GREMLIN Database
YQCG - Ribonuclease YqcG
UniProt: P45942 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 531 (466)
Sequences: 177 (120)
Seq/√Len: 5.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_D44_E4.2490.94
57_Y143_F3.6160.87
121_A127_N3.1480.78
78_L85_L2.9260.73
318_G335_A2.9090.72
456_V466_K2.8310.70
15_K82_P2.8150.70
426_K431_Y2.7780.69
250_N253_W2.6780.66
66_Q93_A2.5890.63
12_E37_V2.4460.58
442_R446_W2.4300.58
468_D471_W2.3900.56
121_A128_D2.3700.56
446_W450_K2.2820.53
89_N164_V2.2800.53
466_K470_P2.2660.52
124_D127_N2.2150.50
123_K134_P2.1850.49
440_G456_V2.1840.49
420_N428_P2.1270.47
415_S419_T2.1070.47
78_L204_Y2.0590.45
57_Y93_A2.0530.45
331_R335_A2.0400.45
471_W474_G2.0390.44
424_K430_T2.0340.44
432_K440_G2.0310.44
470_P474_G2.0260.44
34_F78_L1.9990.43
446_W474_G1.9770.42
451_D454_G1.9740.42
458_D465_M1.9620.42
467_K474_G1.9470.41
349_Q361_A1.9290.41
460_L466_K1.9220.41
96_E114_I1.9170.40
438_R458_D1.9120.40
459_P464_V1.8940.40
453_T456_V1.8910.40
415_S422_S1.8770.39
64_A164_V1.8750.39
455_S459_P1.8670.39
429_K432_K1.8640.39
94_Y222_K1.8610.39
335_A361_A1.8490.38
461_T465_M1.8400.38
451_D460_L1.8130.37
121_A134_P1.7860.36
438_R453_T1.7740.36
334_K337_D1.7720.36
448_N452_S1.7610.35
129_I138_F1.7600.35
467_K470_P1.7550.35
427_V452_S1.7530.35
448_N458_D1.7400.35
422_S431_Y1.7400.35
283_P288_K1.7210.34
461_T464_V1.7200.34
387_L402_I1.7080.34
78_L169_T1.7060.34
438_R449_A1.7060.34
422_S430_T1.6900.33
37_V145_N1.6820.33
442_R465_M1.6700.33
310_G375_G1.6670.33
15_K108_Y1.6630.32
430_T434_P1.6560.32
448_N460_L1.6560.32
464_V467_K1.6560.32
439_K448_N1.6480.32
465_M471_W1.6450.32
455_S464_V1.6300.31
450_K468_D1.6290.31
440_G451_D1.6150.31
436_Y452_S1.6130.31
109_T142_T1.6090.31
150_A154_R1.6070.31
57_Y84_F1.6050.31
461_T467_K1.6010.31
422_S434_P1.5920.30
319_G337_D1.5810.30
440_G444_K1.5800.30
440_G445_V1.5760.30
319_G380_K1.5730.30
456_V471_W1.5660.30
457_K467_K1.5510.29
450_K454_G1.5480.29
450_K458_D1.5350.29
386_S406_L1.5340.29
361_A378_V1.5270.28
461_T474_G1.5200.28
441_V447_E1.5160.28
116_S145_N1.5140.28
301_A305_Y1.5130.28
152_K169_T1.4950.28
458_D470_P1.4930.28
85_L113_S1.4820.27
440_G443_D1.4820.27
116_S120_K1.4800.27
436_Y441_V1.4780.27
121_A143_F1.4750.27
423_K430_T1.4750.27
430_T437_F1.4680.27
452_S458_D1.4670.27
452_S468_D1.4660.27
313_G318_G1.4610.27
415_S424_K1.4510.26
318_G331_R1.4450.26
444_K468_D1.4430.26
454_G458_D1.4420.26
459_P465_M1.4400.26
