GREMLIN Database
ARSB - Arsenite resistance protein ArsB
UniProt: P45946 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 346 (301)
Sequences: 5907 (3387)
Seq/√Len: 195.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
133_D281_V7.7701.00
57_Y199_T7.2281.00
270_F274_K3.7511.00
279_Y283_T3.3441.00
69_G73_K3.2801.00
177_T180_E3.2621.00
57_Y195_A3.0501.00
127_N132_G3.0441.00
278_N281_V3.0111.00
273_K282_T2.8381.00
111_L256_P2.8041.00
85_N119_C2.7381.00
297_A315_A2.6241.00
272_G282_T2.5911.00
272_G285_L2.5211.00
92_L263_L2.4491.00
261_F325_V2.3851.00
113_M301_A2.3761.00
83_V87_I2.2521.00
116_L155_Y2.2341.00
67_E70_R2.2271.00
66_E69_G2.2031.00
321_V325_V2.1441.00
86_W151_F2.1271.00
89_G264_M2.0911.00
194_I198_V2.0711.00
277_A285_L2.0461.00
269_F282_T2.0431.00
126_W287_F2.0401.00
79_I83_V2.0301.00
147_F151_F2.0261.00
82_L147_F1.9781.00
17_L21_L1.9671.00
20_A24_G1.9521.00
251_V255_I1.9471.00
137_A284_T1.9391.00
93_M115_G1.9351.00
266_F270_F1.9291.00
94_F98_I1.9141.00
96_L256_P1.8801.00
329_L333_A1.8771.00
70_R73_K1.8311.00
106_E310_G1.8261.00
18_A22_G1.8151.00
46_I50_I1.7911.00
97_A108_M1.7881.00
127_N284_T1.7381.00
84_Q268_S1.7201.00
92_L264_M1.7071.00
91_T95_I1.6991.00
95_I99_I1.6951.00
179_A183_K1.6631.00
127_N137_A1.6581.00
263_L267_V1.6081.00
64_R200_R1.6041.00
198_V202_I1.5841.00
228_L232_I1.5471.00
318_G322_E1.5401.00
133_D280_A1.5311.00
80_L275_I1.5301.00
80_L285_L1.4971.00
119_C141_V1.4871.00
34_G37_N1.4501.00
24_G27_F1.4451.00
186_F191_V1.4411.00
114_I318_G1.4361.00
282_T286_A1.4251.00
277_A281_V1.4041.00
117_A297_A1.3871.00
322_E326_M1.3861.00
35_G39_L1.3771.00
326_M330_V1.3681.00
21_L25_L1.3651.00
197_M201_Y1.3631.00
334_L337_Q1.3581.00
29_F32_F1.3391.00
242_V245_S1.3361.00
50_I53_V1.3341.00
283_T333_A1.3311.00
306_G309_S1.3261.00
75_I79_I1.3211.00
328_A332_V1.3211.00
272_G277_A1.3191.00
26_G33_V1.3141.00
278_N282_T1.3121.00
77_V277_A1.3041.00
86_W144_N1.2921.00
84_Q289_A1.2921.00
151_F154_V1.2681.00
30_P33_V1.2441.00
18_A229_L1.2401.00
22_G229_L1.2391.00
269_F279_Y1.2381.00
64_R67_E1.2371.00
35_G38_K1.2281.00
203_F206_V1.2261.00
199_T203_F1.2191.00
123_V292_N1.2151.00
14_W18_A1.2121.00
74_D133_D1.2111.00
109_I160_V1.2101.00
101_L256_P1.2031.00
155_Y159_F1.1921.00
116_L156_A1.1891.00
85_N141_V1.1871.00
282_T336_F1.1851.00
85_N292_N1.1841.00
32_F35_G1.1711.00
31_S34_G1.1681.00
139_G142_A1.1621.00
223_I227_A1.1531.00
