.00
66_E	69_G	2.203	1.00
321_V	325_V	2.144	1.00
86_W	151_F	2.127	1.00
89_G	264_M	2.091	1.00
194_I	198_V	2.071	1.00
277_A	285_L	2.046	1.00
269_F	282_T	2.043	1.00
126_W	287_F	2.040	1.00
79_I	83_V	2.030	1.00
147_F	151_F	2.026	1.00
82_L	147_F	1.978	1.00
17_L	21_L	1.967	1.00
20_A	24_G	1.952	1.00
251_V	255_I	1.947	1.00
137_A	284_T	1.939	1.00
93_M	115_G	1.935	1.00
266_F	270_F	1.929	1.00
94_F	98_I	1.914	1.00
96_L	256_P	1.880	1.00
329_L	333_A	1.877	1.00
70_R	73_K	1.831	1.00
106_E	310_G	1.826	1.00
18_A	22_G	1.815	1.00
46_I	50_I	1.791	1.00
97_A	108_M	1.788	1.00
127_N	284_T	1.738	1.00
84_Q	268_S	1.720	1.00
92_L	264_M	1.707	1.00
91_T	95_I	1.699	1.00
95_I	99_I	1.695	1.00
179_A	183_K	1.663	1.00
127_N	137_A	1.658	1.00
263_L	267_V	1.608	1.00
64_R	200_R	1.604	1.00
198_V	202_I	1.584	1.00
228_L	232_I	1.547	1.00
318_G	322_E	1.540	1.00
133_D	280_A	1.531	1.00
80_L	275_I	1.530	1.00
80_L	285_L	1.497	1.00
119_C	141_V	1.487	1.00
34_G	37_N	1.450	1.00
24_G	27_F	1.445	1.00
186_F	191_V	1.441	1.00
114_I	318_G	1.436	1.00
282_T	286_A	1.425	1.00
277_A	281_V	1.404	1.00
117_A	297_A	1.387	1.00
322_E	326_M	1.386	1.00
35_G	39_L	1.377	1.00
326_M	330_V	1.368	1.00
21_L	25_L	1.365	1.00
197_M	201_Y	1.363	1.00
334_L	337_Q	1.358	1.00
29_F	32_F	1.339	1.00
242_V	245_S	1.336	1.00
50_I	53_V	1.334	1.00
283_T	333_A	1.331	1.00
306_G	309_S	1.326	1.00
75_I	79_I	1.321	1.00
328_A	332_V	1.321	1.00
272_G	277_A	1.319	1.00
26_G	33_V	1.314	1.00
278_N	282_T	1.312	1.00
77_V	277_A	1.304	1.00
86_W	144_N	1.292	1.00
84_Q	289_A	1.292	1.00
151_F	154_V	1.268	1.00
30_P	33_V	1.244	1.00
18_A	229_L	1.240	1.00
22_G	229_L	1.239	1.00
269_F	279_Y	1.238	1.00
64_R	67_E	1.237	1.00
35_G	38_K	1.228	1.00
203_F	206_V	1.226	1.00
199_T	203_F	1.219	1.00
123_V	292_N	1.215	1.00
14_W	18_A	1.212	1.00
74_D	133_D	1.211	1.00
109_I	160_V	1.210	1.00
101_L	256_P	1.203	1.00
155_Y	159_F	1.192	1.00
116_L	156_A	1.189	1.00
85_N	141_V	1.187	1.00
282_T	336_F	1.185	1.00
85_N	292_N	1.184	1.00
32_F	35_G	1.171	1.00
31_S	34_G	1.168	1.00
139_G	142_A	1.162	1.00
223_I	227_A	1.153	1.00
220_I	223_I	1.151	1.00
262_V	266_F	1.145	1.00
215_V	219_K	1.141	1.00
60_L	196_G	1.133	1.00
24_G	28_I	1.127	1.00
84_Q	88_I	1.127	1.00
95_I	98_I	1.125	1.00
81_S	140_L	1.123	1.00
70_R	139_G	1.118	1.00
187_I	191_V	1.104	1.00
77_V	136_Y	1.104	1.00
104_K	108_M	1.093	1.00
151_F	155_Y	1.092	1.00
84_Q	271_L	1.092	1.00
120_I	123_V	1.087	1.00
148_Q	152_F	1.087	1.00
56_M	60_L	1.083	1.00
82_L	143_F	1.083	1.00
92_L	95_I	1.078	1.00
31_S	35_G	1.074	1.00
269_F	286_A	1.072	1.00
76_K	277_A	1.067	1.00
332_V	336_F	1.067	1.00
107_Y	253_V	1.057	1.00