436_Y445_V1.4230.26
152_K183_Q1.4180.26
85_L164_V1.4080.25
351_S366_E1.4060.25
442_R460_L1.3950.25
425_P432_K1.3930.25
149_S183_Q1.3900.25
70_L88_A1.3830.25
426_K460_L1.3820.25
446_W458_D1.3820.25
459_P462_K1.3760.24
369_T373_M1.3740.24
458_D466_K1.3730.24
451_D457_K1.3680.24
466_K471_W1.3660.24
438_R446_W1.3660.24
422_S429_K1.3640.24
439_K444_K1.3620.24
456_V459_P1.3610.24
422_S432_K1.3600.24
421_T424_K1.3570.24
319_G325_T1.3560.24
27_M94_Y1.3540.24
120_K127_N1.3450.24
450_K471_W1.3300.23
430_T442_R1.3190.23
354_G357_G1.3160.23
463_Q471_W1.3110.23
314_K317_K1.3090.23
467_K471_W1.3070.23
35_K85_L1.3060.23
454_G468_D1.3040.23
284_V288_K1.3020.23
446_W460_L1.3010.23
81_I94_Y1.2940.22
249_A254_Y1.2890.22
449_A463_Q1.2870.22
416_E437_F1.2860.22
256_K287_E1.2820.22
128_D144_K1.2800.22
258_W261_V1.2780.22
452_S459_P1.2720.22
438_R447_E1.2700.22
313_G317_K1.2660.22
118_Q122_M1.2620.22
68_I75_I1.2620.22
121_A145_N1.2620.22
423_K456_V1.2580.22
440_G463_Q1.2500.21
441_V465_M1.2490.21
445_V463_Q1.2470.21
334_K338_V1.2460.21
118_Q139_S1.2440.21
438_R466_K1.2410.21
464_V470_P1.2370.21
449_A457_K1.2350.21
444_K447_E1.2320.21
128_D145_N1.2300.21
118_Q138_F1.2280.21
461_T466_K1.2280.21
37_V199_A1.2270.21
452_S462_K1.2240.21
447_E460_L1.2110.21
270_G294_R1.2110.21
314_K334_K1.2100.21
447_E456_V1.2030.20
35_K164_V1.1990.20
366_E371_R1.1940.20
458_D461_T1.1930.20
37_V222_K1.1880.20
324_S331_R1.1840.20
64_A89_N1.1820.20
452_S455_S1.1810.20
452_S461_T1.1800.20
333_D336_L1.1780.20
431_Y434_P1.1710.20
321_A324_S1.1670.20
355_L363_G1.1640.20
118_Q147_L1.1620.19
414_V424_K1.1620.19
14_E82_P1.1610.19
459_P468_D1.1600.19
12_E93_A1.1550.19
439_K443_D1.1430.19
434_P446_W1.1420.19
325_T345_F1.1380.19
444_K462_K1.1380.19
450_K459_P1.1370.19
417_A420_N1.1370.19
170_S191_N1.1360.19
145_N166_Q1.1320.19
118_Q129_I1.1310.19
454_G459_P1.1300.19
462_K465_M1.1300.19
3_V37_V1.1280.19
324_S335_A1.1230.19
57_Y133_L1.1150.18
436_Y448_N1.1130.18
317_K348_L1.1120.18
59_D185_D1.1120.18
14_E25_S1.1050.18
188_A191_N1.1030.18
54_K172_Y1.1020.18
37_V52_N1.1020.18
130_N143_F1.1000.18
429_K456_V1.0880.18
78_L108_Y1.0870.18
416_E420_N1.0850.18
450_K464_V1.0830.18
436_Y456_V1.0770.18
143_F146_E1.0730.18
46_S74_K1.0720.18
279_D288_K1.0700.18
328_A339_Y1.0670.18
461_T470_P1.0650.17
116_S143_F1.0610.17
452_S456_V1.0610.17
454_G460_L1.0590.17
445_V449_A1.0580.17
88_A184_A1.0570.17
290_T293_Q1.0570.17
446_W459_P1.0570.17
449_A456_V1.0560.17