220_I223_I1.1511.00
262_V266_F1.1451.00
215_V219_K1.1411.00
60_L196_G1.1331.00
24_G28_I1.1271.00
84_Q88_I1.1271.00
95_I98_I1.1251.00
81_S140_L1.1231.00
70_R139_G1.1181.00
187_I191_V1.1041.00
77_V136_Y1.1041.00
104_K108_M1.0931.00
151_F155_Y1.0921.00
84_Q271_L1.0921.00
120_I123_V1.0871.00
148_Q152_F1.0871.00
56_M60_L1.0831.00
82_L143_F1.0831.00
92_L95_I1.0781.00
31_S35_G1.0741.00
269_F286_A1.0721.00
76_K277_A1.0671.00
332_V336_F1.0671.00
107_Y253_V1.0571.00
228_L231_T1.0531.00
294_F319_P1.0501.00
176_I181_V1.0491.00
122_M265_F1.0461.00
271_L275_I1.0421.00
262_V328_A1.0311.00
124_I288_T1.0241.00
78_L143_F1.0231.00
23_I26_G1.0061.00
280_A284_T0.9981.00
269_F336_F0.9971.00
119_C140_L0.9961.00
258_L325_V0.9931.00
322_E325_V0.9891.00
27_F244_V0.9881.00
66_E70_R0.9871.00
102_P108_M0.9850.99
221_S224_T0.9850.99
279_Y282_T0.9740.99
214_K217_I0.9670.99
229_L232_I0.9630.99
178_M182_A0.9600.99
112_I116_L0.9530.99
319_P323_V0.9520.99
91_T159_F0.9500.99
200_R204_V0.9430.99
240_G244_V0.9350.99
318_G323_V0.9350.99
240_G245_S0.9340.99
331_K335_W0.9310.99
130_S330_V0.9290.99
16_F327_I0.9230.99
34_G38_K0.9220.99
74_D281_V0.9140.99
85_N137_A0.9130.99
135_E138_A0.9130.99
53_V195_A0.9070.99
183_K187_I0.9060.99
77_V281_V0.9020.99
265_F329_L0.8950.99
145_S293_N0.8870.99
226_I230_F0.8830.99
131_K337_Q0.8810.99
112_I159_F0.8790.99
81_S285_L0.8760.99
80_L277_A0.8760.99
145_S296_L0.8690.99
104_K252_R0.8670.99
287_F291_S0.8670.99
97_A112_I0.8640.99
253_V257_L0.8620.99
315_A318_G0.8610.99
233_I236_F0.8570.99
11_L14_W0.8540.99
180_E183_K0.8530.99
96_L263_L0.8530.99
318_G326_M0.8500.99
36_L39_L0.8450.98
258_L324_P0.8450.98
241_D245_S0.8390.98
144_N292_N0.8380.98
96_L259_I0.8370.98
286_A333_A0.8310.98
204_V207_K0.8310.98
89_G115_G0.8230.98
224_T231_T0.8200.98
233_I237_S0.8100.98
104_K107_Y0.8090.98
182_A186_F0.8080.98
185_V190_G0.8070.98
259_I263_L0.8070.98
46_I49_A0.8060.98
52_L56_M0.8060.98
12_T16_F0.8030.98
288_T292_N0.8020.98
243_I246_L0.8020.98
202_I205_K0.8000.98
198_V201_Y0.7980.98
65_Y201_Y0.7970.98
17_L24_G0.7960.98
119_C137_A0.7930.98
270_F273_K0.7870.98
258_L321_V0.7830.97
85_N288_T0.7820.97
120_I288_T0.7810.97
137_A288_T0.7810.97
225_L230_F0.7760.97
321_V324_P0.7760.97
204_V214_K0.7740.97
124_I141_V0.7730.97
68_I71_V0.7710.97
318_G324_P0.7670.97
13_I22_G0.7630.97
83_V271_L0.7590.97
126_W235_M0.7580.97
61_A189_L0.7580.97
273_K279_Y0.7540.97
247_P251_V0.7510.97
