GREMLIN Database
YQCF - Antitoxin YqcF
UniProt: P45941 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (180)
Sequences: 100 (89)
Seq/√Len: 6.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
127_M172_L5.5290.99
77_A86_Y3.1790.85
45_P155_P3.1740.85
176_L181_I2.9130.80
48_G94_A2.8680.78
18_F109_I2.7050.74
125_H134_W2.4850.67
11_A22_P2.4510.66
62_I71_L2.4500.66
37_D150_W2.3350.62
52_Y182_D2.2590.59
18_F51_S2.2220.58
18_F76_V2.1960.57
172_L176_L2.1770.56
101_N152_M2.0230.51
50_T180_Q2.0000.50
109_I164_A1.8820.45
75_I93_C1.8700.45
125_H151_L1.8370.44
98_I128_F1.8040.43
106_P125_H1.7170.39
45_P51_S1.6970.39
127_M138_L1.6910.39
165_E191_V1.6780.38
74_E188_R1.6620.38
91_S183_I1.6600.37
114_I125_H1.6450.37
54_T75_I1.6360.37
75_I153_A1.6350.37
11_A20_G1.5990.35
20_G150_W1.5810.35
56_G168_G1.4920.32
172_L181_I1.4750.31
54_T151_L1.4360.30
111_K126_I1.4070.29
90_L98_I1.4030.29
104_C163_V1.3990.29
126_I145_N1.3920.29
164_A172_L1.3910.29
88_N117_Y1.3750.28
142_E166_K1.3600.28
128_F152_M1.3570.28
157_S190_S1.3390.27
106_P151_L1.3380.27
51_S127_M1.3270.27
43_D75_I1.3240.27
38_I175_L1.3240.27
159_G190_S1.3220.27
160_E188_R1.3110.26
74_E160_E1.3110.26
100_S148_V1.2840.25
38_I135_E1.2750.25
77_A87_A1.2720.25
58_S173_Q1.2710.25
170_D175_L1.2570.25
11_A26_K1.2280.24
34_S99_N1.2240.24
76_V185_D1.2180.24
173_Q182_D1.2150.24
87_A190_S1.1990.23
29_D95_F1.1840.23
71_L149_T1.1820.23
100_S187_K1.1760.23
141_L154_L1.1750.23
68_G174_D1.1750.23
62_I72_R1.1660.22
51_S183_I1.1550.22
43_D174_D1.1520.22
96_N128_F1.1490.22
14_V21_K1.1490.22
39_L53_S1.1480.22
55_L86_Y1.1460.22
16_G68_G1.1270.21
62_I110_F1.1150.21
22_P37_D1.1150.21
73_I114_I1.1120.21
53_S185_D1.1120.21
60_H82_A1.1010.21
36_I132_F1.0980.21
175_L179_K1.0820.20
74_E131_P1.0740.20
131_P188_R1.0740.20
88_N106_P1.0690.20
53_S110_F1.0670.20
111_K115_S1.0580.20
129_V186_I1.0520.19
94_A113_V1.0480.19
58_S104_C1.0480.19
60_H67_N1.0400.19
138_L161_L1.0290.19
82_A119_Q1.0290.19
22_P150_W1.0240.19
148_V153_A1.0240.19
126_I184_F1.0220.19
14_V39_L1.0210.19
132_F152_M1.0090.18
95_F151_L1.0080.18
32_K162_Q1.0030.18
156_I163_V0.9910.18
13_T16_G0.9900.18
159_G167_H0.9810.18
29_D99_N0.9810.18
29_D97_I0.9800.18
50_T72_R0.9600.17
59_D154_L0.9590.17
115_S126_I0.9500.17
55_L156_I0.9470.17
155_P172_L0.9380.17
96_N187_K0.9360.17
78_A164_A0.9200.17
88_N92_T0.9150.16
132_F153_A0.9090.16
48_G64_Y0.9090.16
83_S184_F0.9070.16
123_M186_I0.9040.16
53_S112_N0.9030.16
110_F135_E0.9020.16
13_T126_I0.8930.16
92_T117_Y0.8870.16
52_Y90_L0.8800.16
92_T190_S0.8760.16
106_P114_I0.8760.16
32_K190_S0.8700.16
106_P148_V0.8660.15
52_Y118_D0.8530.15
32_K126_I0.8510.15
168_G188_R0.8480.15
74_E168_G0.8480.15
54_T145_N0.8480.15
57_L107_G0.8370.15
129_V165_E0.8370.15
70_P164_A0.8310.15
148_V186_I0.8290.15
89_V176_L0.8180.15
62_I138_L0.8100.14
45_P142_E0.8100.14
119_Q154_L0.8080.14
58_S112_N0.8070.14
63_N113_V0.8070.14
82_A97_I0.8050.14
12_R16_G0.8040.14
148_V185_D0.8020.14
65_E137_D0.8000.14