250_N260_A1.0560.17
457_K463_Q1.0550.17
323_Y327_K1.0530.17
430_T445_V1.0530.17
440_G446_W1.0520.17
423_K431_Y1.0480.17
316_A335_A1.0480.17
443_D447_E1.0470.17
124_D133_L1.0460.17
415_S418_S1.0430.17
464_V474_G1.0410.17
444_K456_V1.0370.17
460_L464_V1.0370.17
437_F458_D1.0330.17
57_Y121_A1.0330.17
130_N134_P1.0330.17
313_G324_S1.0310.17
251_R254_Y1.0300.17
464_V471_W1.0280.17
127_N134_P1.0260.17
121_A144_K1.0210.17
441_V445_V1.0210.17
22_D94_Y1.0210.17
377_K380_K1.0190.17
286_G289_L1.0170.17
143_F155_K1.0130.16
442_R445_V1.0110.16
454_G461_T1.0100.16
452_S460_L1.0090.16
436_Y459_P1.0070.16
427_V432_K1.0060.16
448_N459_P1.0040.16
331_R343_K1.0030.16
64_A93_A1.0000.16
420_N438_R0.9970.16
121_A124_D0.9970.16
438_R467_K0.9870.16
466_K474_G0.9830.16
456_V470_P0.9820.16
427_V431_Y0.9810.16
169_T191_N0.9810.16
448_N461_T0.9760.16
431_Y437_F0.9740.16
446_W461_T0.9720.16
458_D474_G0.9700.16
57_Y66_Q0.9670.16
317_K341_T0.9580.15
451_D459_P0.9580.15
417_A422_S0.9530.15
116_S119_K0.9520.15
64_A190_M0.9500.15
456_V460_L0.9440.15
22_D27_M0.9440.15
453_T464_V0.9430.15
438_R450_K0.9430.15
431_Y440_G0.9420.15
463_Q467_K0.9410.15
423_K449_A0.9390.15
447_E468_D0.9380.15
457_K466_K0.9370.15
462_K468_D0.9360.15
446_W452_S0.9340.15
251_R255_E0.9340.15
152_K170_S0.9310.15
431_Y445_V0.9310.15
431_Y442_R0.9280.15
443_D450_K0.9260.15
423_K450_K0.9260.15
417_A434_P0.9250.15
420_N431_Y0.9230.15
277_A281_V0.9230.15
337_D348_L0.9210.15
436_Y442_R0.9190.15
255_E270_G0.9190.15
454_G457_K0.9180.15
440_G460_L0.9170.15
460_L470_P0.9170.15
316_A319_G0.9170.15
417_A446_W0.9160.15
95_I159_E0.9140.15
424_K434_P0.9120.15
439_K447_E0.9090.15
445_V457_K0.9020.14
123_K143_F0.9020.14
15_K158_I0.9010.14
406_L410_S0.9010.14
318_G378_V0.8990.14
357_G363_G0.8990.14
434_P450_K0.8980.14
460_L465_M0.8980.14
14_E85_L0.8960.14
130_N133_L0.8950.14
34_F164_V0.8920.14
432_K448_N0.8860.14
460_L471_W0.8850.14
436_Y444_K0.8850.14
376_N381_E0.8830.14
440_G465_M0.8810.14
418_S422_S0.8800.14
252_P264_F0.8780.14
465_M474_G0.8770.14
460_L468_D0.8760.14
451_D467_K0.8760.14
432_K446_W0.8720.14
464_V468_D0.8720.14
445_V450_K0.8720.14
453_T467_K0.8710.14
459_P471_W0.8700.14
455_S461_T0.8680.14
284_V324_S0.8680.14
10_L21_K0.8680.14
424_K441_V0.8670.14
75_I201_P0.8650.14
84_F141_E0.8600.14
436_Y447_E0.8570.14
85_L95_I0.8560.14
465_M470_P0.8560.14
453_T459_P0.8540.14
267_E289_L0.8530.14
452_S467_K0.8520.14
336_L339_Y0.8520.14
430_T450_K0.8510.14