228_L	231_T	1.053	1.00
294_F	319_P	1.050	1.00
176_I	181_V	1.049	1.00
122_M	265_F	1.046	1.00
271_L	275_I	1.042	1.00
262_V	328_A	1.031	1.00
124_I	288_T	1.024	1.00
78_L	143_F	1.023	1.00
23_I	26_G	1.006	1.00
280_A	284_T	0.998	1.00
269_F	336_F	0.997	1.00
119_C	140_L	0.996	1.00
258_L	325_V	0.993	1.00
322_E	325_V	0.989	1.00
27_F	244_V	0.988	1.00
66_E	70_R	0.987	1.00
102_P	108_M	0.985	0.99
221_S	224_T	0.985	0.99
279_Y	282_T	0.974	0.99
214_K	217_I	0.967	0.99
229_L	232_I	0.963	0.99
178_M	182_A	0.960	0.99
112_I	116_L	0.953	0.99
319_P	323_V	0.952	0.99
91_T	159_F	0.950	0.99
200_R	204_V	0.943	0.99
240_G	244_V	0.935	0.99
318_G	323_V	0.935	0.99
240_G	245_S	0.934	0.99
331_K	335_W	0.931	0.99
130_S	330_V	0.929	0.99
16_F	327_I	0.923	0.99
34_G	38_K	0.922	0.99
74_D	281_V	0.914	0.99
85_N	137_A	0.913	0.99
135_E	138_A	0.913	0.99
53_V	195_A	0.907	0.99
183_K	187_I	0.906	0.99
77_V	281_V	0.902	0.99
265_F	329_L	0.895	0.99
145_S	293_N	0.887	0.99
226_I	230_F	0.883	0.99
131_K	337_Q	0.881	0.99
112_I	159_F	0.879	0.99
81_S	285_L	0.876	0.99
80_L	277_A	0.876	0.99
145_S	296_L	0.869	0.99
104_K	252_R	0.867	0.99
287_F	291_S	0.867	0.99
97_A	112_I	0.864	0.99
253_V	257_L	0.862	0.99
315_A	318_G	0.861	0.99
233_I	236_F	0.857	0.99
11_L	14_W	0.854	0.99
180_E	183_K	0.853	0.99
96_L	263_L	0.853	0.99
318_G	326_M	0.850	0.99
36_L	39_L	0.845	0.98
258_L	324_P	0.845	0.98
241_D	245_S	0.839	0.98
144_N	292_N	0.838	0.98
96_L	259_I	0.837	0.98
286_A	333_A	0.831	0.98
204_V	207_K	0.831	0.98
89_G	115_G	0.823	0.98
224_T	231_T	0.820	0.98
233_I	237_S	0.810	0.98
104_K	107_Y	0.809	0.98
182_A	186_F	0.808	0.98
185_V	190_G	0.807	0.98
259_I	263_L	0.807	0.98
46_I	49_A	0.806	0.98
52_L	56_M	0.806	0.98
12_T	16_F	0.803	0.98
288_T	292_N	0.802	0.98
243_I	246_L	0.802	0.98
202_I	205_K	0.800	0.98
198_V	201_Y	0.798	0.98
65_Y	201_Y	0.797	0.98
17_L	24_G	0.796	0.98
119_C	137_A	0.793	0.98
270_F	273_K	0.787	0.98
258_L	321_V	0.783	0.97
85_N	288_T	0.782	0.97
120_I	288_T	0.781	0.97
137_A	288_T	0.781	0.97
225_L	230_F	0.776	0.97
321_V	324_P	0.776	0.97
204_V	214_K	0.774	0.97
124_I	141_V	0.773	0.97
68_I	71_V	0.771	0.97
318_G	324_P	0.767	0.97
13_I	22_G	0.763	0.97
83_V	271_L	0.759	0.97
126_W	235_M	0.758	0.97
61_A	189_L	0.758	0.97
273_K	279_Y	0.754	0.97
247_P	251_V	0.751	0.97
111_L	257_L	0.750	0.97
286_A	336_F	0.747	0.97
37_N	238_L	0.745	0.97
97_A	101_L	0.743	0.97
141_V	288_T	0.742	0.96
242_V	246_L	0.741	0.96
216_F	219_K	0.741	0.96
140_L	285_L	0.740	0.96
319_P	322_E	0.737	0.96
109_I	156_A	0.736	0.96
33_V	37_N	0.734	0.96
15_I	19_M	0.733	0.96
21_L	24_G	0.732	0.96
25_L	29_F	0.732	0.96
85_N	140_L	0.731	0.96