27_Y41_V0.7990.14
16_G23_K0.7940.14
111_K114_I0.7930.14
134_W151_L0.7920.14
158_E180_Q0.7910.14
93_C138_L0.7860.14
126_I131_P0.7840.14
80_E148_V0.7770.14
153_A172_L0.7680.14
51_S119_Q0.7670.14
10_I103_T0.7650.14
16_G165_E0.7630.14
13_T17_A0.7600.14
73_I89_V0.7600.14
152_M183_I0.7600.14
123_M157_S0.7530.13
27_Y88_N0.7530.13
62_I149_T0.7530.13
73_I151_L0.7460.13
134_W157_S0.7460.13
95_F148_V0.7450.13
76_V144_S0.7430.13
106_P152_M0.7390.13
67_N145_N0.7340.13
37_D117_Y0.7290.13
129_V164_A0.7290.13
81_S187_K0.7280.13
123_M133_L0.7270.13
10_I25_T0.7270.13
104_C144_S0.7260.13
10_I34_S0.7240.13
95_F181_I0.7230.13
73_I152_M0.7210.13
120_E142_E0.7200.13
49_I181_I0.7180.13
20_G39_L0.7120.13
51_S109_I0.7080.13
154_L169_S0.7000.12
39_L75_I0.6970.12
55_L169_S0.6950.12
36_I56_G0.6880.12
11_A150_W0.6870.12
89_V183_I0.6870.12
13_T73_I0.6850.12
57_L185_D0.6810.12
103_T154_L0.6810.12
155_P186_I0.6810.12
82_A135_E0.6780.12
12_R174_D0.6720.12
67_N73_I0.6710.12
131_P160_E0.6690.12
38_I88_N0.6690.12
56_G173_Q0.6680.12
180_Q190_S0.6670.12
35_S167_H0.6640.12
125_H150_W0.6610.12
151_L157_S0.6560.12
77_A170_D0.6550.12
53_S121_T0.6540.12
65_E111_K0.6540.12
166_K187_K0.6530.12
69_T174_D0.6530.12
148_V155_P0.6520.12
69_T82_A0.6500.12
147_N178_S0.6420.12
134_W183_I0.6380.12
134_W156_I0.6370.12
31_N143_F0.6360.11
67_N110_F0.6350.11
91_S116_M0.6300.11
54_T74_E0.6290.11
54_T188_R0.6290.11
89_V170_D0.6280.11
94_A132_F0.6260.11
39_L44_Q0.6230.11
62_I102_F0.6190.11
121_T163_V0.6180.11
133_L183_I0.6160.11
11_A129_V0.6130.11
12_R52_Y0.6120.11
110_F126_I0.6110.11
105_A127_M0.6090.11
139_E147_N0.6010.11
68_G82_A0.6000.11
60_H166_K0.5930.11
132_F178_S0.5910.11
90_L160_E0.5870.11
120_E189_E0.5860.11
19_G39_L0.5790.11
13_T23_K0.5790.11
67_N167_H0.5730.11
166_K171_Y0.5680.10
158_E162_Q0.5670.10
10_I77_A0.5670.10
56_G182_D0.5670.10
12_R120_E0.5660.10
144_S171_Y0.5590.10
45_P50_T0.5580.10
27_Y183_I0.5580.10
38_I182_D0.5580.10
165_E171_Y0.5550.10
99_N119_Q0.5500.10
61_S79_M0.5480.10
29_D50_T0.5460.10
106_P158_E0.5420.10
69_T126_I0.5410.10
141_L156_I0.5390.10
144_S191_V0.5390.10
63_N78_A0.5340.10
55_L134_W0.5340.10
63_N138_L0.5300.10
93_C154_L0.5300.10
166_K174_D0.5270.10
67_N126_I0.5270.10
90_L161_L0.5260.10
64_Y112_N0.5240.10
55_L191_V0.5220.10
14_V17_A0.5190.10
95_F128_F0.5180.10
76_V86_Y0.5170.10
14_V170_D0.5140.10
110_F182_D0.5110.10
15_L20_G0.5080.10
120_E166_K0.5050.10
48_G170_D0.5040.10
63_N71_L0.5040.10
67_N154_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3k5jA 1 0.9062 100 0.527 Contact Map
4kmaA 1 0.9688 99.9 0.656 Contact Map
4bl9A 1 0.9792 99.9 0.662 Contact Map
4kmdA 2 0.974 99.9 0.665 Contact Map
4km9A 1 0.974 99.8 0.695 Contact Map
4hs5A 1 0.1875 26.9 0.953 Contact Map
3oeqA 3 0.276 20.7 0.956 Contact Map
4jpdA 5 0.1927 14.8 0.958 Contact Map
3t3lA 1 0.1927 8.9 0.962 Contact Map
1ez4A 4 0.8438 6.7 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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