12_E94_Y0.8500.14
456_V461_T0.8500.14
170_S222_K0.8490.14
418_S432_K0.8490.14
37_V61_A0.8480.14
328_A335_A0.8470.14
372_D377_K0.8460.14
283_P290_T0.8440.14
438_R465_M0.8430.14
424_K431_Y0.8420.14
438_R442_R0.8400.13
455_S470_P0.8400.13
425_P456_V0.8390.13
453_T466_K0.8370.13
440_G447_E0.8370.13
34_F70_L0.8360.13
468_D474_G0.8310.13
358_L375_G0.8260.13
313_G331_R0.8250.13
431_Y453_T0.8250.13
124_D134_P0.8230.13
338_V342_P0.8230.13
442_R450_K0.8220.13
462_K474_G0.8210.13
444_K466_K0.8210.13
453_T457_K0.8210.13
422_S427_V0.8190.13
416_E419_T0.8180.13
440_G455_S0.8160.13
41_D109_T0.8140.13
453_T458_D0.8130.13
36_A68_I0.8100.13
453_T463_Q0.8090.13
438_R448_N0.8090.13
434_P454_G0.8090.13
450_K457_K0.8090.13
129_I147_L0.8090.13
185_D204_Y0.8080.13
31_K61_A0.8040.13
426_K429_K0.8020.13
12_E68_I0.8020.13
404_K407_N0.8010.13
446_W455_S0.8000.13
442_R461_T0.8000.13
442_R451_D0.7970.13
16_R20_Y0.7960.13
37_V170_S0.7930.13
108_Y159_E0.7920.13
335_A339_Y0.7920.13
172_Y201_P0.7910.13
318_G345_F0.7900.13
433_R456_V0.7870.13
10_L35_K0.7870.13
457_K465_M0.7840.13
386_S395_V0.7830.13
418_S444_K0.7810.13
451_D461_T0.7790.13
276_R297_A0.7790.13
418_S423_K0.7700.12
273_D294_R0.7670.12
78_L164_V0.7660.12
426_K430_T0.7650.12
354_G378_V0.7620.12
97_E161_M0.7620.12
420_N456_V0.7620.12
441_V460_L0.7590.12
4_F17_A0.7570.12
438_R441_V0.7570.12
441_V446_W0.7560.12
417_A421_T0.7540.12
417_A432_K0.7530.12
452_S471_W0.7530.12
37_V113_S0.7500.12
457_K471_W0.7500.12
317_K334_K0.7490.12
438_R454_G0.7460.12
350_N386_S0.7450.12
449_A454_G0.7440.12
423_K438_R0.7420.12
437_F464_V0.7410.12
424_K428_P0.7400.12
48_K51_N0.7390.12
436_Y461_T0.7390.12
451_D466_K0.7360.12
432_K436_Y0.7360.12
369_T374_F0.7320.12
446_W451_D0.7290.12
453_T461_T0.7290.12
450_K455_S0.7290.12
155_K158_I0.7280.12
417_A426_K0.7280.12
425_P454_G0.7280.12
369_T378_V0.7270.12
424_K468_D0.7220.12
432_K451_D0.7210.12
313_G335_A0.7200.12
422_S440_G0.7190.12
439_K451_D0.7140.12
33_A98_T0.7120.12
419_T444_K0.7120.12
428_P444_K0.7120.12
437_F461_T0.7110.12
449_A471_W0.7110.12
14_E78_L0.7100.12
294_R306_I0.7090.12
111_S206_A0.7090.12
463_Q468_D0.7090.12
415_S434_P0.7070.11
46_S89_N0.7050.11
36_A94_Y0.7050.11
461_T471_W0.7040.11
430_T447_E0.7030.11
440_G453_T0.7030.11
441_V448_N0.7030.11
70_L82_P0.7020.11
425_P433_R0.7010.11
31_K119_K0.7000.11
436_Y458_D0.6940.11
418_S445_V0.6940.11
441_V459_P0.6930.11
433_R446_W0.6920.11
335_A376_N0.6910.11
392_A395_V0.6900.11
