GREMLIN Database
YQCK - Uncharacterized protein YqcK
UniProt: P45945 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (134)
Sequences: 505 (254)
Seq/√Len: 21.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
12_S15_K4.5141.00
13_L17_I3.9801.00
17_I31_V3.9181.00
23_V80_L3.5441.00
92_D119_K2.8460.99
91_M101_D2.7990.99
9_N61_N2.3590.97
37_K66_Q2.1060.94
130_S133_C2.0510.94
30_K121_N1.7700.87
37_K46_N1.7650.87
119_K123_E1.7280.86
5_H46_N1.6640.84
4_V45_L1.6290.82
37_K116_F1.6230.82
75_K79_R1.6030.81
38_F49_L1.5840.80
112_E123_E1.5810.80
132_C135_T1.5750.80
68_D72_E1.5650.80
6_V36_A1.5540.79
57_G110_G1.5450.79
77_K106_T1.5350.78
38_F100_Q1.5120.77
5_H37_K1.5040.77
11_V31_V1.5000.77
7_G50_N1.4920.76
107_D110_G1.4770.76
79_R93_T1.4460.74
21_E25_G1.4210.73
107_D111_N1.4090.72
116_F125_Q1.3470.68
11_V33_T1.3370.68
40_L43_P1.3080.66
34_D48_T1.2950.65
77_K89_E1.2720.64
21_E27_K1.2680.64
92_D101_D1.2510.63
27_K78_K1.2410.62
47_F65_F1.2340.61
60_V123_E1.2300.61
73_V100_Q1.2070.60
49_L100_Q1.2040.59
130_S135_T1.2030.59
37_K48_T1.1840.58
33_T51_V1.1830.58
46_N116_F1.1790.58
129_S132_C1.1760.58
131_S135_T1.1640.57
122_S125_Q1.1240.54
46_N66_Q1.1210.54
50_N73_V1.1180.54
14_E71_E1.1110.53
76_H112_E1.0860.52
7_G73_V1.0780.51
2_K72_E1.0680.50
126_K129_S1.0660.50
78_K81_E1.0560.50
88_R93_T1.0540.49
19_F105_I1.0510.49
67_V93_T1.0450.49
14_E31_V1.0380.48
90_E134_V1.0380.48
88_R91_M1.0380.48
74_L82_K1.0360.48
4_V65_F1.0310.48
7_G49_L1.0280.48
23_V87_A1.0260.48
5_H66_Q1.0190.47
81_E88_R1.0170.47
50_N122_S1.0110.47
38_F73_V1.0080.46
18_N33_T0.9910.45
26_V40_L0.9860.45
43_P72_E0.9820.45
67_V101_D0.9820.45
71_E129_S0.9810.44
22_K85_F0.9630.43
6_V65_F0.9590.43
7_G48_T0.9410.42
5_H48_T0.9400.42
74_L78_K0.9350.41
9_N32_K0.9300.41
30_K115_F0.9200.40
77_K97_Y0.9050.39
50_N66_Q0.9040.39
86_F105_I0.9030.39
85_F105_I0.8990.39
14_E33_T0.8880.38
60_V111_N0.8850.38
76_H80_L0.8840.38
52_A112_E0.8810.38
26_V129_S0.8790.38
17_I36_A0.8750.38
71_E94_T0.8740.37
94_T122_S0.8630.37
63_F90_E0.8610.37
18_N22_K0.8600.37
57_G112_E0.8580.36
70_L101_D0.8540.36
41_E44_G0.8530.36
3_Y48_T0.8530.36
6_V120_S0.8480.36
57_G119_K0.8440.36
14_E21_E0.8390.35
17_I68_D0.8380.35
53_D56_K0.8380.35
85_F88_R0.8370.35
40_L72_E0.8220.34
83_E122_S0.8220.34
73_V118_T0.8210.34
21_E69_S0.8180.34
103_F112_E0.8170.34
7_G34_D0.8140.34
42_T72_E0.8090.33
32_K61_N0.8070.33
27_K75_K0.8060.33
26_V80_L0.7950.33
14_E129_S0.7950.33
21_E68_D0.7940.33
93_T105_I0.7870.32
103_F115_F0.7850.32
12_S33_T0.7790.32
38_F42_T0.7650.31
44_G85_F0.7560.30
4_V50_N0.7410.29
1_M23_V0.7290.29
57_G106_T0.7290.29
16_S25_G0.7280.29
24_F40_L0.7230.28
37_K47_F0.7180.28
16_S109_D0.7110.28
37_K50_N0.7100.28
74_L128_D0.7090.28
34_D51_V0.7080.28
127_Q131_S0.7080.28
49_L73_V0.7070.28
100_Q118_T0.7010.27
44_G63_F0.7000.27
9_N57_G0.6920.27
83_E131_S0.6910.27
5_H116_F0.6850.26
61_N109_D0.6810.26
60_V112_E0.6770.26
25_G78_K0.6740.26
17_I21_E0.6600.25
34_D46_N0.6590.25
3_Y39_L0.6550.25
46_N50_N0.6510.25
16_S93_T0.6480.24
2_K6_V0.6460.24
67_V97_Y0.6320.24
31_V45_L0.6310.24
9_N30_K0.6180.23
21_E26_V0.6170.23
76_H115_F0.6060.22
17_I130_S0.6030.22
11_V56_K0.5960.22
39_L46_N0.5950.22
5_H50_N0.5940.22
69_S86_F0.5940.22
63_F115_F0.5930.22
17_I42_T0.5880.22
13_L71_E0.5840.21
9_N52_A0.5840.21
29_V75_K0.5820.21
100_Q103_F0.5800.21
30_K80_L0.5780.21
65_F116_F0.5750.21
84_G136_P0.5740.21
41_E71_E0.5710.21
120_S123_E0.5670.21
92_D116_F0.5660.21
6_V63_F0.5640.21
39_L116_F0.5620.20
80_L115_F0.5610.20
128_D132_C0.5560.20
77_K103_F0.5520.20
60_V82_K0.5500.20
22_K83_E0.5480.20
1_M4_V0.5460.20
85_F92_D0.5460.20
7_G100_Q0.5410.20
11_V109_D0.5410.20
32_K89_E0.5400.19
82_K91_M0.5370.19
29_V44_G0.5320.19
80_L89_E0.5260.19
56_K78_K0.5250.19
45_L65_F0.5250.19
2_K41_E0.5240.19
16_S88_R0.5210.19
8_V47_F0.5140.18
67_V115_F0.5130.18
18_N105_I0.5070.18
15_K25_G0.5070.18
12_S28_A0.5070.18
77_K101_D0.5070.18
69_S101_D0.5050.18
78_K130_S0.5030.18
77_K81_E0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1xqaA 2 0.7603 99.7 0.732 Contact Map
2kjzA 2 0.7877 99.6 0.75 Contact Map
3rriA 3 0.8562 99.6 0.752 Contact Map
2rk0A 4 0.8356 99.6 0.753 Contact Map
4pavA 9 0.7671 99.6 0.756 Contact Map
1twuA 2 0.8288 99.5 0.757 Contact Map
4z04A 2 0.8219 99.5 0.758 Contact Map
3e5dA 2 0.7808 99.5 0.759 Contact Map
3l20A 2 0.8219 99.5 0.764 Contact Map
3vcxA 2 0.774 99.5 0.765 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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