218_P	222_P	0.731	0.96
88_I	267_V	0.730	0.96
119_C	287_F	0.730	0.96
154_V	158_I	0.728	0.96
139_G	143_F	0.728	0.96
81_S	288_T	0.727	0.96
299_A	303_G	0.716	0.96
119_C	145_S	0.712	0.96
205_K	214_K	0.709	0.95
228_L	239_K	0.706	0.95
11_L	15_I	0.704	0.95
200_R	214_K	0.704	0.95
117_A	152_F	0.704	0.95
48_L	290_G	0.697	0.95
22_G	25_L	0.696	0.95
205_K	215_V	0.695	0.95
85_N	144_N	0.693	0.95
51_G	227_A	0.691	0.95
80_L	271_L	0.688	0.95
176_I	180_E	0.688	0.95
121_A	126_W	0.688	0.95
272_G	276_G	0.687	0.95
216_F	220_I	0.685	0.95
67_E	135_E	0.685	0.95
50_I	54_L	0.684	0.94
123_V	137_A	0.682	0.94
273_K	276_G	0.681	0.94
119_C	122_M	0.680	0.94
333_A	336_F	0.680	0.94
80_L	272_G	0.679	0.94
103_D	252_R	0.678	0.94
150_L	154_V	0.671	0.94
47_P	50_I	0.668	0.94
179_A	182_A	0.666	0.94
32_F	39_L	0.666	0.94
32_F	36_L	0.666	0.94
19_M	232_I	0.665	0.94
128_D	131_K	0.665	0.94
126_W	322_E	0.663	0.94
248_L	251_V	0.662	0.93
131_K	334_L	0.662	0.93
72_F	139_G	0.661	0.93
316_V	320_L	0.660	0.93
96_L	101_L	0.657	0.93
255_I	258_L	0.656	0.93
62_K	217_I	0.656	0.93
108_M	111_L	0.655	0.93
51_G	231_T	0.653	0.93
102_P	105_P	0.652	0.93
202_I	206_V	0.652	0.93
126_W	291_S	0.650	0.93
265_F	286_A	0.648	0.93
123_V	288_T	0.646	0.93
317_I	322_E	0.645	0.93
103_D	107_Y	0.644	0.93
128_D	134_T	0.643	0.92
265_F	268_S	0.643	0.92
15_I	18_A	0.643	0.92
136_Y	281_V	0.641	0.92
331_K	334_L	0.640	0.92
183_K	186_F	0.639	0.92
178_M	181_V	0.638	0.92
132_G	283_T	0.637	0.92
15_I	22_G	0.637	0.92
232_I	236_F	0.636	0.92
113_M	152_F	0.636	0.92
239_K	242_V	0.633	0.92
82_L	139_G	0.633	0.92
48_L	298_I	0.632	0.92
110_G	314_A	0.631	0.92
193_F	323_V	0.631	0.92
17_L	20_A	0.631	0.92
120_I	293_N	0.630	0.92
93_M	111_L	0.629	0.92
133_D	278_N	0.628	0.92
119_C	126_W	0.627	0.92
237_S	240_G	0.626	0.91
54_L	223_I	0.624	0.91
108_M	112_I	0.623	0.91
298_I	315_A	0.621	0.91
319_P	326_M	0.620	0.91
55_M	122_M	0.618	0.91
34_G	275_I	0.618	0.91
13_I	17_L	0.616	0.91
244_V	247_P	0.615	0.91
122_M	144_N	0.611	0.90
22_G	26_G	0.611	0.90
240_G	243_I	0.610	0.90
70_R	74_D	0.609	0.90
138_A	193_F	0.606	0.90
318_G	321_V	0.605	0.90
98_I	108_M	0.605	0.90
11_L	22_G	0.603	0.90
122_M	228_L	0.601	0.90
48_L	295_E	0.601	0.90
96_L	111_L	0.597	0.89
130_S	326_M	0.594	0.89
286_A	290_G	0.594	0.89
289_A	292_N	0.593	0.89
294_F	322_E	0.593	0.89
18_A	21_L	0.593	0.89
230_F	233_I	0.592	0.89
126_W	231_T	0.592	0.89
115_G	264_M	0.591	0.89
121_A	294_F	0.591	0.89
49_A	53_V	0.591	0.89
117_A	148_Q	0.590	0.89
298_I	302_V	0.590	0.89
214_K	218_P	0.589	0.89
87_I	91_T	0.588	0.89
317_I	325_V	0.587	0.89
27_F	242_V	0.586	0.89
124_I	138_A	0.585	0.88
