GREMLIN Database
RAPE - Response regulator aspartate phosphatase E
UniProt: P45943 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 375 (296)
Sequences: 2272 (1965)
Seq/√Len: 114.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
192_N195_K4.7251.00
273_K276_Q4.5731.00
348_K351_D4.4261.00
234_N237_K4.3291.00
111_E114_R3.9191.00
184_A200_L3.7251.00
151_M154_I3.5981.00
226_G242_I3.5941.00
143_S159_A3.5091.00
103_G119_Y3.2071.00
312_D315_K3.0811.00
102_R106_E2.8071.00
339_G343_F2.7371.00
268_Y276_Q2.4781.00
139_Y158_Y2.4471.00
304_D320_F2.4041.00
239_A264_L2.3701.00
116_I146_Y2.3571.00
343_F351_D2.2891.00
264_L268_Y2.1891.00
351_D354_I2.1781.00
276_Q279_D2.1751.00
142_L146_Y2.1631.00
184_A203_A2.1431.00
225_L229_Y2.1111.00
239_A271_Q2.0961.00
119_Y141_K2.0831.00
197_L225_L2.0791.00
317_L343_F2.0441.00
222_F241_Y2.0351.00
265_A281_F2.0251.00
243_E264_L2.0171.00
120_K142_L1.9511.00
160_E183_I1.8951.00
269_F281_F1.8921.00
183_I187_Y1.8691.00
229_Y237_K1.8311.00
303_L307_Y1.8171.00
99_N118_Y1.8041.00
281_F302_A1.7801.00
187_Y195_K1.7691.00
142_L158_Y1.7571.00
106_E111_E1.7551.00
187_Y192_N1.7291.00
340_G356_F1.7011.00
239_A268_Y1.6911.00
336_A355_C1.6591.00
146_Y154_I1.6571.00
267_I271_Q1.6401.00
180_H199_H1.6161.00
197_L228_C1.6091.00
317_L339_G1.6061.00
265_A284_G1.5951.00
229_Y234_N1.5741.00
225_L241_Y1.5591.00
278_M282_R1.5281.00
239_A243_E1.5271.00
343_F355_C1.5231.00
261_Y280_C1.5171.00
343_F348_K1.5081.00
268_Y273_K1.4951.00
195_K198_P1.4751.00
140_F182_V1.4571.00
304_D323_L1.4511.00
278_M307_Y1.4421.00
106_E114_R1.4371.00
161_L164_N1.4311.00
321_S339_G1.4301.00
317_L321_S1.4301.00
315_K318_N1.4291.00
143_S158_Y1.4251.00
114_R117_T1.4161.00
181_F224_N1.3871.00
202_E205_K1.3821.00
197_L229_Y1.3821.00
264_L280_C1.3721.00
201_Q225_L1.3721.00
116_I142_L1.3621.00
261_Y283_K1.3601.00
237_K240_R1.3551.00
104_M119_Y1.3541.00
197_L201_Q1.3541.00
344_D357_K1.3371.00
242_I263_D1.3081.00
184_A199_H1.3061.00
184_A196_A1.2981.00
103_G122_A1.2981.00
162_S165_I1.2930.99
239_A267_I1.2910.99
307_Y315_K1.2860.99
197_L232_M1.2840.99
122_A125_K1.2800.99
146_Y151_M1.2570.99
340_G359_M1.2430.99
138_F142_L1.2320.99
159_A182_V1.2190.99
158_Y162_S1.2180.99
143_S162_S1.2180.99
185_G200_L1.2120.99
103_G107_F1.1880.99
180_H261_Y1.1790.99
268_Y280_C1.1710.99
278_M303_L1.1690.99
246_L257_L1.1620.99
47_D50_I1.1600.99
99_N121_K1.1560.99
