GREMLIN Database
YQCA - Uncharacterized protein YqcA
UniProt: P45936 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 192 (170)
Sequences: 393 (347)
Seq/√Len: 26.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
45_Q52_T4.9431.00
156_P173_A4.4861.00
165_L173_A4.3261.00
156_P165_L4.1141.00
49_T80_I3.7081.00
112_L115_E3.6801.00
118_F141_K3.6431.00
15_L21_M2.7421.00
70_D78_R2.7180.99
55_L79_L2.6420.99
41_D52_T2.6340.99
51_A55_L2.5840.99
45_Q53_W2.4300.99
62_L83_M2.2100.98
41_D45_Q2.1300.97
67_E70_D2.0360.96
160_K177_K1.9810.96
164_I167_N1.9570.95
11_L25_L1.8730.94
59_E75_R1.8610.94
173_A177_K1.8580.94
171_R175_E1.8460.93
55_L76_R1.8420.93
118_F145_L1.8330.93
23_E26_K1.8130.93
55_L72_D1.7410.91
160_K169_R1.6650.89
48_V79_L1.6470.89
138_E141_K1.6040.87
14_F17_K1.5850.87
48_V83_M1.5690.86
141_K147_Y1.5630.86
163_V168_R1.5490.85
95_E99_N1.5400.85
137_L147_Y1.5340.85
9_A79_L1.5210.84
7_M25_L1.4660.82
58_W83_M1.4450.81
25_L28_E1.4350.81
157_L166_N1.3910.78
160_K171_R1.3600.77
173_A176_L1.3470.76
171_R177_K1.3420.76
169_R176_L1.3330.75
41_D53_W1.3260.75
165_L171_R1.3070.74
165_L175_E1.2810.72
15_L24_L1.2490.70
142_P145_L1.2120.68
170_Y174_S1.2110.68
91_Y111_L1.1940.67
126_D149_L1.1930.67
168_R173_A1.1880.66
48_V62_L1.1830.66
6_E33_E1.1680.65
46_L144_H1.1660.65
165_L172_K1.1590.64
10_Y31_E1.1540.64
7_M29_A1.1500.64
27_A40_F1.1470.64
101_F133_L1.1350.63
74_I78_R1.1300.62
170_Y177_K1.1130.61
51_A76_R1.1040.61
168_R171_R1.0960.60
165_L169_R1.0880.59
169_R177_K1.0820.59
163_V171_R1.0730.58
171_R174_S1.0500.57
160_K174_S1.0300.55
71_T81_S1.0270.55
82_K139_N1.0260.55
170_Y176_L1.0220.55
165_L176_L1.0140.54
50_T76_R1.0100.54
8_T22_A1.0100.54
95_E108_Q0.9950.53
118_F147_Y0.9930.53
111_L145_L0.9910.52
53_W82_K0.9870.52
169_R175_E0.9850.52
157_L160_K0.9810.52
28_E32_F0.9750.51
29_A33_E0.9740.51
119_K150_R0.9730.51
6_E79_L0.9660.50
171_R176_L0.9610.50
170_Y175_E0.9520.49
133_L149_L0.9490.49
45_Q58_W0.9480.49
15_L18_L0.9470.49
127_M151_A0.9470.49
160_K173_A0.9400.49
159_I176_L0.9250.47
88_P111_L0.9130.47
53_W144_H0.9050.46
158_Q174_S0.9000.46
165_L168_R0.8800.44
169_R174_S0.8780.44
137_L141_K0.8760.44
8_T25_L0.8660.43
90_T116_Y0.8650.43
156_P177_K0.8530.42
165_L177_K0.8530.42
160_K166_N0.8470.42
156_P175_E0.8380.41
62_L79_L0.8350.41
84_S97_A0.8310.41
54_G66_R0.8270.40
167_N175_E0.8200.40
118_F138_E0.8180.40
85_N139_N0.8180.40
99_N119_K0.8170.40
70_D132_E0.8090.39
167_N171_R0.8030.39
102_L124_I0.8020.38
110_R120_V0.7980.38
163_V173_A0.7970.38
160_K168_R0.7950.38
27_A38_S0.7950.38
112_L117_R0.7940.38
169_R173_A0.7910.38
89_A92_R0.7830.37
167_N170_Y0.7700.36
134_I149_L0.7700.36
45_Q54_G0.7690.36
6_E29_A0.7670.36
126_D130_M0.7580.35
77_L100_R0.7560.35
64_V111_L0.7550.35
155_E158_Q0.7390.34
70_D74_I0.7360.34
162_T166_N0.7350.34
45_Q144_H0.7340.34