450_K460_L0.6890.11
350_N362_N0.6860.11
421_T431_Y0.6830.11
427_V456_V0.6830.11
453_T460_L0.6810.11
146_E151_E0.6810.11
363_G366_E0.6790.11
37_V68_I0.6770.11
444_K455_S0.6760.11
462_K471_W0.6750.11
421_T430_T0.6750.11
432_K455_S0.6750.11
118_Q130_N0.6750.11
68_I159_E0.6730.11
430_T438_R0.6730.11
428_P432_K0.6710.11
436_Y446_W0.6710.11
314_K318_G0.6700.11
453_T471_W0.6700.11
94_Y137_L0.6650.11
116_S144_K0.6650.11
323_Y372_D0.6620.11
116_S134_P0.6620.11
96_E110_K0.6610.11
333_D337_D0.6580.11
252_P295_V0.6560.11
91_S94_Y0.6560.11
426_K438_R0.6550.11
390_A407_N0.6550.11
419_T423_K0.6540.11
459_P470_P0.6540.11
421_T425_P0.6540.11
57_Y88_A0.6530.11
455_S460_L0.6530.11
425_P428_P0.6520.11
313_G316_A0.6510.11
459_P466_K0.6500.11
314_K325_T0.6500.11
438_R460_L0.6460.11
450_K453_T0.6450.11
432_K461_T0.6450.11
420_N430_T0.6430.11
318_G336_L0.6420.11
446_W463_Q0.6410.11
313_G323_Y0.6410.11
311_W343_K0.6390.11
317_K336_L0.6390.11
339_Y362_N0.6390.11
424_K449_A0.6390.11
25_S51_N0.6380.11
414_V431_Y0.6370.11
91_S137_L0.6370.11
307_P317_K0.6360.11
434_P466_K0.6360.11
447_E452_S0.6350.11
427_V430_T0.6340.11
272_Y286_G0.6330.11
120_K130_N0.6300.10
423_K454_G0.6300.10
85_L89_N0.6270.10
21_K148_S0.6270.10
4_F46_S0.6270.10
54_K118_Q0.6270.10
253_W257_S0.6250.10
89_N93_A0.6250.10
120_K133_L0.6250.10
421_T442_R0.6240.10
140_T147_L0.6220.10
428_P431_Y0.6210.10
312_A315_L0.6210.10
82_P108_Y0.6210.10
440_G457_K0.6200.10
447_E455_S0.6200.10
453_T468_D0.6180.10
418_S438_R0.6170.10
452_S465_M0.6150.10
443_D448_N0.6150.10
417_A423_K0.6120.10
50_A54_K0.6110.10
296_A299_A0.6100.10
437_F454_G0.6080.10
425_P438_R0.6070.10
278_A315_L0.6060.10
443_D454_G0.6050.10
419_T424_K0.6030.10
78_L88_A0.6010.10
433_R465_M0.6010.10
78_L89_N0.6000.10
460_L463_Q0.5990.10
430_T436_Y0.5990.10
430_T444_K0.5980.10
143_F147_L0.5980.10
429_K474_G0.5970.10
443_D451_D0.5970.10
459_P463_Q0.5950.10
44_E198_S0.5950.10
413_R446_W0.5940.10
318_G376_N0.5940.10
445_V474_G0.5930.10
448_N453_T0.5930.10
331_R337_D0.5910.10
94_Y134_P0.5900.10
439_K454_G0.5900.10
457_K461_T0.5900.10
78_L82_P0.5890.10
455_S465_M0.5880.10
144_K202_I0.5870.10
424_K456_V0.5870.10
446_W465_M0.5850.10
451_D456_V0.5830.10
449_A466_K0.5820.10
36_A109_T0.5820.10
327_K336_L0.5810.10
450_K474_G0.5810.10
434_P474_G0.5810.10
333_D340_K0.5800.10
36_A64_A0.5790.10
451_D455_S0.5760.10
321_A332_A0.5740.10
458_D464_V0.5730.10
91_S119_K0.5720.10
318_G361_A0.5710.10
462_K470_P0.5710.10