183_I199_H1.1550.99
160_E195_K1.1480.99
236_N271_Q1.1460.99
162_S179_C1.1410.99
313_T346_N1.1360.99
319_I323_L1.1280.99
222_F245_A1.1170.98
123_E139_Y1.1170.98
79_Y82_K1.1100.98
200_L224_N1.1080.98
106_E118_Y1.1070.98
156_M186_N1.1000.98
219_A245_A1.0980.98
300_F319_I1.0930.98
241_Y245_A1.0930.98
196_A228_C1.0900.98
143_S155_S1.0860.98
49_L53_Q1.0680.98
119_Y122_A1.0630.98
79_Y83_I1.0610.98
226_G238_A1.0600.98
156_M187_Y1.0560.98
99_N122_A1.0530.98
344_D356_F1.0470.98
36_E39_I1.0420.98
221_A228_C1.0400.98
156_M183_I1.0330.97
116_I149_M1.0320.97
226_G245_A1.0260.97
265_A280_C1.0230.97
139_Y161_L1.0170.97
244_Q247_V1.0140.97
246_L261_Y1.0110.97
242_I264_L1.0070.97
116_I120_K1.0030.97
304_D307_Y1.0020.97
245_A260_A1.0010.97
159_A163_Y0.9930.97
335_L339_G0.9900.97
45_D48_L0.9850.97
47_D54_L0.9820.97
76_L79_Y0.9770.96
222_F244_Q0.9760.96
336_A359_M0.9720.96
139_Y162_S0.9720.96
224_N227_N0.9720.96
177_I207_A0.9690.96
246_L260_A0.9680.96
50_I58_R0.9680.96
319_I322_R0.9660.96
339_G355_C0.9630.96
262_H266_L0.9630.96
45_D49_L0.9610.96
40_E43_E0.9580.96
163_Y167_K0.9560.96
354_I358_K0.9560.96
245_A248_Q0.9530.96
304_D316_L0.9520.96
122_A138_F0.9510.96
156_M190_L0.9460.96
63_L67_L0.9380.96
181_F221_A0.9380.96
117_T121_K0.9300.95
81_N84_E0.9270.95
227_N263_D0.9240.95
140_F162_S0.9200.95
46_Q53_Q0.9190.95
333_E340_G0.9120.95
278_M306_L0.9080.95
48_L55_M0.9050.95
181_F203_A0.9040.95
355_C358_K0.9030.95
353_I357_K0.9000.94
227_N242_I0.9000.94
100_F104_M0.8990.94
110_G150_K0.8960.94
176_R180_H0.8940.94
350_E357_K0.8930.94
115_A119_Y0.8930.94
51_Y57_F0.8920.94
308_I342_L0.8900.94
353_I356_F0.8840.94
59_H62_M0.8810.94
258_P288_A0.8780.94
47_D57_F0.8750.94
45_D53_Q0.8720.93
107_F119_Y0.8720.93
262_H302_A0.8710.93
258_P284_G0.8700.93
59_H63_L0.8630.93
36_E44_E0.8580.93
47_D61_I0.8480.92
336_A358_K0.8480.92
54_L57_F0.8470.92
45_D51_Y0.8460.92
46_Q49_L0.8440.92
36_E40_E0.8410.92
166_Y169_H0.8320.92
48_L51_Y0.8320.92
143_S182_V0.8240.91
306_L310_N0.8210.91
73_R76_L0.8200.91
349_I353_I0.8190.91
222_F248_Q0.8190.91
301_E305_V0.8170.91
181_F185_G0.8160.91
200_L225_L0.8130.91
180_H202_E0.8110.91
305_V309_R0.8110.91
188_D228_C0.8090.91
244_Q248_Q0.8090.91
204_L222_F0.8040.90
54_L58_R0.8030.90
226_G241_Y0.8030.90
139_Y222_F0.7950.90
118_Y122_A0.7940.90
96_Y122_A0.7890.90
243_E276_Q0.7860.89
116_I145_V0.7830.89
104_M141_K0.7820.89
123_E138_F0.7780.89