156_P168_R0.7310.34
166_N175_E0.7300.33
56_E66_R0.7280.33
89_A98_L0.7260.33
162_T177_K0.7210.33
163_V170_Y0.7200.33
159_I168_R0.7140.32
155_E175_E0.7120.32
151_A156_P0.7120.32
120_V155_E0.7110.32
73_E120_V0.7090.32
17_K30_P0.7050.32
116_Y145_L0.7040.32
121_D150_R0.7030.32
54_G58_W0.7020.32
103_K120_V0.6990.31
159_I163_V0.6940.31
156_P160_K0.6870.31
165_L170_Y0.6860.31
138_E147_Y0.6860.31
48_V107_A0.6850.31
98_L124_I0.6810.30
131_S134_I0.6810.30
17_K22_A0.6780.30
112_L119_K0.6710.30
31_E47_F0.6650.29
107_A126_D0.6630.29
157_L174_S0.6620.29
166_N176_L0.6610.29
94_I109_V0.6600.29
41_D58_W0.6580.29
151_A173_A0.6580.29
47_F59_E0.6470.28
8_T15_L0.6450.28
101_F130_M0.6440.28
109_V120_V0.6430.28
102_L123_D0.6420.28
6_E9_A0.6360.28
163_V167_N0.6350.27
7_M18_L0.6340.27
174_S177_K0.6340.27
45_Q82_K0.6300.27
26_K32_F0.6290.27
88_P144_H0.6270.27
119_K148_T0.6220.27
31_E54_G0.6220.27
94_I106_S0.6210.27
97_A118_F0.6160.26
20_E28_E0.6160.26
9_A29_A0.6050.26
46_L94_I0.6030.26
159_I177_K0.5980.25
167_N177_K0.5960.25
21_M92_R0.5960.25
162_T170_Y0.5910.25
154_N176_L0.5910.25
91_Y109_V0.5890.25
77_L130_M0.5870.25
98_L127_M0.5820.24
64_V95_E0.5770.24
51_A54_G0.5750.24
73_E76_R0.5750.24
160_K176_L0.5740.24
89_A93_A0.5740.24
121_D154_N0.5730.24
99_N112_L0.5720.24
81_S154_N0.5700.24
162_T168_R0.5660.24
27_A159_I0.5650.24
114_G162_T0.5640.23
49_T78_R0.5640.23
48_V80_I0.5620.23
156_P176_L0.5620.23
56_E79_L0.5620.23
135_E140_M0.5620.23
18_L21_M0.5600.23
54_G137_L0.5580.23
22_A26_K0.5560.23
155_E160_K0.5560.23
20_E144_H0.5560.23
158_Q167_N0.5510.23
133_L140_M0.5490.23
11_L57_R0.5450.22
108_Q124_I0.5450.22
14_F36_N0.5440.22
126_D131_S0.5440.22
30_P36_N0.5430.22
24_L60_K0.5430.22
169_R172_K0.5400.22
94_I130_M0.5400.22
163_V169_R0.5400.22
98_L102_L0.5380.22
166_N172_K0.5370.22
163_V175_E0.5370.22
8_T16_T0.5360.22
50_T90_T0.5350.22
32_F158_Q0.5350.22
102_L106_S0.5330.22
89_A113_P0.5310.22
47_F75_R0.5300.22
98_L137_L0.5300.22
7_M20_E0.5290.22
156_P171_R0.5200.21
10_Y20_E0.5180.21
84_S100_R0.5180.21
8_T14_F0.5180.21
98_L103_K0.5160.21
156_P163_V0.5150.21
17_K137_L0.5140.21
66_R69_G0.5120.21
89_A94_I0.5110.21
44_D57_R0.5080.21
157_L171_R0.5070.21
27_A73_E0.5050.20
68_S137_L0.5030.20
164_I170_Y0.5020.20
115_E145_L0.5020.20
22_A33_E0.5010.20
88_P98_L0.5010.20
85_N98_L0.5000.20
87_P98_L0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vlfB 1 0.3646 33.4 0.938 Contact Map
3kw6A 1 0.3698 14.9 0.947 Contact Map
4jpoC 1 0.375 14.3 0.948 Contact Map
3ajiB 1 0.3646 12 0.95 Contact Map
3n4sA 2 0.2031 10.6 0.951 Contact Map
5afrA 2 0 9.6 0.952 Contact Map
3chbD 3 0.4375 7.4 0.954 Contact Map
4q86A 3 0.4844 6.7 0.955 Contact Map
3smaA 2 0.5208 6.5 0.955 Contact Map
1oksA 1 0.276 5.9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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