431_Y446_W0.5710.10
31_K79_T0.5700.10
418_S456_V0.5690.10
323_Y331_R0.5680.10
427_V439_K0.5660.10
444_K453_T0.5650.10
422_S459_P0.5650.10
444_K459_P0.5640.10
331_R347_A0.5640.10
358_L369_T0.5630.10
380_K383_Q0.5630.10
424_K427_V0.5620.10
448_N464_V0.5620.10
8_T82_P0.5610.10
445_V465_M0.5610.10
439_K461_T0.5600.10
439_K455_S0.5580.10
451_D470_P0.5580.10
235_Q244_E0.5580.10
447_E451_D0.5550.10
373_M378_V0.5550.10
21_K156_E0.5540.10
430_T448_N0.5540.10
324_S333_D0.5540.10
271_Y284_V0.5520.10
105_A146_E0.5500.09
337_D340_K0.5500.09
451_D465_M0.5490.09
386_S407_N0.5480.09
418_S449_A0.5470.09
319_G341_T0.5460.09
32_K150_A0.5450.09
107_A207_K0.5450.09
149_S155_K0.5450.09
3_V52_N0.5440.09
319_G323_Y0.5440.09
123_K133_L0.5420.09
313_G336_L0.5400.09
434_P440_G0.5400.09
455_S474_G0.5390.09
260_A265_T0.5390.09
418_S434_P0.5390.09
437_F456_V0.5380.09
37_V188_A0.5380.09
429_K448_N0.5380.09
423_K426_K0.5380.09
442_R453_T0.5360.09
434_P445_V0.5350.09
422_S426_K0.5350.09
334_K347_A0.5350.09
446_W466_K0.5340.09
313_G321_A0.5320.09
359_A363_G0.5320.09
68_I93_A0.5320.09
372_D376_N0.5310.09
427_V437_F0.5300.09
59_D204_Y0.5290.09
438_R470_P0.5290.09
54_K201_P0.5290.09
436_Y470_P0.5280.09
447_E459_P0.5270.09
37_V116_S0.5260.09
442_R454_G0.5260.09
377_K381_E0.5230.09
449_A452_S0.5220.09
423_K442_R0.5220.09
458_D468_D0.5220.09
438_R452_S0.5200.09
450_K462_K0.5200.09
432_K437_F0.5190.09
454_G474_G0.5180.09
134_P140_T0.5180.09
438_R443_D0.5170.09
424_K443_D0.5170.09
95_I220_D0.5170.09
421_T466_K0.5170.09
449_A455_S0.5160.09
336_L340_K0.5150.09
426_K462_K0.5150.09
440_G448_N0.5140.09
46_S70_L0.5140.09
89_N108_Y0.5130.09
323_Y339_Y0.5120.09
446_W454_G0.5120.09
417_A433_R0.5120.09
421_T456_V0.5110.09
336_L376_N0.5110.09
434_P464_V0.5100.09
317_K327_K0.5090.09
460_L474_G0.5070.09
447_E453_T0.5070.09
385_Q463_Q0.5040.09
417_A465_M0.5030.09
457_K460_L0.5020.09
392_A405_K0.5020.09
430_T467_K0.5000.09
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwoA 6 0.2712 81.5 0.97 Contact Map
2bk6A 6 0.2787 80.6 0.97 Contact Map
4m32A 6 0.2938 80.2 0.97 Contact Map
1jigA 6 0.2618 79 0.971 Contact Map
1o9rA 6 0.2957 78.1 0.971 Contact Map
3iq1A 6 0.2844 78 0.971 Contact Map
2chpA 6 0.2712 77.6 0.971 Contact Map
2yjkA 6 0.2881 77.2 0.971 Contact Map
1ji5A 6 0.2599 75.5 0.972 Contact Map
2fjcA 7 0.2806 75.5 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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