92_L	96_L	0.583	0.88
55_M	60_L	0.583	0.88
267_V	271_L	0.581	0.88
311_A	318_G	0.579	0.88
269_F	273_K	0.576	0.88
231_T	238_L	0.576	0.88
125_V	228_L	0.574	0.88
205_K	335_W	0.573	0.87
82_L	140_L	0.573	0.87
113_M	156_A	0.573	0.87
114_I	319_P	0.572	0.87
217_I	232_I	0.571	0.87
228_L	295_E	0.570	0.87
14_W	17_L	0.569	0.87
225_L	232_I	0.569	0.87
273_K	278_N	0.569	0.87
120_I	145_S	0.568	0.87
120_I	291_S	0.568	0.87
97_A	111_L	0.568	0.87
73_K	79_I	0.567	0.87
119_C	288_T	0.566	0.87
58_P	220_I	0.566	0.87
295_E	322_E	0.565	0.87
116_L	152_F	0.564	0.87
124_I	137_A	0.563	0.87
24_G	38_K	0.563	0.87
38_K	47_P	0.563	0.87
96_L	260_Y	0.562	0.86
154_V	157_Y	0.561	0.86
274_K	335_W	0.560	0.86
314_A	318_G	0.559	0.86
24_G	35_G	0.559	0.86
295_E	299_A	0.556	0.86
198_V	254_A	0.555	0.86
214_K	274_K	0.555	0.86
227_A	231_T	0.554	0.86
24_G	251_V	0.552	0.85
85_N	124_I	0.551	0.85
39_L	50_I	0.550	0.85
14_W	229_L	0.550	0.85
25_L	28_I	0.549	0.85
294_F	325_V	0.548	0.85
137_A	141_V	0.545	0.85
14_W	22_G	0.545	0.85
24_G	36_L	0.543	0.85
72_F	75_I	0.543	0.85
225_L	236_F	0.542	0.84
264_M	290_G	0.542	0.84
78_L	139_G	0.540	0.84
19_M	23_I	0.539	0.84
144_N	151_F	0.539	0.84
146_I	150_L	0.539	0.84
291_S	323_V	0.536	0.84
28_I	32_F	0.536	0.84
127_N	298_I	0.535	0.84
114_I	322_E	0.535	0.84
18_A	36_L	0.533	0.83
318_G	325_V	0.531	0.83
214_K	245_S	0.529	0.83
77_V	285_L	0.529	0.83
260_Y	295_E	0.527	0.83
138_A	141_V	0.526	0.83
219_K	223_I	0.526	0.83
12_T	18_A	0.525	0.83
74_D	77_V	0.525	0.83
214_K	233_I	0.524	0.82
315_A	322_E	0.524	0.82
29_F	33_V	0.523	0.82
195_A	199_T	0.523	0.82
123_V	284_T	0.520	0.82
217_I	221_S	0.517	0.82
33_V	36_L	0.516	0.81
215_V	218_P	0.515	0.81
222_P	226_I	0.514	0.81
148_Q	155_Y	0.514	0.81
232_I	235_M	0.514	0.81
103_D	108_M	0.514	0.81
77_V	140_L	0.512	0.81
54_L	58_P	0.512	0.81
311_A	322_E	0.511	0.81
52_L	294_F	0.510	0.81
61_A	199_T	0.510	0.81
101_L	252_R	0.508	0.80
293_N	296_L	0.507	0.80
312_A	323_V	0.507	0.80
140_L	144_N	0.503	0.80
217_I	233_I	0.502	0.80
261_F	264_M	0.500	0.79
142_A	185_V	0.500	0.79
84_Q	87_I	0.500	0.79
261_F	329_L	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zuxA	1	0.8902	100	0.286	Contact Map
4n7wA	2	0.8873	100	0.306	Contact Map
4bwzA	2	0.9162	96.8	0.894	Contact Map
4czbA	2	0.9075	95.6	0.904	Contact Map
4cz8A	2	0.9277	95.4	0.906	Contact Map
1zcdA	1	0.896	56.3	0.943	Contact Map
3w4tA	1	0.9422	40.7	0.948	Contact Map
4lz6A	1	0.9566	33.9	0.95	Contact Map
4humA	1	0.9595	20.9	0.955	Contact Map
2nwlA	3	0.8324	12.4	0.959	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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