111_L257_L0.7500.97
286_A336_F0.7470.97
37_N238_L0.7450.97
97_A101_L0.7430.97
141_V288_T0.7420.96
242_V246_L0.7410.96
216_F219_K0.7410.96
140_L285_L0.7400.96
319_P322_E0.7370.96
109_I156_A0.7360.96
33_V37_N0.7340.96
15_I19_M0.7330.96
21_L24_G0.7320.96
25_L29_F0.7320.96
85_N140_L0.7310.96
218_P222_P0.7310.96
88_I267_V0.7300.96
119_C287_F0.7300.96
154_V158_I0.7280.96
139_G143_F0.7280.96
81_S288_T0.7270.96
299_A303_G0.7160.96
119_C145_S0.7120.96
205_K214_K0.7090.95
228_L239_K0.7060.95
11_L15_I0.7040.95
200_R214_K0.7040.95
117_A152_F0.7040.95
48_L290_G0.6970.95
22_G25_L0.6960.95
205_K215_V0.6950.95
85_N144_N0.6930.95
51_G227_A0.6910.95
80_L271_L0.6880.95
176_I180_E0.6880.95
121_A126_W0.6880.95
272_G276_G0.6870.95
216_F220_I0.6850.95
67_E135_E0.6850.95
50_I54_L0.6840.94
123_V137_A0.6820.94
273_K276_G0.6810.94
119_C122_M0.6800.94
333_A336_F0.6800.94
80_L272_G0.6790.94
103_D252_R0.6780.94
150_L154_V0.6710.94
47_P50_I0.6680.94
179_A182_A0.6660.94
32_F39_L0.6660.94
32_F36_L0.6660.94
19_M232_I0.6650.94
128_D131_K0.6650.94
126_W322_E0.6630.94
248_L251_V0.6620.93
131_K334_L0.6620.93
72_F139_G0.6610.93
316_V320_L0.6600.93
96_L101_L0.6570.93
255_I258_L0.6560.93
62_K217_I0.6560.93
108_M111_L0.6550.93
51_G231_T0.6530.93
102_P105_P0.6520.93
202_I206_V0.6520.93
126_W291_S0.6500.93
265_F286_A0.6480.93
123_V288_T0.6460.93
317_I322_E0.6450.93
103_D107_Y0.6440.93
128_D134_T0.6430.92
265_F268_S0.6430.92
15_I18_A0.6430.92
136_Y281_V0.6410.92
331_K334_L0.6400.92
183_K186_F0.6390.92
178_M181_V0.6380.92
132_G283_T0.6370.92
15_I22_G0.6370.92
232_I236_F0.6360.92
113_M152_F0.6360.92
239_K242_V0.6330.92
82_L139_G0.6330.92
48_L298_I0.6320.92
110_G314_A0.6310.92
193_F323_V0.6310.92
17_L20_A0.6310.92
120_I293_N0.6300.92
93_M111_L0.6290.92
133_D278_N0.6280.92
119_C126_W0.6270.92
237_S240_G0.6260.91
54_L223_I0.6240.91
108_M112_I0.6230.91
298_I315_A0.6210.91
319_P326_M0.6200.91
55_M122_M0.6180.91
34_G275_I0.6180.91
13_I17_L0.6160.91
244_V247_P0.6150.91
122_M144_N0.6110.90
22_G26_G0.6110.90
240_G243_I0.6100.90
70_R74_D0.6090.90
138_A193_F0.6060.90
318_G321_V0.6050.90
98_I108_M0.6050.90
11_L22_G0.6030.90
122_M228_L0.6010.90
48_L295_E0.6010.90
96_L111_L0.5970.89
130_S326_M0.5940.89
286_A290_G0.5940.89
289_A292_N0.5930.89
294_F322_E0.5930.89
18_A21_L0.5930.89
230_F233_I0.5920.89
126_W231_T0.5920.89
115_G264_M0.5910.89
121_A294_F0.5910.89
49_A53_V0.5910.89
117_A148_Q0.5900.89