153_H157_H0.7730.89
199_H203_A0.7720.88
300_F323_L0.7690.88
223_F260_A0.7680.88
278_M285_I0.7610.88
235_L267_I0.7600.88
146_Y307_Y0.7590.88
54_L70_D0.7580.88
258_P265_A0.7580.88
280_C284_G0.7560.87
180_H203_A0.7540.87
307_Y312_D0.7500.87
182_V185_G0.7490.87
136_A162_S0.7430.87
65_Y124_R0.7420.86
160_E187_Y0.7390.86
44_E48_L0.7370.86
140_F178_Q0.7360.86
39_I43_E0.7350.86
62_M65_Y0.7330.86
163_Y176_R0.7300.86
51_Y55_M0.7270.85
121_K124_R0.7250.85
230_H235_L0.7230.85
337_L340_G0.7230.85
191_E231_K0.7150.84
103_G118_Y0.7140.84
199_H202_E0.7120.84
207_A218_Y0.7110.84
58_R61_I0.7100.84
204_L218_Y0.7060.84
103_G115_A0.7030.83
300_F303_L0.7020.83
75_E82_K0.7010.83
317_L320_F0.7000.83
139_Y142_L0.6990.83
263_D266_L0.6960.83
199_H229_Y0.6960.83
51_Y54_L0.6920.82
120_K146_Y0.6920.82
65_Y69_S0.6880.82
302_A305_V0.6850.82
197_L234_N0.6850.82
188_D200_L0.6840.82
107_F112_Y0.6810.81
317_L346_N0.6810.81
116_I299_L0.6800.81
38_D43_E0.6760.81
242_I267_I0.6760.81
67_L70_D0.6740.81
194_E232_M0.6740.81
102_R118_Y0.6720.81
238_A242_I0.6710.80
51_Y58_R0.6670.80
152_T186_N0.6650.80
305_V338_L0.6640.80
236_N239_A0.6610.79
113_T149_M0.6610.79
107_F145_V0.6590.79
163_Y180_H0.6570.79
223_F226_G0.6520.78
83_I87_K0.6500.78
313_T316_L0.6490.78
149_M272_G0.6470.78
319_I329_Y0.6470.78
264_L339_G0.6440.78
284_G287_S0.6440.78
195_K199_H0.6440.78
101_F104_M0.6430.78
333_E359_M0.6420.77
344_D347_G0.6400.77
340_G344_D0.6380.77
93_M99_N0.6380.77
84_E87_K0.6380.77
263_D302_A0.6360.77
340_G343_F0.6350.77
75_E78_E0.6320.76
181_F223_F0.6290.76
100_F141_K0.6270.76
80_L84_E0.6250.76
241_Y244_Q0.6230.75
162_S167_K0.6190.75
115_A122_A0.6190.75
302_A307_Y0.6190.75
203_A221_A0.6190.75
65_Y68_P0.6190.75
297_M304_D0.6180.75
321_S325_N0.6180.75
44_E47_D0.6160.74
278_M310_N0.6140.74
53_Q56_A0.6120.74
274_K278_M0.6120.74
133_I139_Y0.6120.74
203_A265_A0.6100.74
308_I345_Y0.6090.74
320_F339_G0.6090.74
310_N318_N0.6090.74
277_A281_F0.6080.74
55_M58_R0.6060.73
282_R286_R0.6000.73
343_F346_N0.5990.72
296_F299_L0.5980.72
332_L336_A0.5970.72
320_F335_L0.5970.72
57_F66_T0.5960.72
103_G226_G0.5950.72
137_E141_K0.5940.72
158_Y161_L0.5940.72
356_F360_V0.5930.72
203_A206_G0.5910.71
167_K176_R0.5910.71
304_D338_L0.5900.71
184_A302_A0.5900.71
120_K124_R0.5900.71
234_N243_E0.5900.71
337_L341_N0.5870.71
157_H164_N0.5860.71
310_N315_K0.5850.71
36_E265_A0.5850.71
37_R44_E0.5840.71
96_Y101_F0.5830.70
269_F302_A0.5810.70
226_G304_D0.5810.70
283_K286_R0.5800.70
263_D267_I0.5790.70
140_F179_C0.5780.70
307_Y319_I0.5770.70
55_M61_I0.5770.70
187_Y199_H0.5740.69
60_K66_T0.5740.69
343_F356_F0.5680.68
331_Y334_E0.5680.68
123_E142_L0.5670.68
193_H228_C0.5670.68
119_Y227_N0.5660.68
147_Y186_N0.5650.68
147_Y159_A0.5640.68
52_Y58_R0.5640.68
64_E68_P0.5630.68
71_E76_L0.5620.68
223_F263_D0.5620.68
196_A200_L0.5610.67
258_P262_H0.5610.67
318_N321_S0.5600.67
156_M160_E0.5600.67
177_I203_A0.5590.67
141_K144_E0.5580.67
268_Y272_G0.5580.67
142_L145_V0.5570.67
229_Y268_Y0.5560.67
349_I352_S0.5560.67
289_V292_K0.5560.67
222_F261_Y0.5550.67
61_I69_S0.5540.67
57_F61_I0.5540.67
79_Y86_H0.5530.66
122_A323_L0.5530.66
60_K65_Y0.5510.66
39_I47_D0.5500.66
314_P317_L0.5490.66
296_F300_F0.5480.66
207_A217_I0.5480.66
180_H222_F0.5470.66
74_M86_H0.5470.66
167_K202_E0.5450.65
66_T69_S0.5440.65
282_R315_K0.5430.65
356_F359_M0.5400.65
316_L319_I0.5400.65
133_I145_V0.5400.65
154_I157_H0.5390.64
86_H89_K0.5390.64
57_F68_P0.5360.64
59_H68_P0.5330.64
334_E341_N0.5300.63
64_E80_L0.5290.63
95_A102_R0.5290.63
107_F141_K0.5280.63
55_M68_P0.5250.62
223_F259_Q0.5240.62
141_K149_M0.5230.62
106_E229_Y0.5230.62
43_E56_A0.5220.62
238_A267_I0.5210.62
302_A311_G0.5210.62
324_E358_K0.5210.62
115_A145_V0.5200.62
121_K125_K0.5200.62
179_C183_I0.5180.61
63_L68_P0.5180.61
218_Y257_L0.5180.61
70_D78_E0.5150.61
159_A179_C0.5150.61
53_Q290_D0.5150.61
78_E81_N0.5140.61
52_Y57_F0.5140.61
98_Y105_Y0.5130.61
37_R43_E0.5130.61
324_E339_G0.5130.61
201_Q237_K0.5120.60
60_K63_L0.5120.60
245_A284_G0.5090.60
185_G224_N0.5080.60
77_S86_H0.5080.60
100_F138_F0.5070.60
48_L64_E0.5050.59
106_E117_T0.5040.59
183_I303_L0.5040.59
58_R63_L0.5040.59
83_I88_K0.5030.59
262_H299_L0.5030.59
53_Q58_R0.5030.59
261_Y300_F0.5020.59
92_N99_N0.5020.59
59_H65_Y0.5010.59
136_A143_S0.5000.59
71_E74_M0.5000.59
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ulqA 1 0.976 100 0.268 Contact Map
4i1aA 2 0.9547 100 0.277 Contact Map
3q15A 2 0.9653 100 0.28 Contact Map
4gyoA 2 0.952 100 0.287 Contact Map
4gpkA 3 0.9093 100 0.345 Contact Map
1w3bA 2 0.8187 100 0.352 Contact Map
4l9pA 1 0.744 100 0.362 Contact Map
3dssA 1 0.7013 100 0.366 Contact Map
3q7aA 1 0.736 100 0.373 Contact Map
4ui9C 2 0.856 100 0.376 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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