298_I302_V0.5900.89
214_K218_P0.5890.89
87_I91_T0.5880.89
317_I325_V0.5870.89
27_F242_V0.5860.89
124_I138_A0.5850.88
92_L96_L0.5830.88
55_M60_L0.5830.88
267_V271_L0.5810.88
311_A318_G0.5790.88
269_F273_K0.5760.88
231_T238_L0.5760.88
125_V228_L0.5740.88
205_K335_W0.5730.87
82_L140_L0.5730.87
113_M156_A0.5730.87
114_I319_P0.5720.87
217_I232_I0.5710.87
228_L295_E0.5700.87
14_W17_L0.5690.87
225_L232_I0.5690.87
273_K278_N0.5690.87
120_I145_S0.5680.87
120_I291_S0.5680.87
97_A111_L0.5680.87
73_K79_I0.5670.87
119_C288_T0.5660.87
58_P220_I0.5660.87
295_E322_E0.5650.87
116_L152_F0.5640.87
124_I137_A0.5630.87
24_G38_K0.5630.87
38_K47_P0.5630.87
96_L260_Y0.5620.86
154_V157_Y0.5610.86
274_K335_W0.5600.86
314_A318_G0.5590.86
24_G35_G0.5590.86
295_E299_A0.5560.86
198_V254_A0.5550.86
214_K274_K0.5550.86
227_A231_T0.5540.86
24_G251_V0.5520.85
85_N124_I0.5510.85
39_L50_I0.5500.85
14_W229_L0.5500.85
25_L28_I0.5490.85
294_F325_V0.5480.85
137_A141_V0.5450.85
14_W22_G0.5450.85
24_G36_L0.5430.85
72_F75_I0.5430.85
225_L236_F0.5420.84
264_M290_G0.5420.84
78_L139_G0.5400.84
19_M23_I0.5390.84
144_N151_F0.5390.84
146_I150_L0.5390.84
291_S323_V0.5360.84
28_I32_F0.5360.84
127_N298_I0.5350.84
114_I322_E0.5350.84
18_A36_L0.5330.83
318_G325_V0.5310.83
214_K245_S0.5290.83
77_V285_L0.5290.83
260_Y295_E0.5270.83
138_A141_V0.5260.83
219_K223_I0.5260.83
12_T18_A0.5250.83
74_D77_V0.5250.83
214_K233_I0.5240.82
315_A322_E0.5240.82
29_F33_V0.5230.82
195_A199_T0.5230.82
123_V284_T0.5200.82
217_I221_S0.5170.82
33_V36_L0.5160.81
215_V218_P0.5150.81
222_P226_I0.5140.81
148_Q155_Y0.5140.81
232_I235_M0.5140.81
103_D108_M0.5140.81
77_V140_L0.5120.81
54_L58_P0.5120.81
311_A322_E0.5110.81
52_L294_F0.5100.81
61_A199_T0.5100.81
101_L252_R0.5080.80
293_N296_L0.5070.80
312_A323_V0.5070.80
140_L144_N0.5030.80
217_I233_I0.5020.80
261_F264_M0.5000.79
142_A185_V0.5000.79
84_Q87_I0.5000.79
261_F329_L0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.8902 100 0.286 Contact Map
4n7wA 2 0.8873 100 0.306 Contact Map
4bwzA 2 0.9162 96.8 0.894 Contact Map
4czbA 2 0.9075 95.6 0.904 Contact Map
4cz8A 2 0.9277 95.4 0.906 Contact Map
1zcdA 1 0.896 56.3 0.943 Contact Map
3w4tA 1 0.9422 40.7 0.948 Contact Map
4lz6A 1 0.9566 33.9 0.95 Contact Map
4humA 1 0.9595 20.9 0.955 Contact Map
2nwlA 3 0.8324 12.4 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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